JP6574136B2 - Ｅｇｆｒの発現をサイレンシングするためのｄｎａザイム - Google Patents

Ｅｇｆｒの発現をサイレンシングするためのｄｎａザイム Download PDF

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JP6574136B2
JP6574136B2 JP2015552899A JP2015552899A JP6574136B2 JP 6574136 B2 JP6574136 B2 JP 6574136B2 JP 2015552899 A JP2015552899 A JP 2015552899A JP 2015552899 A JP2015552899 A JP 2015552899A JP 6574136 B2 JP6574136 B2 JP 6574136B2
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oligonucleotide
egfr
modified
nucleotide
cells
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JP2016504046A5 (enExample
JP2016504046A (ja
Inventor
パン−チル ヤン，
パン−チル ヤン，
ウェイ−ユン ライ，
ウェイ−ユン ライ，
コナン ペック，
コナン ペック，
チェン−ジュ チャン，
チェン−ジュ チャン，
チ−ユアン チェン，
チ−ユアン チェン，
シェン−チェン ヤン，
シェン−チェン ヤン，
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Academia Sinica
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Academia Sinica
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/127—DNAzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/34—Allele or polymorphism specific uses

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Saccharide Compounds (AREA)
JP2015552899A 2013-01-14 2014-01-14 Ｅｇｆｒの発現をサイレンシングするためのｄｎａザイム Expired - Fee Related JP6574136B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361752117P 2013-01-14 2013-01-14
US61/752,117 2013-01-14
PCT/US2014/011496 WO2014110577A1 (en) 2013-01-14 2014-01-14 Dnazyme for silencing the expression of egfr

Publications (3)

Publication Number Publication Date
JP2016504046A JP2016504046A (ja) 2016-02-12
JP2016504046A5 JP2016504046A5 (enExample) 2017-02-09
JP6574136B2 true JP6574136B2 (ja) 2019-09-18

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JP2015552899A Expired - Fee Related JP6574136B2 (ja) 2013-01-14 2014-01-14 Ｅｇｆｒの発現をサイレンシングするためのｄｎａザイム

Country Status (7)

Country Link
US (1) US9856480B2 (enExample)
EP (1) EP2943578B1 (enExample)
JP (1) JP6574136B2 (enExample)
KR (1) KR20150136588A (enExample)
CN (1) CN105264084A (enExample)
CA (1) CA2898200A1 (enExample)
WO (1) WO2014110577A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220061311A1 (en) * 2018-11-05 2022-03-03 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for reducing cryopreservation toxicity
IL302594A (en) * 2020-11-09 2023-07-01 1E Therapeutics Ltd Catalytic sequence based methods of treating or preventing bacterial infections
CN116286831B (zh) * 2023-01-29 2024-02-20 珠海市人民医院 靶向egfr t790m突变体的核酸适配体及其在制备治疗肺癌药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US7365185B2 (en) * 2000-07-19 2008-04-29 Monsanto Technology Llc Genomic plant sequences and uses thereof
AU3497701A (en) * 2000-02-08 2001-08-20 Ribozyme Pharmaceuticals, Inc. Nucleozymes with endonuclease activity
EP1767632A3 (en) * 2001-05-29 2009-12-30 Sirna Therpeutics, Inc. A method for local administration of synthetic double-stranded oligonucleotides targeting a VEGF receptor
US6890719B2 (en) * 2002-05-10 2005-05-10 The Board Of Trustess Of The University Of Illinois Fluorescence based biosensor
GB0224663D0 (en) * 2002-10-23 2002-12-04 Isis Innovation DNAzyme
WO2005108570A1 (ja) * 2004-05-11 2005-11-17 National University Corporation Yokohama National University 核酸酵素複合体
EP1766068A4 (en) * 2004-06-04 2010-03-03 Genentech Inc EGFR Mutations
BRPI0607235A2 (pt) * 2005-02-24 2009-08-25 Amgen Inc mutações do receptor do fator de crescimento epidérmico
CA2683559C (en) 2007-04-13 2019-09-24 Dana Farber Cancer Institute, Inc. Methods for treating cancer resistant to erbb therapeutics
CN103080314B (zh) * 2010-09-30 2016-04-13 Lsip基金运营联合公司 显性突变基因表达抑制剂

Also Published As

Publication number Publication date
EP2943578A4 (en) 2017-01-25
WO2014110577A8 (en) 2015-10-08
WO2014110577A1 (en) 2014-07-17
CA2898200A1 (en) 2014-07-17
EP2943578B1 (en) 2019-04-10
CN105264084A (zh) 2016-01-20
KR20150136588A (ko) 2015-12-07
US9856480B2 (en) 2018-01-02
JP2016504046A (ja) 2016-02-12
US20160145625A1 (en) 2016-05-26
EP2943578A1 (en) 2015-11-18

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