JP6793640B2 - Ｈｓｐ９０阻害物質およびｈｓｐ７０誘導物質としての修飾エーテル基を有するビフェニルアミド - Google Patents

Ｈｓｐ９０阻害物質およびｈｓｐ７０誘導物質としての修飾エーテル基を有するビフェニルアミド Download PDF

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JP6793640B2
JP6793640B2 JP2017520743A JP2017520743A JP6793640B2 JP 6793640 B2 JP6793640 B2 JP 6793640B2 JP 2017520743 A JP2017520743 A JP 2017520743A JP 2017520743 A JP2017520743 A JP 2017520743A JP 6793640 B2 JP6793640 B2 JP 6793640B2
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JP2017521496A (ja
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ブライアン エス．ジェイ． ブラッグ
ブライアン エス．ジェイ． ブラッグ
リック ティー． ドブロフスキー
リック ティー． ドブロフスキー
メーシー アニカ
メーシー アニカ
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ザ ユニバーシティ オブ カンザス
ザ ユニバーシティ オブ カンザス
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    • C07—ORGANIC CHEMISTRY
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
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    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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JP2017520743A 2014-06-24 2015-06-24 Ｈｓｐ９０阻害物質およびｈｓｐ７０誘導物質としての修飾エーテル基を有するビフェニルアミド Active JP6793640B2 (ja)

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US201462016473P 2014-06-24 2014-06-24
US62/016,473 2014-06-24
PCT/US2015/037478 WO2015200514A2 (en) 2014-06-24 2015-06-24 Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers

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JP2020186914A Active JP7105851B2 (ja) 2014-06-24 2020-11-10 Ｈｓｐ９０阻害物質およびｈｓｐ７０誘導物質としての修飾エーテル基を有するビフェニルアミド

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CN (1) CN106536498A (enExample)
AU (2) AU2015279926B2 (enExample)
CA (2) CA3289739A1 (enExample)
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CA3289739A1 (en) 2014-06-24 2025-11-29 The University Of Kansas Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers
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CA3289739A1 (en) 2014-06-24 2025-11-29 The University Of Kansas Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers

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JP2017521496A (ja) 2017-08-03
WO2015200514A2 (en) 2015-12-30
KR20170035911A (ko) 2017-03-31
CO2017000552A2 (es) 2017-04-28
MX2016017133A (es) 2018-01-12
BR112016029672A2 (pt) 2017-08-22
SG10201811574YA (en) 2019-01-30
US11098008B2 (en) 2021-08-24
SG11201610677XA (en) 2017-01-27
EP4494702A2 (en) 2025-01-22
CA2952029C (en) 2026-04-07
US11708319B2 (en) 2023-07-25
US10590065B2 (en) 2020-03-17
AU2021200969B2 (en) 2022-08-04
IL249712B (en) 2021-04-29
CA2952029A1 (en) 2015-12-30
CN106536498A (zh) 2017-03-22
AU2015279926B2 (en) 2020-12-24
MX388516B (es) 2025-03-20
WO2015200514A3 (en) 2016-02-25
US20220041543A1 (en) 2022-02-10
CL2016003276A1 (es) 2017-05-26
KR102536408B1 (ko) 2023-05-23
JP7105851B2 (ja) 2022-07-25
AU2015279926A1 (en) 2017-02-16
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US20200270201A1 (en) 2020-08-27
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IL249712A0 (en) 2017-02-28
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NZ728482A (en) 2022-11-25
EA201790070A1 (ru) 2017-10-31
EP4494702A3 (en) 2025-02-26
US20180057446A1 (en) 2018-03-01
AU2021200969A1 (en) 2021-03-11
JP2021042217A (ja) 2021-03-18
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EP3160977A2 (en) 2017-05-03

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