CA2898200A1 - Dnazyme for silencing the expression of egfr - Google Patents
Dnazyme for silencing the expression of egfr Download PDFInfo
- Publication number
- CA2898200A1 CA2898200A1 CA2898200A CA2898200A CA2898200A1 CA 2898200 A1 CA2898200 A1 CA 2898200A1 CA 2898200 A CA2898200 A CA 2898200A CA 2898200 A CA2898200 A CA 2898200A CA 2898200 A1 CA2898200 A1 CA 2898200A1
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- Prior art keywords
- egfr
- modified
- oligonucleotide
- cell
- sequence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/127—DNAzymes
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
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- General Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361752117P | 2013-01-14 | 2013-01-14 | |
| US61/752,117 | 2013-01-14 | ||
| PCT/US2014/011496 WO2014110577A1 (en) | 2013-01-14 | 2014-01-14 | Dnazyme for silencing the expression of egfr |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2898200A1 true CA2898200A1 (en) | 2014-07-17 |
Family
ID=51167450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2898200A Abandoned CA2898200A1 (en) | 2013-01-14 | 2014-01-14 | Dnazyme for silencing the expression of egfr |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9856480B2 (enExample) |
| EP (1) | EP2943578B1 (enExample) |
| JP (1) | JP6574136B2 (enExample) |
| KR (1) | KR20150136588A (enExample) |
| CN (1) | CN105264084A (enExample) |
| CA (1) | CA2898200A1 (enExample) |
| WO (1) | WO2014110577A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220061311A1 (en) * | 2018-11-05 | 2022-03-03 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for reducing cryopreservation toxicity |
| IL302594A (en) * | 2020-11-09 | 2023-07-01 | 1E Therapeutics Ltd | Catalytic sequence based methods of treating or preventing bacterial infections |
| CN116286831B (zh) * | 2023-01-29 | 2024-02-20 | 珠海市人民医院 | 靶向egfr t790m突变体的核酸适配体及其在制备治疗肺癌药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040031072A1 (en) * | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| US7365185B2 (en) * | 2000-07-19 | 2008-04-29 | Monsanto Technology Llc | Genomic plant sequences and uses thereof |
| AU3497701A (en) * | 2000-02-08 | 2001-08-20 | Ribozyme Pharmaceuticals, Inc. | Nucleozymes with endonuclease activity |
| EP1767632A3 (en) * | 2001-05-29 | 2009-12-30 | Sirna Therpeutics, Inc. | A method for local administration of synthetic double-stranded oligonucleotides targeting a VEGF receptor |
| US6890719B2 (en) * | 2002-05-10 | 2005-05-10 | The Board Of Trustess Of The University Of Illinois | Fluorescence based biosensor |
| GB0224663D0 (en) * | 2002-10-23 | 2002-12-04 | Isis Innovation | DNAzyme |
| WO2005108570A1 (ja) * | 2004-05-11 | 2005-11-17 | National University Corporation Yokohama National University | 核酸酵素複合体 |
| EP1766068A4 (en) * | 2004-06-04 | 2010-03-03 | Genentech Inc | EGFR Mutations |
| BRPI0607235A2 (pt) * | 2005-02-24 | 2009-08-25 | Amgen Inc | mutações do receptor do fator de crescimento epidérmico |
| CA2683559C (en) | 2007-04-13 | 2019-09-24 | Dana Farber Cancer Institute, Inc. | Methods for treating cancer resistant to erbb therapeutics |
| CN103080314B (zh) * | 2010-09-30 | 2016-04-13 | Lsip基金运营联合公司 | 显性突变基因表达抑制剂 |
-
2014
- 2014-01-14 CA CA2898200A patent/CA2898200A1/en not_active Abandoned
- 2014-01-14 CN CN201480004837.1A patent/CN105264084A/zh active Pending
- 2014-01-14 EP EP14737655.2A patent/EP2943578B1/en active Active
- 2014-01-14 KR KR1020157022001A patent/KR20150136588A/ko not_active Ceased
- 2014-01-14 JP JP2015552899A patent/JP6574136B2/ja not_active Expired - Fee Related
- 2014-01-14 WO PCT/US2014/011496 patent/WO2014110577A1/en not_active Ceased
- 2014-01-14 US US14/760,904 patent/US9856480B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2943578A4 (en) | 2017-01-25 |
| WO2014110577A8 (en) | 2015-10-08 |
| WO2014110577A1 (en) | 2014-07-17 |
| EP2943578B1 (en) | 2019-04-10 |
| CN105264084A (zh) | 2016-01-20 |
| JP6574136B2 (ja) | 2019-09-18 |
| KR20150136588A (ko) | 2015-12-07 |
| US9856480B2 (en) | 2018-01-02 |
| JP2016504046A (ja) | 2016-02-12 |
| US20160145625A1 (en) | 2016-05-26 |
| EP2943578A1 (en) | 2015-11-18 |
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