JP6483250B2 - エルゴチオネインおよび関連化合物の合成方法 - Google Patents

エルゴチオネインおよび関連化合物の合成方法 Download PDF

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JP6483250B2
JP6483250B2 JP2017515766A JP2017515766A JP6483250B2 JP 6483250 B2 JP6483250 B2 JP 6483250B2 JP 2017515766 A JP2017515766 A JP 2017515766A JP 2017515766 A JP2017515766 A JP 2017515766A JP 6483250 B2 JP6483250 B2 JP 6483250B2
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ergothioneine
compound
sulfoxide
esh
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JP2017536086A (ja
JP2017536086A5 (enExample
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モーガマット・アンウォー・ジャーディン
ルテテ・ペギー・コンデ
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University of Cape Town
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University of Cape Town
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2017515766A 2014-09-22 2015-09-22 エルゴチオネインおよび関連化合物の合成方法 Active JP6483250B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1416678.9A GB201416678D0 (en) 2014-09-22 2014-09-22 Process For Synthesizing Ergothioneine And Its Intermediates
GB1416678.9 2014-09-22
PCT/IB2015/001668 WO2016046618A1 (en) 2014-09-22 2015-09-22 Process for synthesizing ergothioneine and related compounds

Publications (3)

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JP2017536086A JP2017536086A (ja) 2017-12-07
JP2017536086A5 JP2017536086A5 (enExample) 2018-11-01
JP6483250B2 true JP6483250B2 (ja) 2019-03-13

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JP2017515766A Active JP6483250B2 (ja) 2014-09-22 2015-09-22 エルゴチオネインおよび関連化合物の合成方法

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US (1) US9908854B2 (enExample)
EP (1) EP3197874B1 (enExample)
JP (1) JP6483250B2 (enExample)
CN (1) CN107108520B (enExample)
GB (1) GB201416678D0 (enExample)
WO (1) WO2016046618A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105949130B (zh) * 2016-04-29 2018-10-19 华南农业大学 一种利用超声-微波辅助结合真空冷冻干燥提取食用菌麦角硫因的方法
CN111170945B (zh) * 2020-01-15 2022-03-29 中国科学院西北高原生物研究所 黄蘑菇中天然抗氧化氨基酸衍生物的分离工艺及其应用
JP6864131B1 (ja) * 2020-03-04 2021-04-28 長瀬産業株式会社 Ｌ−エルゴチオネイン含有組成物
CN111574458B (zh) * 2020-06-11 2023-04-07 上海克琴科技有限公司 一种麦角硫因的合成方法
CN114409608B (zh) * 2022-01-24 2022-09-02 广州金娜宝生物科技有限公司 一种麦角硫因的合成方法
CN119032084A (zh) * 2022-04-22 2024-11-26 南京纽邦生物科技有限公司 麦角硫因的化学合成方法和使用方法
CN116102502A (zh) * 2022-11-28 2023-05-12 南京艾希帝生物科技有限公司 一种麦角硫因的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950889B1 (fr) * 2009-10-06 2011-11-18 Tetrahedron Procede de synthese de l'ergothioneine et analogues
US10167490B2 (en) 2012-12-21 2019-01-01 Ergo Health Llc Ergothioneine production through metabolic engineering

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Publication number Publication date
WO2016046618A1 (en) 2016-03-31
CN107108520A (zh) 2017-08-29
CN107108520B (zh) 2018-11-02
GB201416678D0 (en) 2014-11-05
JP2017536086A (ja) 2017-12-07
EP3197874A1 (en) 2017-08-02
EP3197874B1 (en) 2019-04-24
US20170305865A1 (en) 2017-10-26
US9908854B2 (en) 2018-03-06

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