JP6784600B2 - シードトレイン法およびその使用 - Google Patents
シードトレイン法およびその使用 Download PDFInfo
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- JP6784600B2 JP6784600B2 JP2016572251A JP2016572251A JP6784600B2 JP 6784600 B2 JP6784600 B2 JP 6784600B2 JP 2016572251 A JP2016572251 A JP 2016572251A JP 2016572251 A JP2016572251 A JP 2016572251A JP 6784600 B2 JP6784600 B2 JP 6784600B2
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- cells
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009553P | 2014-06-09 | 2014-06-09 | |
| US62/009,553 | 2014-06-09 | ||
| PCT/US2015/034709 WO2015191462A1 (en) | 2014-06-09 | 2015-06-08 | Seed train processes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Division JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521057A JP2017521057A (ja) | 2017-08-03 |
| JP2017521057A5 JP2017521057A5 (cg-RX-API-DMAC7.html) | 2018-07-12 |
| JP6784600B2 true JP6784600B2 (ja) | 2020-11-11 |
Family
ID=53477008
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572251A Active JP6784600B2 (ja) | 2014-06-09 | 2015-06-08 | シードトレイン法およびその使用 |
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Country Status (18)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2717927T3 (es) | 2013-02-22 | 2019-06-26 | Genzyme Corp | Procedimientos de cultivo por perfusión de microportadores y usos de los mismos |
| US9909101B2 (en) | 2013-02-22 | 2018-03-06 | Genzyme Corporation | Methods of perfusion culturing using a shake flask and microcarriers |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| MX383857B (es) | 2014-12-22 | 2025-03-14 | Genzyme Corp | Métodos de cultivo de una célula de mamífero. |
| KR20180074775A (ko) * | 2015-10-26 | 2018-07-03 | 론자 리미티드 | 생물약제의 생산을 위한 제조 설비 |
| KR102479228B1 (ko) * | 2016-12-22 | 2022-12-21 | 도아고세이가부시키가이샤 | 접착제 조성물 그리고 이것을 사용한 커버레이 필름, 본딩 시트, 동장 적층판 및 전자파 실드재 |
| JP2020533983A (ja) * | 2017-09-15 | 2020-11-26 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 目的のポリペプチドのラージスケールの製造間のオンラインバイオマス静電容量モニタリング |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| EP3650528A1 (en) | 2018-11-08 | 2020-05-13 | Aglaris Ltd | Cell culture system and method |
| JP7365419B2 (ja) * | 2019-01-25 | 2023-10-19 | エンゼン・バイオサイエンシズ・リミテッド | 治療用タンパク質を生産するための自動化統合連続システム及びバイオプロセス |
| AU2020223376A1 (en) * | 2019-02-15 | 2021-07-22 | Just - Evotec Biologics, Inc. | Automated biomanufacturing systems, facilities, and processes |
| JP2022533252A (ja) * | 2019-05-24 | 2022-07-21 | ルビウス セラピューティクス， インコーポレイテッド | 脱核赤血球細胞を生成する方法 |
| GB2629063B (en) * | 2019-06-17 | 2025-02-12 | Deka Products Lp | System and method for cell and tissue preparation |
| GB201908612D0 (en) * | 2019-06-17 | 2019-07-31 | Ge Healthcare Bio Sciences Ab | A method for separating biomolecules |
| CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| EP3831924A1 (en) * | 2019-12-03 | 2021-06-09 | Sartorius Stedim Data Analytics AB | Adapting control of a cell culture in a production scale vessel with regard to a starting medium |
| WO2024006236A1 (en) * | 2022-06-28 | 2024-01-04 | Amgen Inc. | Flexible facility configurations for therapeutic product manufacturing |
| JP2025527931A (ja) * | 2022-09-06 | 2025-08-22 | アムジェン インコーポレイテッド | 大規模バイオリアクタシステム及び方法 |
| CN120882853A (zh) * | 2023-03-13 | 2025-10-31 | 美国安进公司 | 用于种子制备优化的系统和方法 |
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| DE102008019691A1 (de) | 2008-04-15 | 2009-10-29 | Technische Universität Ilmenau | Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion |
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| US9909101B2 (en) | 2013-02-22 | 2018-03-06 | Genzyme Corporation | Methods of perfusion culturing using a shake flask and microcarriers |
| JP6608705B2 (ja) | 2013-03-08 | 2019-11-20 | ジェンザイム・コーポレーション | 治療用タンパク質の連続的な精製 |
| HUE056073T2 (hu) | 2013-03-15 | 2022-01-28 | Genzyme Corp | Magas denzitású sejtbanki tárolási eljárások |
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| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| LT3926051T (lt) | 2014-06-04 | 2024-06-10 | Amgen Inc. | Žinduolių ląstelių kultūros surinkimo metodai |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN104450597B (zh) | 2014-12-10 | 2020-07-28 | 青岛农业大学 | 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法 |
| MX383857B (es) | 2014-12-22 | 2025-03-14 | Genzyme Corp | Métodos de cultivo de una célula de mamífero. |
-
2015
- 2015-06-05 TW TW109131864A patent/TWI776235B/zh active
- 2015-06-05 TW TW104118240A patent/TWI707949B/zh active
- 2015-06-05 TW TW111129481A patent/TW202246486A/zh unknown
- 2015-06-08 AU AU2015274897A patent/AU2015274897B2/en active Active
- 2015-06-08 KR KR1020227022305A patent/KR102584375B1/ko active Active
- 2015-06-08 HU HUE15730933A patent/HUE047683T2/hu unknown
- 2015-06-08 DK DK15730933.7T patent/DK3152299T3/da active
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