JP6764007B2 - 重合体多層膜を有するコンタクトレンズの製造方法 - Google Patents
重合体多層膜を有するコンタクトレンズの製造方法 Download PDFInfo
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- JP6764007B2 JP6764007B2 JP2019124559A JP2019124559A JP6764007B2 JP 6764007 B2 JP6764007 B2 JP 6764007B2 JP 2019124559 A JP2019124559 A JP 2019124559A JP 2019124559 A JP2019124559 A JP 2019124559A JP 6764007 B2 JP6764007 B2 JP 6764007B2
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- polymer
- multilayer film
- contact lens
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- lens
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- 229920000642 polymer Polymers 0.000 title claims description 84
- 238000004519 manufacturing process Methods 0.000 title claims description 47
- 238000000034 method Methods 0.000 title claims description 21
- 229920006254 polymer film Polymers 0.000 claims description 31
- 238000006243 chemical reaction Methods 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 27
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 19
- 229940005550 sodium alginate Drugs 0.000 claims description 19
- 239000000661 sodium alginate Substances 0.000 claims description 19
- 235000010413 sodium alginate Nutrition 0.000 claims description 19
- 239000007853 buffer solution Substances 0.000 claims description 17
- 125000003636 chemical group Chemical group 0.000 claims description 15
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 11
- 239000000178 monomer Substances 0.000 claims description 11
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 11
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 11
- 235000010443 alginic acid Nutrition 0.000 claims description 9
- 229920000615 alginic acid Polymers 0.000 claims description 9
- 229960001126 alginic acid Drugs 0.000 claims description 8
- 239000000783 alginic acid Substances 0.000 claims description 8
- 150000004781 alginic acids Chemical class 0.000 claims description 8
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 8
- 150000002500 ions Chemical class 0.000 claims description 8
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
- 238000001179 sorption measurement Methods 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 229920002401 polyacrylamide Polymers 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 125000001174 sulfone group Chemical group 0.000 claims description 5
- 229960003638 dopamine Drugs 0.000 claims description 4
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 4
- 238000000465 moulding Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims description 3
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims description 3
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical compound CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 claims description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims description 2
- OXJGJKIURHREKH-UHFFFAOYSA-O CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical compound CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C OXJGJKIURHREKH-UHFFFAOYSA-O 0.000 claims 1
- 238000012412 chemical coupling Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 description 14
- -1 polyethylene Polymers 0.000 description 13
- 239000000463 material Substances 0.000 description 12
- 239000004743 Polypropylene Substances 0.000 description 11
- 238000000576 coating method Methods 0.000 description 11
- 229920001155 polypropylene Polymers 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000000203 mixture Substances 0.000 description 7
- 239000003054 catalyst Substances 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 210000001508 eye Anatomy 0.000 description 5
- 230000021615 conjugation Effects 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000001723 curing Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920001477 hydrophilic polymer Polymers 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- VLKLFDWKBJDWSL-UHFFFAOYSA-P C(C(=C)C)(=O)OCCP(=O)=C(O)C[N+](C)(C)C.C(C(=C)C)(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical compound C(C(=C)C)(=O)OCCP(=O)=C(O)C[N+](C)(C)C.C(C(=C)C)(=O)OCCP(=O)=C(O)C[N+](C)(C)C VLKLFDWKBJDWSL-UHFFFAOYSA-P 0.000 description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000012062 aqueous buffer Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229920000547 conjugated polymer Polymers 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000005660 hydrophilic surface Effects 0.000 description 2
- 230000009851 immunogenic response Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004528 spin coating Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
- LLLWMXQKXWIRDZ-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one Chemical compound C=CN1CCCC1=O.C=CN1CCCC1=O LLLWMXQKXWIRDZ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000003848 UV Light-Curing Methods 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- RGEUJMSAPBESFR-UHFFFAOYSA-L disodium hydrogen phosphate tetrahydrate Chemical compound O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O RGEUJMSAPBESFR-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 239000005518 polymer electrolyte Substances 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000001029 thermal curing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW107138116A TWI690424B (zh) | 2018-10-29 | 2018-10-29 | 具有聚合物多層膜的隱形眼鏡之製備方法 |
| TW107138116 | 2018-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020071471A JP2020071471A (ja) | 2020-05-07 |
| JP6764007B2 true JP6764007B2 (ja) | 2020-09-30 |
Family
ID=67412576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019124559A Active JP6764007B2 (ja) | 2018-10-29 | 2019-07-03 | 重合体多層膜を有するコンタクトレンズの製造方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6764007B2 (zh) |
| CN (1) | CN110082931A (zh) |
| TW (1) | TWI690424B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112225844A (zh) * | 2020-09-24 | 2021-01-15 | 周振宇 | 一种隐形眼镜材料、含有其的隐形眼镜及其制备方法 |
| JP2022164588A (ja) * | 2021-04-16 | 2022-10-27 | ペガヴィジョン コーポレーション | コンタクトレンズ及びその製造方法 |
| CN113311597A (zh) * | 2021-05-29 | 2021-08-27 | 江苏视准医疗器械有限公司 | 一种表面润滑程度高的隐形眼镜及其制备方法 |
| CN116438276A (zh) * | 2021-11-12 | 2023-07-14 | 晶硕光学股份有限公司 | 隐形眼镜及其制造方法 |
| CN114839798A (zh) * | 2022-04-11 | 2022-08-02 | 深圳先进技术研究院 | 基于薄膜光子晶体的结构色隐形眼镜及其制备方法 |
| TWI806607B (zh) * | 2022-05-13 | 2023-06-21 | 昱嘉科技股份有限公司 | 具有抗摩擦性與高保濕性之隱形眼鏡及其製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56149014A (en) * | 1980-04-22 | 1981-11-18 | Agency Of Ind Science & Technol | Soft contact lens |
| PL341346A1 (en) * | 1998-01-09 | 2001-04-09 | Novartis Ag | Polymeric coatings |
| US6793973B2 (en) * | 2000-02-04 | 2004-09-21 | Novartis Ag | Single-dip process for achieving a layer-by-layer-like coating |
| AR038269A1 (es) * | 2002-01-09 | 2005-01-12 | Novartis Ag | Articulos polimericos que tienen un recubrimiento lubrico, y metodo para fabricarlos |
| MY152305A (en) * | 2008-03-18 | 2014-09-15 | Novartis Ag | Coating process for ophthalmic lenses |
| EP2705808B1 (en) * | 2010-07-30 | 2024-05-01 | Alcon Inc. | Silicone hydrogel lenses with water-rich surfaces |
| US9011932B2 (en) * | 2010-09-16 | 2015-04-21 | Bausch & Lomb Incorporated | Contact lens care system with peroxide |
| US9395468B2 (en) * | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| CN103146010A (zh) * | 2013-01-21 | 2013-06-12 | 温州医学院 | 人工晶状体表面仿生自组装多层膜的修饰工艺以及带有表面仿生自组装多层膜的人工晶状体 |
| WO2015014381A1 (en) * | 2013-07-31 | 2015-02-05 | Essilor International (Compagnie Generale D'optique) | Additive manufacturing processes for transparent ophthalmic lens |
| JP2017505922A (ja) * | 2013-11-15 | 2017-02-23 | タンジブル サイエンス リミテッド ライアビリティ カンパニー | 親水性層を有するコンタクトレンズ |
| CA2947829C (en) * | 2014-05-09 | 2018-08-21 | Interojo Inc. | Hydrogel contact lens having wet surface, and manufacturing method therefor |
| TW201617692A (zh) * | 2014-07-21 | 2016-05-16 | 視覺動力公司 | 隱形眼鏡及製造隱形眼鏡之方法 |
| WO2018135421A1 (ja) * | 2017-01-17 | 2018-07-26 | 日油株式会社 | コンタクトレンズ用モノマー組成物、コンタクトレンズ用重合体及びその製造方法、並びにコンタクトレンズ及びその製造方法 |
-
2018
- 2018-10-29 TW TW107138116A patent/TWI690424B/zh active
-
2019
- 2019-03-19 CN CN201910207550.3A patent/CN110082931A/zh active Pending
- 2019-07-03 JP JP2019124559A patent/JP6764007B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW202015902A (zh) | 2020-05-01 |
| JP2020071471A (ja) | 2020-05-07 |
| TWI690424B (zh) | 2020-04-11 |
| CN110082931A (zh) | 2019-08-02 |
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