JP6640725B2 - ｓｐａｄｉｎのレトロ−インベルソ類似体は増大された抗うつ作用を示す - Google Patents

ｓｐａｄｉｎのレトロ−インベルソ類似体は増大された抗うつ作用を示す Download PDF

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JP6640725B2
JP6640725B2 JP2016548687A JP2016548687A JP6640725B2 JP 6640725 B2 JP6640725 B2 JP 6640725B2 JP 2016548687 A JP2016548687 A JP 2016548687A JP 2016548687 A JP2016548687 A JP 2016548687A JP 6640725 B2 JP6640725 B2 JP 6640725B2
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analog
spadin
seq
propeptide
mixture
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JP2017505772A (ja
JP2017505772A5 (enExample
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ガウドリアウルト ゲオルゲス
ガウドリアウルト ゲオルゲス
ヘウルテアウク カトリーヌ
ヘウルテアウク カトリーヌ
マゼラ ジャン
マゼラ ジャン
ボルソト マルク
ボルソト マルク
モハ オウ マティ ハミド
モハ オウ マティ ハミド
ベイシエレ ジュリエ
ベイシエレ ジュリエ
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セントレ ナショナル デ ラ レチャーチェ シャーティフィック
セントレ ナショナル デ ラ レチャーチェ シャーティフィック
ウニヴェルシテ デ ニシエ ソプフィア アントイポリス
ウニヴェルシテ デ ニシエ ソプフィア アントイポリス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016548687A 2014-01-27 2015-01-27 ｓｐａｄｉｎのレトロ−インベルソ類似体は増大された抗うつ作用を示す Expired - Fee Related JP6640725B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461931954P 2014-01-27 2014-01-27
US61/931,954 2014-01-27
PCT/IB2015/000338 WO2015110915A2 (en) 2014-01-27 2015-01-27 Retro-inverso analogs of spadin display increased antidepressant effects

Related Child Applications (1)

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JP2019174139A Division JP2020023508A (ja) 2014-01-27 2019-09-25 ｓｐａｄｉｎのレトロ−インベルソ類似体は増大された抗うつ作用を示す

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JP2017505772A JP2017505772A (ja) 2017-02-23
JP2017505772A5 JP2017505772A5 (enExample) 2018-03-08
JP6640725B2 true JP6640725B2 (ja) 2020-02-05

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JP2016548687A Expired - Fee Related JP6640725B2 (ja) 2014-01-27 2015-01-27 ｓｐａｄｉｎのレトロ−インベルソ類似体は増大された抗うつ作用を示す
JP2019174139A Pending JP2020023508A (ja) 2014-01-27 2019-09-25 ｓｐａｄｉｎのレトロ−インベルソ類似体は増大された抗うつ作用を示す

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US (1) US10251937B2 (enExample)
EP (1) EP3099313B1 (enExample)
JP (2) JP6640725B2 (enExample)
CA (1) CA2938019A1 (enExample)
WO (1) WO2015110915A2 (enExample)

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Publication number Priority date Publication date Assignee Title
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
FR3057266B1 (fr) * 2016-10-11 2021-05-21 Centre Nat Rech Scient Peptides derives du propeptide ntsr3 et leur utilisation dans le traitement de la depression
FR3057267A1 (fr) * 2016-10-11 2018-04-13 Centre National De La Recherche Scientifique - Cnrs - Procede de diagnostic/determination de l'efficacite de traitement de la depression
KR102250582B1 (ko) * 2018-05-11 2021-05-12 고려대학교 산학협력단 별아교세포 특이적 수동전도도 억제약물의 스크리닝 시스템 및 이의 활용
FR3099932B1 (fr) 2019-08-13 2022-11-25 Univ Limoges Peptides dérivés de la sortiline
US20240294603A1 (en) * 2023-03-02 2024-09-05 Transdermal Biotechnology, Inc. Systems and methods for delivery of spadin for treatment of depression or other indications
US11980651B1 (en) 2023-06-21 2024-05-14 Transdermal Biotechnology, Inc. Systems and methods for treatment of hearing using dihexa

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US20050272652A1 (en) * 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
ATE545429T1 (de) * 2002-12-20 2012-03-15 Lundbeck & Co As H Modulation der neurotrophinaktivität;screeningsverfahren
EP2077278A1 (fr) * 2007-12-21 2009-07-08 Centre National de la Recherche Scientifique (CNRS) Peptide dérivé du récepteur 3 de la neurotensine et utilisation dans le traitemement de maladies psychiatriques
CN102131826B (zh) * 2008-04-27 2014-07-02 H.隆德贝克有限公司 人类分拣蛋白的晶体结构及其用于鉴定分拣蛋白的配体的用途
CA2822854C (en) 2010-12-29 2020-01-07 Medincell Biodegradable drug delivery compositions
US20120322060A1 (en) * 2011-04-13 2012-12-20 Centre National De Le Recherche Scientifique - Cnrs - Diagnosis and monitoring treatment of psychiatric diseases with spadin and related methods
ES2938586T3 (es) * 2012-06-27 2023-04-12 Medincell S A Liberación de fármacos biodegradables para composiciones hidrófobas

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Publication number Publication date
JP2017505772A (ja) 2017-02-23
WO2015110915A2 (en) 2015-07-30
US20170072013A1 (en) 2017-03-16
EP3099313B1 (en) 2021-04-21
WO2015110915A3 (en) 2015-11-26
JP2020023508A (ja) 2020-02-13
CA2938019A1 (en) 2015-07-30
EP3099313A2 (en) 2016-12-07
US10251937B2 (en) 2019-04-09

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