JP6637410B2 - 操作されたフェニルアラニンアンモニアリアーゼポリペプチド - Google Patents
操作されたフェニルアラニンアンモニアリアーゼポリペプチド Download PDFInfo
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- JP6637410B2 JP6637410B2 JP2016509098A JP2016509098A JP6637410B2 JP 6637410 B2 JP6637410 B2 JP 6637410B2 JP 2016509098 A JP2016509098 A JP 2016509098A JP 2016509098 A JP2016509098 A JP 2016509098A JP 6637410 B2 JP6637410 B2 JP 6637410B2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| EP3145536B1 (en) * | 2014-04-16 | 2021-10-27 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| EP3882259B1 (en) | 2015-05-13 | 2026-01-28 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| CN106636048A (zh) * | 2016-12-14 | 2017-05-10 | 江南大学 | 一株酶活提高的苯丙氨酸脱氨酶突变体 |
| CN106755160B (zh) * | 2017-01-17 | 2019-08-02 | 湖州颐辉生物科技有限公司 | 一种组氨酸解氨酶及其用途 |
| AU2018217495B2 (en) * | 2017-02-13 | 2021-03-04 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
| CN110914288B (zh) * | 2017-05-27 | 2023-05-05 | 宁波酶赛生物工程有限公司 | 工程化醛缩酶多肽及其应用 |
| EP3642221A1 (en) | 2017-06-21 | 2020-04-29 | Synlogic Operating Company, Inc. | Bacteria for the treatment of disorders |
| EP3807409A4 (en) * | 2018-06-12 | 2022-08-03 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| EP3820833A4 (en) * | 2018-07-12 | 2022-08-03 | Codexis, Inc. | MODIFIED AMMONIA-LYASE PHENYLALANINE POLYPEPTIDES |
| JP7780186B2 (ja) * | 2018-10-29 | 2025-12-04 | コデクシス， インコーポレイテッド | 操作されたｄｎａポリメラーゼバリアント |
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| WO2021188819A1 (en) * | 2020-03-20 | 2021-09-23 | Synlogic Operating Company, Inc. | Microorganisms engineered to reduce hyperphenylalaninemia |
| WO2022146718A1 (en) * | 2020-12-31 | 2022-07-07 | Synlogic Operating Company, Inc. | Microorganisms engineered to reduce hyperphenylalaninemia |
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| CN114015636B (zh) * | 2021-12-08 | 2023-09-29 | 天地壹号饮料股份有限公司 | 重组醋酸菌及其制备方法和应用 |
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