JP6548897B2 - 同種異系細胞の医療用途の誘導のための方法及び組成物並びに治療的利用 - Google Patents

同種異系細胞の医療用途の誘導のための方法及び組成物並びに治療的利用 Download PDF

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JP6548897B2
JP6548897B2 JP2014550544A JP2014550544A JP6548897B2 JP 6548897 B2 JP6548897 B2 JP 6548897B2 JP 2014550544 A JP2014550544 A JP 2014550544A JP 2014550544 A JP2014550544 A JP 2014550544A JP 6548897 B2 JP6548897 B2 JP 6548897B2
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JP2014550544A 2011-12-30 2012-12-31 同種異系細胞の医療用途の誘導のための方法及び組成物並びに治療的利用 Active JP6548897B2 (ja)

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US201161582070P 2011-12-30 2011-12-30
US61/582,070 2011-12-30
US201261591211P 2012-01-26 2012-01-26
US61/591,211 2012-01-26
PCT/US2012/072331 WO2013102219A1 (en) 2011-12-30 2012-12-31 Methods and compositions for the clinical derivation of an allogenic cell and therapeutic uses

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JP2015503918A JP2015503918A (ja) 2015-02-05
JP2015503918A5 JP2015503918A5 (enExample) 2016-02-18
JP6548897B2 true JP6548897B2 (ja) 2019-07-24

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EP (2) EP2798058B1 (enExample)
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CA (2) CA3113484A1 (enExample)
DK (1) DK3321355T3 (enExample)
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HR (1) HRP20211373T1 (enExample)
HU (1) HUE056817T2 (enExample)
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PT (1) PT3321355T (enExample)
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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2623940C (en) 2005-09-27 2017-01-10 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and methods of use
US9526770B2 (en) 2011-04-28 2016-12-27 Tissuetech, Inc. Methods of modulating bone remodeling
CA2837878A1 (en) 2011-06-10 2012-12-13 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
JP6343671B2 (ja) * 2013-12-12 2018-06-13 サムスン ライフ パブリック ウェルフェア ファウンデーション トロンビンを利用した幹細胞由来のエキソソームの生成促進方法
US9919011B2 (en) 2014-03-18 2018-03-20 Samsung Life Public Welfare Foundation Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome
AU2015264025A1 (en) * 2014-05-21 2016-12-01 Mimedx Group, Inc. Micronized Wharton's jelly
TW201603818A (zh) 2014-06-03 2016-02-01 組織科技股份有限公司 組成物及方法
EP3167049A4 (en) 2014-07-08 2017-11-29 MIMEDX Group Inc. Micronized wharton's jelly
WO2016138025A2 (en) 2015-02-23 2016-09-01 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
JP2018516869A (ja) 2015-05-20 2018-06-28 ティッシュテック,インク. 上皮細胞の増殖および上皮間葉転換を防ぐための組成物および方法
KR20170020273A (ko) 2015-08-12 2017-02-22 (주)차바이오텍 향상된 탯줄 유래 부착형 줄기세포, 그의 제조방법 및 용도
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
EP3474869B1 (en) * 2016-06-24 2025-04-09 Osiris Therapeutics, Inc. Human tissue derived compositions and uses thereof
KR102048228B1 (ko) 2016-12-02 2019-11-25 가톨릭대학교 산학협력단 T 세포 자극용 엑소좀 및 이의 약제학적 용도
KR101864234B1 (ko) * 2017-07-04 2018-06-04 인하대학교 산학협력단 음경해면체 유래 엑소좀을 유효성분으로 포함하는, 발기부전 예방, 개선 또는 치료용 조성물
US11285177B2 (en) 2018-01-03 2022-03-29 Globus Medical, Inc. Allografts containing viable cells and methods thereof
CN108239621B (zh) * 2018-01-24 2020-08-18 北京臻溪谷医学研究中心(有限合伙) 一种胎盘亚全能干细胞分离、扩增、冻存、复苏干细胞的方法
US20230357724A1 (en) 2019-01-16 2023-11-09 University Of Utah Research Foundation Human umbilical cord mesenchymal stem cell sheets and methods for their production
EP3911734A4 (en) * 2019-01-16 2022-11-09 University of Utah Research Foundation USING MESENCHYMATOUS STEM CELL SHEETS TO PREVENT UTERINE SCARS
US20230338428A1 (en) * 2020-09-08 2023-10-26 Amit Patel Allogenic umbilical cord stem cells for treating severe respiratory conditions
US20230057957A1 (en) * 2021-08-23 2023-02-23 Therapeutic Solutions International, Inc. Umbilical cord mesenchymal stem cells for treatment of chronic obstructive pulmonary disease and lung degeneration
US20230293598A1 (en) * 2022-03-15 2023-09-21 Narkeshyo LLC Prevention of radiation exposure associated pathology by treatment with umbilical cord derived regenerative cells
US20240003871A1 (en) * 2022-06-29 2024-01-04 FUJIFILM Cellular Dynamics, Inc. Ipsc-derived astrocytes and methods of use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
EP1082410B1 (en) 1998-05-29 2007-08-01 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
US20030161818A1 (en) 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
JP4790592B2 (ja) 2003-02-11 2011-10-12 ダビース,ジヨン・イー ヒト臍帯のウォートンジェリーからの前駆細胞
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
NZ553695A (en) * 2004-08-16 2009-10-30 Cellres Corp Pte Ltd Isolation of stem/progenitor cells from amniotic membrane of umbilical cord
WO2007106089A1 (en) 2006-03-14 2007-09-20 Spherical Dynamics, Inc. System for and method for psychological assessment
HRP20130765T1 (hr) * 2007-02-12 2013-10-25 Anthrogenesis Corporation Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice
PT103843B (pt) 2007-10-04 2008-08-12 Medinfar Produtos Farmaceutico Método de isolamento de células precursoras a partir do cordão umbilical humano
WO2010060031A1 (en) * 2008-11-21 2010-05-27 Anthrogenesis Corporation Treatment of diseases, disorders or conditions of the lung using placental cells
CN101748096B (zh) * 2008-12-17 2013-03-13 北京汉氏联合生物技术有限公司 亚全能干细胞、其制备方法及其用途
CA2756670A1 (en) 2009-03-26 2010-09-30 The Regents Of The University Of California Mesenchymal stem cells producing inhibitory rna for disease modification
IN2012DN02532A (enExample) * 2009-09-23 2015-08-28 Davinci Bioscineces Llc
CN101890050B (zh) * 2010-07-14 2012-07-04 江苏大学 脐带间质干细胞来源膜性囊泡及其应用
EP2540819A1 (en) 2011-06-27 2013-01-02 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Method for cultivating cells in platelet-lysate-containing medium
US20210355437A1 (en) 2015-09-02 2021-11-18 Restem Llc Factor rich product from umbilical cord mesenchymal stem cells

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ES2890126T3 (es) 2022-01-17
US20220041992A1 (en) 2022-02-10
SI3321355T1 (sl) 2021-11-30
CA3113484A1 (en) 2013-07-04
US9803176B2 (en) 2017-10-31
ES2656614T3 (es) 2018-02-27
CA2862661C (en) 2021-05-25
PT3321355T (pt) 2021-09-28
JP2015503918A (ja) 2015-02-05
EP3321355B1 (en) 2021-08-25
US20220251515A1 (en) 2022-08-11
EP2798058A1 (en) 2014-11-05
PL3321355T3 (pl) 2021-12-27
EP2798058A4 (en) 2015-05-20
EP3321355A1 (en) 2018-05-16
US12441986B2 (en) 2025-10-14
DK3321355T3 (da) 2021-11-08
WO2013102219A1 (en) 2013-07-04
CA2862661A1 (en) 2013-07-04
HRP20211373T1 (hr) 2021-11-26
EP2798058B1 (en) 2017-10-18
US20220251514A1 (en) 2022-08-11
US20220251513A1 (en) 2022-08-11
HUE056817T2 (hu) 2022-03-28
US20190218519A1 (en) 2019-07-18
US20250346865A1 (en) 2025-11-13

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