MY191016A - 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors - Google Patents

4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors

Info

Publication number
MY191016A
MY191016A MYPI2017702034A MYPI2017702034A MY191016A MY 191016 A MY191016 A MY 191016A MY PI2017702034 A MYPI2017702034 A MY PI2017702034A MY PI2017702034 A MYPI2017702034 A MY PI2017702034A MY 191016 A MY191016 A MY 191016A
Authority
MY
Malaysia
Prior art keywords
pyrazines
pyrazolo
substituted
kinase inhibitors
janus kinase
Prior art date
Application number
MYPI2017702034A
Other languages
English (en)
Inventor
Erik James Hicken
Shelley Allen
Mark Laurence Boys
Mark J Chicarelli
Jay Bradford Fell
John P Fischer
John Gaudino
Ronald Jay Hinklin
Christopher F Kraser
Ellen Laird
John E Robinson
Tony P Tang
Laurence E Burgess
Robert Andrew Rieger
Jed Pheneger
Yoshitaka Satoh
Katerina Leftheris
Raj K Raheja
Brydon L Bennett
Original Assignee
Array Biopharma Inc
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Celgene Corp filed Critical Array Biopharma Inc
Publication of MY191016A publication Critical patent/MY191016A/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/20—Pills, tablets, discs, rods
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
MYPI2017702034A 2014-12-05 2015-12-04 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors MY191016A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462088068P 2014-12-05 2014-12-05
PCT/US2015/064062 WO2016090285A1 (en) 2014-12-05 2015-12-04 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
MY191016A true MY191016A (en) 2022-05-28

Family

ID=55069089

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2017702034A MY191016A (en) 2014-12-05 2015-12-04 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors

Country Status (29)

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US (3) US10189845B2 (enExample)
EP (2) EP3878451A1 (enExample)
JP (2) JP6641373B2 (enExample)
KR (1) KR20170090476A (enExample)
CN (1) CN107278203B (enExample)
AU (1) AU2015357585B2 (enExample)
BR (1) BR112017011798A2 (enExample)
CA (1) CA2969709A1 (enExample)
CL (1) CL2017001422A1 (enExample)
CO (1) CO2017006674A2 (enExample)
CR (1) CR20170309A (enExample)
DK (1) DK3227297T3 (enExample)
ES (1) ES2865483T3 (enExample)
HR (1) HRP20210501T1 (enExample)
HU (1) HUE054371T2 (enExample)
IL (1) IL252656A0 (enExample)
MX (1) MX386316B (enExample)
MY (1) MY191016A (enExample)
PH (1) PH12017501032A1 (enExample)
PL (1) PL3227297T3 (enExample)
PT (1) PT3227297T (enExample)
RS (1) RS61693B1 (enExample)
RU (2) RU2742938C2 (enExample)
SG (1) SG11201704542SA (enExample)
SI (1) SI3227297T1 (enExample)
TW (1) TWI725004B (enExample)
UA (1) UA120065C2 (enExample)
WO (1) WO2016090285A1 (enExample)
ZA (1) ZA201704494B (enExample)

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KR20170090476A (ko) 2014-12-05 2017-08-07 어레이 바이오파마 인크. 야누스 키나제 저해제로서의 4,6-치환된-피라졸로[1,5-a]피라진
MX383747B (es) 2016-02-24 2025-03-14 Pfizer Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de quinasas janus (jak)
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
PT3472153T (pt) 2016-06-16 2021-12-31 Denali Therapeutics Inc Pirimidin-2-ilamino-1h-pirazóis como inibidores de lrrk2 para uso no tratamento de distúrbios neurodegenerativos
GB201617758D0 (en) * 2016-10-20 2016-12-07 Almac Discovery Limited Pharmaceutical compounds
JP6888101B2 (ja) * 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物
WO2018217946A1 (en) * 2017-05-24 2018-11-29 Denali Therapeutics Inc. Compounds, compositions and methods
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3740486A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111630054B (zh) 2018-01-18 2023-05-09 奥瑞生物药品公司 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
ES2922314T3 (es) 2018-09-10 2022-09-13 Array Biopharma Inc Compuestos heterocíclicos condensados como inhibidores de cinasa RET
PL3954689T3 (pl) * 2019-04-12 2024-08-05 Primegene (Beijing) Co., Ltd. Związki pochodne pirazolopirazyny, kompozycja farmaceutyczna i ich zastosowanie
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を予防するための方法および組成物
CN113150012B (zh) * 2020-01-22 2023-03-24 浙江海正药业股份有限公司 吡唑并[1,5-a]吡嗪类衍生物及其制备方法和用途
BR112022020020A2 (pt) 2020-04-04 2022-11-22 Pfizer Métodos de tratamento da doença do coronavírus 2019
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
AU2022387652B2 (en) * 2021-11-12 2025-10-16 Cms Research & Development Pte. Ltd. Pyrazolo fused ring compound and use thereof
EP4711367A1 (en) * 2023-05-12 2026-03-18 CMS Research & Development Pte. Ltd. Pyrazolopyrazine compound and method for preparing crystal form thereof

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EP2516434B1 (en) 2009-12-23 2015-05-27 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors
CA2787714C (en) * 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
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KR20130094710A (ko) * 2010-04-14 2013-08-26 어레이 바이오파마 인크. Ｊａｋ 키나아제의 억제제로서 5,7-치환된-이미다조［1,2-ｃ］피리미딘
SG11201401342VA (en) * 2011-10-12 2014-09-26 Array Biopharma Inc 5,7-substituted-imidazo[1,2-c]pyrimidines
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US10730880B2 (en) 2020-08-04
PT3227297T (pt) 2021-04-09
RU2017123387A3 (enExample) 2019-06-03
WO2016090285A1 (en) 2016-06-09
ES2865483T3 (es) 2021-10-15
EP3878451A1 (en) 2021-09-15
JP2018507167A (ja) 2018-03-15
TWI725004B (zh) 2021-04-21
RU2021102805A (ru) 2021-02-12
TW201632523A (zh) 2016-09-16
EP3227297B1 (en) 2021-01-20
PL3227297T3 (pl) 2021-10-25
UA120065C2 (uk) 2019-09-25
RU2017123387A (ru) 2019-01-11
RU2742938C2 (ru) 2021-02-11
US20190177328A1 (en) 2019-06-13
US20170362240A1 (en) 2017-12-21
KR20170090476A (ko) 2017-08-07
US10189845B2 (en) 2019-01-29
PH12017501032A1 (en) 2017-11-27
IL252656A0 (en) 2017-07-31
US20200291039A1 (en) 2020-09-17
EP3227297A1 (en) 2017-10-11
JP6641373B2 (ja) 2020-02-05
JP2020055859A (ja) 2020-04-09
SG11201704542SA (en) 2017-07-28
US11028093B2 (en) 2021-06-08
CL2017001422A1 (es) 2018-01-05
CR20170309A (es) 2018-02-02
HUE054371T2 (hu) 2021-09-28
MX2017007284A (es) 2017-08-25
AU2015357585B2 (en) 2020-07-02
SI3227297T1 (sl) 2021-04-30
AU2015357585A1 (en) 2017-07-13
CA2969709A1 (en) 2016-06-09
RS61693B1 (sr) 2021-05-31
ZA201704494B (en) 2022-03-30
DK3227297T3 (da) 2021-04-06
CN107278203A (zh) 2017-10-20
MX386316B (es) 2025-03-18
CN107278203B (zh) 2020-05-19
BR112017011798A2 (pt) 2017-12-26
CO2017006674A2 (es) 2017-10-20
HRP20210501T1 (hr) 2021-05-14

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