JP6606509B2 - 体液中の検体を検出するためのバイオアッセイシステム及び方法 - Google Patents

体液中の検体を検出するためのバイオアッセイシステム及び方法 Download PDF

Info

Publication number
JP6606509B2
JP6606509B2 JP2016558198A JP2016558198A JP6606509B2 JP 6606509 B2 JP6606509 B2 JP 6606509B2 JP 2016558198 A JP2016558198 A JP 2016558198A JP 2016558198 A JP2016558198 A JP 2016558198A JP 6606509 B2 JP6606509 B2 JP 6606509B2
Authority
JP
Japan
Prior art keywords
antibody
target analyte
resonant
bound
nanoparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016558198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017508975A (ja
JP2017508975A5 (enExample
Inventor
ケリモ,ジョゼフ
ツェン,ハンソン
シャルラック,ロン
ブランケンスタイン,ゲルト
Original Assignee
インストゥルメンテーション ラボラトリー カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インストゥルメンテーション ラボラトリー カンパニー filed Critical インストゥルメンテーション ラボラトリー カンパニー
Publication of JP2017508975A publication Critical patent/JP2017508975A/ja
Publication of JP2017508975A5 publication Critical patent/JP2017508975A5/ja
Application granted granted Critical
Publication of JP6606509B2 publication Critical patent/JP6606509B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2016558198A 2014-03-24 2015-03-20 体液中の検体を検出するためのバイオアッセイシステム及び方法 Active JP6606509B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461969371P 2014-03-24 2014-03-24
US61/969,371 2014-03-24
PCT/US2015/021651 WO2015148290A1 (en) 2014-03-24 2015-03-20 Bioassay system and method for detecting analytes in body fluids

Publications (3)

Publication Number Publication Date
JP2017508975A JP2017508975A (ja) 2017-03-30
JP2017508975A5 JP2017508975A5 (enExample) 2019-09-12
JP6606509B2 true JP6606509B2 (ja) 2019-11-13

Family

ID=52991948

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016558198A Active JP6606509B2 (ja) 2014-03-24 2015-03-20 体液中の検体を検出するためのバイオアッセイシステム及び方法

Country Status (8)

Country Link
US (1) US20150268237A1 (enExample)
EP (1) EP3123172B1 (enExample)
JP (1) JP6606509B2 (enExample)
CN (1) CN106461559B (enExample)
AU (1) AU2015236470B2 (enExample)
CA (1) CA2943254C (enExample)
ES (1) ES2854352T3 (enExample)
WO (1) WO2015148290A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11016087B2 (en) * 2016-02-09 2021-05-25 Sekisui Chemical Co., Ltd. Implement for inspection, inspecting device and inspecting method
JP6633978B2 (ja) * 2016-06-17 2020-01-22 積水化学工業株式会社 検査キット及び検査方法
US10877192B2 (en) 2017-04-18 2020-12-29 Saudi Arabian Oil Company Method of fabricating smart photonic structures for material monitoring
US10401155B2 (en) 2017-05-12 2019-09-03 Saudi Arabian Oil Company Apparatus and method for smart material analysis
US12019074B2 (en) * 2017-06-08 2024-06-25 Lumito Ab Method of analysing a sample for at least one analyte
CN107356570B (zh) * 2017-06-08 2020-10-27 大连海事大学 一种固态上转换荧光探针及其制备方法与应用
US10746534B2 (en) 2017-07-03 2020-08-18 Saudi Arabian Oil Company Smart coating device for storage tank monitoring and calibration
JP2020526768A (ja) * 2017-07-11 2020-08-31 アヴィアーナ モレキュラー テクノロジーズ,エルエルシー バイオセンサーデバイスにおける信号増幅
CN108163802B (zh) * 2017-12-06 2020-02-07 北京纳百生物科技有限公司 一种抗原检测材料及其制备方法和应用
CN112313501A (zh) * 2018-07-31 2021-02-02 积水化学工业株式会社 检测方法、检测用器具和检测装置
CN108957839B (zh) * 2018-08-09 2022-09-30 京东方科技集团股份有限公司 显示装置、显示面板、彩膜基板及彩膜
CN109470652A (zh) * 2018-10-24 2019-03-15 北京邮电大学 基于Fano谐振的椭圆空气孔部分刻蚀型光子晶体传感器
US11391730B2 (en) * 2019-12-31 2022-07-19 Robert Bosch Gmbh Sensor refresh systems
CN120712049A (zh) 2022-12-15 2025-09-26 阿达普提克斯生物科学公司 用于分析物检测的系统和方法
WO2025100392A1 (ja) * 2023-11-06 2025-05-15 公立大学法人大阪 光学センサ、被検出物質の検出システムおよび光学センサの製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
DK0723146T3 (da) * 1992-09-14 2004-08-30 Stanford Res Inst Int Opkonverterende reportermolekyler til biologiske og andre assays ved anvendelse af laser-excitationsteknikker
JP2001116699A (ja) * 1999-10-21 2001-04-27 Ngk Insulators Ltd 遺伝子診断方法
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US6560020B1 (en) * 2001-01-16 2003-05-06 Holotek, Llc Surface-relief diffraction grating
US7008559B2 (en) * 2001-06-06 2006-03-07 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
EP1616169B1 (en) * 2003-03-27 2009-06-24 Corning Incorporated Label-free evanescent-field detection of biological and chemical agents
JP2007240361A (ja) * 2006-03-09 2007-09-20 Sekisui Chem Co Ltd 局在プラズモン増強センサ
EP1912067A1 (en) * 2006-10-12 2008-04-16 Eppendorf Array Technologies S.A. Method for quantification of a target compound obtained from a biological sample upon chips
ES2490613T3 (es) * 2008-12-22 2014-09-04 F. Hoffmann-La Roche Ag ARMET como marcador de cáncer
CN102375060B (zh) * 2010-08-19 2014-12-31 中国人民解放军军事医学科学院微生物流行病研究所 一种基于上转换发光十通道免疫层析的食源性致病菌检测试纸盘
SG10201604680UA (en) * 2011-12-19 2016-07-28 Univ Nanyang Tech Synthesis of upconversion nanocomposites for photodynamic therapy
JP5975480B2 (ja) * 2012-01-31 2016-08-23 国立研究開発法人産業技術総合研究所 バイオチップ、バイオアッセイ用キット、及びバイオアッセイ方法
US20150353821A1 (en) * 2012-07-12 2015-12-10 National University Of Singapore An upconversion fluorescent nanoparticle

Also Published As

Publication number Publication date
US20150268237A1 (en) 2015-09-24
CN106461559A (zh) 2017-02-22
JP2017508975A (ja) 2017-03-30
CA2943254A1 (en) 2015-10-01
CN106461559B (zh) 2020-07-03
AU2015236470B2 (en) 2019-03-07
EP3123172B1 (en) 2021-01-13
WO2015148290A1 (en) 2015-10-01
CA2943254C (en) 2021-05-04
EP3123172A1 (en) 2017-02-01
ES2854352T3 (es) 2021-09-21
AU2015236470A1 (en) 2016-10-06

Similar Documents

Publication Publication Date Title
EP3123172B1 (en) Bioassay system and method for detecting analytes in body fluids
JP3645907B2 (ja) 漸減励起された発光を検出する方法
JP7008334B2 (ja) 光学的検出方法及び光学的検出装置
JP2010518389A (ja) エバネセント導波管及び集積センサを用いるバイオセンサ
JP2009511896A (ja) 全ポリマー光導波路センサ
JP2011503536A (ja) マイクロエレクトロニクスセンサ
JP4885019B2 (ja) 表面プラズモン増強蛍光センサ
JP2017508975A5 (enExample)
JP2010145272A (ja) プラズモン励起センサを用いたアッセイ法
JP5315381B2 (ja) 蛍光検出装置、蛍光検出用の試料セルおよび蛍光検出方法
EP2060904A1 (en) Plasmon grating biosensor
US20080179540A1 (en) Surface plasmon enhanced fluorescence sensor
Stringer et al. Quantum dot-based biosensor for detection of human cardiac troponin I using a liquid-core waveguide
WO2021131331A1 (ja) 蛍光検出用生体分子検査チップ
JP2009080011A (ja) 蛍光検出方法
JP2012530894A (ja) 発光ダイオードにより光学的マイクロキャビティを動作させるための装置及び方法
JP6913966B2 (ja) センサチップ、目的物質検出装置及び目的物質検出方法
WO2014188620A1 (ja) センサ、検査方法
Välimäki et al. A novel platform for highly surface-sensitive fluorescent measurements applying simultaneous total internal reflection excitation and super critical angle detection
JP2011127991A (ja) プラズモン励起センサおよび該センサを用いたアッセイ法
WO2014007134A1 (ja) センサーチップ
JP2005156527A (ja) 光学的測定装置及びそれを用いた特異的結合物の光学的測定方法
US7701579B2 (en) Fluorescence sensor
JP7486205B2 (ja) 検出装置及び検出方法
JP2011169609A (ja) プラズモン励起センサを用いたアッセイ法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171221

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180912

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180927

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181218

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190510

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20190725

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191002

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191018

R150 Certificate of patent or registration of utility model

Ref document number: 6606509

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250