JP6707532B2 - 低用量経口イソトレチノイン医薬組成物 - Google Patents
低用量経口イソトレチノイン医薬組成物 Download PDFInfo
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- JP6707532B2 JP6707532B2 JP2017517643A JP2017517643A JP6707532B2 JP 6707532 B2 JP6707532 B2 JP 6707532B2 JP 2017517643 A JP2017517643 A JP 2017517643A JP 2017517643 A JP2017517643 A JP 2017517643A JP 6707532 B2 JP6707532 B2 JP 6707532B2
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- oil
- isotretinoin
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- 229960005280 isotretinoin Drugs 0.000 title claims description 79
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 title claims 7
- 239000008194 pharmaceutical composition Substances 0.000 title description 12
- 239000000203 mixture Substances 0.000 claims description 58
- 239000002245 particle Substances 0.000 claims description 26
- 239000002775 capsule Substances 0.000 claims description 21
- 239000006185 dispersion Substances 0.000 claims description 21
- 239000008203 oral pharmaceutical composition Substances 0.000 claims description 21
- 239000003921 oil Substances 0.000 claims description 12
- 235000019198 oils Nutrition 0.000 claims description 12
- -1 sorbitan fatty acid esters Chemical class 0.000 claims description 11
- 239000003981 vehicle Substances 0.000 claims description 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- 235000012424 soybean oil Nutrition 0.000 claims description 7
- 239000003549 soybean oil Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 235000019489 Almond oil Nutrition 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- 235000019482 Palm oil Nutrition 0.000 claims description 2
- 235000021314 Palmitic acid Nutrition 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 235000019485 Safflower oil Nutrition 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 235000019486 Sunflower oil Nutrition 0.000 claims description 2
- 239000008168 almond oil Substances 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 239000003945 anionic surfactant Substances 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
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- 235000019519 canola oil Nutrition 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 239000003093 cationic surfactant Substances 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
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- 239000002385 cottonseed oil Substances 0.000 claims description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 239000008169 grapeseed oil Substances 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 235000021313 oleic acid Nutrition 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 239000002540 palm oil Substances 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 235000005713 safflower oil Nutrition 0.000 claims description 2
- 239000003813 safflower oil Substances 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000002600 sunflower oil Substances 0.000 claims description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims 1
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- 229940068965 polysorbates Drugs 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- SHGAZHPCJJPHSC-XFYACQKRSA-N isotretinoin Chemical compound OC(=O)/C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-XFYACQKRSA-N 0.000 description 82
- 238000012360 testing method Methods 0.000 description 11
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- 238000000034 method Methods 0.000 description 6
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- 208000002874 Acne Vulgaris Diseases 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 235000020937 fasting conditions Nutrition 0.000 description 2
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- 206010025135 lupus erythematosus Diseases 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
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- 210000002784 stomach Anatomy 0.000 description 2
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- DJENHUUHOGXXCB-UHFFFAOYSA-N 2-butyl-6-methoxyphenol Chemical compound CCCCC1=CC=CC(OC)=C1O DJENHUUHOGXXCB-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
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- 206010014561 Emphysema Diseases 0.000 description 1
- OVGORFFCBUIFIA-UHFFFAOYSA-N Fenipentol Chemical compound CCCCC(O)C1=CC=CC=C1 OVGORFFCBUIFIA-UHFFFAOYSA-N 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
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- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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Description
(a)イソトレチノイン;及び
(b)油性ビヒクルと
を含む低用量医薬組成物を提供する。
(a)イソトレチノインを油性キャリア中に分散させることと、
(b)分散体を粉砕して所望の粒径を得ることと、
(c)上記分散体に1種以上の賦形剤を添加することと、
(d)所望により、油性キャリアを工程(c)の分散体に添加することと、
(e)分散体をカプセルに充填することと
を含む。
1.ブチルヒドロキシアニソールおよびポリソルベート80を大豆油(全組成物の39.36%w/v)中に溶解させて透明溶液を形成した。
2.イソトレチノインを工程1の溶液に撹拌しながら添加し、均一分散体を得た。
3.工程2の分散体を粉砕し、D90が約20μmとなるような粒径のイソトレチノインを得た。
4.大豆油の残りの量(全組成物の52.08%w/v)を撹拌しながら工程3の微粉化分散体に添加し、均一分散体を得た。
5.工程5の分散体を硬ゼラチンカプセルに充填した。
下の表に示されるように、実施例1(イソトレチノイン16mgを含有)の医薬組成物を、FDAにより推奨される溶出媒体中の放出特性に関して、市販のイソトレチノイン配合物(「Absorica」(登録商標)20mgカプセル)と比較した。
基準(R):「Absorica」(登録商標)20mgカプセル
試験(T):イソトレチノイン16mgカプセル(実施例1)
実施例1(イソトレチノイン16mgを含有)の医薬組成物を、15人の健常成人男性被検者について飽食条件下で市販のイソトレチノイン配合物(20mg 「Absorica」(登録商標)カプセル)と比較した。
基準(R):「Absorica」(登録商標)20mgカプセル
試験(T):イソトレチノイン16mgカプセル(実施例1)
・飽食条件においては、試験プロトタイプは基準製品に対してAUC0〜tが90.12%、AUC0〜infが91.59%のT/R比を有し、同程度の吸収を示す。これらの値は80%〜125%の規制で認められる基準内にある。しかしながら、吸収速度(Cmax)については、91.54%〜134.76%の90% CI範囲をもって比はわずかに高くなる(111.07%)ことが観察される。
実施例1(16mg試験カプセル)の医薬組成物を15人の健常成人男性被検者について飽食条件および絶食条件で比較した。
試験(A):絶食条件下のイソトレチノイン16mgカプセル(実施例1)
試験(B):飽食条件下のイソトレチノイン16mgカプセル(実施例1)
・絶食条件および飽食条件下における試験プロトタイプを比較すると、吸収速度(Cmax)のB/A比はほぼ一致している(99.22%)ことが観察される。B/A比がAUC値については高くても(約116%〜117%)、3つのPKパラメータ(Cmax、AUC0〜t、AUC0〜inf)、全ての90%CIは、80%〜125%の規制で認められる基準内にある。
・16mg試験プロトタイプは、飽食条件下において基準製品(「Absorica」(登録商標)20mg)と同等の生物学的利用能を有する。これは試験用量の最高20%の低減を積極的に支持する。
・食品は試験プロトタイプの薬物吸収の速度および程度に著しく影響を与えることが示されていない。実際に、T/R比およびPKパラメータの90%CIは、80%〜125%の規制で認められる基準内にある。
1.ブチルヒドロキシアニソールおよびポリソルベート80を大豆油中に溶解させて透明溶液を形成した。
2.イソトレチノインを工程1の溶液に撹拌しながら添加し、均一分散体を得た。
3.工程2の分散体を粉砕し、D90が約20μmとなるような粒径のイソトレチノインを得た。
4.工程3の分散体を硬ゼラチンカプセルに充填した。
5.工程4の充填済みカプセルを、ゼラチン溶液を使用して封止した。
1.ブチルヒドロキシアニソールを大豆油(全組成物の39.36%w/v)中に溶解させて透明溶液を形成した。
2.イソトレチノインを工程1の溶液に撹拌しながら添加し、均一分散体を得た。
3.工程2の分散体を粉砕し、D90が約20μmとなるような粒径のイソトレチノインを得た。
4.大豆油の残りの量(全組成物の53.93%w/v)を撹拌しながら工程3の微粉化分散体に添加し、均一分散体を得た。
5.工程4の分散体を硬ゼラチンカプセルに充填した。
6.工程5の充填済みカプセルを、ゼラチン溶液を使用して封止した。
Claims (8)
- イソトレチノイン及び医薬として許容可能な賦形剤を含む、カプセル形態の低用量経口医薬組成物であって、
前記組成物は、経口投与した場合に、市販のカプセルと比較して20%少ない、約8mg、16mg、20mg、24mg、28mg、又は32mgの量のイソトレチノインの用量範囲を与え、ここで、市販のカプセルは、10mg、20mg、25mg、30mg、35mg、又は40mgの容量範囲であり、
D90が30μm未満となる前記組成物中のイソトレチノインの粒径分布であり、
前記組成物は、油性ビヒクル、界面活性剤、及び酸化防止剤を含み、前記油性ビヒクルは、前記組成物の総重量の約71%w/w〜約95%w/wの量で存在し、
前記組成物は、ワックスを含まない、低用量経口医薬組成物。 - 前記組成物は、カプセルに充填された分散体の形態である、請求項1に記載の低用量経口医薬組成物。
- 前記油性ビヒクルは、落花生油、オリーブ油、大豆油、核油、アーモンド油、ベニバナ油、ヒマワリ油、パーム油、ゴマ油、キャノーラ油、トウモロコシ油、ヒマシ油、ココヤシ油、綿実油、ブドウ種子油、又はこれらの組み合わせである、請求項1に記載の低用量経口医薬組成物。
- 前記界面活性剤は、アニオン性、カチオン性、又は非イオン性界面活性剤;ソルビタン脂肪酸エステル;ラウリン酸、パルミチン酸、ステアリン酸、及びオレイン酸から調製されたポリソルベート;ポリエチレングリコールのモノニルフェニルエーテル;ポリオキシエチレンモノエステル;ジオクチルナトリウムスルホサクシネート;ラウリル硫酸ナトリウム;レシチン;プロピレングリコールの脂肪酸エステル;グリセロールの脂肪酸エステル;ポロキサマー;並びにこれらの混合物からなる群から選択される、請求項1に記載の低用量経口医薬組成物。
- 前記界面活性剤は、前記組成物の総重量の約0.05%w/v〜約10.0%w/vの量で存在する、請求項4に記載の低用量経口医薬組成物。
- D50が40μm未満、35μm未満、30μm未満、25μm未満、20μm未満、15μm未満、10μm未満、又は5μm未満となるイソトレチノインの粒径分布である、請求項1に記載の低用量経口医薬組成物。
- D50が15μm未満となるイソトレチノインの粒径分布である、請求項6に記載の低用量経口医薬組成物。
- D10が20μm未満、18μm未満、17μm未満、15μm未満、12μm未満、10μm未満、8μm未満、7μm未満、5μm未満、または2μm未満となるイソトレチノインの粒径分布である、請求項1に記載の低用量経口医薬組成物。
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PCT/IB2015/054080 WO2016051288A1 (en) | 2014-10-01 | 2015-05-29 | Low dose oral pharmaceutical composition of isotretinoin |
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MA40447A (fr) * | 2014-07-31 | 2016-02-04 | Sun Pharmaceutical Ind Ltd | Composition pharmaceutique orale d'isotrétinoïne |
US10517846B2 (en) | 2016-05-26 | 2019-12-31 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions for treating acne |
WO2018073751A1 (en) * | 2016-10-17 | 2018-04-26 | Sun Pharmaceutical Industries Limited | Method of treating acne |
US10716774B1 (en) | 2018-01-05 | 2020-07-21 | Yale Pharmaceuticals LLC | Pharmaceutical compositions containing isotretinoin with improved dissolution profile and enhanced stability |
WO2023080189A1 (ja) * | 2021-11-04 | 2023-05-11 | 興和株式会社 | 医薬品 |
TW202320776A (zh) * | 2021-11-04 | 2023-06-01 | 日商興和股份有限公司 | 膠囊劑 |
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PE20001227A1 (es) * | 1998-10-30 | 2000-11-06 | Hoffmann La Roche | Procesos para producir una composicion de isotretinoina |
US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
FR2807662A1 (fr) * | 2000-04-12 | 2001-10-19 | Cll Pharma | Procede pour stabiliser la granulometrie d'un principe actif verulent disperse dans un liquide et ses applications |
ATE270544T1 (de) * | 2000-09-22 | 2004-07-15 | Galephar M F | Halbfeste arzneizubereitung enthaltend isotretinoin |
BR0117191A (pt) * | 2001-12-06 | 2005-05-10 | Ranbaxy Lab Ltd | Composições nanoparticuladas de isotretinoina |
US10028972B2 (en) * | 2010-10-21 | 2018-07-24 | Cadila Healthcare Limited | Pharmaceutical compositions of anti-acne agents |
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US9078925B2 (en) * | 2012-06-18 | 2015-07-14 | Galephar Pharmaceutical Research, Inc. | Pharmaceutical semi-solid composition of isotretinoin |
RU2017141029A (ru) * | 2015-05-25 | 2019-06-25 | Сан Фармасьютикал Индастриз Лимитед | Фармацевтическая пероральная композиция изотретиноина для применения один раз в сутки |
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US20160128962A1 (en) | 2016-05-12 |
AU2015326489A1 (en) | 2017-04-27 |
EP3200877A1 (en) | 2017-08-09 |
CA2963206A1 (en) | 2016-04-07 |
JP2017530149A (ja) | 2017-10-12 |
MX2020009444A (es) | 2020-10-08 |
CA2963206C (en) | 2023-09-26 |
WO2016051288A1 (en) | 2016-04-07 |
BR112017006779A2 (pt) | 2018-01-09 |
RU2017114924A3 (ja) | 2019-01-16 |
EP3200877A4 (en) | 2018-05-23 |
CA3207801A1 (en) | 2016-04-07 |
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