JP6788028B2 - アフィニティークロマトグラフ装置 - Google Patents
アフィニティークロマトグラフ装置 Download PDFInfo
- Publication number
- JP6788028B2 JP6788028B2 JP2018552179A JP2018552179A JP6788028B2 JP 6788028 B2 JP6788028 B2 JP 6788028B2 JP 2018552179 A JP2018552179 A JP 2018552179A JP 2018552179 A JP2018552179 A JP 2018552179A JP 6788028 B2 JP6788028 B2 JP 6788028B2
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- affinity
- particle size
- inorganic particles
- housing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012528 membrane Substances 0.000 claims description 245
- 239000010954 inorganic particle Substances 0.000 claims description 136
- 229920006254 polymer film Polymers 0.000 claims description 129
- 239000002245 particle Substances 0.000 claims description 128
- 239000002131 composite material Substances 0.000 claims description 95
- 102000004169 proteins and genes Human genes 0.000 claims description 91
- 108090000623 proteins and genes Proteins 0.000 claims description 91
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 74
- 239000000203 mixture Substances 0.000 claims description 62
- 239000003446 ligand Substances 0.000 claims description 50
- -1 polypropylene Polymers 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 48
- 229920005597 polymer membrane Polymers 0.000 claims description 38
- 229920001169 thermoplastic Polymers 0.000 claims description 35
- 239000012530 fluid Substances 0.000 claims description 32
- 239000004743 Polypropylene Substances 0.000 claims description 29
- 229920001155 polypropylene Polymers 0.000 claims description 29
- 230000027455 binding Effects 0.000 claims description 28
- 239000007787 solid Substances 0.000 claims description 24
- 239000000377 silicon dioxide Substances 0.000 claims description 20
- 150000002118 epoxides Chemical class 0.000 claims description 11
- 229920002313 fluoropolymer Polymers 0.000 claims description 11
- 239000004811 fluoropolymer Substances 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 7
- 229920001282 polysaccharide Polymers 0.000 claims description 7
- 239000005017 polysaccharide Substances 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 239000010457 zeolite Substances 0.000 claims description 4
- 102000009109 Fc receptors Human genes 0.000 claims description 3
- 108010087819 Fc receptors Proteins 0.000 claims description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 3
- 229910021536 Zeolite Inorganic materials 0.000 claims description 3
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 239000011737 fluorine Substances 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- 229910044991 metal oxide Inorganic materials 0.000 claims description 3
- 150000004706 metal oxides Chemical class 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 101710120037 Toxin CcdB Proteins 0.000 claims 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 2
- 239000004812 Fluorinated ethylene propylene Substances 0.000 claims 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims 1
- 229920009441 perflouroethylene propylene Polymers 0.000 claims 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 84
- 239000010408 film Substances 0.000 description 81
- 239000000243 solution Substances 0.000 description 81
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 71
- 239000004810 polytetrafluoroethylene Substances 0.000 description 71
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 52
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 48
- 239000008367 deionised water Substances 0.000 description 48
- 229910021641 deionized water Inorganic materials 0.000 description 48
- 229910000029 sodium carbonate Inorganic materials 0.000 description 42
- 239000000872 buffer Substances 0.000 description 33
- 239000010409 thin film Substances 0.000 description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 24
- 230000008569 process Effects 0.000 description 18
- 238000009472 formulation Methods 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 14
- 238000002835 absorbance Methods 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 12
- 150000001299 aldehydes Chemical group 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000008351 acetate buffer Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000004804 winding Methods 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 7
- 238000010998 test method Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 229910000033 sodium borohydride Inorganic materials 0.000 description 6
- 239000012279 sodium borohydride Substances 0.000 description 6
- 102000014914 Carrier Proteins Human genes 0.000 description 5
- 108091008324 binding proteins Proteins 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 5
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000001042 affinity chromatography Methods 0.000 description 4
- 239000003518 caustics Substances 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 229920000098 polyolefin Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 4
- 238000000935 solvent evaporation Methods 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- BPSIOYPQMFLKFR-UHFFFAOYSA-N trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CO[Si](OC)(OC)CCCOCC1CO1 BPSIOYPQMFLKFR-UHFFFAOYSA-N 0.000 description 4
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 229910000077 silane Inorganic materials 0.000 description 3
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- PTIBVSAWRDGWAE-UHFFFAOYSA-K trisodium;phosphate;heptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O PTIBVSAWRDGWAE-UHFFFAOYSA-K 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 229920000936 Agarose Polymers 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- XBTFCKDUEPHYJN-UHFFFAOYSA-N CO[SiH](OC)OC.C(CCC)=O Chemical compound CO[SiH](OC)OC.C(CCC)=O XBTFCKDUEPHYJN-UHFFFAOYSA-N 0.000 description 2
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000005352 clarification Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 229920001187 thermosetting polymer Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 108091006020 Fc-tagged proteins Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 229920005603 alternating copolymer Polymers 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- GANXFQTZEVGPPI-UHFFFAOYSA-N fluorosulfonyloxyethene Chemical compound FS(=O)(=O)OC=C GANXFQTZEVGPPI-UHFFFAOYSA-N 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 229920000052 poly(p-xylylene) Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000004634 thermosetting polymer Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/10—Spiral-wound membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
- B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
- B01D69/148—Organic/inorganic mixed matrix membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/02—Inorganic material
- B01D71/024—Oxides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/02—Inorganic material
- B01D71/028—Molecular sieves
- B01D71/0281—Zeolites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/04—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
- B01J20/048—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium containing phosphorus, e.g. phosphates, apatites, hydroxyapatites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/16—Alumino-silicates
- B01J20/18—Synthetic zeolitic molecular sieves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28028—Particles immobilised within fibres or filaments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
- B01J20/28035—Membrane, sheet, cloth, pad, lamellar or mat with more than one layer, e.g. laminates, separated sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2319/00—Membrane assemblies within one housing
- B01D2319/04—Elements in parallel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/02—Inorganic material
- B01D71/024—Oxides
- B01D71/027—Silicium oxide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N2030/524—Physical parameters structural properties
- G01N2030/527—Physical parameters structural properties sorbent material in form of a membrane
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6017—Fluid distributors
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Manufacturing & Machinery (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Geology (AREA)
- Dispersion Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Description
試験方法
10%のブレークスルーで動的結合能力を判定する方法
実施例
実施例1−積層膜
実施例2−螺旋巻き膜
実施例3
実施例4
実施例5−多孔質シリカ混合物を含む積層膜装置
実施例6−多孔質シリカ混合物を含む螺旋巻き膜装置
Claims (38)
- 筐体、
流体の前記筐体への流入を可能にする入口、
前記筐体の両端に配置された第1および第2の流れ分配器、
流体の前記筐体からの流出を可能にする出口、ならびに
前記筐体内に配置された巻き膜複合体を含み、前記巻き膜複合体は
少なくとも1つの公称粒径を有する無機粒子を含有する少なくとも1つの高分子膜、ここで前記高分子膜は発泡フッ素系高分子膜である、および
少なくとも1つの非透過性層を含み、
前記高分子膜および前記無機粒子のうちの少なくとも一方は親和性リガンドと共有結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、アフィニティークロマトグラフ装置。 - 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項1に記載のアフィニティークロマトグラフ装置。
- 前記無機粒子はシリカ、ゼオライト、ヒドロキシアパタイト、金属酸化物、およびこれらの組み合わせから選択される、請求項1に記載のアフィニティークロマトグラフ装置。
- 前記無機粒子は単一の公称粒径を有する、請求項1に記載のアフィニティークロマトグラフ装置。
- 前記無機粒子は第1の公称粒径を有するものと第2の公称粒径を有するものを含む、請求項1に記載のアフィニティークロマトグラフ装置。
- 前記高分子膜は第1の公称粒径を有する第1の無機粒子と第2の公称粒径を有する第2の無機粒子を含む、請求項1に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は同じ種類の粒子である、請求項6に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は異なる種類の粒子を含む、請求項6に記載のアフィニティークロマトグラフ装置。
- 前記親和性リガンドはタンパク質A、タンパク質G、タンパク質L、ヒトFc受容体タンパク質、抗体、多糖、およびこれらの組み合わせから選択される、請求項1に記載のアフィニティークロマトグラフ装置。
- 前記第1の公称粒径は約0.1μm、約0.5μm、約1μm、約5μm、約10μm、約15μm、約20μm、および約25μmから選択される、請求項5又は6に記載のアフィニティークロマトグラフ装置。
- 前記熱可塑性高分子膜の熱可塑性高分子はポリプロピレン、ポリエチレン、フッ素系エチレンプロピレン、およびこれらの組み合わせから選択される、請求項2に記載のアフィニティークロマトグラフ装置。
- 筐体、
流体の前記筐体への流入を可能にする入口、
前記筐体の両端に配置された第1および第2の流れ分配器、
流体の前記筐体からの流出を可能にする出口、ならびに
前記筐体内に配置された巻き膜複合体を含み、前記巻き膜複合体は
第1の公称粒径を有する第1の無機粒子を含有する第1の高分子膜、
第2の公称粒径を有する第2の無機粒子を含有する第2の高分子膜、および
少なくとも1つの非透過性層を含み、
前記第1の高分子膜、前記第2の高分子膜、前記第1の無機粒子、および前記第2の無機粒子のうちの少なくとも1つは親和性リガンドと共有結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、アフィニティークロマトグラフ装置。 - 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子はシリカ、ゼオライト、ヒドロキシアパタイト、金属酸化物、およびこれらの組み合わせから選択される、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は単一の公称粒径を有する、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は同じ種類の粒子である、請求項15に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は異なる種類の粒子を含む、請求項15に記載のアフィニティークロマトグラフ装置。
- 前記第1の無機粒子は第1の公称粒径を有し、前記第2の無機粒子は第2の公称粒径を有する、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は同じ種類の粒子である、請求項18に記載のアフィニティークロマトグラフ装置。
- 前記第1および第2の無機粒子は異なる種類の粒子を含む、請求項18に記載のアフィニティークロマトグラフ装置。
- 前記第1の高分子膜は第1の公称粒径を有する第1の無機粒子と第2の公称粒径を有する第2の無機粒子を含む、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第2の高分子膜は第1の公称粒径を有する第1の無機粒子と第2の公称粒径を有する第2の無機粒子を含む、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第1の高分子膜は第1の公称粒径を有する第1の無機粒子と第2の公称粒径を有する第2の無機粒子を含み、
前記第2の高分子膜は第3の公称粒径を有する第2の無機粒子と第4の公称粒径を有する第2の無機粒子を含む、請求項12に記載のアフィニティークロマトグラフ装置。 - 前記第1及び第2の高分子膜は発泡フッ素系高分子膜である、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記親和性リガンドはタンパク質A、タンパク質G、タンパク質L、ヒトFc受容体タンパク質、抗体、多糖、およびこれらの組み合わせから選択される、請求項12に記載のアフィニティークロマトグラフ装置。
- 前記第1の公称粒径および前記第2の公称粒径は約0.1μm、約0.5μm、約1μm、約5μm、約10μm、約15μm、約20μm、および約25μmから選択される、請求項12に記載のアフィニティークロマトグラフ装置。
- 標的タンパク質または標的抗体を水性混合物から分離する方法であって、
水性混合物をクロマトグラフ装置に通す工程を含み、クロマトグラフ装置は
筐体、
前記筐体の両端に配置された第1および第2の流れ分配器、ならびに
前記筐体内に配置された巻き膜複合体を含み、前記巻き膜複合体は
少なくとも1つの公称粒径を有する無機粒子を含有する少なくとも1つの高分子膜、ここで前記高分子膜は発泡フッ素系高分子膜である、および
少なくとも1つの非透過性層を含み、
前記高分子膜および前記無機粒子のうちの少なくとも一方は親和性リガンドと共有結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、方法。 - 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項27に記載のアフィニティークロマトグラフ装置。
- 標的タンパク質または標的抗体を水性混合物から分離する方法であって、
水性混合物をクロマトグラフ装置に通す工程を含み、前記クロマトグラフ装置は
筐体、
前記筐体の両端に配置された第1および第2の流れ分配器、ならびに
前記筐体内に配置された巻き膜複合体を含み、前記巻き膜複合体は
第1の公称粒径を有する第1の無機粒子を含有する第1の高分子膜、
第2の公称粒径を有する第2の無機粒子を含有する第2の高分子膜、および
少なくとも1つの非透過性層を含み、
前記第1の高分子膜、前記第2の高分子膜、前記第1の無機粒子、および前記第2の無機粒子のうちの少なくとも1つは親和性リガンドに共有結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、方法。 - 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項29に記載のアフィニティークロマトグラフ装置。
- 複数のウェル、および
前記ウェルのそれぞれの中に配置された巻き膜複合体を含み、前記巻き膜複合体は、
少なくとも1つの公称粒径を有する無機粒子を含有する少なくとも1つの高分子膜、ここで前記高分子膜は発泡フッ素系高分子膜である、および
少なくとも1つの非透過性層を含み、
前記高分子膜および前記無機粒子のうちの少なくとも一方は親和性リガンドと共有結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、複数ウェル型アフィニティークロマトグラフ装置。 - 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項31に記載の複数ウェル型アフィニティークロマトグラフ装置。
- 複数のウェル、および
前記ウェルのそれぞれに配置された巻き膜複合体を含み、前記巻き膜複合体は
第1の公称粒径を有する第1の無機粒子を含有する第1の高分子膜、
第2の公称粒径を有する第2の無機粒子を含有する第2の高分子膜、および
少なくとも1つの非透過性層を含み、
前記第1の高分子膜、前記第2の高分子膜、前記第1の無機粒子、および前記第2の無機粒子のうちの少なくとも1つは親和性リガンドに共有結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、複数ウェル型アフィニティークロマトグラフ装置。 - 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項33に記載の複数ウェル型アフィニティークロマトグラフ装置。
- 筐体、
流体の前記筐体への流入を可能にする入口、
前記筐体の両端に配置された第1および第2の流れ分配器、
流体の前記筐体からの流出を可能にする出口、および
前記筐体内に配置され、少なくとも1つの公称粒径を有する無機粒子を含有する少なくとも1つの高分子膜を含む巻き膜複合体を含み、
前記無機粒子はこの無機粒子に結合したエポキシド官能基とアルデヒド官能基の両方を含み、
前記エポキシド官能基および前記アルデヒド官能基のうちの少なくとも1つは親和性リガンドに結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、アフィニティークロマトグラフ装置。 - 前記巻き膜複合体は少なくとも1つの非透過性層をさらに含む、請求項35に記載のアフィニティークロマトグラフ装置。
- 前記少なくとも1つの非透過性層は中実状態の少なくとも1つの熱可塑性高分子膜を含む、請求項36に記載のアフィニティークロマトグラフ装置。
- 筐体、
流体の前記筐体への流入を可能にする入口、
前記筐体の両端に配置された第1および第2の流れ分配器、
流体の前記筐体からの流出を可能にする出口、ならびに
前記筐体内に配置され、少なくとも1つの公称粒径を有する無機粒子を含有する少なくとも1つの高分子膜を含む積層膜複合体を含み、
前記無機粒子はこの無機粒子に結合したエポキシド官能基とアルデヒド官能基の両方を含み、
前記エポキシド官能基および前記アルデヒド官能基のうちの少なくとも一方は親和性リガンドに結合しており、前記親和性リガンドは標的タンパク質または標的抗体に可逆的に結合し得る、アフィニティークロマトグラフ装置。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/094,428 | 2016-04-08 | ||
US15/094,428 US10525376B2 (en) | 2015-07-20 | 2016-04-08 | Affinity chromatography devices |
US15/409,733 | 2017-01-19 | ||
US15/409,733 US10526367B2 (en) | 2015-07-20 | 2017-01-19 | Affinity chromatography devices |
PCT/US2017/024686 WO2017176522A1 (en) | 2016-04-08 | 2017-03-29 | Affinity chromatography devices |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019513546A JP2019513546A (ja) | 2019-05-30 |
JP6788028B2 true JP6788028B2 (ja) | 2020-11-18 |
Family
ID=58537085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018552179A Active JP6788028B2 (ja) | 2016-04-08 | 2017-03-29 | アフィニティークロマトグラフ装置 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP3439761B1 (ja) |
JP (1) | JP6788028B2 (ja) |
KR (1) | KR102216602B1 (ja) |
CN (1) | CN109069949B (ja) |
AU (1) | AU2017246152B2 (ja) |
CA (1) | CA3016900C (ja) |
SG (1) | SG11201808869WA (ja) |
WO (1) | WO2017176522A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113260441A (zh) * | 2018-11-05 | 2021-08-13 | W.L.戈尔及同仁股份有限公司 | 螺旋缠绕蛋白分离装置 |
CA3118156A1 (en) | 2018-12-12 | 2020-06-18 | Purilogics, LLC | Affinity membrane and method of preparation |
JP2023529799A (ja) * | 2020-05-12 | 2023-07-12 | スリーエム イノベイティブ プロパティズ カンパニー | ウイルスクリアランスクロマトグラフィーデバイスの膜封止層及びスペーサリング |
JP2023541169A (ja) * | 2020-09-11 | 2023-09-28 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | フィブリル化ポリマー膜を含むアフィニティークロマトグラフィーデバイス及びそれを含むマニホールド |
CN116033949A (zh) * | 2020-09-11 | 2023-04-28 | W.L.戈尔及同仁股份有限公司 | 包括原纤维化热处理聚合物膜的亲和色谱装置以及包括该亲和色谱装置的集合器 |
CN112251320A (zh) * | 2020-10-09 | 2021-01-22 | 广州广立生物科技有限公司 | 生物颗粒纯化装置及纯化方法 |
EP4218981A1 (en) * | 2022-02-01 | 2023-08-02 | W. L. Gore & Associates, Inc. | Affinity chromatography devices containing a fibrillated polymer membrane for the separation of mrna and viral vectors from an aqueous mixture |
EP4218980A1 (en) * | 2022-02-01 | 2023-08-02 | W.L. Gore & Associates Inc. | Affinity chromatography devices containing a heat treated fibrillated polymer membrane for the separation of mrna and viral vectors from an aqueous mixture |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA962021A (en) | 1970-05-21 | 1975-02-04 | Robert W. Gore | Porous products and process therefor |
GB1538810A (en) | 1976-08-10 | 1979-01-24 | Sumitomo Electric Industries | Hydrophilic porous fluorocarbon structures and process for their production |
DE3627063A1 (de) * | 1986-08-09 | 1988-02-11 | Diagen Inst Molekularbio | Verfahren zur abtrennung und reinigung von biopolymeren durch affinitaetschromatographie |
GB2201904B (en) * | 1987-02-14 | 1990-12-19 | Domnick Hunter Filters Ltd | Device for liquid chromatography or immobilised enzyme reaction |
JPH01114746A (ja) * | 1987-10-29 | 1989-05-08 | Matsushita Electric Ind Co Ltd | バイオセンサ |
US4810381A (en) * | 1987-12-28 | 1989-03-07 | Minnesota Mining And Manufacturing Company | Composite chromatographic article |
EP0352917B1 (en) * | 1988-07-06 | 1994-04-27 | Eastman Kodak Company | The selective removal of chemical species from a fluid |
US5183545A (en) | 1989-04-28 | 1993-02-02 | Branca Phillip A | Electrolytic cell with composite, porous diaphragm |
DK259789D0 (da) * | 1989-05-26 | 1989-05-26 | Kem En Tec Ltd Aps | Partikulaert materiale |
GB9001011D0 (en) * | 1990-01-17 | 1990-03-14 | Chancellor Masters | Apparatus and method for affinity separation |
GB9017655D0 (en) * | 1990-08-11 | 1990-09-26 | Kodak Ltd | Apparatus for the selective removal of chemical species from a fluid |
US5362859A (en) * | 1992-07-27 | 1994-11-08 | Sepracor, Inc. | High-capacity affinity supports and methods for the preparation and use of same |
JP3298890B2 (ja) | 1994-09-02 | 2002-07-08 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 多孔質ポリテトラフルオロエチレン混合物 |
US5476589A (en) | 1995-03-10 | 1995-12-19 | W. L. Gore & Associates, Inc. | Porpous PTFE film and a manufacturing method therefor |
JPH09234097A (ja) * | 1995-12-28 | 1997-09-09 | Mochida Pharmaceut Co Ltd | 過酸化水素付加物を用いた分析方法 |
US5914182A (en) | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
JP4603655B2 (ja) * | 2000-05-31 | 2010-12-22 | 株式会社テクノメデイカ | 中性脂肪測定用センサ |
DE10114537A1 (de) * | 2001-03-21 | 2002-10-24 | Elipsa Gmbh | Array von Filtrationsmembranen mit systematisch variierenden Trenneigenschaften, Verfahren zur Herstellung und Verwendung |
US6541589B1 (en) | 2001-10-15 | 2003-04-01 | Gore Enterprise Holdings, Inc. | Tetrafluoroethylene copolymer |
JP4328545B2 (ja) * | 2003-02-14 | 2009-09-09 | 株式会社テクノメデイカ | 血液成分測定用使捨センサカード |
DE10344820B4 (de) * | 2003-09-26 | 2009-04-16 | Sartorius Stedim Biotech Gmbh | Adsorptionsmembranen, Verfahren zur Herstellung derselben und Verwendung der Adsorptionsmembranen in Vorrichtungen |
SE0402558D0 (sv) * | 2004-10-21 | 2004-10-21 | Amersham Biosciences Ab | A process for the purification of antibodies |
US7531611B2 (en) | 2005-07-05 | 2009-05-12 | Gore Enterprise Holdings, Inc. | Copolymers of tetrafluoroethylene |
US7306729B2 (en) | 2005-07-18 | 2007-12-11 | Gore Enterprise Holdings, Inc. | Porous PTFE materials and articles produced therefrom |
CN101365948B (zh) * | 2006-01-06 | 2012-11-07 | Emd密理博公司 | 亲和层析基质及其制备和使用方法 |
US8637144B2 (en) | 2007-10-04 | 2014-01-28 | W. L. Gore & Associates, Inc. | Expandable TFE copolymers, method of making, and porous, expended articles thereof |
MX2011003338A (es) * | 2008-09-30 | 2011-09-27 | Menai Medical Technologies Ltd | Sistema de medicion de muestras. |
US8658707B2 (en) | 2009-03-24 | 2014-02-25 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products |
US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
US8591932B2 (en) | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
WO2014052962A1 (en) * | 2012-09-28 | 2014-04-03 | Case Western Reserve University | System and method for detecting lysyl oxidase-like 2 protein (loxl2) and breast cancer |
US20140151279A1 (en) * | 2012-12-03 | 2014-06-05 | Renewable Process Technologies, Llc | System and method for film-based chromatographic separation |
DK3263637T3 (da) | 2013-01-30 | 2020-11-02 | Gore & Ass | Fremgangsmåde til fremstilling af porøse artikler ud fra ultrahøjmolekylært polyethylen |
US9803192B2 (en) * | 2013-10-04 | 2017-10-31 | Cornell University | Programmable and reconfigurable microcolumn affinity chromatography device, system, and methods of use thereof |
JP6240543B2 (ja) * | 2014-03-28 | 2017-11-29 | 大日本印刷株式会社 | 電極チップおよび化学物質の定量方法 |
US9441088B2 (en) | 2014-07-29 | 2016-09-13 | W. L. Gore & Associates, Inc. | Articles produced from VDF-co-(TFE or TrFE) polymers |
US9932429B2 (en) | 2014-07-29 | 2018-04-03 | W. L. Gore & Associates, Inc. | Method for producing porous articles from alternating poly(ethylene tetrafluoroethylene) and articles produced therefrom |
US20160032069A1 (en) | 2014-07-29 | 2016-02-04 | W. L. Gore & Associates, Inc. | Porous Articles Formed From Polyparaxylylene and Processes For Forming The Same |
US20160136914A1 (en) | 2014-07-29 | 2016-05-19 | W. L. Gore & Associates, Inc. | Porous Articles Formed From Polyparaxylylene and Processes For Forming The Same |
US10525376B2 (en) * | 2015-07-20 | 2020-01-07 | W. L. Gore & Associates, Inc. | Affinity chromatography devices |
-
2017
- 2017-03-29 JP JP2018552179A patent/JP6788028B2/ja active Active
- 2017-03-29 AU AU2017246152A patent/AU2017246152B2/en active Active
- 2017-03-29 WO PCT/US2017/024686 patent/WO2017176522A1/en active Application Filing
- 2017-03-29 EP EP17717041.2A patent/EP3439761B1/en active Active
- 2017-03-29 KR KR1020187032468A patent/KR102216602B1/ko active IP Right Grant
- 2017-03-29 CA CA3016900A patent/CA3016900C/en active Active
- 2017-03-29 CN CN201780021009.2A patent/CN109069949B/zh active Active
- 2017-03-29 SG SG11201808869WA patent/SG11201808869WA/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN109069949A (zh) | 2018-12-21 |
KR20180127502A (ko) | 2018-11-28 |
AU2017246152B2 (en) | 2020-06-11 |
SG11201808869WA (en) | 2018-11-29 |
CN109069949B (zh) | 2021-03-16 |
AU2017246152A1 (en) | 2018-09-20 |
EP3439761A1 (en) | 2019-02-13 |
EP3439761B1 (en) | 2024-02-28 |
JP2019513546A (ja) | 2019-05-30 |
CA3016900C (en) | 2022-07-12 |
WO2017176522A1 (en) | 2017-10-12 |
KR102216602B1 (ko) | 2021-02-17 |
CA3016900A1 (en) | 2017-10-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6788028B2 (ja) | アフィニティークロマトグラフ装置 | |
AU2020201663B2 (en) | Affinity chromatography devices | |
US10526367B2 (en) | Affinity chromatography devices | |
JP2023541169A (ja) | フィブリル化ポリマー膜を含むアフィニティークロマトグラフィーデバイス及びそれを含むマニホールド | |
CA3189382A1 (en) | Affinity chromatography devices containing a heat treated fibrillated polymer membrane and manifolds containing the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20181004 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190924 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191105 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200127 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200616 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200901 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200929 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201029 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6788028 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |