JP6600694B2 - 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 - Google Patents

上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 Download PDF

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JP6600694B2
JP6600694B2 JP2017548965A JP2017548965A JP6600694B2 JP 6600694 B2 JP6600694 B2 JP 6600694B2 JP 2017548965 A JP2017548965 A JP 2017548965A JP 2017548965 A JP2017548965 A JP 2017548965A JP 6600694 B2 JP6600694 B2 JP 6600694B2
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mouse
locus
endogenous
nucleic acid
cell
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JP2018512842A (ja
JP2018512842A5 (https=
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ブルチン イキズ，
マイケル ラクロワ−フラリッシュ，
スーザン ディー． クロール，
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017548965A 2015-03-16 2016-03-16 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 Active JP6600694B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562133909P 2015-03-16 2015-03-16
US62/133,909 2015-03-16
US201562250229P 2015-11-03 2015-11-03
US62/250,229 2015-11-03
PCT/US2016/022685 WO2016149398A1 (en) 2015-03-16 2016-03-16 Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception

Related Child Applications (1)

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JP2019184476A Division JP2020005660A (ja) 2015-03-16 2019-10-07 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物

Publications (3)

Publication Number Publication Date
JP2018512842A JP2018512842A (ja) 2018-05-24
JP2018512842A5 JP2018512842A5 (https=) 2019-04-25
JP6600694B2 true JP6600694B2 (ja) 2019-10-30

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JP2017548965A Active JP6600694B2 (ja) 2015-03-16 2016-03-16 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物
JP2019184476A Pending JP2020005660A (ja) 2015-03-16 2019-10-07 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物
JP2020152914A Active JP7193509B2 (ja) 2015-03-16 2020-09-11 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物
JP2021215389A Withdrawn JP2022048157A (ja) 2015-03-16 2021-12-29 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物

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JP2020152914A Active JP7193509B2 (ja) 2015-03-16 2020-09-11 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物
JP2021215389A Withdrawn JP2022048157A (ja) 2015-03-16 2021-12-29 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物

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US (3) US10285387B2 (https=)
EP (2) EP3270688B1 (https=)
JP (4) JP6600694B2 (https=)
KR (2) KR102424119B1 (https=)
CN (1) CN107690279B (https=)
AU (2) AU2016233250C1 (https=)
BR (1) BR112017019620A2 (https=)
CA (1) CA2978096C (https=)
ES (2) ES2955841T3 (https=)
IL (2) IL274285B (https=)
MX (2) MX380521B (https=)
RU (1) RU2744831C2 (https=)
SG (2) SG10201912899QA (https=)
WO (1) WO2016149398A1 (https=)

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MY198884A (en) 2013-08-07 2023-10-02 Regeneron Pharma Lincrna-deficient non-human animals
CN109862785B (zh) * 2016-09-30 2022-09-06 瑞泽恩制药公司 C9orf72基因座中具有六核苷酸重复扩增的非人类动物
CN111849899B (zh) * 2017-07-28 2022-06-14 杨涛 定向诱导hiPSC分化为神经细胞体系的诱导培养基
CN107586791B (zh) * 2017-10-26 2018-09-21 四川省人民医院 一种共济失调动物模型的构建方法以及应用

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JP2022048157A (ja) 2022-03-25
KR102616160B1 (ko) 2023-12-22
EP3685662B9 (en) 2023-10-04
US20210392865A1 (en) 2021-12-23
EP3270688B1 (en) 2020-08-12
SG10201912899QA (en) 2020-02-27
AU2016233250C1 (en) 2022-08-18
IL254333B (en) 2020-05-31
JP2018512842A (ja) 2018-05-24
ES2955841T3 (es) 2023-12-07
EP3270688A1 (en) 2018-01-24
RU2017135557A3 (https=) 2019-07-29
CA2978096C (en) 2022-06-28
AU2016233250A1 (en) 2017-09-14
IL254333A0 (en) 2017-11-30
MX2021002852A (es) 2021-05-28
US20190261610A1 (en) 2019-08-29
MX2017011918A (es) 2018-05-22
AU2022200784A1 (en) 2022-02-24
IL274285A (en) 2020-06-30
RU2017135557A (ru) 2019-04-17
EP3685662A1 (en) 2020-07-29
CA2978096A1 (en) 2016-09-22
AU2016233250B2 (en) 2022-03-03
NZ734906A (en) 2022-02-25
US20160270377A1 (en) 2016-09-22
US10285387B2 (en) 2019-05-14
MX380521B (es) 2025-04-01
JP2020005660A (ja) 2020-01-16
JP7193509B2 (ja) 2022-12-20
EP3685662C0 (en) 2023-06-07
BR112017019620A2 (pt) 2018-05-15
KR102424119B1 (ko) 2022-07-25
SG11201706809WA (en) 2017-09-28
CN107690279B (zh) 2021-07-02
EP3685662B1 (en) 2023-06-07
HK1249360A1 (zh) 2018-11-02
ES2830173T3 (es) 2021-06-03
CN107690279A (zh) 2018-02-13
RU2744831C2 (ru) 2021-03-16
WO2016149398A1 (en) 2016-09-22
KR20170127459A (ko) 2017-11-21
IL274285B (en) 2022-07-01
AU2022200784B2 (en) 2024-02-15
KR20220108828A (ko) 2022-08-03
JP2020198892A (ja) 2020-12-17

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