JP6693969B2 - 治療用ホモ二量体およびその使用 - Google Patents

治療用ホモ二量体およびその使用 Download PDF

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Publication number
JP6693969B2
JP6693969B2 JP2017544990A JP2017544990A JP6693969B2 JP 6693969 B2 JP6693969 B2 JP 6693969B2 JP 2017544990 A JP2017544990 A JP 2017544990A JP 2017544990 A JP2017544990 A JP 2017544990A JP 6693969 B2 JP6693969 B2 JP 6693969B2
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JP
Japan
Prior art keywords
homodimer
administered
administration
mammalian subject
pharmaceutically acceptable
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JP2017544990A
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English (en)
Japanese (ja)
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JP2018500386A5 (enExample
JP2018500386A (ja
Inventor
ロジャーズ、アルピ
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Individual
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Publication of JP2018500386A5 publication Critical patent/JP2018500386A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017544990A 2014-11-18 2015-11-16 治療用ホモ二量体およびその使用 Active JP6693969B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1420445.7A GB2532426B (en) 2014-11-18 2014-11-18 Therapeutic homodimer and uses thereof
GB1420445.7 2014-11-18
PCT/EP2015/076712 WO2016079066A1 (en) 2014-11-18 2015-11-16 Therapeutic homodimer and uses thereof

Publications (3)

Publication Number Publication Date
JP2018500386A JP2018500386A (ja) 2018-01-11
JP2018500386A5 JP2018500386A5 (enExample) 2018-12-27
JP6693969B2 true JP6693969B2 (ja) 2020-05-13

Family

ID=52248504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017544990A Active JP6693969B2 (ja) 2014-11-18 2015-11-16 治療用ホモ二量体およびその使用

Country Status (19)

Country Link
US (2) US20180015136A1 (enExample)
EP (1) EP3220939B1 (enExample)
JP (1) JP6693969B2 (enExample)
KR (1) KR20170083064A (enExample)
CN (1) CN107206048B (enExample)
AU (1) AU2015348673B2 (enExample)
BR (1) BR112017010346A2 (enExample)
CA (1) CA2967140C (enExample)
CY (1) CY1124859T1 (enExample)
DK (1) DK3220939T3 (enExample)
EA (1) EA034876B1 (enExample)
ES (1) ES2886001T3 (enExample)
GB (1) GB2532426B (enExample)
IL (1) IL252349B (enExample)
MA (1) MA40969A (enExample)
MX (1) MX392248B (enExample)
SG (1) SG11201703757PA (enExample)
WO (1) WO2016079066A1 (enExample)
ZA (1) ZA201703580B (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0516527D0 (en) * 2005-08-11 2005-09-21 Arpi Matossian Rogers Peptides
DK2594591T3 (en) * 2005-08-11 2018-07-30 Matossian Rogers Arpi TCR-V-BETA RELATED PEPTIDES FOR TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASE

Also Published As

Publication number Publication date
IL252349B (en) 2022-02-01
MA40969A (fr) 2021-04-28
CN107206048B (zh) 2021-02-26
EP3220939A1 (en) 2017-09-27
BR112017010346A2 (pt) 2018-05-15
CA2967140C (en) 2021-09-21
AU2015348673A1 (en) 2017-06-01
CA2967140A1 (en) 2016-05-26
HK1223287A1 (zh) 2017-07-28
GB201420445D0 (en) 2014-12-31
ZA201703580B (en) 2018-08-29
ES2886001T3 (es) 2021-12-16
GB2532426A (en) 2016-05-25
WO2016079066A1 (en) 2016-05-26
DK3220939T3 (da) 2021-08-30
MX2017006278A (es) 2017-10-24
CN107206048A (zh) 2017-09-26
KR20170083064A (ko) 2017-07-17
GB2532426B (en) 2016-11-02
EP3220939B1 (en) 2021-06-30
IL252349A0 (en) 2017-07-31
EA201791103A1 (ru) 2017-09-29
AU2015348673B2 (en) 2019-01-03
NZ731655A (en) 2020-09-25
SG11201703757PA (en) 2017-06-29
CY1124859T1 (el) 2022-11-25
MX392248B (es) 2025-03-24
US20210060118A1 (en) 2021-03-04
EA034876B1 (ru) 2020-04-01
US20180015136A1 (en) 2018-01-18
JP2018500386A (ja) 2018-01-11

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