JP2017521057A5 - - Google Patents
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- JP2017521057A5 JP2017521057A5 JP2016572251A JP2016572251A JP2017521057A5 JP 2017521057 A5 JP2017521057 A5 JP 2017521057A5 JP 2016572251 A JP2016572251 A JP 2016572251A JP 2016572251 A JP2016572251 A JP 2016572251A JP 2017521057 A5 JP2017521057 A5 JP 2017521057A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- culture
- cell culture
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims 49
- 238000004113 cell culture Methods 0.000 claims 28
- 239000001963 growth medium Substances 0.000 claims 18
- 210000004962 mammalian cell Anatomy 0.000 claims 13
- 230000010412 perfusion Effects 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 238000010257 thawing Methods 0.000 claims 4
- 238000003306 harvesting Methods 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000011437 continuous method Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 description 8
- 239000012528 membrane Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009553P | 2014-06-09 | 2014-06-09 | |
| US62/009,553 | 2014-06-09 | ||
| PCT/US2015/034709 WO2015191462A1 (en) | 2014-06-09 | 2015-06-08 | Seed train processes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Division JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521057A JP2017521057A (ja) | 2017-08-03 |
| JP2017521057A5 true JP2017521057A5 (cg-RX-API-DMAC7.html) | 2018-07-12 |
| JP6784600B2 JP6784600B2 (ja) | 2020-11-11 |
Family
ID=53477008
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572251A Active JP6784600B2 (ja) | 2014-06-09 | 2015-06-08 | シードトレイン法およびその使用 |
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Country Status (18)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2717927T3 (es) | 2013-02-22 | 2019-06-26 | Genzyme Corp | Procedimientos de cultivo por perfusión de microportadores y usos de los mismos |
| US9909101B2 (en) | 2013-02-22 | 2018-03-06 | Genzyme Corporation | Methods of perfusion culturing using a shake flask and microcarriers |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| MX383857B (es) | 2014-12-22 | 2025-03-14 | Genzyme Corp | Métodos de cultivo de una célula de mamífero. |
| KR20180074775A (ko) * | 2015-10-26 | 2018-07-03 | 론자 리미티드 | 생물약제의 생산을 위한 제조 설비 |
| KR102479228B1 (ko) * | 2016-12-22 | 2022-12-21 | 도아고세이가부시키가이샤 | 접착제 조성물 그리고 이것을 사용한 커버레이 필름, 본딩 시트, 동장 적층판 및 전자파 실드재 |
| JP2020533983A (ja) * | 2017-09-15 | 2020-11-26 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 目的のポリペプチドのラージスケールの製造間のオンラインバイオマス静電容量モニタリング |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| EP3650528A1 (en) | 2018-11-08 | 2020-05-13 | Aglaris Ltd | Cell culture system and method |
| JP7365419B2 (ja) * | 2019-01-25 | 2023-10-19 | エンゼン・バイオサイエンシズ・リミテッド | 治療用タンパク質を生産するための自動化統合連続システム及びバイオプロセス |
| AU2020223376A1 (en) * | 2019-02-15 | 2021-07-22 | Just - Evotec Biologics, Inc. | Automated biomanufacturing systems, facilities, and processes |
| JP2022533252A (ja) * | 2019-05-24 | 2022-07-21 | ルビウス セラピューティクス， インコーポレイテッド | 脱核赤血球細胞を生成する方法 |
| GB2629063B (en) * | 2019-06-17 | 2025-02-12 | Deka Products Lp | System and method for cell and tissue preparation |
| GB201908612D0 (en) * | 2019-06-17 | 2019-07-31 | Ge Healthcare Bio Sciences Ab | A method for separating biomolecules |
| CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| EP3831924A1 (en) * | 2019-12-03 | 2021-06-09 | Sartorius Stedim Data Analytics AB | Adapting control of a cell culture in a production scale vessel with regard to a starting medium |
| WO2024006236A1 (en) * | 2022-06-28 | 2024-01-04 | Amgen Inc. | Flexible facility configurations for therapeutic product manufacturing |
| JP2025527931A (ja) * | 2022-09-06 | 2025-08-22 | アムジェン インコーポレイテッド | 大規模バイオリアクタシステム及び方法 |
| CN120882853A (zh) * | 2023-03-13 | 2025-10-31 | 美国安进公司 | 用于种子制备优化的系统和方法 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| RU2058992C1 (ru) | 1993-07-14 | 1996-04-27 | Антипин Георгий Васильевич | Способ получения кормового белка и устройство для его осуществления |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| RU2215748C2 (ru) | 1999-04-09 | 2003-11-10 | Сентро Де Инмунология Молекулар | Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция |
| US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| EP1395647B1 (en) * | 2000-12-20 | 2006-11-22 | Bayer Pharmaceuticals Corporation | A device and method for seed-train expansion of mammalian cells |
| JP2005509406A (ja) | 2001-05-09 | 2005-04-14 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 哺乳動物細胞株のための低温保存袋アセンブリー |
| ATE494358T1 (de) | 2001-08-31 | 2011-01-15 | Bayer Schering Pharma Ag | Vorrichtung und verfahren zur fermentation in hohen zelldichten |
| JP4351049B2 (ja) | 2001-10-02 | 2009-10-28 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 真核細胞中で組換えタンパク質を生産する方法 |
| AU2002348151A1 (en) | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| US6953692B2 (en) * | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| US20050019914A1 (en) * | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| DE102005007512A1 (de) | 2004-02-20 | 2005-09-08 | CESCO Bioengineering Co., Ltd., Chutung | Vorrichtung und Verfahren zum Präparieren und Kultivieren von Zellen |
| US7294484B2 (en) * | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
| AU2005287162B2 (en) | 2004-09-16 | 2010-12-23 | Becton, Dickinson And Company | Perfusion bioreactor for culturing cells |
| EP2550971B1 (en) | 2004-09-30 | 2016-11-09 | Bayer HealthCare LLC | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules |
| WO2006138143A1 (en) | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
| DK1891205T3 (en) | 2005-06-15 | 2018-03-19 | Zhejiang Jinyishengshi Bioengineering Co Ltd | SUSPENSION CULTURE CONTAINERS |
| WO2008024769A2 (en) | 2006-08-21 | 2008-02-28 | Raven Biotechnologies, Inc. | Intensified perfusion production method |
| US20080207487A1 (en) | 2006-11-02 | 2008-08-28 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
| WO2008106515A1 (en) | 2007-02-27 | 2008-09-04 | The Board Of Trustees Of The University Of Illinois | Insert device for multiwell plate |
| WO2008107388A1 (en) * | 2007-03-02 | 2008-09-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Improvement of protein production |
| CN101678244B (zh) | 2007-04-17 | 2013-06-19 | 深度控股有限公司 | 用于连续膜吸附的方法和装置 |
| US9109193B2 (en) | 2007-07-30 | 2015-08-18 | Ge Healthcare Bio-Sciences Corp. | Continuous perfusion bioreactor system |
| ES2657055T3 (es) * | 2007-08-09 | 2018-03-01 | Wyeth Llc | Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores |
| WO2009034186A2 (en) | 2007-09-13 | 2009-03-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Process for cell cultivation |
| US20090233334A1 (en) | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
| DE102008019691A1 (de) | 2008-04-15 | 2009-10-29 | Technische Universität Ilmenau | Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion |
| WO2010005746A1 (en) | 2008-06-16 | 2010-01-14 | Amprotein Corporation | Bioreactors |
| WO2010120514A2 (en) | 2009-03-31 | 2010-10-21 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| CA2766902C (en) | 2009-07-06 | 2021-07-06 | Genentech, Inc. | Method of culturing eukaryotic cells |
| KR102027596B1 (ko) * | 2010-12-06 | 2019-10-01 | 타폰 바이오시스템즈, 인코포레이티드 | 생물학적 산물을 위한 연속 처리 방법 |
| HRP20211494T1 (hr) | 2011-01-17 | 2021-12-24 | F. Hoffmann - La Roche Ag | Uređaj za odvajanje |
| US9163089B2 (en) | 2011-05-12 | 2015-10-20 | Probiogen Ag | Enhancement of protein production yield mediated by a fast shuttling CDC42 GTPase |
| LT2726600T (lt) * | 2011-07-01 | 2017-05-25 | Amgen Inc. | Žinduolių ląstelių kultūra |
| AR089231A1 (es) * | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
| US20150004686A1 (en) | 2012-02-02 | 2015-01-01 | Corning Incorporated | Automatic continuous perfusion cell culture microplate consumables |
| JP2015517804A (ja) | 2012-04-01 | 2015-06-25 | イー・エム・デイー・ミリポア・コーポレイシヨン | 細胞培養及び傾斜移動アッセイ方法及び装置 |
| EP2912160B1 (en) * | 2012-10-23 | 2020-07-29 | Genzyme Corporation | Perfusion culturing methods and uses thereof |
| ES2717927T3 (es) | 2013-02-22 | 2019-06-26 | Genzyme Corp | Procedimientos de cultivo por perfusión de microportadores y usos de los mismos |
| US9909101B2 (en) | 2013-02-22 | 2018-03-06 | Genzyme Corporation | Methods of perfusion culturing using a shake flask and microcarriers |
| JP6608705B2 (ja) | 2013-03-08 | 2019-11-20 | ジェンザイム・コーポレーション | 治療用タンパク質の連続的な精製 |
| HUE056073T2 (hu) | 2013-03-15 | 2022-01-28 | Genzyme Corp | Magas denzitású sejtbanki tárolási eljárások |
| KR20230142653A (ko) | 2013-09-16 | 2023-10-11 | 젠자임 코포레이션 | 세포 배양물을 가공하는 방법 및 시스템 |
| WO2015095809A1 (en) | 2013-12-20 | 2015-06-25 | Biogen Idec Ma Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
| TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| LT3926051T (lt) | 2014-06-04 | 2024-06-10 | Amgen Inc. | Žinduolių ląstelių kultūros surinkimo metodai |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN104450597B (zh) | 2014-12-10 | 2020-07-28 | 青岛农业大学 | 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法 |
| MX383857B (es) | 2014-12-22 | 2025-03-14 | Genzyme Corp | Métodos de cultivo de una célula de mamífero. |
-
2015
- 2015-06-05 TW TW109131864A patent/TWI776235B/zh active
- 2015-06-05 TW TW104118240A patent/TWI707949B/zh active
- 2015-06-05 TW TW111129481A patent/TW202246486A/zh unknown
- 2015-06-08 AU AU2015274897A patent/AU2015274897B2/en active Active
- 2015-06-08 KR KR1020227022305A patent/KR102584375B1/ko active Active
- 2015-06-08 HU HUE15730933A patent/HUE047683T2/hu unknown
- 2015-06-08 DK DK15730933.7T patent/DK3152299T3/da active
- 2015-06-08 ES ES21161811T patent/ES3043610T3/es active Active
- 2015-06-08 KR KR1020177000249A patent/KR102416402B1/ko active Active
- 2015-06-08 EP EP19209942.2A patent/EP3628730A1/en active Pending
- 2015-06-08 JP JP2016572251A patent/JP6784600B2/ja active Active
- 2015-06-08 EP EP21161811.1A patent/EP3858983B1/en active Active
- 2015-06-08 MX MX2016016301A patent/MX373323B/es active IP Right Grant
- 2015-06-08 BR BR112016028891-2A patent/BR112016028891B1/pt active IP Right Grant
- 2015-06-08 EP EP15730933.7A patent/EP3152299B1/en not_active Revoked
- 2015-06-08 CN CN201580042488.7A patent/CN106574249B/zh active Active
- 2015-06-08 CN CN202010299662.9A patent/CN111575225B/zh active Active
- 2015-06-08 US US14/733,630 patent/US10570367B2/en active Active
- 2015-06-08 RU RU2016151316A patent/RU2694327C2/ru active
- 2015-06-08 CA CA2951551A patent/CA2951551C/en active Active
- 2015-06-08 SG SG11201610216UA patent/SG11201610216UA/en unknown
- 2015-06-08 WO PCT/US2015/034709 patent/WO2015191462A1/en not_active Ceased
- 2015-06-08 IL IL290096A patent/IL290096B2/en unknown
- 2015-06-08 ES ES15730933T patent/ES2773630T3/es active Active
-
2016
- 2016-12-08 MX MX2020004073A patent/MX2020004073A/es unknown
- 2016-12-08 IL IL249452A patent/IL249452B/en active IP Right Grant
-
2020
- 2020-02-19 CY CY20201100157T patent/CY1122803T1/el unknown
- 2020-02-24 US US16/799,592 patent/US20200377850A1/en active Pending
- 2020-10-22 JP JP2020177043A patent/JP7089000B2/ja active Active
-
2021
- 2021-03-18 IL IL281626A patent/IL281626B/en unknown
- 2021-10-05 AU AU2021245116A patent/AU2021245116B2/en active Active
-
2022
- 2022-06-08 JP JP2022092635A patent/JP7360504B2/ja active Active
-
2023
- 2023-06-15 AU AU2023203734A patent/AU2023203734A1/en not_active Abandoned
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