JP6549132B2 - ヒトペリオスチンを検出する新規アッセイ - Google Patents

ヒトペリオスチンを検出する新規アッセイ Download PDF

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JP6549132B2
JP6549132B2 JP2016544101A JP2016544101A JP6549132B2 JP 6549132 B2 JP6549132 B2 JP 6549132B2 JP 2016544101 A JP2016544101 A JP 2016544101A JP 2016544101 A JP2016544101 A JP 2016544101A JP 6549132 B2 JP6549132 B2 JP 6549132B2
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Japan
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periostin
serum
patient
antibody
sample
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JP2017507322A (ja
JP2017507322A5 (cg-RX-API-DMAC7.html
Inventor
チョードフリー，パーサ
バーケイ，リーナ
リアン，メイナ
リー，ヤン−ウェ
シュトライヒャー，ケイティ
ラナデ，コウストゥブ
グラント，エタン
グリーンリーズ，リディア
ヤオ，イホン
パーカー，メリッサ
デイヴィス，ジェラード
ジーンブランク，ニコレット
ブロフィー，スーザン
ディル，ブルース
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Abbott Laboratories
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Abbott Laboratories
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6884—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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JP2016544101A 2014-02-07 2015-02-05 ヒトペリオスチンを検出する新規アッセイ Expired - Fee Related JP6549132B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461936967P 2014-02-07 2014-02-07
US61/936,967 2014-02-07
PCT/US2015/014671 WO2015120185A1 (en) 2014-02-07 2015-02-05 Novel assay to detect human periostin

Publications (3)

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JP2017507322A JP2017507322A (ja) 2017-03-16
JP2017507322A5 JP2017507322A5 (cg-RX-API-DMAC7.html) 2017-08-17
JP6549132B2 true JP6549132B2 (ja) 2019-07-24

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JP2016544101A Expired - Fee Related JP6549132B2 (ja) 2014-02-07 2015-02-05 ヒトペリオスチンを検出する新規アッセイ
JP2016545358A Pending JP2017506064A (ja) 2014-02-07 2015-02-05 ヒトペリオスチンを検出する新規アッセイ
JP2019139534A Pending JP2020000236A (ja) 2014-02-07 2019-07-30 ヒトペリオスチンを検出する新規アッセイ

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JP2016545358A Pending JP2017506064A (ja) 2014-02-07 2015-02-05 ヒトペリオスチンを検出する新規アッセイ
JP2019139534A Pending JP2020000236A (ja) 2014-02-07 2019-07-30 ヒトペリオスチンを検出する新規アッセイ

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US (3) US9862762B2 (cg-RX-API-DMAC7.html)
EP (2) EP3102951A1 (cg-RX-API-DMAC7.html)
JP (3) JP6549132B2 (cg-RX-API-DMAC7.html)
KR (2) KR20160122756A (cg-RX-API-DMAC7.html)
CN (2) CN106164675B (cg-RX-API-DMAC7.html)
AU (2) AU2015214089A1 (cg-RX-API-DMAC7.html)
BR (2) BR112016017926A2 (cg-RX-API-DMAC7.html)
CA (2) CA2936258A1 (cg-RX-API-DMAC7.html)
HK (2) HK1232238A1 (cg-RX-API-DMAC7.html)
MX (2) MX2016009450A (cg-RX-API-DMAC7.html)
RU (2) RU2016135418A (cg-RX-API-DMAC7.html)
SG (2) SG11201606322XA (cg-RX-API-DMAC7.html)
TW (1) TW201542589A (cg-RX-API-DMAC7.html)
WO (2) WO2015120185A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018538249A (ja) 2015-11-04 2018-12-27 アストラゼネカ アクチボラグ 好酸球性疾患における好酸球標的化治療薬に対する臨床応答の予測変数としてのジペプチジルペプチダーゼ−４およびペリオスチン
JP7006599B2 (ja) * 2016-08-10 2022-02-10 株式会社シノテスト 試料に含まれるペリオスチンの測定試薬、ペリオスチン測定用前処理剤、ペリオスチン測定方法及びペリオスチン測定の感度の改善方法
JPWO2018194134A1 (ja) * 2017-04-20 2020-02-27 株式会社シノテスト 抗ペリオスチン抗体固定化担体、ペリオスチン測定試薬、及び抗ペリオスチン抗体固定化担体における抗体の安定化方法
JP2021518387A (ja) 2018-03-19 2021-08-02 バイオヴェンチャーズ リミテッド ライアビリティ カンパニー ペリオスチン抗体およびその使用方法
CN109879963A (zh) * 2019-03-15 2019-06-14 辽宁何氏医学院 一种抑制组织器官纤维化和新生血管形成的单克隆抗体及其制备方法和应用
EP3959221A4 (en) 2019-04-26 2024-01-10 Cornell University KLEBSIELLA VACCINE AND METHODS OF USE
TW202342979A (zh) * 2021-12-28 2023-11-01 日商積水醫療股份有限公司 檢測方法及檢測試劑
CN115078734A (zh) * 2022-06-15 2022-09-20 苏州方达新药开发有限公司 一种细胞因子融合蛋白的检测分析方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
GB0407315D0 (en) 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
KR101232342B1 (ko) 2005-05-30 2013-02-13 가부시키가이샤 오간 테크놀로지즈 이의 제조 방법, 이의 집합체 및 조직의 제조 방법
EP1957530A2 (en) 2005-10-21 2008-08-20 Novartis AG Human antibodies against il13 and therapeutic uses
US8017119B2 (en) * 2005-12-28 2011-09-13 Daiichi Sankyo Company, Ltd. Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
BRPI0620747A2 (pt) * 2005-12-28 2011-11-22 Osaka University anticorpo contra periostina, e uma composição farmacêutica compreendendo este para prevenir ou tratar uma doença na qual está envolvida periostina
CA2690888C (en) 2007-06-27 2016-02-09 Asubio Pharma Co., Ltd. Cancer therapeutic composition comprising antibody against peptide encoded by exon-17 site of periostin
MX348362B (es) 2008-03-31 2017-06-07 Genentech Inc * Composiciones y metodos para tratar y diagnosticar asma.
JP2011516549A (ja) 2008-04-11 2011-05-26 バイオジェン アイデック マサチューセッツ インコーポレイテッド 抗ｉｇｆ−１ｒ抗体と他の化合物との治療的併用
FR2946349B1 (fr) 2009-06-03 2013-10-04 Synarc Sas Sequences, anticorps, procedes et necessaires pour la detection et le dosage in vitro de la periostine, en vue du diagnostic du suivi ou du pronostic de pathologies ou de phenomenes biologiques impliquant la periostine
TWI666447B (zh) * 2010-12-16 2019-07-21 建南德克公司 關於ｔｈ２抑制作用之診斷及治療
JP2014518626A (ja) 2011-05-18 2014-08-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 被験者が慢性腎疾患を有する、または発症するリスクがあるかどうかを決定するための方法
WO2012158954A1 (en) 2011-05-18 2012-11-22 Medimmune, Llc Methods of diagnosing and treating pulmonary diseases or disorders
US9347954B2 (en) * 2011-09-06 2016-05-24 Shino-Test Corporation Antibody capable of binding to specific region of periostin, and method of measuring periostin using the same
JP5797148B2 (ja) 2011-09-12 2015-10-21 富士フイルム株式会社 コレステリック液晶性混合物、フィルム、選択反射板、積層体および合わせガラス
WO2013038696A1 (ja) * 2011-09-15 2013-03-21 国立大学法人名古屋大学 胸膜中皮腫患者の早期発見のための分子マーカー及びその発現解析方法
AU2013222129B2 (en) 2012-02-24 2018-02-15 Children's Hospital Medical Center Esophageal microRNA expression profiles in eosinophilic esophagitis
PL2875049T3 (pl) * 2012-07-18 2019-07-31 Institut National De La Santé Et De La Recherche Médicale (Inserm) Sposoby zapobiegania i leczenia przewlekłej choroby nerek (ckd)
EP3099323A4 (en) * 2014-01-27 2017-10-04 Medlmmune, LLC Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung

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