JP6787888B2 - 抗il−1ベータ抗体及び使用方法 - Google Patents

抗il−1ベータ抗体及び使用方法 Download PDF

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Publication number
JP6787888B2
JP6787888B2 JP2017525023A JP2017525023A JP6787888B2 JP 6787888 B2 JP6787888 B2 JP 6787888B2 JP 2017525023 A JP2017525023 A JP 2017525023A JP 2017525023 A JP2017525023 A JP 2017525023A JP 6787888 B2 JP6787888 B2 JP 6787888B2
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antibody
beta
amino acid
human
domain
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Expired - Fee Related
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Japanese (ja)
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JP2017534646A (ja
JP2017534646A5 (Direct
Inventor
ブロイアー,セバスティアン
デングル,シュテファン
ガスナー,クリスティアン
ジョルジュ,ギー
グリューナー,ザビーネ
ハルトマン,グイド
ヒュールスマン,ペーター・ミヒャエル
ムンディグル,オラフ
シューマッハー,ラルフ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/245IL-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017525023A 2014-11-10 2015-11-06 抗il−1ベータ抗体及び使用方法 Expired - Fee Related JP6787888B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14192523.0 2014-11-10
EP14192523 2014-11-10
PCT/EP2015/075875 WO2016075034A1 (en) 2014-11-10 2015-11-06 ANTI-IL-1beta ANTIBODIES AND METHODS OF USE

Publications (3)

Publication Number Publication Date
JP2017534646A JP2017534646A (ja) 2017-11-24
JP2017534646A5 JP2017534646A5 (Direct) 2018-12-06
JP6787888B2 true JP6787888B2 (ja) 2020-11-18

Family

ID=51868114

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017525023A Expired - Fee Related JP6787888B2 (ja) 2014-11-10 2015-11-06 抗il−1ベータ抗体及び使用方法

Country Status (15)

Country Link
US (1) US10344085B2 (Direct)
EP (1) EP3218402A1 (Direct)
JP (1) JP6787888B2 (Direct)
KR (1) KR20170081253A (Direct)
CN (1) CN107074942A (Direct)
AR (1) AR102594A1 (Direct)
AU (1) AU2015345320A1 (Direct)
BR (1) BR112017009817A2 (Direct)
CA (1) CA2963719A1 (Direct)
IL (1) IL251165A0 (Direct)
MX (1) MX2017005987A (Direct)
RU (1) RU2017120358A (Direct)
SG (1) SG11201702550WA (Direct)
TW (1) TW201632552A (Direct)
WO (1) WO2016075034A1 (Direct)

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CA2963175A1 (en) 2014-11-10 2016-05-19 F. Hoffmann-La Roche Ag Bispecific antibodies and methods of use in ophthalmology
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
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WO2018212556A1 (en) * 2017-05-16 2018-11-22 Cj Healthcare Corporation A method for purifying an antibody or an antibody fragment thereof using affinity chromatography
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CN110818793A (zh) * 2018-08-14 2020-02-21 中山康方生物医药有限公司 抗IL-1β的抗体、其药物组合物及其用途
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US11851499B2 (en) 2019-06-11 2023-12-26 Bioatla, Inc. Conditionally active anti-EpCAM antibodies, antibody fragments, their immunoconjugates and uses thereof
CN114524875B (zh) * 2021-11-11 2023-07-25 江苏莱森生物科技研究院有限公司 偶联IL-1β单克隆抗体的纳米硅球及应用
CN117126278B (zh) * 2023-10-26 2024-01-05 中国科学院苏州纳米技术与纳米仿生研究所 一种单克隆抗体及其应用

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KR20170082520A (ko) 2014-11-10 2017-07-14 에프. 호프만-라 로슈 아게 항-pdgf-b 항체 및 이의 사용 방법
KR20170081253A (ko) 2014-11-10 2017-07-11 에프. 호프만-라 로슈 아게 항-il-1베타 항체 및 이의 사용 방법
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Also Published As

Publication number Publication date
RU2017120358A3 (Direct) 2019-05-29
WO2016075034A1 (en) 2016-05-19
IL251165A0 (en) 2017-04-30
MX2017005987A (es) 2017-06-29
BR112017009817A2 (pt) 2018-02-14
US20170247447A1 (en) 2017-08-31
AR102594A1 (es) 2017-03-08
EP3218402A1 (en) 2017-09-20
RU2017120358A (ru) 2018-12-13
AU2015345320A1 (en) 2017-04-06
KR20170081253A (ko) 2017-07-11
JP2017534646A (ja) 2017-11-24
CN107074942A (zh) 2017-08-18
CA2963719A1 (en) 2016-05-19
TW201632552A (zh) 2016-09-16
US10344085B2 (en) 2019-07-09
SG11201702550WA (en) 2017-04-27

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