JP6636031B2 - 治療用化合物およびその使用 - Google Patents

治療用化合物およびその使用 Download PDF

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Publication number
JP6636031B2
JP6636031B2 JP2017539594A JP2017539594A JP6636031B2 JP 6636031 B2 JP6636031 B2 JP 6636031B2 JP 2017539594 A JP2017539594 A JP 2017539594A JP 2017539594 A JP2017539594 A JP 2017539594A JP 6636031 B2 JP6636031 B2 JP 6636031B2
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Japan
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alkyl
optionally substituted
heterocyclyl
hydrogen
group
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JP2017539594A
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JP2018505169A5 (enExample
JP2018505169A (ja
Inventor
ブライアン ケー． アルブレヒト，
ブライアン ケー． アルブレヒト，
ジェイムズ エドモンド オーディア，
ジェイムズ エドモンド オーディア，
アレクサンドル コート，
アレクサンドル コート，
マーティン デュプレシス，
マーティン デュプレシス，
ビクター エス． ゲーリング，
ビクター エス． ゲーリング，
アンドリュー チャールズ グッド，
アンドリュー チャールズ グッド，
ジーン−クリストフ ハーマンジ，
ジーン−クリストフ ハーマンジ，
イブ レブラン，
イブ レブラン，
クリストファー ジー． ナスヴェスチャック，
クリストファー ジー． ナスヴェスチャック，
アレクサンダー エム． テイラー，
アレクサンダー エム． テイラー，
リシ ジー． ヴァスワニ，
リシ ジー． ヴァスワニ，
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Constellation Pharmaceuticals Inc
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Constellation Pharmaceuticals Inc
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    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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