JP6641373B2 - ヤヌスキナーゼ阻害薬としての４，６−置換−ピラゾロ［１，５−ａ］ピラジン - Google Patents

ヤヌスキナーゼ阻害薬としての４，６−置換−ピラゾロ［１，５−ａ］ピラジン Download PDF

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JP6641373B2
JP6641373B2 JP2017529681A JP2017529681A JP6641373B2 JP 6641373 B2 JP6641373 B2 JP 6641373B2 JP 2017529681 A JP2017529681 A JP 2017529681A JP 2017529681 A JP2017529681 A JP 2017529681A JP 6641373 B2 JP6641373 B2 JP 6641373B2
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pyrazol
pyrazolo
pyrazin
alkyl
pentan
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JP2018507167A (ja
JP2018507167A5 (enExample
Inventor
シェリー アレン，
シェリー アレン，
マーク ローレンス ボイス，
マーク ローレンス ボイス，
マーク ジェイ． チカレッリ，
マーク ジェイ． チカレッリ，
ジェイ ブラッドフォード フェル，
ジェイ ブラッドフォード フェル，
ジョン ピー． フィッシャー，
ジョン ピー． フィッシャー，
ジョン ガウディーノ，
ジョン ガウディーノ，
エリック ジェイムス ヒッケン，
エリック ジェイムス ヒッケン，
ロナルド ジェイ ヒンクリン，
ロナルド ジェイ ヒンクリン，
クリストファー エフ． クレイサー，
クリストファー エフ． クレイサー，
エレン レアード，
エレン レアード，
ジョン イー． ロビンソン，
ジョン イー． ロビンソン，
トニー ピー． タン，
トニー ピー． タン，
ローレンス イー． バージェス，
ローレンス イー． バージェス，
ロバート アンドリュー リーガー，
ロバート アンドリュー リーガー，
ジェド フェネガー，
ジェド フェネガー，
ヨシタカ サトウ，
ヨシタカ サトウ，
カテリーナ レフテリス，
カテリーナ レフテリス，
ラジ ケー． ラヘジャ，
ラジ ケー． ラヘジャ，
ブライドン エル． ベネット，
ブライドン エル． ベネット，
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Celgene Corp
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Celgene Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2017529681A 2014-12-05 2015-12-04 ヤヌスキナーゼ阻害薬としての４，６−置換−ピラゾロ［１，５−ａ］ピラジン Expired - Fee Related JP6641373B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088068P 2014-12-05 2014-12-05
US62/088,068 2014-12-05
PCT/US2015/064062 WO2016090285A1 (en) 2014-12-05 2015-12-04 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

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JP2019223760A Division JP2020055859A (ja) 2014-12-05 2019-12-11 ヤヌスキナーゼ阻害薬としての４，６−置換−ピラゾロ［１，５−ａ］ピラジン

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JP2018507167A JP2018507167A (ja) 2018-03-15
JP2018507167A5 JP2018507167A5 (enExample) 2019-01-24
JP6641373B2 true JP6641373B2 (ja) 2020-02-05

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JP2019223760A Pending JP2020055859A (ja) 2014-12-05 2019-12-11 ヤヌスキナーゼ阻害薬としての４，６−置換−ピラゾロ［１，５−ａ］ピラジン

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CN112996794A (zh) 2018-09-10 2021-06-18 阿雷生物药品公司 作为ret激酶抑制剂的稠合杂环化合物
JP7256291B2 (ja) * 2019-04-12 2023-04-11 プライムジーン（ベイジン）カンパニー リミテッド ピラゾロピラジン誘導の化合物、医薬組成物およびその使用
KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
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