JP6783244B2 - 口渇の軽減のための組成物 - Google Patents

口渇の軽減のための組成物 Download PDF

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Publication number
JP6783244B2
JP6783244B2 JP2017550461A JP2017550461A JP6783244B2 JP 6783244 B2 JP6783244 B2 JP 6783244B2 JP 2017550461 A JP2017550461 A JP 2017550461A JP 2017550461 A JP2017550461 A JP 2017550461A JP 6783244 B2 JP6783244 B2 JP 6783244B2
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Japan
Prior art keywords
concentration
xylitol
formulation
mucosal adhesive
water
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JP2017550461A
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English (en)
Japanese (ja)
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JP2017537983A5 (enExample
JP2017537983A (ja
Inventor
スワンソン、ジェロム、イー．
Original Assignee
エレべイト オーラル ケア、エルエルシー
エレべイト オーラル ケア、エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2017550461A 2014-12-10 2015-11-20 口渇の軽減のための組成物 Active JP6783244B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462089942P 2014-12-10 2014-12-10
US62/089,942 2014-12-10
PCT/US2015/061743 WO2016094054A1 (en) 2014-12-10 2015-11-20 Composition for the relief of dry mouth

Publications (3)

Publication Number Publication Date
JP2017537983A JP2017537983A (ja) 2017-12-21
JP2017537983A5 JP2017537983A5 (enExample) 2018-12-06
JP6783244B2 true JP6783244B2 (ja) 2020-11-11

Family

ID=56107939

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017550461A Active JP6783244B2 (ja) 2014-12-10 2015-11-20 口渇の軽減のための組成物

Country Status (9)

Country Link
US (1) US10772908B2 (enExample)
EP (1) EP3229792B1 (enExample)
JP (1) JP6783244B2 (enExample)
AU (1) AU2015361122B2 (enExample)
CA (1) CA2970146C (enExample)
ES (1) ES2982077T3 (enExample)
MX (1) MX388182B (enExample)
PL (1) PL3229792T3 (enExample)
WO (1) WO2016094054A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190015529A1 (en) 2016-01-10 2019-01-17 Smilesonica Inc. Viscosity and stability modified ultrasound gel
CN105833278B (zh) * 2016-04-25 2018-05-08 北京嘉安医疗器械科技有限公司 用于治疗口腔干燥和口腔疾病的组合物
CA3054654A1 (en) 2017-02-22 2018-08-30 Smilesonica Inc. Artificial saliva, related methods, and uses
CA3195741A1 (en) * 2020-10-15 2022-04-21 Peter M. Milgrom A thickened silver diamine fluoride composition

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970747A (en) * 1974-03-11 1976-07-20 Colgate-Palmolive Company Humectant sweetener
US4340583A (en) * 1979-05-23 1982-07-20 J. M. Huber Corporation High fluoride compatibility dentifrice abrasives and compositions
US4997654A (en) * 1989-08-14 1991-03-05 Warner-Lambert Company Method for increasing salivation for xerostomia patients
US5496558A (en) * 1993-03-02 1996-03-05 Block Drug Company Inc. Solid form xerostomia product
US5900230A (en) 1997-08-18 1999-05-04 Squigle, Inc. Dental products to treat and prevent periodontal disease
EP1068871A1 (en) * 1999-07-07 2001-01-17 Jean-Paul Perraudin Novel methods and medicament for treating infections diseases involving microbial biofilms
ATE466566T1 (de) 2004-08-02 2010-05-15 Glaxo Group Ltd Neue zusammensetzung gegen xerostomie
WO2009108713A2 (en) * 2008-02-25 2009-09-03 Signum Biosciences, Inc. Topical compositions and methods utilizing peptides containing lipid-modified cysteine-containing peptides
US8735374B2 (en) 2009-07-31 2014-05-27 Intelgenx Corp. Oral mucoadhesive dosage form
JP5433355B2 (ja) * 2009-09-16 2014-03-05 サンスター株式会社 口腔用組成物
US8658139B1 (en) * 2010-02-27 2014-02-25 Squigle, Inc. Prevention and treatment of oral diseases
WO2011130009A1 (en) 2010-04-14 2011-10-20 Isp Investments Inc. Oral care compositions
WO2011162756A1 (en) 2010-06-23 2011-12-29 Colgate-Palmolive Company Therapeutic oral composition
US20120053130A1 (en) * 2010-08-30 2012-03-01 Bristol-Myers Squibb Company Composition for enhancing absorption of a drug and method
JP6143675B2 (ja) 2010-12-16 2017-06-07 セルジーン コーポレイション 難溶性薬物の制御放出経口剤形及びその使用
SG190974A1 (en) 2010-12-23 2013-07-31 Colgate Palmolive Co Aqueous oral care composition comprising xanthan gum, cellulose gum and carbomer
LT2758037T (lt) 2011-09-23 2018-06-25 Emerald Hilton Davis, Llc Savitvarkė nanostruktūros dalelė ir jos gavimo būdas
AU2011383326B2 (en) * 2011-12-15 2016-01-28 Colgate-Palmolive Company Aqueous oral care compositions
US9724542B2 (en) 2012-10-12 2017-08-08 Premier Dental Products Company Remineralizing and desensitizing compositions, treatments and methods of manufacture

Also Published As

Publication number Publication date
AU2015361122B2 (en) 2020-12-17
US10772908B2 (en) 2020-09-15
US20170354676A1 (en) 2017-12-14
EP3229792A1 (en) 2017-10-18
EP3229792A4 (en) 2018-08-08
PL3229792T3 (pl) 2024-06-10
ES2982077T3 (es) 2024-10-14
EP3229792B1 (en) 2024-02-07
EP3229792C0 (en) 2024-02-07
AU2015361122A1 (en) 2017-06-22
JP2017537983A (ja) 2017-12-21
CA2970146C (en) 2023-10-31
CA2970146A1 (en) 2016-06-16
MX2017007597A (es) 2018-03-01
MX388182B (es) 2025-03-19
WO2016094054A1 (en) 2016-06-16

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