JP6505682B2 - ヘテロ環式化合物およびそれらの使用方法 - Google Patents
ヘテロ環式化合物およびそれらの使用方法 Download PDFInfo
- Publication number
- JP6505682B2 JP6505682B2 JP2016524633A JP2016524633A JP6505682B2 JP 6505682 B2 JP6505682 B2 JP 6505682B2 JP 2016524633 A JP2016524633 A JP 2016524633A JP 2016524633 A JP2016524633 A JP 2016524633A JP 6505682 B2 JP6505682 B2 JP 6505682B2
- Authority
- JP
- Japan
- Prior art keywords
- nhc
- phenyl
- alkyl
- alkynyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 COC([C@](Cc1c(*)c(*)ccc1C1)N1C(C(*)c1ccccc1)=*)=[U] Chemical compound COC([C@](Cc1c(*)c(*)ccc1C1)N1C(C(*)c1ccccc1)=*)=[U] 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013902513A AU2013902513A0 (en) | 2013-07-08 | Method of treatment or prophylaxis | |
| AU2013902513 | 2013-07-08 | ||
| PCT/AU2014/050116 WO2015003223A1 (en) | 2013-07-08 | 2014-07-08 | Heterocyclic compounds and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525093A JP2016525093A (ja) | 2016-08-22 |
| JP2016525093A5 JP2016525093A5 (https=) | 2017-08-17 |
| JP6505682B2 true JP6505682B2 (ja) | 2019-04-24 |
Family
ID=52279233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524633A Expired - Fee Related JP6505682B2 (ja) | 2013-07-08 | 2014-07-08 | ヘテロ環式化合物およびそれらの使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9714224B2 (https=) |
| EP (1) | EP3019477B1 (https=) |
| JP (1) | JP6505682B2 (https=) |
| CN (1) | CN105358532B (https=) |
| ES (1) | ES2883155T3 (https=) |
| NZ (1) | NZ630908A (https=) |
| PL (1) | PL3019477T3 (https=) |
| PT (1) | PT3019477T (https=) |
| WO (1) | WO2015003223A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013202982C1 (en) | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
| PL3268356T3 (pl) * | 2015-03-12 | 2022-01-24 | Novartis Ag | Związki heterocykliczne i sposoby ich stosowania |
| CN106478502B (zh) * | 2015-08-29 | 2021-04-27 | 上海翰森生物医药科技有限公司 | 1,2,3,4-四氢异喹啉衍生物、其制备方法和应用 |
| WO2018224037A1 (zh) * | 2017-06-09 | 2018-12-13 | 南京明德新药研发股份有限公司 | 作为at2r受体拮抗剂的羧酸衍生物 |
| US11485725B2 (en) | 2017-12-15 | 2022-11-01 | Auransa Inc. | Derivatives of piperlongumine and uses thereof |
| CN112313222B (zh) * | 2018-06-19 | 2024-01-26 | 浙江海正药业股份有限公司 | 四氢异喹啉类衍生物、其制备方法及其用途 |
| WO2020012266A1 (en) * | 2018-07-12 | 2020-01-16 | Novartis Ag | Biocatalytic synthesis of olodanrigan (ema401) from 3-(2-(benzyloxy)-3-methoxyphenyl)propenoic acid with phenylalanine ammonia lyase |
| US12559449B2 (en) | 2019-05-10 | 2026-02-24 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Aromatic ring or heteroaromatic ring derivatives, preparation method therefor and use thereof |
| CN111620816B (zh) * | 2020-05-27 | 2023-06-02 | 上海赛默罗生物科技有限公司 | 螺桨烷类衍生物、其制备方法、药物组合物和用途 |
| CN113880825B (zh) | 2020-07-01 | 2025-03-14 | 浙江海正药业股份有限公司 | 四氢异喹啉类衍生物的盐、其制备方法及其医药应用 |
| CN111777555B (zh) * | 2020-09-04 | 2020-12-01 | 上海赛默罗生物科技有限公司 | 脂肪环烷衍生物、其制备方法、药物组合物和其应用 |
| WO2023006893A1 (en) | 2021-07-30 | 2023-02-02 | Confo Therapeutics N.V. | Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling |
| CN117603088A (zh) * | 2023-10-28 | 2024-02-27 | 广东工业大学 | 一种基于氨基酸乙酯的芳香醛席夫碱及其在不对称烷基化中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55127373A (en) * | 1979-03-26 | 1980-10-02 | Takeda Chem Ind Ltd | Tetrahydroisoquinoline compound and its preparation |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| US5236934A (en) * | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
| AU2002357692A1 (en) * | 2001-11-09 | 2003-05-26 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
| WO2006055951A2 (en) * | 2004-11-19 | 2006-05-26 | Portola Pharmaceuticals, Inc. | Tetrahydroisoquinolines as factor xa inhibitors |
| PT1830869E (pt) | 2004-12-24 | 2013-08-22 | Spinifex Pharm Pty Ltd | Método de tratamento ou profilaxia |
| CA2646379C (en) * | 2006-03-20 | 2014-12-23 | The University Of Queensland | Method of treatment or prophylaxis inflammatory pain |
| US9095587B2 (en) * | 2010-01-19 | 2015-08-04 | Spinifex Pharmaceuticals Pty Ltd | Methods and compositions for improved nerve conduction velocity |
| ES2570135T3 (es) * | 2010-07-21 | 2016-05-17 | Novartis Ag | Sal y solvatos de un derivado de tetrahidroisoquinolina |
| AU2013202982C1 (en) | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
| PL2807153T3 (pl) | 2012-01-25 | 2020-09-07 | Novartis Ag | Związki heterocykliczne i sposoby ich zastosowania |
| PT2807171T (pt) | 2012-01-25 | 2020-11-03 | Novartis Ag | Compostos heterocíclicos e métodos para a sua utilização |
-
2014
- 2014-07-08 NZ NZ630908A patent/NZ630908A/en unknown
- 2014-07-08 PL PL14823688T patent/PL3019477T3/pl unknown
- 2014-07-08 EP EP14823688.8A patent/EP3019477B1/en active Active
- 2014-07-08 ES ES14823688T patent/ES2883155T3/es active Active
- 2014-07-08 US US14/903,166 patent/US9714224B2/en active Active
- 2014-07-08 CN CN201480038866.XA patent/CN105358532B/zh active Active
- 2014-07-08 PT PT148236888T patent/PT3019477T/pt unknown
- 2014-07-08 WO PCT/AU2014/050116 patent/WO2015003223A1/en not_active Ceased
- 2014-07-08 JP JP2016524633A patent/JP6505682B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016525093A (ja) | 2016-08-22 |
| US20160145213A1 (en) | 2016-05-26 |
| EP3019477A4 (en) | 2017-01-11 |
| CN105358532A (zh) | 2016-02-24 |
| NZ630908A (en) | 2017-08-25 |
| PL3019477T3 (pl) | 2021-11-22 |
| EP3019477B1 (en) | 2021-05-26 |
| CN105358532B (zh) | 2019-07-23 |
| PT3019477T (pt) | 2021-08-20 |
| WO2015003223A1 (en) | 2015-01-15 |
| ES2883155T3 (es) | 2021-12-07 |
| EP3019477A1 (en) | 2016-05-18 |
| US9714224B2 (en) | 2017-07-25 |
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