JP6696915B2 - Ｍｉｃ−１融合タンパク質及びその使用 - Google Patents
Ｍｉｃ−１融合タンパク質及びその使用 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07—ORGANIC CHEMISTRY
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14173664 | 2014-06-24 | ||
| EP14173664.5 | 2014-06-24 | ||
| PCT/EP2015/063596 WO2015197446A1 (en) | 2014-06-24 | 2015-06-17 | Mic-1 fusion proteins and uses thereof |
Publications (3)
| Publication Number | Publication Date |
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| JP2017528419A JP2017528419A (ja) | 2017-09-28 |
| JP2017528419A5 JP2017528419A5 (enExample) | 2018-07-12 |
| JP6696915B2 true JP6696915B2 (ja) | 2020-05-20 |
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| JP2016574944A Expired - Fee Related JP6696915B2 (ja) | 2014-06-24 | 2015-06-17 | Ｍｉｃ−１融合タンパク質及びその使用 |
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| AU (1) | AU2015279525A1 (enExample) |
| BR (1) | BR112016029848A2 (enExample) |
| CA (1) | CA2952293A1 (enExample) |
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| US10752664B2 (en) | 2011-04-08 | 2020-08-25 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) |
| EA037355B1 (ru) | 2013-07-31 | 2021-03-17 | Эмджен Инк. | Конструкции на основе фактора дифференцировки и роста 15 (gdf-15) |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| CN108367053A (zh) | 2015-12-22 | 2018-08-03 | 诺华股份有限公司 | 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法 |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| AU2017269496B2 (en) * | 2016-05-24 | 2021-03-25 | Novo Nordisk A/S | MIC-1 compounds and use thereof |
| GB201615844D0 (en) * | 2016-09-16 | 2016-11-02 | Genagon Therapeutics Ab | Agents for use in therapy |
| US20200069774A1 (en) | 2016-12-06 | 2020-03-05 | St Vincent's Hospital Sydney Limited | Treatment of obesity and eating disorders |
| GB201700553D0 (en) * | 2017-01-12 | 2017-03-01 | Genagon Therapeutics Ab | Therapeutic agents |
| GB201700567D0 (en) | 2017-01-12 | 2017-03-01 | Genagon Therapeutics Ab | Therapeutic agents |
| MA50141A (fr) | 2017-04-20 | 2020-07-29 | Novo Nordisk As | Procédés de purification de protéines de fusion d'albumine |
| TWI710377B (zh) | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Ｍｉｃ－１化合物及其用途 |
| US11260108B2 (en) | 2017-09-10 | 2022-03-01 | Novo Nordisk A/S | MIC-1 and GLP-1 for use in the treatment of obesity |
| JP2021519590A (ja) | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 糖タンパク質の製造 |
| TWI724392B (zh) | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
| CR20200510A (es) | 2018-04-09 | 2020-11-26 | Amgen Inc | Protreínas de fusión del factor de diferenciación de crecimiento 15 |
| CN112543869A (zh) | 2018-08-10 | 2021-03-23 | 诺华股份有限公司 | Gfral细胞外结构域和使用方法 |
| US12268733B2 (en) | 2018-08-10 | 2025-04-08 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| CN113226351B (zh) | 2018-10-22 | 2025-01-14 | 詹森药业有限公司 | 胰高血糖素样肽1(glp1)-生长分化因子15(gdf15)融合蛋白及其用途 |
| EP4041281B1 (en) | 2019-10-04 | 2025-11-26 | Amgen Inc. | Use of gdf15 for treating cardiometabolic syndrome and other conditions |
| MX2022006173A (es) * | 2019-11-26 | 2022-06-14 | Yuhan Corp | Proteinas de fusion gdf15 de accion prolongada y composicion farmaceutica que comprende la misma. |
| IL293616A (en) * | 2019-12-09 | 2022-08-01 | Alexion Pharma Inc | Alkaline phosphatase polypeptides and methods of using them |
| AU2020400805B2 (en) * | 2019-12-11 | 2024-03-28 | Lg Chem, Ltd. | Fusion polypeptide comprising GDF15 and polypeptide region capable of O-glycosylation |
| EP4081241A4 (en) * | 2019-12-24 | 2024-05-01 | Juvena Therapeutics, Inc. | REGENERATIVE POLYPEPTIDES AND THEIR USES |
| EP4085077A4 (en) | 2019-12-31 | 2024-01-17 | Beijing QL Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| WO2021194257A1 (ko) * | 2020-03-25 | 2021-09-30 | (주) 업테라 | 세포 투과성 펩티드 이량체, 이의 제조방법 및 이를 이용한 카고 전달 시스템 |
| KR102195740B1 (ko) * | 2020-03-25 | 2020-12-28 | 서울대학교산학협력단 | 세포 투과성 펩티드 이량체, 이의 제조방법 및 이를 이용한 카고 전달 시스템 |
| EP4237438A4 (en) * | 2020-10-27 | 2024-11-27 | Beijing QL Biopharmaceutical Co., Ltd. | GDF15 FUSION PROTEINS AND THEIR USE |
| CN112694520B (zh) * | 2020-12-02 | 2023-01-17 | 图凌(杭州)生物医药有限公司 | 一种人工多肽hm、其抗体及在病理检测中的应用 |
| MX2023009463A (es) | 2021-02-12 | 2023-09-21 | Alexion Pharma Inc | Polipeptidos de fosfatasa alcalina y metodos para su uso. |
| WO2022219495A1 (en) | 2021-04-12 | 2022-10-20 | Novartis Ag | 2-((4-((s)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-imidazole derivatives as activators of the glp1 receptor for the treatment of obesity |
| TW202342014A (zh) | 2022-02-10 | 2023-11-01 | 瑞士商諾華公司 | １，３－苯并二氧戊環衍生物 |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2529300T3 (es) | 2000-04-12 | 2015-02-18 | Novozymes Biopharma Dk A/S | Proteínas de fusión de albúmina |
| CN1241946C (zh) | 2002-07-01 | 2006-02-15 | 美国福源集团 | 对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白 |
| SI2441466T1 (sl) | 2004-04-13 | 2015-01-30 | St Vincent's Hospital Sydney Limited Centre For Immunology | Sredstvo, ki inhibira MIC-1 |
| US7576190B2 (en) * | 2004-05-13 | 2009-08-18 | Eli Lilly And Company | FGF-21 fusion proteins |
| CA2575441A1 (en) * | 2004-07-26 | 2006-02-02 | Asterion Limited | Linkers |
| CN103298935A (zh) | 2007-08-15 | 2013-09-11 | 阿穆尼克斯公司 | 用于改善生物活性多肽性能的组合物和方法 |
| MX2014009129A (es) * | 2012-01-26 | 2014-11-21 | Amgen Inc | Polipeptidos de factor 15 de diferenciacion de crecimiento (gdf-15). |
| CA2862516C (en) * | 2012-03-27 | 2023-02-14 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| WO2014120619A2 (en) | 2013-01-30 | 2014-08-07 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| EA037355B1 (ru) | 2013-07-31 | 2021-03-17 | Эмджен Инк. | Конструкции на основе фактора дифференцировки и роста 15 (gdf-15) |
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- 2015-06-17 TW TW104119532A patent/TW201613958A/zh unknown
- 2015-06-17 US US14/742,159 patent/US9272019B2/en not_active Expired - Fee Related
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- 2015-06-17 JP JP2016574944A patent/JP6696915B2/ja not_active Expired - Fee Related
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| TW201613958A (en) | 2016-04-16 |
| JP2017528419A (ja) | 2017-09-28 |
| RU2017101436A (ru) | 2018-07-24 |
| IL249327A0 (en) | 2017-02-28 |
| RU2017101436A3 (enExample) | 2019-02-13 |
| EP3160496B1 (en) | 2021-03-03 |
| AR100945A1 (es) | 2016-11-09 |
| CA2952293A1 (en) | 2015-12-30 |
| KR20170020383A (ko) | 2017-02-22 |
| EP3160496A1 (en) | 2017-05-03 |
| US20160129083A1 (en) | 2016-05-12 |
| ZA201608214B (en) | 2018-11-28 |
| CN106459222A (zh) | 2017-02-22 |
| US20160015784A1 (en) | 2016-01-21 |
| MX2016016063A (es) | 2017-03-10 |
| AU2015279525A1 (en) | 2016-12-15 |
| BR112016029848A2 (pt) | 2017-10-24 |
| US9272019B2 (en) | 2016-03-01 |
| US9956264B2 (en) | 2018-05-01 |
| WO2015197446A1 (en) | 2015-12-30 |
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