JP6529565B2 - 衝撃波バルーンカテーテル装置 - Google Patents
衝撃波バルーンカテーテル装置 Download PDFInfo
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- JP6529565B2 JP6529565B2 JP2017212658A JP2017212658A JP6529565B2 JP 6529565 B2 JP6529565 B2 JP 6529565B2 JP 2017212658 A JP2017212658 A JP 2017212658A JP 2017212658 A JP2017212658 A JP 2017212658A JP 6529565 B2 JP6529565 B2 JP 6529565B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/22022—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement using electric discharge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22029—Means for measuring shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
- A61B17/2251—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320725—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with radially expandable cutting or abrading elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22001—Angioplasty, e.g. PCTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
- A61B2017/22021—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter electric leads passing through the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B2017/22024—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement with a part reflecting mechanical vibrations, e.g. for focusing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B2017/22025—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement applying a shock wave
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22057—Optical properties
- A61B2017/22058—Optical properties reflective
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22061—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation for spreading elements apart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22062—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation to be filled with liquid
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Description
00の図である。回路100は、R波検出器102と、高電圧スイッチ32を制御する制御器104とを備える。機械的な衝撃は、心筋を刺激し、不整脈を生じさせることがある。パルス(又はパルスの破裂)をR波と同期させることにより、本明細書で検討したような短い持続時間の衝撃波が心臓を刺激することは考えにくいが、心臓の血管又は心臓の近傍の血管に用いたときに安全性が追加される。図示のバルーンは電流からの患者の電気的絶縁を与えるが、流体として血液を用いる非バルーン又は非絶縁の方法が用いられてもよい。この場合、R波との同期は不要な不整脈に対する安全性を著しく高める。
Claims (10)
- 血管形成術用のカテーテルであって、
血管内に嵌まり込むサイズとされた細長いキャリアであって、前記キャリアは、前記血管を通るように延びるガイドワイヤ用管腔を有し、前記細長いキャリアは、遠位端および外側表面を有する、キャリアと、
前記キャリアの遠位端の近くに配置された血管形成術用のバルーンであって、前記バルーンの遠位端は、前記キャリアの遠位端の近くにおいて前記キャリアに密着され、前記バルーンは、前記バルーンを膨張させる流体を受け入れるように配列され、前記バルーンは、前記血管の壁に接触するように構成されており、前記細長いキャリアの前記外側表面は、前記バルーンが膨張されているとき、前記流体に接触し、前記細長いキャリアの前記遠位端は、前記バルーンの外側に位置決めされる、バルーンと、
一対の電極を含むアーク発生器であって、前記電極は、前記バルーンと非接触の関係で前記バルーン内に位置決めされている、アーク発生器と
を含み、
前記一対の電極は、前記バルーンが膨張されているとき、前記細長いキャリアの外側に、かつ、前記流体内に位置決めされ、前記一対の電極は、前記バルーンと前記細長いキャリアの前記外側表面との間に位置決めされ、
前記アーク発生器は、前記電極間にプラズマアークを生じさせるのに十分な高電圧パルスを生成して前記バルーン内に機械的衝撃波をもたらし、
前記機械的衝撃波は、前記流体を通り、前記バルーンを通り、前記血管の前記壁を通って石灰化病変部に到達し、
前記バルーンは、前記機械的衝撃波の形成中に損傷を受けないままであるように配列されている、カテーテル。 - 前記バルーンは、前記バルーンの膨張が前記血管の前記壁を拡張させるようにさらに構成されている、請求項1に記載のカテーテル。
- 前記一対の電極は、一対の金属電極を含む、請求項1または請求項2に記載のカテーテル。
- 前記バルーンは、非柔軟な材料で作られている、請求項1または請求項2に記載のカテーテル。
- 前記バルーンは、柔軟な材料で作られている、請求項1または請求項2に記載のカテーテル。
- 前記バルーンは、表面を有し、前記カテーテルは、前記バルーンの前記表面に形成された少なくとも1つの突起をさらに含む、請求項1または請求項2に記載のカテーテル。
- 反射されたエネルギーを感知するセンサーをさらに含む、請求項1または請求項2に記載のカテーテル。
- 前記バルーンの中に配置された反射体であって、前記機械的衝撃波の焦点を合わせる反射体をさらに含む、請求項1または請求項2に記載のカテーテル。
- システムであって、前記システムは、
血管内に嵌まり込むサイズとされた細長いキャリアであって、前記キャリアは、前記血管を通るように延びるガイドワイヤ用管腔を有し、前記細長いキャリアは、遠位端および外側表面を有する、キャリアと、前記キャリアの遠位端の近くに配置された血管形成術用のバルーンであって、前記バルーンの遠位端は、前記キャリアの遠位端の近くにおいて前記キャリアに密着され、前記バルーンは、前記バルーンを膨張させる流体を受け入れるように配列され、前記バルーンは、前記血管の壁に接触するように構成されており、前記細長いキャリアの前記外側表面は、前記バルーンが膨張されているとき、前記流体に接触し、前記細長いキャリアの前記遠位端は、前記バルーンの外側に位置決めされる、バルーンと、一対の電極を含むアーク発生器であって、前記電極は、前記バルーンと非接触の関係で前記バルーン内に位置決めされている、アーク発生器とを含み、前記一対の電極は、前記バルーンが膨張されているとき、前記細長いキャリアの外側に、かつ、前記流体内に位置決めされ、前記一対の電極は、前記バルーンと前記細長いキャリアの前記外側表面との間に位置決めされる、血管形成術用のカテーテルと、
前記アーク発生器に高電圧パルスを提供するように構成された電源と
を含み、
前記高電圧パルスは、前記電極間にプラズマアークを生じさせて前記バルーン内に機械的衝撃波をもたらすのに十分であり、
前記機械的衝撃波は、前記流体を通り、前記バルーンを通り、前記血管の前記壁を通って石灰化病変部に到達し、
前記バルーンは、前記機械的衝撃波の形成中に損傷を受けないままであるように配列されている、システム。 - 前記バルーンは、前記バルーンの膨張が前記血管の前記壁を拡張させるようにさらに構成されている、請求項9に記載のシステム。
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Application Number | Priority Date | Filing Date | Title |
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US6117008P | 2008-06-13 | 2008-06-13 | |
US61/061,170 | 2008-06-13 |
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JP2016094326A Division JP2016137333A (ja) | 2008-06-13 | 2016-05-10 | 衝撃波バルーンカテーテル装置 |
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JP2018015649A JP2018015649A (ja) | 2018-02-01 |
JP6529565B2 true JP6529565B2 (ja) | 2019-06-12 |
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JP2011513694A Active JP5636363B2 (ja) | 2008-06-13 | 2009-06-11 | 衝撃波バルーンカテーテル装置 |
JP2014158517A Withdrawn JP2014208305A (ja) | 2008-06-13 | 2014-08-04 | 衝撃波バルーンカテーテル装置 |
JP2016094326A Withdrawn JP2016137333A (ja) | 2008-06-13 | 2016-05-10 | 衝撃波バルーンカテーテル装置 |
JP2017212658A Active JP6529565B2 (ja) | 2008-06-13 | 2017-11-02 | 衝撃波バルーンカテーテル装置 |
JP2017212659A Pending JP2018015650A (ja) | 2008-06-13 | 2017-11-02 | 衝撃波バルーンカテーテル装置 |
JP2019076442A Withdrawn JP2019107561A (ja) | 2008-06-13 | 2019-04-12 | 衝撃波バルーンカテーテル装置 |
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JP2011513694A Active JP5636363B2 (ja) | 2008-06-13 | 2009-06-11 | 衝撃波バルーンカテーテル装置 |
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JP2016094326A Withdrawn JP2016137333A (ja) | 2008-06-13 | 2016-05-10 | 衝撃波バルーンカテーテル装置 |
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JP2019076442A Withdrawn JP2019107561A (ja) | 2008-06-13 | 2019-04-12 | 衝撃波バルーンカテーテル装置 |
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EP2300091A2 (en) | 2011-03-30 |
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EP2300091B1 (en) | 2018-03-21 |
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US10039561B2 (en) | 2018-08-07 |
US10959743B2 (en) | 2021-03-30 |
WO2009152352A2 (en) | 2009-12-17 |
CA2727429C (en) | 2016-01-26 |
US20180317946A1 (en) | 2018-11-08 |
WO2009152352A8 (en) | 2010-12-09 |
AU2009257368A1 (en) | 2009-12-17 |
EP2300091A4 (en) | 2013-11-13 |
ES2671898T3 (es) | 2018-06-11 |
CA2727429A1 (en) | 2009-12-17 |
US8956371B2 (en) | 2015-02-17 |
JP2019107561A (ja) | 2019-07-04 |
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US20230380849A1 (en) | 2023-11-30 |
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