PE20151775A1 - Polipeptidos de fenilalanina amoniaco liasa modificados por ingenieria genetica - Google Patents

Polipeptidos de fenilalanina amoniaco liasa modificados por ingenieria genetica

Info

Publication number
PE20151775A1
PE20151775A1 PE2015002177A PE2015002177A PE20151775A1 PE 20151775 A1 PE20151775 A1 PE 20151775A1 PE 2015002177 A PE2015002177 A PE 2015002177A PE 2015002177 A PE2015002177 A PE 2015002177A PE 20151775 A1 PE20151775 A1 PE 20151775A1
Authority
PE
Peru
Prior art keywords
polypeptides
phenylalanine ammonia
liasa
modified
genetic engineering
Prior art date
Application number
PE2015002177A
Other languages
English (en)
Inventor
Gjalt W Huisman
Nicholas J Agard
Benjamin Mijts
Jonathan Vroom
Xiyun Zhang
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of PE20151775A1 publication Critical patent/PE20151775A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La invencion proporciona polipeptidos de fenilalanina amoniaco-liasa (PAL) modificados por ingenieria genetica y composiciones de los mismos, asi como polinucleotidos que codifican para los polipeptidos de fenilalanina amoniaco-liasa (PAL) modificados por ingenieria genetica
PE2015002177A 2013-04-18 2014-04-17 Polipeptidos de fenilalanina amoniaco liasa modificados por ingenieria genetica PE20151775A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361813586P 2013-04-18 2013-04-18
US201361897932P 2013-10-31 2013-10-31

Publications (1)

Publication Number Publication Date
PE20151775A1 true PE20151775A1 (es) 2015-12-02

Family

ID=51729192

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015002177A PE20151775A1 (es) 2013-04-18 2014-04-17 Polipeptidos de fenilalanina amoniaco liasa modificados por ingenieria genetica

Country Status (26)

Country Link
US (17) US9611468B2 (es)
EP (3) EP3521423B1 (es)
JP (5) JP6637410B2 (es)
KR (1) KR102218930B1 (es)
CN (2) CN105324483B (es)
AU (2) AU2014253900C1 (es)
CA (1) CA2909719C (es)
CY (1) CY1121891T1 (es)
DK (2) DK2986722T3 (es)
EA (1) EA034034B1 (es)
ES (2) ES2890955T3 (es)
HR (1) HRP20190928T1 (es)
HU (2) HUE043549T2 (es)
IL (1) IL242067B (es)
LT (1) LT2986722T (es)
MX (1) MX366196B (es)
MY (1) MY193198A (es)
NZ (1) NZ713396A (es)
PE (1) PE20151775A1 (es)
PH (1) PH12015502412B1 (es)
PL (1) PL2986722T3 (es)
PT (1) PT2986722T (es)
RS (1) RS58802B1 (es)
SG (1) SG11201508598YA (es)
SI (1) SI2986722T1 (es)
WO (1) WO2014172541A2 (es)

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CN116847860A (zh) * 2020-12-31 2023-10-03 同生运营公司 经工程化以减轻高苯丙氨酸血症的微生物
CN114015636B (zh) * 2021-12-08 2023-09-29 天地壹号饮料股份有限公司 重组醋酸菌及其制备方法和应用
CN114457151A (zh) * 2022-01-27 2022-05-10 宁夏医科大学总医院 一种用于检测苯丙氨酸羟化酶基因突变的检测试剂盒及其检测方法
CN117417925A (zh) * 2022-07-18 2024-01-19 浙江泽科塔生物医药有限公司 Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN115518691B (zh) * 2022-10-14 2023-11-21 天津大学 一种具有类漆酶活性的人工酶及制备方法和应用
CN116478975B (zh) * 2023-06-16 2023-09-01 苏州优信合生技术有限公司 高活性苯丙氨酸解氨酶突变体及其表达菌株

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CA2909719C (en) 2022-09-27
US20190055535A1 (en) 2019-02-21
US10487319B2 (en) 2019-11-26
KR102218930B1 (ko) 2021-02-23
JP2020185016A (ja) 2020-11-19
US20140314843A1 (en) 2014-10-23
DK3521423T3 (da) 2021-09-06
CY1121891T1 (el) 2020-10-14
DK2986722T3 (da) 2019-05-13
CA2909719A1 (en) 2014-10-23
MX2015014662A (es) 2016-03-03
US20200032236A1 (en) 2020-01-30
US20190055536A1 (en) 2019-02-21
LT2986722T (lt) 2019-09-10
KR20150143816A (ko) 2015-12-23
US11136571B2 (en) 2021-10-05
US20200231959A1 (en) 2020-07-23
AU2014253900C1 (en) 2020-04-02
AU2019272057A1 (en) 2019-12-19
US20200040325A1 (en) 2020-02-06
IL242067B (en) 2018-03-29
CN105324483B (zh) 2018-11-30
US20200199566A1 (en) 2020-06-25
PH12015502412A1 (en) 2016-02-22
EP2986722A4 (en) 2017-02-22
JP6637410B2 (ja) 2020-01-29
US10941391B2 (en) 2021-03-09
AU2014253900A1 (en) 2015-11-12
RS58802B1 (sr) 2019-07-31
US10160963B2 (en) 2018-12-25
US10975367B2 (en) 2021-04-13
WO2014172541A2 (en) 2014-10-23
ES2729048T3 (es) 2019-10-30
EP3521423B1 (en) 2021-07-21
ES2890955T3 (es) 2022-01-25
HUE055899T2 (hu) 2022-01-28
AU2019272057B2 (en) 2021-05-27
CN109486803B (zh) 2022-10-25
HUE043549T2 (hu) 2019-08-28
US11913045B2 (en) 2024-02-27
BR112015026160A2 (pt) 2017-10-10
US10294468B2 (en) 2019-05-21
US20200032234A1 (en) 2020-01-30
US10494623B2 (en) 2019-12-03
US20180016568A1 (en) 2018-01-18
NZ713396A (en) 2020-06-26
US10144924B2 (en) 2018-12-04
WO2014172541A3 (en) 2015-02-19
EA201591995A1 (ru) 2016-04-29
JP2020185017A (ja) 2020-11-19
SI2986722T1 (sl) 2019-07-31
HRP20190928T1 (hr) 2019-07-26
JP7129715B2 (ja) 2022-09-02
US20180037880A1 (en) 2018-02-08
CN105324483A (zh) 2016-02-10
EA034034B1 (ru) 2019-12-20
EP2986722A2 (en) 2016-02-24
EP2986722B1 (en) 2019-04-03
PH12015502412B1 (en) 2016-02-22
US11401515B2 (en) 2022-08-02
PL2986722T3 (pl) 2019-10-31
MY193198A (en) 2022-09-26
EP3971288A1 (en) 2022-03-23
US10717974B2 (en) 2020-07-21
US10870843B2 (en) 2020-12-22
US20170191050A1 (en) 2017-07-06
US20200032233A1 (en) 2020-01-30
US20190241882A1 (en) 2019-08-08
US9611468B2 (en) 2017-04-04
US11130947B2 (en) 2021-09-28
JP2018166524A (ja) 2018-11-01
MX366196B (es) 2019-07-01
SG11201508598YA (en) 2015-11-27
US20210222146A1 (en) 2021-07-22
JP2016516428A (ja) 2016-06-09
JP2022183356A (ja) 2022-12-08
PT2986722T (pt) 2019-06-21
AU2014253900B2 (en) 2019-09-19
US20190040377A1 (en) 2019-02-07
US10640759B2 (en) 2020-05-05
US20200399627A1 (en) 2020-12-24
EP3521423A1 (en) 2019-08-07
US10358639B2 (en) 2019-07-23
US20200032235A1 (en) 2020-01-30
CN109486803A (zh) 2019-03-19

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