JP6608366B2 - 真菌防除のための相乗的殺真菌性混合物および組成物 - Google Patents

真菌防除のための相乗的殺真菌性混合物および組成物 Download PDF

Info

Publication number
JP6608366B2
JP6608366B2 JP2016543745A JP2016543745A JP6608366B2 JP 6608366 B2 JP6608366 B2 JP 6608366B2 JP 2016543745 A JP2016543745 A JP 2016543745A JP 2016543745 A JP2016543745 A JP 2016543745A JP 6608366 B2 JP6608366 B2 JP 6608366B2
Authority
JP
Japan
Prior art keywords
compound
formula
synergistic
synergistic fungicidal
concentration ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016543745A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017508719A5 (enExample
JP2017508719A (ja
Inventor
オーウェン,ジョン,ダブリュ.
ヤオ,チェンリン
ロースバッハ,ベス
Original Assignee
アダマ・マクテシム・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アダマ・マクテシム・リミテッド filed Critical アダマ・マクテシム・リミテッド
Publication of JP2017508719A publication Critical patent/JP2017508719A/ja
Publication of JP2017508719A5 publication Critical patent/JP2017508719A5/ja
Application granted granted Critical
Publication of JP6608366B2 publication Critical patent/JP6608366B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/34Nitriles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/50Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • A01N43/6531,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/88Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with three ring hetero atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N45/00Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
    • A01N45/02Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A01N47/04Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A01N47/14Di-thio analogues thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/24Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2016543745A 2013-12-31 2014-12-30 真菌防除のための相乗的殺真菌性混合物および組成物 Active JP6608366B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361922630P 2013-12-31 2013-12-31
US201361922640P 2013-12-31 2013-12-31
US201361922616P 2013-12-31 2013-12-31
US61/922,640 2013-12-31
US61/922,616 2013-12-31
US61/922,630 2013-12-31
PCT/US2014/072747 WO2015103261A1 (en) 2013-12-31 2014-12-30 Synergistic fungicidal mixtures for fungal control in cereals

Publications (3)

Publication Number Publication Date
JP2017508719A JP2017508719A (ja) 2017-03-30
JP2017508719A5 JP2017508719A5 (enExample) 2018-03-29
JP6608366B2 true JP6608366B2 (ja) 2019-11-20

Family

ID=53480350

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016543745A Active JP6608366B2 (ja) 2013-12-31 2014-12-30 真菌防除のための相乗的殺真菌性混合物および組成物
JP2016543731A Active JP6767868B2 (ja) 2013-12-31 2014-12-30 真菌防除のための相乗的殺真菌性混合物および組成物
JP2016543740A Active JP6609257B2 (ja) 2013-12-31 2014-12-30 真菌防除のための相乗的殺真菌性混合物および組成物
JP2020082014A Pending JP2020143097A (ja) 2013-12-31 2020-05-07 真菌防除のための相乗的殺真菌性混合物および組成物
JP2022076711A Pending JP2022115995A (ja) 2013-12-31 2022-05-06 穀類における真菌防除のための相乗的殺真菌性混合物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2016543731A Active JP6767868B2 (ja) 2013-12-31 2014-12-30 真菌防除のための相乗的殺真菌性混合物および組成物
JP2016543740A Active JP6609257B2 (ja) 2013-12-31 2014-12-30 真菌防除のための相乗的殺真菌性混合物および組成物
JP2020082014A Pending JP2020143097A (ja) 2013-12-31 2020-05-07 真菌防除のための相乗的殺真菌性混合物および組成物
JP2022076711A Pending JP2022115995A (ja) 2013-12-31 2022-05-06 穀類における真菌防除のための相乗的殺真菌性混合物

Country Status (32)

Country Link
US (37) US9532570B2 (enExample)
EP (3) EP3096619B1 (enExample)
JP (5) JP6608366B2 (enExample)
CN (6) CN106061262A (enExample)
AP (3) AP2016009343A0 (enExample)
AU (6) AU2014373850A1 (enExample)
BR (3) BR112016015157A2 (enExample)
CA (3) CA2935547C (enExample)
CL (5) CL2016001678A1 (enExample)
CR (3) CR20160344A (enExample)
CU (3) CU24463B1 (enExample)
DK (2) DK3091835T3 (enExample)
DO (3) DOP2016000165A (enExample)
EA (3) EA030030B1 (enExample)
EC (3) ECSP16064260A (enExample)
ES (1) ES3039914T3 (enExample)
FI (2) FI3091835T3 (enExample)
HR (1) HRP20251086T1 (enExample)
HU (1) HUE072634T2 (enExample)
IL (3) IL246462B (enExample)
LT (2) LT3091835T (enExample)
MX (4) MX394300B (enExample)
NI (3) NI201600097A (enExample)
NZ (5) NZ738965A (enExample)
PE (3) PE20161026A1 (enExample)
PH (3) PH12016501285B1 (enExample)
PL (1) PL3096619T4 (enExample)
PT (2) PT3091835T (enExample)
RS (2) RS67373B1 (enExample)
SI (1) SI3096619T1 (enExample)
UA (3) UA123696C2 (enExample)
WO (3) WO2015103259A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018508468A (ja) * 2014-12-23 2018-03-29 アダマ・マクテシム・リミテッド 種子処理としての5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オン

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015008444A (es) 2012-12-28 2015-09-23 Dow Agrosciences Llc Derivados de n-(sustituido)-5-flouro-4-imino-3-metil-2-oxo-3,4-dih idropirimidin-1 (2h)-carboximida.
JP6324994B2 (ja) 2012-12-28 2018-05-16 アダマ・マクテシム・リミテッド N−(置換)−5−フルオロ−4−イミノ−3−メチル−2−オキソ−3,4−ジヒドロピリミジン−1(2h)−カルボキシレート誘導体
ES2874475T3 (es) 2012-12-31 2021-11-05 Adama Makhteshim Ltd Derivados de la 3,4-dihidropirimidin-2(1h)-ona 3-alquil-5-fluoro-4-iminosustituida como fungicidas
US9532570B2 (en) 2013-12-31 2017-01-03 Adama Makhteshim Ltd. Synergistic fungicidal mixtures comprising 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one for fungal control in cereals
EA036389B1 (ru) 2013-12-31 2020-11-03 Адама Мактешим Лтд. 5-фтор-4-имино-3-(алкил/замещенный алкил)-1-(арилсульфонил)-3,4-дигидропиримидин-2(1h)-он и способы их получения
CN113173838A (zh) 2014-12-30 2021-07-27 美国陶氏益农公司 具有杀真菌活性的吡啶酰胺化合物
CN105191706A (zh) * 2015-08-20 2015-12-30 贵阳中医学院 一种有效防治太子参叶斑病的方法
UY36964A (es) * 2015-10-27 2017-05-31 Bayer Cropscience Ag Combinaciones de principios activos que comprenden un derivado de (tio) carboxamida y un compuesto funguicida
WO2017110864A1 (ja) * 2015-12-25 2017-06-29 住友化学株式会社 植物病害防除組成物およびその用途
JP6922272B2 (ja) * 2016-03-11 2021-08-18 住友化学株式会社 植物病害防除組成物及び植物病害防除方法
JP6862939B2 (ja) * 2016-03-11 2021-04-21 住友化学株式会社 植物病害防除組成物及び植物病害防除方法
GB201610264D0 (en) * 2016-06-13 2016-07-27 Syngenta Participations Ag Pesticidal compositions
CN114424771A (zh) 2017-03-07 2022-05-03 Upl有限公司 杀真菌组合
CN107058529B (zh) * 2017-03-23 2022-01-25 四川省农业科学院作物研究所 一种选育小麦条锈病持久抗性材料的方法
TW201902357A (zh) * 2017-05-02 2019-01-16 美商陶氏農業科學公司 用作種子處理之無環吡啶醯胺
TWI774761B (zh) * 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於穀物中的真菌防治之協同性混合物
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
TWI774760B (zh) * 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於蔬菜中的真菌防治之協同性混合物
WO2019038583A1 (en) 2017-07-17 2019-02-28 Adama Makhteshim Ltd. 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2-ONE POLYMORPHS
CN109384728A (zh) * 2017-08-07 2019-02-26 华东理工大学 嘧菌酯通道型溶剂化物及其制备方法
CR20210270A (es) 2018-11-05 2021-07-20 Adama Makhteshim Ltd Mezclas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2-ona, y métodos de uso de los mismos
JP2022541318A (ja) * 2019-07-22 2022-09-22 アダマ・マクテシム・リミテッド 殺菌組合せ物、混合物および組成物、ならびにそれらの使用
CN114599639A (zh) 2019-09-23 2022-06-07 阿达玛马克西姆有限公司 用于制备5-(氟-4-亚氨基-3-甲基)-1-甲苯磺酰基-3,4-二氢嘧啶-(1h)-酮的方法
EP4044811A4 (en) 2019-10-18 2023-09-27 Corteva Agriscience LLC METHOD FOR SYNTHESIS OF PICOLINAMIDS
CR20220610A (es) 2020-05-04 2023-01-10 Adama Makhteshim Ltd Mezclas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2-ona, y métodos de uso de las mismas
EP4649827A2 (en) * 2020-07-08 2025-11-19 Adama Makhteshim Ltd. Fungicidal mixtures
EP4284173A1 (en) 2021-01-27 2023-12-06 Adama Makhteshim Ltd. 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1 h)-one for controlling plant diseases
BR112023023105A2 (pt) 2021-05-04 2024-01-30 Adama Makhteshim Ltd Formas cristalinas de 5-fluoro-4-imino-3-metil-1-tosil-3,4-di-hidropirimidin-2-ona, e misturas, composições e métodos de uso das mesmas
AU2023207319A1 (en) * 2022-01-12 2024-07-25 Adama Makhteshim Ltd. Fungicidal mixtures comprising combination containing phthalimide fungicides
EP4486126A1 (en) 2022-03-03 2025-01-08 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
WO2023228148A1 (en) 2022-05-26 2023-11-30 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
AU2023318916A1 (en) * 2022-08-03 2025-02-20 Adama Makhteshim Ltd. 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1h)-one for fungicide-resistant fungus
CN120129460A (zh) * 2022-10-26 2025-06-10 德州作物科学股份有限公司 抗真菌组合物及其使用方法
WO2024105097A1 (en) * 2022-11-17 2024-05-23 Upl Mauritius Limited Method of controlling phytopathogenic fungi
CN120882310A (zh) * 2023-03-09 2025-10-31 安道麦马克西姆有限公司 杀真菌组合、混合物及组合物以及其用途
CN120882311A (zh) 2023-03-14 2025-10-31 安道麦马克西姆有限公司 含有5-(氟-4-亚氨基-3-甲基)-1-甲苯磺酰基-3,4二氢嘧啶-(1h)-酮及其衍生物以及uv吸收剂的液体组合物
CN116725037A (zh) * 2023-06-19 2023-09-12 广西壮族自治区亚热带作物研究所(广西亚热带农产品加工研究所) 一种防治火龙果溃疡病的杀菌剂组合物
WO2025031846A1 (en) * 2023-08-09 2025-02-13 Basf Se Fungicidal ternary mixtures comprising 5-fluoro-4-imino-3-methyl-1-(p-tolylsulfonyl)pyrimidin-2-one
WO2025031845A1 (en) * 2023-08-09 2025-02-13 Basf Se Fungicidal compositions comprising 5-fluoro-4-imino-3-methyl-1-(p-tolylsulfonyl)pyrimidin-2-one
WO2025046581A1 (en) * 2023-08-31 2025-03-06 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereo
IL308593A (en) * 2023-11-15 2025-06-01 Adama Makhteshim Ltd Reducing environmental impact of fungicidal enhancement
WO2025114931A1 (en) * 2023-11-28 2025-06-05 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3309359A (en) 1965-10-22 1967-03-14 Hoffmann La Roche N-mono-acyl-5-fluorocytosine derivatives and process
US3368938A (en) 1966-01-13 1968-02-13 Hoffmann La Roche Controlling fungi with 5-fluorocytosine
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
US3868373A (en) 1970-01-27 1975-02-25 Hoffmann La Roche 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines
US4009272A (en) * 1971-10-23 1977-02-22 Bayer Aktiengesellschaft Penicillins
CH579057A5 (enExample) 1973-09-07 1976-08-31 Hoffmann La Roche
FR2530636A1 (fr) 1982-07-23 1984-01-27 Rhone Poulenc Agrochimie Nouveaux derives de la tetrahydro-2,3,6,7 5h-thiazolo (3,2-a) pyrimidine, leur preparation et leur utilisation comme herbicides
JPS601793A (ja) 1983-06-16 1985-01-07 松下電器産業株式会社 高周波加熱装置
EP0139613A1 (de) 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-Nitrophenyl)-4-aminopyrimidin-Derivate, deren Herstellung und Verwendung
JPS6128658A (ja) 1984-07-16 1986-02-08 アイエス興産株式会社 防水立上り押え工事用平板ブロツク
US4845081A (en) 1984-10-18 1989-07-04 University Of Florida Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes
IT1196465B (it) 1986-07-07 1988-11-16 Montedison Spa Miscele fungicide
EP0332579B1 (de) 1988-03-09 1994-08-10 Ciba-Geigy Ag Mittel zum Schutz von Pflanzen gegen Krankheiten
DE3821711A1 (de) 1988-06-28 1990-02-08 Bayer Ag Thiazolopyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
JP3109012B2 (ja) 1992-06-18 2000-11-13 クミアイ化学工業株式会社 チアゾロ[5,4−d]ピリミジン誘導体及び農園芸用殺菌剤
JP3217191B2 (ja) 1992-07-16 2001-10-09 ビーエーエスエフ アクチェンゲゼルシャフト ヘテロ芳香族化合物およびこれを含有する植物保護剤
CN1105113C (zh) 1995-07-05 2003-04-09 纳幕尔杜邦公司 杀真菌嘧啶酮
TR199801813T2 (xx) 1996-03-11 1998-12-21 Novartis Ag B�cek �ld�r�c� olarak pirimidin-4- on t�revleri.
HRP970239B1 (en) 1997-05-09 2004-04-30 Inst Ru Er Bouekovic Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity
GT199900185A (es) 1998-11-06 2001-04-18 Novedosa pirimidin-4-enamina como fungicida.
AU2002212015B2 (en) 2000-10-13 2007-01-25 Shire Canada Inc. Dioxolane analogs for improved inter-cellular delivery
WO2003018051A1 (en) 2001-08-27 2003-03-06 Vic Jira Anti-fungal composition
EP1731523A4 (en) 2004-04-01 2009-08-12 Takeda Pharmaceutical THIAZOLOPYRIMIDINDERIVAT
US8679514B2 (en) * 2005-07-27 2014-03-25 Basf Se Fungicidal mixtures based on azolopyrimidinylamines
AU2012216760B2 (en) * 2005-09-29 2013-07-04 Syngenta Participations Ag Fungicidal compositions
US20090163567A1 (en) 2005-11-22 2009-06-25 Ishihara Sangyo Kaisha, Ltd Germicide composition for agricultural and gardening applications and method for controlling plant disease
US20080004253A1 (en) 2006-06-30 2008-01-03 Bryan James Branstetter Thiazolopyrimidine modulators of TRPV1
US20100029483A1 (en) 2006-10-16 2010-02-04 Rhodia Inc. Agricultural adjuvant compositions, pesticide compositions, and methods for using such compositions
US20100056468A1 (en) 2007-01-08 2010-03-04 University Health Network Pyrimidine Derivatives As Anticancer Agents
PT2193716E (pt) * 2007-04-25 2011-04-19 Syngenta Participations Ag Composições fungicidas
US20100267555A1 (en) * 2007-11-16 2010-10-21 Basf Se Fungicidal mixtures II
DK2252594T3 (en) 2008-01-22 2015-11-23 Dow Agrosciences Llc 4-amino-5-fluoro-pyrimidine derivatives as fungicides
MX2011001091A (es) 2008-08-01 2011-03-15 Dow Agrosciences Llc Uso de 5-fluorocitosina como un fungicida.
EP2326327B1 (en) 2008-09-17 2016-03-23 SRI International Analogs of indole-3-carbinol and their use as agents against infection
SI2389375T1 (sl) 2009-01-23 2015-11-30 Euro-Celtique S.A. Derivati hidroksamske kisline
WO2010092014A2 (en) * 2009-02-11 2010-08-19 Basf Se Pesticidal mixtures
KR101737138B1 (ko) * 2009-03-26 2017-05-17 바이엘 크롭사이언스 엘피 유해 진균을 방제하기 위한 합성 및 생물학적 살진균제의 용도
WO2010139653A1 (en) 2009-06-04 2010-12-09 Basf Se Fungicidal mixtures comprising heteraromatic sulfonamides
WO2010145999A2 (de) 2009-06-18 2010-12-23 Basf Se Fungizide mischungen
UA107671C2 (en) 2009-08-07 2015-02-10 Dow Agrosciences Llc N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives
BR112012002807B1 (pt) 2009-08-07 2018-07-10 Adama Makhteshim Ltd. Derivados de 5-flúor-2-oxopirimidina-1(2h)- caboxilato, composição e processo para controle e prevenção de ataque fúngico em uma planta de ataque fúngico em uma planta
UA106889C2 (uk) 2009-08-07 2014-10-27 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні n1-ацил-5-фторпіримідинону
AU2010279411B2 (en) * 2009-08-07 2014-10-23 Adama Makhteshim Ltd. N1-sulfonyl-5-fluoropyrimidinone derivatives
UA112284C2 (uk) 2009-08-07 2016-08-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні 5-фторпіримідинону
NZ625074A (en) * 2009-10-07 2015-11-27 Dow Agrosciences Llc Synergistic fungicidal mixtures for fungal control in cereals
AU2010303832B2 (en) 2009-10-07 2015-02-12 Dow Agrosciences Llc Synergistic fungicidal composition containing 5-fluorocytosine for fungal control in cereals
HRP20161107T1 (hr) * 2010-04-26 2016-12-30 Adama Makhteshim Ltd Derivati n3-supstituiranog-n1-sulfonil-5-fluoropirimidinona
EP3058823A1 (en) * 2010-08-05 2016-08-24 Bayer Intellectual Property GmbH Active compound combinations comprising prothioconazole and fluxapyroxad for controlling oil seed rape diseases
CN102150675B (zh) * 2010-12-14 2013-11-06 陕西韦尔奇作物保护有限公司 一种含有克菌丹与硫代氨基甲酸酯类化合物的杀菌组合物
PH12013501231A1 (en) * 2010-12-16 2018-01-17 Dow Agrosciences Llc Synergistic fungicidal interactions of 5-fluorocytosine and other fungicides
EP2471363A1 (de) * 2010-12-30 2012-07-04 Bayer CropScience AG Verwendung von Aryl-, Heteroaryl- und Benzylsulfonamidocarbonsäuren, -carbonsäureestern, -carbonsäureamiden und -carbonitrilen oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen
UY34136A (es) * 2011-06-17 2013-01-03 Basf Se Mezclas fungicidas sinérgicas que comprenden 2,3,5,6-tetraciano-[1,4]ditiína
BR112013029745A2 (pt) * 2011-06-17 2018-12-11 Basf Se uso de compostos da fórmula i, método para combater fungos prejudiciais e semente revestida com pelo menos um composto da fórmula i
CN103841953A (zh) * 2011-08-15 2014-06-04 宝洁公司 减少气味的方法
AR087549A1 (es) 2011-08-17 2014-04-03 Dow Agrosciences Llc Derivados de 5-fluor-4-imino-3-(sustituido)-3,4-dihidropirimidin-2(1h)ona
WO2013113773A1 (en) * 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
US9385377B2 (en) 2012-11-07 2016-07-05 Toyota Jidosha Kabushiki Kaisha Method for producing a catalyst for fuel cells
EP3689142A1 (en) 2012-12-28 2020-08-05 Adama Makhteshim Ltd. 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives
MX2015008444A (es) 2012-12-28 2015-09-23 Dow Agrosciences Llc Derivados de n-(sustituido)-5-flouro-4-imino-3-metil-2-oxo-3,4-dih idropirimidin-1 (2h)-carboximida.
JP6324994B2 (ja) 2012-12-28 2018-05-16 アダマ・マクテシム・リミテッド N−(置換)−5−フルオロ−4−イミノ−3−メチル−2−オキソ−3,4−ジヒドロピリミジン−1(2h)−カルボキシレート誘導体
ES2874475T3 (es) 2012-12-31 2021-11-05 Adama Makhteshim Ltd Derivados de la 3,4-dihidropirimidin-2(1h)-ona 3-alquil-5-fluoro-4-iminosustituida como fungicidas
EA036389B1 (ru) 2013-12-31 2020-11-03 Адама Мактешим Лтд. 5-фтор-4-имино-3-(алкил/замещенный алкил)-1-(арилсульфонил)-3,4-дигидропиримидин-2(1h)-он и способы их получения
US9532570B2 (en) * 2013-12-31 2017-01-03 Adama Makhteshim Ltd. Synergistic fungicidal mixtures comprising 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one for fungal control in cereals
MA41272A (fr) 2014-12-23 2017-10-31 Adama Makhteshim Ltd 5-fluoro-4-imino-3-(alkyle/alkyle substitué)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one en tant que traitement des semences

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018508468A (ja) * 2014-12-23 2018-03-29 アダマ・マクテシム・リミテッド 種子処理としての5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オン
JP2020196729A (ja) * 2014-12-23 2020-12-10 アダマ・マクテシム・リミテッド 種子処理としての5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オン

Also Published As

Publication number Publication date
AU2017261459B2 (en) 2019-03-28
US20220000114A1 (en) 2022-01-06
US20180303094A1 (en) 2018-10-25
US9532570B2 (en) 2017-01-03
PL3096619T3 (pl) 2025-11-03
CL2016001679A1 (es) 2017-03-24
US12127560B2 (en) 2024-10-29
US20170086459A1 (en) 2017-03-30
US20200113182A1 (en) 2020-04-16
AU2014373850A1 (en) 2016-08-11
US20210161138A1 (en) 2021-06-03
DK3091835T3 (da) 2025-11-03
US20220000113A1 (en) 2022-01-06
US20150181875A1 (en) 2015-07-02
RS67373B1 (sr) 2025-11-28
WO2015103262A1 (en) 2015-07-09
AU2017261457B2 (en) 2019-03-28
JP2022115995A (ja) 2022-08-09
IL246461A0 (en) 2016-08-31
CN115380909A (zh) 2022-11-25
MX2016008749A (es) 2017-06-23
BR112016015158A2 (pt) 2017-08-08
EA030056B1 (ru) 2018-06-29
US10426167B2 (en) 2019-10-01
PH12016501283B1 (en) 2022-07-20
US20210392893A1 (en) 2021-12-23
AP2016009340A0 (en) 2016-07-31
HUE072634T2 (hu) 2025-11-28
EP3091835A1 (en) 2016-11-16
US20250017208A1 (en) 2025-01-16
EP3091835B1 (en) 2025-07-30
CN106028816A (zh) 2016-10-12
PH12016501285A1 (en) 2016-08-15
NI201600096A (es) 2016-08-09
US20220117229A1 (en) 2022-04-21
PH12016501283A1 (en) 2016-08-15
CN115380909B (zh) 2024-08-02
PE20161027A1 (es) 2016-10-07
US20200221698A1 (en) 2020-07-16
AU2017261457A1 (en) 2017-11-30
PE20161026A1 (es) 2016-10-07
IL246461B (en) 2021-02-28
UA124962C2 (uk) 2021-12-22
US20200100500A1 (en) 2020-04-02
US20190380342A1 (en) 2019-12-19
SI3096619T1 (sl) 2025-10-30
US10045533B2 (en) 2018-08-14
EA201691345A1 (ru) 2016-11-30
JP6767868B2 (ja) 2020-10-14
NI201600095A (es) 2016-08-09
US20200229438A1 (en) 2020-07-23
US20210037822A1 (en) 2021-02-11
US20200337309A1 (en) 2020-10-29
AU2014373853A1 (en) 2016-08-11
ES3039914T3 (en) 2025-10-27
HRP20251086T1 (hr) 2025-11-07
IL246462B (en) 2021-02-28
US20210274785A1 (en) 2021-09-09
CR20160345A (es) 2017-02-21
DK3096619T3 (da) 2025-09-08
FI3096619T3 (fi) 2025-09-03
NI201600097A (es) 2016-08-09
LT3091835T (lt) 2025-11-25
CN114931141B (zh) 2024-08-02
NZ738966A (en) 2021-12-24
US20210289785A1 (en) 2021-09-23
CR20160342A (es) 2016-12-14
US10426165B2 (en) 2019-10-01
CN114794123A (zh) 2022-07-29
UA123696C2 (uk) 2021-05-19
CA2935673C (en) 2023-03-14
EA029457B1 (ru) 2018-03-30
PE20161025A1 (es) 2016-10-07
NZ738961A (en) 2021-12-24
EP3096619A4 (en) 2017-09-06
US9526245B2 (en) 2016-12-27
LT3096619T (lt) 2025-09-25
US10051862B2 (en) 2018-08-21
FI3091835T3 (fi) 2025-11-13
CN114794123B (zh) 2024-11-12
EP3096619A1 (en) 2016-11-30
EA201691346A1 (ru) 2016-11-30
US20200113183A1 (en) 2020-04-16
UA124136C2 (uk) 2021-07-28
CN114931141A (zh) 2022-08-23
US20170086458A1 (en) 2017-03-30
CL2016001678A1 (es) 2017-03-24
AU2017261459A1 (en) 2017-11-30
PH12016501285B1 (en) 2022-06-17
US20190373891A1 (en) 2019-12-12
MX394300B (es) 2025-03-24
US10045534B2 (en) 2018-08-14
NZ722418A (en) 2018-01-26
AP2016009341A0 (en) 2016-07-31
US20180303095A1 (en) 2018-10-25
US20150181883A1 (en) 2015-07-02
US20220110323A1 (en) 2022-04-14
BR112016015155A2 (pt) 2017-08-08
JP2020143097A (ja) 2020-09-10
DOP2016000165A (es) 2016-09-30
MX2023001391A (es) 2023-03-03
CU24463B1 (es) 2020-01-03
US20200375180A1 (en) 2020-12-03
CL2016001676A1 (es) 2017-03-24
PL3096619T4 (pl) 2025-11-03
RS67219B1 (sr) 2025-10-31
CL2018003643A1 (es) 2019-02-15
PH12016501286A1 (en) 2016-08-15
CA2935547C (en) 2021-08-03
EA201691344A1 (ru) 2016-11-30
US20180303096A1 (en) 2018-10-25
PT3091835T (pt) 2025-11-25
EP3091835A4 (en) 2017-11-01
US20200359625A1 (en) 2020-11-19
US20250228240A1 (en) 2025-07-17
CU20160102A7 (es) 2016-11-29
NZ738965A (en) 2021-12-24
NZ722436A (en) 2018-01-26
CA2935555C (en) 2024-04-30
CL2018003641A1 (es) 2019-02-15
MX2016008748A (es) 2017-02-28
JP2017501196A (ja) 2017-01-12
CU20160100A7 (es) 2016-11-29
JP2017508719A (ja) 2017-03-30
JP2017501198A (ja) 2017-01-12
US20170086460A1 (en) 2017-03-30
US9538753B2 (en) 2017-01-10
CN106061263A (zh) 2016-10-26
DOP2016000164A (es) 2016-09-30
DOP2016000166A (es) 2016-09-30
US20210059253A1 (en) 2021-03-04
CN106061262A (zh) 2016-10-26
AU2014373852A1 (en) 2016-08-11
WO2015103259A1 (en) 2015-07-09
WO2015103261A1 (en) 2015-07-09
IL246462A0 (en) 2016-08-31
CA2935555A1 (en) 2015-07-09
ECSP16064276A (es) 2018-05-31
CA2935673A1 (en) 2015-07-09
US20210289784A1 (en) 2021-09-23
IL246470B (en) 2019-10-31
ECSP16064260A (es) 2018-05-31
CU20160103A7 (es) 2016-11-29
IL246470A0 (en) 2016-08-31
US10426166B2 (en) 2019-10-01
US20210176990A1 (en) 2021-06-17
US20190380343A1 (en) 2019-12-19
MX2016008737A (es) 2017-02-28
AU2017261458A1 (en) 2017-11-30
AP2016009343A0 (en) 2016-07-31
US12342820B2 (en) 2025-07-01
EA030030B1 (ru) 2018-06-29
CR20160344A (es) 2016-12-19
ECSP16064247A (es) 2019-01-31
EP3096619B1 (en) 2025-06-04
EP3102035A1 (en) 2016-12-14
US20150181874A1 (en) 2015-07-02
AU2017261458B2 (en) 2019-03-28
US20200245623A1 (en) 2020-08-06
NZ722419A (en) 2018-01-26
BR112016015157A2 (pt) 2017-08-08
EP3102035A4 (en) 2017-11-01
CA2935547A1 (en) 2015-07-09
US20210059252A1 (en) 2021-03-04
JP6609257B2 (ja) 2019-11-20
US20210176989A1 (en) 2021-06-17
PT3096619T (pt) 2025-09-11

Similar Documents

Publication Publication Date Title
JP6608366B2 (ja) 真菌防除のための相乗的殺真菌性混合物および組成物
JP6352489B2 (ja) 穀類において真菌を制御するための相乗的殺真菌混合物
JP5655080B2 (ja) 穀類において真菌を制御するための5−フルオロシトシンを含有する相乗的殺真菌組成物
JP5683592B2 (ja) 穀類における菌類防除のための5−フルオロピリミジン誘導体を含有する相乗性殺菌剤組成物
JP6560619B2 (ja) 相乗的殺真菌性組成物
JP7249957B2 (ja) 穀類における真菌制御のための相乗的な混合物
CN110868862B (zh) 用于蔬菜中的真菌防治的协同混合物
RU2765230C2 (ru) Синергические смеси для контроля грибов в зерновых культурах
HK40079868A (en) Synergistic fungicidal mixtures for fungal control in cereals
HK40079429A (en) Synergistic fungicidal mixtures for fungal control in cereals
HK40079868B (zh) 用防治谷类中真菌的协同杀真菌混合物
HK40079429B (zh) 用防治谷类中真菌的协同杀真菌混合物
BR122021005821B1 (pt) Composições e misturas fungicidas sinérgicas, e método para controle ou prevenção de ataque fúngico em uma planta
BR122021005784B1 (pt) Composições e misturas fungicidas sinérgicas, e método para controle fúngico em cereais
BR122021005843B1 (pt) Composições e misturas fungicidas sinérgicas, e método para controle ou prevenção de ataque fúngico em uma planta
BR122021005857B1 (pt) Composições e misturas fungicidas sinérgicas, e método para controle ou prevenção de ataque fúngico em uma planta

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171225

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180213

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180816

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180821

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190219

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190924

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191023

R150 Certificate of patent or registration of utility model

Ref document number: 6608366

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250