JP6565121B2 - 代謝障害を治療する方法 - Google Patents
代謝障害を治療する方法 Download PDFInfo
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- JP6565121B2 JP6565121B2 JP2016505495A JP2016505495A JP6565121B2 JP 6565121 B2 JP6565121 B2 JP 6565121B2 JP 2016505495 A JP2016505495 A JP 2016505495A JP 2016505495 A JP2016505495 A JP 2016505495A JP 6565121 B2 JP6565121 B2 JP 6565121B2
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
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- G—PHYSICS
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- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
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| US201361804046P | 2013-03-21 | 2013-03-21 | |
| US61/804,046 | 2013-03-21 | ||
| PCT/US2014/031171 WO2014153385A2 (en) | 2013-03-21 | 2014-03-19 | Methods of treating metabolic disorders |
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| Publication Number | Publication Date |
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| JP2016522163A JP2016522163A (ja) | 2016-07-28 |
| JP2016522163A5 JP2016522163A5 (https=) | 2017-04-13 |
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| US (1) | US9878010B2 (https=) |
| EP (1) | EP2976094B1 (https=) |
| JP (1) | JP6565121B2 (https=) |
| CN (1) | CN105228641A (https=) |
| ES (1) | ES2751391T3 (https=) |
| WO (1) | WO2014153385A2 (https=) |
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| WO2013025817A1 (en) | 2011-08-15 | 2013-02-21 | Children's Hospital Los Angeles | Use of neuregulin-4 for treatment of inflammatory bowel disease and necrotizing enterocolitis |
| AU2015336954A1 (en) * | 2014-10-22 | 2017-06-08 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modulating adipose tissue and adipogenesis |
| EP3247380A1 (en) * | 2015-01-20 | 2017-11-29 | Universiteit Antwerpen | Neuregulin in the treatment of fibrotic disorders |
| EP3355909B1 (en) | 2015-09-28 | 2023-06-07 | Children's Hospital Los Angeles | Methods for treating diseases mediated by erbb4-positive pro-inflammatory macrophages |
| WO2020086667A1 (en) * | 2018-10-25 | 2020-04-30 | American University | Method for promoting adipocyte differentiation and obesity-related disease treatment |
| AR121035A1 (es) | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| CN110279860A (zh) * | 2019-07-31 | 2019-09-27 | 上海交通大学医学院附属瑞金医院 | Nrg4作为靶点在制备糖尿病药物中的应用 |
| CN114075272B (zh) * | 2020-08-10 | 2023-09-22 | 杭州俊丰生物工程有限公司 | 一种人神经调节蛋白4的制备方法 |
| WO2024163874A2 (en) * | 2023-02-03 | 2024-08-08 | Avexegen Therapeutics, Inc. | Stable and controlled release formulations of neuregulin-4 analogs |
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| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| WO2001014415A2 (en) * | 1999-08-20 | 2001-03-01 | Chiron Corporation | Egfh2 genes and gene products |
| US6544759B1 (en) * | 2000-04-21 | 2003-04-08 | Yeda Research And Development Co. Ltd | Polynucleotides encoding a novel growth factor which acts through ErbB-4 kinase receptor tyrosine |
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| AU2003237367A1 (en) * | 2002-06-03 | 2003-12-19 | Chiron Corporation | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer |
| US20050005622A1 (en) * | 2003-07-10 | 2005-01-13 | Powell Brian C. | Condiment holder |
| CA2614664A1 (en) * | 2005-07-14 | 2007-01-25 | Franco Folli | Daily dosage regimen for treating diabetes, obesity,metabolic syndrome and polycystic ovary syndrome |
| ES2315110B1 (es) * | 2006-07-14 | 2009-12-30 | Universidad De Barcelona | Compuestos para el tratamiento de enfermedades relacionadas con la resistencia a la insulina. |
| US20100303757A1 (en) | 2009-05-29 | 2010-12-02 | Allergan, Inc. | Methods of Treating Chronic Neurogenic Inflammation Using Interleukin Retargeted Endopepidases |
| JP2014517279A (ja) | 2011-05-10 | 2014-07-17 | ネステク ソシエテ アノニム | 個別治療管理のための疾患活動性プロファイリングの方法 |
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| US20160279201A1 (en) | 2016-09-29 |
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| CN105228641A (zh) | 2016-01-06 |
| WO2014153385A2 (en) | 2014-09-25 |
| EP2976094B1 (en) | 2019-08-28 |
| ES2751391T3 (es) | 2020-03-31 |
| JP2016522163A (ja) | 2016-07-28 |
| US9878010B2 (en) | 2018-01-30 |
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