JP6632523B2 - 顕微鏡で複数のサンプルを検査するための光学装置および方法 - Google Patents

顕微鏡で複数のサンプルを検査するための光学装置および方法 Download PDF

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JP6632523B2
JP6632523B2 JP2016520481A JP2016520481A JP6632523B2 JP 6632523 B2 JP6632523 B2 JP 6632523B2 JP 2016520481 A JP2016520481 A JP 2016520481A JP 2016520481 A JP2016520481 A JP 2016520481A JP 6632523 B2 JP6632523 B2 JP 6632523B2
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JP2016535861A (ja
JP2016535861A5 (enExample
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クネーベル、ヴェルナー
フーケ、ヴェルンヘル
シエックマン、フランク
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Leica Microsystems CMS GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
    • G01N2021/135—Sample holder displaceable

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2016520481A 2013-06-18 2014-06-18 顕微鏡で複数のサンプルを検査するための光学装置および方法 Active JP6632523B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102013211426.5A DE102013211426A1 (de) 2013-06-18 2013-06-18 Verfahren und optische Vorrichtung zum mikroskopischen Untersuchen einer Vielzahl von Proben
DE102013211426.5 2013-06-18
PCT/EP2014/062907 WO2014202704A1 (de) 2013-06-18 2014-06-18 Verfahren und optische vorrichtung zum mikroskopischen untersuchen einer vielzahl von proben

Publications (3)

Publication Number Publication Date
JP2016535861A JP2016535861A (ja) 2016-11-17
JP2016535861A5 JP2016535861A5 (enExample) 2019-03-07
JP6632523B2 true JP6632523B2 (ja) 2020-01-22

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JP2016520481A Active JP6632523B2 (ja) 2013-06-18 2014-06-18 顕微鏡で複数のサンプルを検査するための光学装置および方法

Country Status (5)

Country Link
US (1) US10458899B2 (enExample)
EP (1) EP3011379B1 (enExample)
JP (1) JP6632523B2 (enExample)
DE (1) DE102013211426A1 (enExample)
WO (1) WO2014202704A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013213781A1 (de) * 2013-03-20 2014-09-25 Leica Microsystems Cms Gmbh Verfahren und optische Anordnung zum Manipulieren und Abbilden einer mikroskopischen Probe
DE102013226277A1 (de) * 2013-12-17 2015-06-18 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zum Untersuchen einer Probe mittels optischer Projektionstomografie
LU92505B1 (de) * 2014-07-22 2016-01-25 Leica Microsystems Verfahren und vorrichtung zum mikroskopischen untersuchen einer probe
US11085901B2 (en) * 2014-08-19 2021-08-10 Dan Slater Acoustical microscope
DE102015114756B4 (de) * 2014-09-25 2021-07-22 Leica Microsystems Cms Gmbh Spiegelvorrichtung
LU93022B1 (de) * 2016-04-08 2017-11-08 Leica Microsystems Verfahren und Mikroskop zum Untersuchen einer Probe
US10310248B2 (en) * 2016-08-18 2019-06-04 Olympus Corporation Microscope including a medium container containing an immersion medium in which a specimen container containing an immersion medium and a sample is immersed
US10690898B2 (en) * 2016-09-15 2020-06-23 Molecular Devices (Austria) GmbH Light-field microscope with selective-plane illumination
JP2018096703A (ja) * 2016-12-08 2018-06-21 オリンパス株式会社 マイクロプレートおよび顕微鏡システム
LU100024B1 (de) * 2017-01-20 2018-07-30 Leica Microsystems Verfahren zum sequentiellen Untersuchen einer Mehrzahl von Proben, Probenträgereinheit und Aufnahmeeinheit für Lichtblattebenenmikroskopie
EP3495865A1 (en) * 2017-12-07 2019-06-12 European Molecular Biology Laboratory A sample holder for imaging a plurality of samples
JP7207860B2 (ja) 2018-04-09 2023-01-18 浜松ホトニクス株式会社 試料観察装置
JP7329113B2 (ja) * 2018-04-09 2023-08-17 浜松ホトニクス株式会社 試料観察装置
DE102018128264B4 (de) * 2018-11-12 2020-08-20 Leica Microsystems Cms Gmbh Lichtblattmikroskop
DE102018222271A1 (de) 2018-12-19 2020-06-25 Carl Zeiss Microscopy Gmbh Verfahren zum Betrieb einer Probenkammer für eine mikroskopische Bildgebung sowie Vorrichtung und Probenkammer
JP7108564B2 (ja) * 2019-03-06 2022-07-28 アンリツ株式会社 Ｘ線検査装置
US20240248011A1 (en) * 2021-05-19 2024-07-25 Leica Microsystems Cms Gmbh Method and apparatus for imaging a biological sample
CN114252371A (zh) * 2021-12-24 2022-03-29 欧波同科技产业有限公司 一种夹杂物分析系统中同时获得不同灰度阶颗粒的方法
CN114264576B (zh) * 2021-12-24 2024-12-17 欧波同科技产业有限公司 一种基于电镜的提高颗粒分析速度的颗粒识别方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002377A (en) 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures
US20030002148A1 (en) 1998-10-24 2003-01-02 Johann Engelhardt Arrangement for optically scanning an object
DE19950225A1 (de) 1998-10-24 2000-05-18 Leica Microsystems Anordnung zur optischen Abtastung eines Objekts
DE10257423A1 (de) 2002-12-09 2004-06-24 Europäisches Laboratorium für Molekularbiologie (EMBL) Mikroskop
WO2005036451A1 (en) * 2003-10-08 2005-04-21 Lifespan Biosciences, Inc. Automated microspcope slide tissue sample mapping and image acquisition
DE102004034957A1 (de) 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Anordnung zur mikroskopischen Beobachtung und/oder Detektion und Verwendung
WO2007065711A1 (en) * 2005-12-09 2007-06-14 Europäisches Laboratorium für Molekularbiologie (EMBL) Miscroscope specimen holder
CA2815953A1 (en) * 2010-11-08 2012-05-18 Reametrix Inc. Sample assembly for a measurement device
DE102011000835C5 (de) * 2011-02-21 2019-08-22 Leica Microsystems Cms Gmbh Abtastmikroskop und Verfahren zur lichtmikroskopischen Abbildung eines Objektes
US9446411B2 (en) * 2011-02-24 2016-09-20 Reametrix, Inc. Sample assembly for a measurement device
US9316824B2 (en) 2011-03-04 2016-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Optomechanical module for converting a microscope to provide selective plane illumination microscopy
DE102011054914A1 (de) * 2011-10-28 2013-05-02 Leica Microsystems Cms Gmbh Verfahren und Anordnung zur Beleuchtung einer Probe

Also Published As

Publication number Publication date
US10458899B2 (en) 2019-10-29
EP3011379A1 (de) 2016-04-27
JP2016535861A (ja) 2016-11-17
EP3011379B1 (de) 2021-08-18
WO2014202704A1 (de) 2014-12-24
DE102013211426A1 (de) 2014-12-18
US20160153892A1 (en) 2016-06-02

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