JP6585577B2 - 材料試料から材料を抽出するための装置、システム、及びその方法 - Google Patents
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
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Description
他の実施形態では、ユーザーはまた、前記切削ビットのZ軸の位置決めを制御することができて、これには、前記ビットを前記生物試料の特定の領域に下げることができるように、53aで示すような位置移動システムを活用する。領域の切断に続いて、前記切削ビットを起こして、前記切削ビットを2つ目の領域、3つ目の領域などへと移動させることができる。前記支持基板上にかかるビット圧力は、さまざまな機構により制御することができる。1実施形態では、かかる制御は、器具ヘッドの重量により与えることができ、前記重量がのしかかり、したがって、例えば、ばね張力などの張力により調整される。
本明細書に説明されているように、前記切断ビットの前記回転は、前記切削ビットに連結されたモーターにより制御することができる。前記抽出装置内の流体の流れを制御するためにプランジャーが用いられるこれらの実施形態においては、前記プランジャーの引き出しおよび押し下げをZ軸アクチュエーターにより制御することができる。1実施形態では、プランジャーの引き出し速度は、XおよびY軸移動の速度に合わせてあることから、XおよびY軸の移動速度が速いほど、プランジャーの引き出し速度が速くなる。また、単に前記ビットを領域へ下げることにより、XおよびY軸移動せずに組織を切断および改修することも可能である。この場合は、前記ビットが前記スライドと接触すると同時に、前記プランジャーがわずかに引き出されるが、プランジャーのさらなる引き出しは、XおよびY軸移動に依存する。
−2つの同心円注射管、および内部管141および外部管143。
−内部管142の一部は、前記切削チップ147を受け入れるように形成されている。
−外部管144の一部は、前記分注液体を前記切削チップに流用するように形成されている。
−前記内部注射管141の前記内部壁に接触する圧縮密閉部材149付きのプランジャー145。これは、前記プランジャーがある側のチャンバー116および前記プランジャーがない側のチャンバー115を作る。
−前記内側と外側チャンバーとの間の前記プランジャー端部に位置する環状密閉部材146。
−前記プランジャーと前記内部注射管との間のスライド可能な密閉部材109。
−前記スライド表面に接触し、組織を移動する前記切削チップ147。
−移動した組織片を吸引するために、前記スライド表面と前記プランジャーがない側のチャンバー115との間に流体連通を提供する前記切削チップ管148。
−前記内部と外部注射管との間の前記プランジャーがある側のチャンバーと前記導管との間に流体連通を提供する2つの穴111。
Claims (12)
- 生物試料から生物材料を選択的に抽出する方法であって、
生物試料から抽出する生物材料の領域を特定する工程と、
前記生物材料の領域に抽出工具を適用して、前記生物試料から生物材料を分離する工程であって、前記抽出工具の回転切断動作を前記生物材料の領域に加えるものである、工程と、
前記生物材料の領域に液体を供給する工程と、
前記液体および前記分離された生物材料を前記生物試料から吸引する工程であって、前記液体を供給すると同時に前記吸引も行うものである、工程と
を有し、
前記生物材料は支持基板によってサポートされているものである
方法。 - 請求項1記載の方法において、前記抽出工具は切削チップを有するものであり、前記生物材料を分離する工程は前記切削チップにより前記回転切断動作を前記生物材料の領域に加えるものである、方法。
- 請求項1記載の方法において、前記回転切断動作はさらに、振動、スライス、およびそれらの組み合わせから成る群から選択される動作を含むものである方法。
- 請求項1記載の方法において、前記液体は、前記生物材料の領域と前記抽出工具との間の界面に供給されるものである方法。
- 請求項1記載の方法において、前記液体は、前記抽出工具に一体化された液体供給ポートと液体吸引ポートにより供給および吸引されるものであり、前記液体供給ポートと液体吸引ポートは離間して別々に設けられているものである、方法。
- 請求項1記載の方法において、前記生物材料の領域を特定する工程は、さらに、
前記生物試料のリアルタイムのデジタル画像を取得する工程と、
前記デジタル画像上で前記生物材料の領域に対応する関心領域を定義する工程と、
を有し、
前記生物試料の移動量は、前記関心領域および/または前記デジタル画像の移動量に反映され、前記生物材料に対して相対的な前記関心領域の位置を維持するものである、
方法。 - 請求項6記載の方法において、前記生物試料は、一連の生物切片を有するものであり、前記生物切片の夫々は抽出すべき生物材料の領域を含み、1生物切片上の前記関心領域は、別の生物切片からの対応する関心領域に基づいて定義されるものである方法。
- 生物試料から生物材料を選択的に抽出する方法であって、
生物試料から抽出する生物材料の領域を特定する工程と、
前記生物材料の領域に抽出工具を適用して、前記生物試料から生物材料を分離する工程であって、前記抽出工具の回転切断動作を前記生物材料の領域に加えるものである、工程と、
前記生物材料の領域に液体を供給する工程と、
前記液体と前記分離された生物材料を前記生物試料から吸引する工程と、
を有し、
前記供給する工程と前記吸引する工程は、離間して別々に設けられた液体供給ポートと液体吸引ポートによってそれぞれ行われるものであり、
前記生物材料は支持基板によってサポートされているものである
方法。 - 請求項8記載の方法において、前記抽出工具は切削チップを有するものであり、前記生物材料を分離する工程は前記切削チップにより前記回転切断動作を前記生物材料の領域に加えるものである、方法。
- 請求項9記載の方法において、前記抽出工具はフライス盤である方法。
- 請求項1または請求項8のいずれかに記載の方法において、前記生物試料は、実質的に平らな表面に置かれるものである方法。
- 請求項8記載の方法において、
前記液体供給ポートと前記液体吸引ポートは前記抽出工具に一体化されて設けらているものである
、方法。
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