JP6588903B2 - 神経変性障害、ならびにその治療及び診断法 - Google Patents
神経変性障害、ならびにその治療及び診断法 Download PDFInfo
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- JP6588903B2 JP6588903B2 JP2016529439A JP2016529439A JP6588903B2 JP 6588903 B2 JP6588903 B2 JP 6588903B2 JP 2016529439 A JP2016529439 A JP 2016529439A JP 2016529439 A JP2016529439 A JP 2016529439A JP 6588903 B2 JP6588903 B2 JP 6588903B2
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
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- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
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- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| US201361904365P | 2013-11-14 | 2013-11-14 | |
| US61/904,365 | 2013-11-14 | ||
| PCT/US2014/065670 WO2015073803A1 (en) | 2013-11-14 | 2014-11-14 | Neurodegenerative disorders and methods of treatment and diagnosis thereof |
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| JP2019167372A Division JP2020063233A (ja) | 2013-11-14 | 2019-09-13 | 神経変性障害、ならびにその治療及び診断法 |
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| JP2016539935A JP2016539935A (ja) | 2016-12-22 |
| JP2016539935A5 JP2016539935A5 (OSRAM) | 2017-12-21 |
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| JP (2) | JP6588903B2 (OSRAM) |
| AU (1) | AU2014348457B2 (OSRAM) |
| CA (1) | CA2929601A1 (OSRAM) |
| ES (1) | ES2774321T3 (OSRAM) |
| WO (1) | WO2015073803A1 (OSRAM) |
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| EP1929995A1 (en) | 2006-12-04 | 2008-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anaplerotic therapy of Huntington disease and other polyglutamine diseases |
| AU2013358951C1 (en) | 2012-12-13 | 2019-06-27 | Baylor Research Institute | Triheptanoin for the treatment of glucose transporter 1 deficiency |
| CA2929601A1 (en) | 2013-11-14 | 2015-05-21 | Karin Borges | Neurodegenerative disorders and methods of treatment and diagnosis thereof |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| WO2017208217A2 (en) * | 2016-06-01 | 2017-12-07 | Aspi Ip Holder Llc | C5 ketone compositions, and related methods, for therapeutic and performance supplementation |
| NZ749389A (en) * | 2016-06-08 | 2022-12-23 | Sunregen Healthcare Ag | Lipids with odd number of carbon atoms and their use as pharmaceutical composition or nutritional supplement |
| WO2019052629A1 (en) * | 2017-09-12 | 2019-03-21 | Sunregen Healthcare Ag | LIPIDS HAVING AN IMPERATIVE NUMBER OF CARBON ATOMS AND THEIR USE AS A PHARMACEUTICAL COMPOSITION OR FOOD SUPPLEMENT |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| CN113917034A (zh) * | 2021-10-19 | 2022-01-11 | 北京豪思生物科技有限公司 | 用于评估阿尔茨海默症的生物标记组合及其应用和试剂盒 |
| WO2024155950A2 (en) * | 2023-01-20 | 2024-07-25 | Keto Innovations, Llc | C5 ketone compositions and related methods for therapeutic and performance supplementation |
| WO2025184834A1 (zh) * | 2024-03-06 | 2025-09-12 | 中国科学院昆明动物研究所 | 一种庚酸酯化合物及其用于制备预防和/或治疗神经退行性疾病的药物或功能食品中的用途 |
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| US4025649A (en) | 1974-08-19 | 1977-05-24 | Labaz | Acetic acid derivatives having pharmacological activity and compositions containing the same |
| DE3032300A1 (de) | 1980-08-27 | 1982-04-01 | Alfred Ing. Wien Lohninger | Mittel zur parenteralen ernaehrung |
| GB2104079B (en) | 1981-08-14 | 1985-08-21 | London Polytech | New aminoacid isomers, their production and their medicinal use |
| US4753963A (en) | 1985-09-26 | 1988-06-28 | The Procter & Gamble Company | Nutritional fat suitable for enteral and parenteral products |
| JP3486778B2 (ja) | 1993-04-02 | 2004-01-13 | 三菱ウェルファーマ株式会社 | アルツハイマー病予防治療剤 |
| US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| US6740679B1 (en) | 1999-02-05 | 2004-05-25 | Baylor University Medical Center | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid |
| KR100702823B1 (ko) | 1999-02-05 | 2007-04-06 | 베일러 리서치 인스티튜트 | Ｃ7 지방산 함유 트리글리세라이드를 포함하는 영양보충물 또는 약제학적 제제 |
| US6335361B1 (en) | 1999-11-03 | 2002-01-01 | Juvenon Inc. | Method of treating benign forgetfulness |
| DE60138019D1 (de) | 2000-05-01 | 2009-04-30 | Accera Inc | Verwendung von triglyceriden mit mittellangen ketten zur behandlung und vorbeugung der alzheimerschen erkrankung |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| CN1756554A (zh) | 2003-03-06 | 2006-04-05 | 艾克塞拉公司 | 新的化学实体和它们用于治疗代谢障碍的方法 |
| WO2004103307A2 (en) | 2003-05-20 | 2004-12-02 | Baylor Research Institute | Method of use of five and fifteen carbon fatty acids |
| MX338247B (es) | 2004-07-02 | 2016-04-07 | Baylor Res Inst | Metodo de tratamiento de enfermedad de almacenamiento de glucogeno o polisacaridos. |
| WO2006037069A1 (en) | 2004-09-28 | 2006-04-06 | Allergan, Inc. | Compositions comprising nb-dnj, ne-dnj or d-glucaro-delta-lactam and their uses for the treatment of pain and other neurological conditions |
| DK2500017T3 (da) | 2006-04-03 | 2017-11-06 | Accera Inc | Anvendelse af ketogene forbindelser til behandling af aldersrelateret hukommelsessvækkelse |
| CA2700431A1 (en) | 2006-09-26 | 2008-04-03 | Baylor Research Institute | Use of odd-chain fatty acids in the modulation of cellular catabolism |
| EP1929995A1 (en) | 2006-12-04 | 2008-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anaplerotic therapy of Huntington disease and other polyglutamine diseases |
| EP2650379B1 (en) | 2007-07-31 | 2015-09-16 | Accera, Inc. | Use of genomic testing and ketogenic compounds for treatment of reduced cognitive function |
| WO2009124250A1 (en) * | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux |
| ES2640777T3 (es) | 2009-12-30 | 2017-11-06 | Baylor Research Institute | Terapia anaplerótica para la enfermedad de Alzheimer |
| US20110301238A1 (en) | 2010-06-02 | 2011-12-08 | Borges Karin | Seizure related disorders and therapeutic methods thereof |
| MX2012014520A (es) * | 2010-06-14 | 2013-03-05 | Baylor Res Inst | Dieta de triheptanoina para tratamiento de enfermedad del cuerpo de poliglucosano (apbd). |
| RU2606763C2 (ru) * | 2010-12-23 | 2017-01-10 | Амазентис Са | Композиции и способы для усиления или поддержания мышечной деятельности |
| EP2599482A1 (en) | 2011-11-30 | 2013-06-05 | Lunamed AG | Low dose therapeutic use of glyceryl tri-(4-phenylbutyrate) |
| AU2013358951C1 (en) | 2012-12-13 | 2019-06-27 | Baylor Research Institute | Triheptanoin for the treatment of glucose transporter 1 deficiency |
| CA2929601A1 (en) | 2013-11-14 | 2015-05-21 | Karin Borges | Neurodegenerative disorders and methods of treatment and diagnosis thereof |
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- 2014-11-14 CA CA2929601A patent/CA2929601A1/en not_active Abandoned
- 2014-11-14 EP EP20150222.6A patent/EP3689343A1/en not_active Withdrawn
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- 2014-11-14 EP EP14861265.8A patent/EP3068492B1/en active Active
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| JP2020063233A (ja) | 2020-04-23 |
| US20180207121A1 (en) | 2018-07-26 |
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| EP3068492A1 (en) | 2016-09-21 |
| AU2014348457A1 (en) | 2016-05-26 |
| JP2016539935A (ja) | 2016-12-22 |
| US9833430B2 (en) | 2017-12-05 |
| CA2929601A1 (en) | 2015-05-21 |
| EP3068492B1 (en) | 2020-01-08 |
| WO2015073803A1 (en) | 2015-05-21 |
| US20160263071A1 (en) | 2016-09-15 |
| EP3068492A4 (en) | 2017-07-05 |
| EP3689343A1 (en) | 2020-08-05 |
| ES2774321T3 (es) | 2020-07-20 |
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