JP6542128B2 - トレプロスチニルのプロドラッグ - Google Patents

トレプロスチニルのプロドラッグ Download PDF

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JP6542128B2
JP6542128B2 JP2015552854A JP2015552854A JP6542128B2 JP 6542128 B2 JP6542128 B2 JP 6542128B2 JP 2015552854 A JP2015552854 A JP 2015552854A JP 2015552854 A JP2015552854 A JP 2015552854A JP 6542128 B2 JP6542128 B2 JP 6542128B2
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substituted
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group
aryl
heteroaryl
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JP2016510323A (ja
JP2016510323A5 (OSRAM
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ジュルグ フィスター
ジュルグ フィスター
ミーナクシ ベンカトラマン
ミーナクシ ベンカトラマン
シャオミン チャン
シャオミン チャン
サイラス ベッカー
サイラス ベッカー
グウェナエラ リスコウリオ
グウェナエラ リスコウリオ
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コルセア ファーマ インコーポレイテッド
コルセア ファーマ インコーポレイテッド
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • C07C69/708—Ethers
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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