JP6781358B1 - 起泡性外用組成物 - Google Patents
起泡性外用組成物 Download PDFInfo
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- JP6781358B1 JP6781358B1 JP2020526043A JP2020526043A JP6781358B1 JP 6781358 B1 JP6781358 B1 JP 6781358B1 JP 2020526043 A JP2020526043 A JP 2020526043A JP 2020526043 A JP2020526043 A JP 2020526043A JP 6781358 B1 JP6781358 B1 JP 6781358B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
Abstract
Description
下記処方に従って、調製した検体をポンプフォーマー容器に充填し、容器から吐出時の泡形成の有無を評価した(表1、図1)。
尚、検体AからIおよびNが高分子界面活性剤である。
下記処方に従って、調製した検体をポンプフォーマー容器に充填して、泡形成の有無、泡質、泡の保持時間及び液だれの有無を測定した(表3および表4)。条件Aでは、健常人の皮膚に近い材質としてポリウレタン素材のマットを用い、条件Bでは比較的重度の乾燥肌を想定したキムタオルを用いて、その上に吐出させた(図2および図3)。また、ポリウレタン素材のマットに吐出後、約45℃に傾けて液だれするかどうか観察した(図4)。
粘度の異なるヒプロメロースを使って、濃度による泡形成の有無を評価した。尚、泡質の評価基準は実施例1と同様である。
実施例2の表3の原料名2に示す処方に、ヘパリン類似物質を0.1あるいは0.3%の濃度で含む2種の組成物を作成し、ポンプフォーマー容器に充填して、泡形成の有無、泡の保持時間及び液だれの有無を測定した(表6)。
Claims (10)
- 高分子界面活性剤を起泡成分として含み、1,3−ブチレングリコールを含む組成物が、ポンプフォーマー容器またはスクイズフォーマー容器内に充填されていること、並びに当該容器内に噴射剤を含まないことに特徴づけられる、使用時に泡を形成する外用製品。
- 高分子界面活性剤がセルロース誘導体、ポリビニルアルコール、ポリビニルピロリドン、ポリエチレングリコール、ポリアクリル酸から選ばれる少なくとも一種である、請求項1に記載の製品。
- セルロース誘導体がヒドロキシプロピルメチルセルロース、ヒドロキシエチルセルロース、メチルセルロースから選ばれる少なくとも一種である、請求項2に記載の製品。
- セルロース誘導体がヒドロキシプロピルメチルセルロースである、請求項3に記載の製品。
- 組成物全量に対しヒドロキシプロピルメチルセルロースを0.2〜3重量%、1,3−ブチレングリコールを15〜40重量%含有する、請求項4に記載の製品。
- 医薬有効成分を少なくとも一種含む、請求項1〜5のいずれかに記載の製品。
- 医薬有効成分がムコ多糖類である請求項6に記載の製品。
- 医薬有効成分の含有量が、組成物全量に対し0.01〜5重量%である、請求項6または7に記載の製品。
- 医薬有効成分としてヘパリン類似物質および/またはヒアルロン酸あるいはその塩を含む請求項8に記載の製品。
- 皮膚疾患の治療のための請求項1〜9のいずれかに記載の製品。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018237587 | 2018-12-19 | ||
JP2018237587 | 2018-12-19 | ||
PCT/JP2019/049587 WO2020130035A1 (ja) | 2018-12-19 | 2019-12-18 | 起泡性外用組成物 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020133025A Division JP2020176148A (ja) | 2018-12-19 | 2020-08-05 | 起泡性外用組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP6781358B1 true JP6781358B1 (ja) | 2020-11-04 |
JPWO2020130035A1 JPWO2020130035A1 (ja) | 2021-02-15 |
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ID=71100860
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020526043A Active JP6781358B1 (ja) | 2018-12-19 | 2019-12-18 | 起泡性外用組成物 |
JP2020133025A Pending JP2020176148A (ja) | 2018-12-19 | 2020-08-05 | 起泡性外用組成物 |
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JP2020133025A Pending JP2020176148A (ja) | 2018-12-19 | 2020-08-05 | 起泡性外用組成物 |
Country Status (4)
Country | Link |
---|---|
JP (2) | JP6781358B1 (ja) |
KR (1) | KR102584365B1 (ja) |
CN (1) | CN113164511A (ja) |
WO (1) | WO2020130035A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
WO2023127941A1 (ja) * | 2021-12-28 | 2023-07-06 | 株式会社 資生堂 | ポンプフォーマー用日焼け止め化粧料 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007137813A (ja) * | 2005-11-17 | 2007-06-07 | Kowa Co | 非エアゾール式のフォーム剤用組成物及び当該組成物を用いたフォーム剤 |
JP2008546692A (ja) * | 2005-06-13 | 2008-12-25 | スリーエム イノベイティブ プロパティズ カンパニー | 発泡性アルコール組成物、系、及び使用方法 |
US20130136805A1 (en) * | 2010-08-13 | 2013-05-30 | Servet Buyuktimkin | Foamable compositions of stabilized chlorite |
JP2016128424A (ja) * | 2014-12-24 | 2016-07-14 | 株式会社ポーラファルマ | スクリーンフォーマー用の外用組成物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5719152B2 (ja) * | 1972-08-12 | 1982-04-21 | ||
ATE544441T1 (de) * | 2007-05-10 | 2012-02-15 | Neubourg Skin Care Gmbh & Co Kg | Tensidfreie schaumformulierungen |
JP5661253B2 (ja) * | 2009-05-18 | 2015-01-28 | 株式会社ダイゾー | エアゾール組成物 |
JP5952084B2 (ja) * | 2012-05-22 | 2016-07-13 | 日進化学株式会社 | エアゾール組成物とその使用方法 |
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2019
- 2019-12-18 CN CN201980083678.1A patent/CN113164511A/zh active Pending
- 2019-12-18 WO PCT/JP2019/049587 patent/WO2020130035A1/ja active Application Filing
- 2019-12-18 KR KR1020217007588A patent/KR102584365B1/ko active IP Right Grant
- 2019-12-18 JP JP2020526043A patent/JP6781358B1/ja active Active
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2020
- 2020-08-05 JP JP2020133025A patent/JP2020176148A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008546692A (ja) * | 2005-06-13 | 2008-12-25 | スリーエム イノベイティブ プロパティズ カンパニー | 発泡性アルコール組成物、系、及び使用方法 |
JP2007137813A (ja) * | 2005-11-17 | 2007-06-07 | Kowa Co | 非エアゾール式のフォーム剤用組成物及び当該組成物を用いたフォーム剤 |
US20130136805A1 (en) * | 2010-08-13 | 2013-05-30 | Servet Buyuktimkin | Foamable compositions of stabilized chlorite |
JP2016128424A (ja) * | 2014-12-24 | 2016-07-14 | 株式会社ポーラファルマ | スクリーンフォーマー用の外用組成物 |
Also Published As
Publication number | Publication date |
---|---|
KR20210106405A (ko) | 2021-08-30 |
JP2020176148A (ja) | 2020-10-29 |
CN113164511A (zh) | 2021-07-23 |
KR102584365B1 (ko) | 2023-10-04 |
WO2020130035A1 (ja) | 2020-06-25 |
JPWO2020130035A1 (ja) | 2021-02-15 |
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