RU2742938C2 - 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ - Google Patents

4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ Download PDF

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RU2742938C2
RU2742938C2 RU2017123387A RU2017123387A RU2742938C2 RU 2742938 C2 RU2742938 C2 RU 2742938C2 RU 2017123387 A RU2017123387 A RU 2017123387A RU 2017123387 A RU2017123387 A RU 2017123387A RU 2742938 C2 RU2742938 C2 RU 2742938C2
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pyrazol
pyrazolo
pyrazin
alkyl
pentan
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RU2017123387A
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Russian (ru)
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RU2017123387A3 (enExample
RU2017123387A (ru
Inventor
Брайдон Л. БЕННЕТ
Радж К. РАХЕДЖА
Катерина Лефтерис
Ёситака САТО
Джед ФЕНЕДЖЕР
Роберт Эндрю РИДЖЕР
Лоренс Э. БЁРДЖЕСС
Тони П. ТЭНГ
Джон Э. Робинсон
Эллен ЛЭЙРД
Кристофер Ф. КРЭЙЗЕР
Рональд Джей Хинклин
Эрик Джеймс ХИКЕН
Джон ГАУДИНО
Джон П. Фишер
Джей Брэдфорд Фелл
Марк Дж. ЧИКАРЕЛЛИ
Марк Лоренс БОЙЗ
Шелли АЛЛЕН
Original Assignee
Эррэй Биофарма Инк.
Селджин Корпорейшн
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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RU2017123387A 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ RU2742938C2 (ru)

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US201462088068P 2014-12-05 2014-12-05
US62/088,068 2014-12-05
PCT/US2015/064062 WO2016090285A1 (en) 2014-12-05 2015-12-04 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

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RU2021102805A Division RU2021102805A (ru) 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ

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RU2017123387A RU2017123387A (ru) 2019-01-11
RU2017123387A3 RU2017123387A3 (enExample) 2019-06-03
RU2742938C2 true RU2742938C2 (ru) 2021-02-11

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RU2021102805A RU2021102805A (ru) 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ

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JP6888101B2 (ja) * 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物
US20200157081A1 (en) * 2017-05-24 2020-05-21 Denali Therapeutics Inc. Compounds, compositions and methods
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
US11524963B2 (en) 2018-01-18 2022-12-13 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
AU2020256720B2 (en) * 2019-04-12 2022-09-01 PrimeGene (Beijing) Co. Ltd. Pyrazolopyrazine derived compounds, pharmaceutical composition and use thereof
KR20230031981A (ko) 2019-05-14 2023-03-07 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
CN113150012B (zh) * 2020-01-22 2023-03-24 浙江海正药业股份有限公司 吡唑并[1,5-a]吡嗪类衍生物及其制备方法和用途
JP2023519738A (ja) 2020-04-04 2023-05-12 ファイザー・インク コロナウイルス疾患２０１９を処置する方法
AU2021287998A1 (en) 2020-06-11 2023-02-02 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
WO2023083200A1 (zh) * 2021-11-12 2023-05-19 南京明德新药研发有限公司 吡唑并环化合物及其应用
AU2024274086A1 (en) * 2023-05-12 2026-01-08 Cms Research & Development Pte. Ltd. Pyrazolopyrazine compound and method for preparing crystal form thereof

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US10189845B2 (en) 2019-01-29
UA120065C2 (uk) 2019-09-25
AU2015357585A1 (en) 2017-07-13
CA2969709A1 (en) 2016-06-09
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SG11201704542SA (en) 2017-07-28
US11028093B2 (en) 2021-06-08
AU2015357585B2 (en) 2020-07-02
IL252656A0 (en) 2017-07-31
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