JP6464258B2 - スキンケア組成物 - Google Patents
スキンケア組成物 Download PDFInfo
- Publication number
- JP6464258B2 JP6464258B2 JP2017510778A JP2017510778A JP6464258B2 JP 6464258 B2 JP6464258 B2 JP 6464258B2 JP 2017510778 A JP2017510778 A JP 2017510778A JP 2017510778 A JP2017510778 A JP 2017510778A JP 6464258 B2 JP6464258 B2 JP 6464258B2
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- JP
- Japan
- Prior art keywords
- dipeptide
- emulsion
- acid
- emulsion according
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 116
- -1 Methylundecylenoyl Chemical group 0.000 claims description 69
- 239000000839 emulsion Substances 0.000 claims description 66
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 64
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 64
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 59
- 229940008099 dimethicone Drugs 0.000 claims description 53
- 150000001413 amino acids Chemical group 0.000 claims description 42
- 229920001296 polysiloxane Polymers 0.000 claims description 37
- 239000012071 phase Substances 0.000 claims description 36
- 108010016626 Dipeptides Proteins 0.000 claims description 25
- 239000008346 aqueous phase Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 16
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- 239000007762 w/o emulsion Substances 0.000 claims description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
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- 229940014843 acetyl dipeptide-1 cetyl ester Drugs 0.000 claims description 8
- 108010074988 acetyltyrosyl-arginine cetyl ester Proteins 0.000 claims description 8
- JFHZXDZUXGBFAQ-KYJUHHDHSA-N hexadecyl (2s)-2-[[(2s)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(C)=O)CC1=CC=C(O)C=C1 JFHZXDZUXGBFAQ-KYJUHHDHSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
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- 235000009566 rice Nutrition 0.000 claims description 6
- LZDNBBYBDGBADK-KBPBESRZSA-N Val-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](N)C(C)C)C(O)=O)=CNC2=C1 LZDNBBYBDGBADK-KBPBESRZSA-N 0.000 claims description 5
- 108010053037 kyotorphin Proteins 0.000 claims description 5
- JXNRXNCCROJZFB-RYUDHWBXSA-N Tyr-Arg Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 JXNRXNCCROJZFB-RYUDHWBXSA-N 0.000 claims description 4
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- CTUFKZFWHRPQEC-HOTGVXAUSA-N (2s)-n-[(2s)-4-amino-1-(benzylamino)-1-oxobutan-2-yl]-1-(3-aminopropanoyl)pyrrolidine-2-carboxamide Chemical compound N([C@@H](CCN)C(=O)NCC=1C=CC=CC=1)C(=O)[C@@H]1CCCN1C(=O)CCN CTUFKZFWHRPQEC-HOTGVXAUSA-N 0.000 claims description 3
- FGSPQNZCLMWQAS-GPXNEJASSA-N (2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O FGSPQNZCLMWQAS-GPXNEJASSA-N 0.000 claims description 3
- QJQNWKPSKDLCOX-UHFFFAOYSA-N 3,3-diamino-2-hydroxybutanoic acid Chemical compound NC(C(C(=O)O)O)(C)N QJQNWKPSKDLCOX-UHFFFAOYSA-N 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- ZUKPVRWZDMRIEO-VKHMYHEASA-N L-cysteinylglycine Chemical compound SC[C@H]([NH3+])C(=O)NCC([O-])=O ZUKPVRWZDMRIEO-VKHMYHEASA-N 0.000 claims description 3
- ZOKVLMBYDSIDKG-CSMHCCOUSA-N Lys-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ZOKVLMBYDSIDKG-CSMHCCOUSA-N 0.000 claims description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 3
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- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims description 3
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- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 229940117982 palmitoyl dipeptide-7 Drugs 0.000 claims description 3
- 150000004492 retinoid derivatives Chemical class 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 3
- BVYVWYKOCOGULA-JBUMCTQMSA-N (2s,3r)-2-[[(2s)-4-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]butanoyl]amino]-3-hydroxybutanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O BVYVWYKOCOGULA-JBUMCTQMSA-N 0.000 claims description 2
- 108010024636 Glutathione Proteins 0.000 claims description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 2
- 125000003047 N-acetyl group Chemical group 0.000 claims description 2
- 235000005205 Pinus Nutrition 0.000 claims description 2
- 241000218602 Pinus <genus> Species 0.000 claims description 2
- 244000046146 Pueraria lobata Species 0.000 claims description 2
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 2
- 235000009499 Vanilla fragrans Nutrition 0.000 claims description 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims description 2
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical compound CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims description 2
- 229960004308 acetylcysteine Drugs 0.000 claims description 2
- 229940045761 evening primrose extract Drugs 0.000 claims description 2
- 235000008524 evening primrose extract Nutrition 0.000 claims description 2
- 150000002212 flavone derivatives Chemical class 0.000 claims description 2
- 229960003180 glutathione Drugs 0.000 claims description 2
- 229940038487 grape extract Drugs 0.000 claims description 2
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims description 2
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 2
- 235000008696 isoflavones Nutrition 0.000 claims description 2
- 229940062851 jujube fruit extract Drugs 0.000 claims description 2
- NCUJRUDLFCGVOE-UHFFFAOYSA-N noreugenin Chemical compound C1=C(O)C=C2OC(C)=CC(=O)C2=C1O NCUJRUDLFCGVOE-UHFFFAOYSA-N 0.000 claims description 2
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- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 3
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- LAMPQFOTAITAOO-JYJNAYRXSA-N (2s)-2-[[(2s)-2-[[(2s)-5-(diaminomethylideneamino)-2-(hexanoylamino)pentanoyl]amino]propanoyl]amino]hexanamide Chemical compound CCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCC)C(N)=O LAMPQFOTAITAOO-JYJNAYRXSA-N 0.000 claims 1
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- UEJYSALTSUZXFV-SRVKXCTJSA-N Rigin Chemical compound NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O UEJYSALTSUZXFV-SRVKXCTJSA-N 0.000 description 11
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 10
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Description
本発明は油中水型エマルション形態にあるスキンケア組成物に関する。水はエマルションの60重量%未満、より好ましくは50重量%未満、より好ましくは45重量%未満の量で存在する。水は、好ましくは、前記エマルション中に10%超、より好ましくは15%超、最も好ましくは20%超の量で存在する。最も好ましくは、水は、エマルション組成物の35%〜45%の範囲で存在する。
R3SiO[R2SiO]xSiR3
(式中、Rは、1〜30個の炭素原子を有するアルキル基(好ましくは、Rはメチルまたはエチル、より好ましくはメチルであり、1分子中に混合アルキル基を用いることもできる)であり、xは、10,000,000を超え得る所望の分子量を達成するように選択される0〜10,000の整数である)で表すことができる。市販のポリアルキルシロキサンとしては、ジメチコンとしても知られるポリジメチルシロキサンが挙げられ、その例として、ShinEtsu、Momentive、Wackerから販売されているもの、およびDow Corning Corporationから販売されているDow Corning 200シリーズが挙げられる。好適なポリジメチルシロキサンの具体例としては、Dow Corning2、20、100、200、225、300およびこれらの混合物が挙げられる。好適なジメチコンとしては、化学式:
(CH3)3SiO[(CH3)2SiO]x[CH3RSiO]ySi(CH3)3
(式中、Rは、2〜30個の炭素原子を有する直鎖または分岐アルキルであり、xおよびyは、それぞれ10,000,000を超え得る所望の分子量を達成するように選択される1以上の整数である)で表されるものが挙げられる。このようなアルキル置換ジメチコンの例としては、セチルジメチコンおよびラウリルジメチコンが挙げられる。
R3SiO[R2SiO]xSiR2OH
および
HOR2SiO[R2SiO]xSiR2OH
(式中、Rはアルキル基であり(好ましくは、Rはメチルまたはエチル、より好ましくはメチルである)、xは、所望の分子量を達成するように選択される0〜500の整数である)で表すことができる。市販のジメチコノールは、通常、ジメチコンまたはシクロメチコンとの混合物として販売されている(例えば、Dow Corning 1401 fluid、1402 fluidおよび1403 fluid)。ポリアルキルアリールシロキサンも組成物に使用するのに適している。
好適な乳化剤としては、スキンケア製品に使用する目的に適した、当業者に知られているあらゆる乳化剤が挙げられる。好ましくは、この乳化剤のHLB値は、14以下、より好ましくは2〜14、さらに好ましくは4〜14である。
Si(CH3)3O[Si(CH3)2O]x[Si(CH3R)O]y[Si(CH3R2)O]zSi(CH3)3
(式中、Rは、直鎖、分岐鎖、または環状のC1〜C30アルキルであり、R2は、−(CH2)n−O−(CH2CHR3O)m−Hおよび−(CH2)n−O−(CH2CHR3O)m−(CH2CHR4O)o−Hからなる群から選択される(式中、nは3〜10の整数であり;R3およびR4は、Hおよび直鎖または分岐のC1〜C6アルキルからなる群から選択され(但し、R3およびR4は同時に同一にならない);m、o、x、およびyは、分子全体の分子量が200〜10,000,000となるように、ゼロ以上の整数から独立に選択され(但し、mおよびoは同時にゼロにならない)、zは独立に1以上の整数から選択される))で表すことができる。これらのコポリオールには位置異性体が存在することも認識される。上に示したR3およびR4基を含むR2部分に関する化学的表現は便宜的に表したものであって、これらに限定することを意味するものではない。
ペプチドは、アミノ酸の連続した配列を含む化合物と定義される。ジペプチドは2個の連続したアミノ酸配列を含む。本明細書において用いられるアミノ酸には、あらゆる天然アミノ酸(D体またはL体の両方)が含まれ、かつ包含される。アミノ酸は、通常、従来使用されている3文字表記の略号で表し、配列は左から右に読む。本発明のエマルションは、アセチルジペプチド−1セチルエステル、アミノヘキサン酸アセチルジペプチド−3、アゼラオイルビスジペプチド−10、クマロイルジペプチド−3、ジセチルジペプチド−9、ジ酢酸ジペプチドジアミノブチロイルベンジルアミド、ジペプチド−1、ジペプチド−10、ジペプチド−11、ジペプチド−12、ジペプチド−15、ジペプチド−16、ジペプチド−17、ジペプチド−18、ジペプチド−19、ジペプチド−2、ジペプチド−20、ジペプチド−3、ジペプチド−4、ジペプチド−5、ジペプチド−6、ジペプチド−7、ジペプチド−8、ジペプチド−8HCL、ジペプチド−9、酢酸ヘキサノイルジペプチド−3ノルロイシン、メチルウンデシレノイルジペプチド−16、ニコチノイルジペプチド−22、ニコチノイルジペプチド−23、ニコチノイルジペプチド−24、ニコチノイルジペプチド−26、オレオイルジペプチド−15、パルミトイルジペプチド−10、パルミトイルジペプチド−13、パルミトイルジペプチド−17、パルミトイルジペプチド−5ジアミノブチロイルヒドロキシトレオニン、パルミトイルジペプチド−5ジアミノヒドロキシ酪酸、パルミトイルジペプチド−7およびこれらの混合物からなる群から選択されるジペプチドを含む。
本発明の好ましい実施形態において、エマルションはさらなるペプチドを含む。好ましくは、前記さらなるペプチドは、トリペプチド、テトラペプチド、ペンタペプチドおよびこれらの混合物からなる群から選択される。トリペプチドとは、連続した3個のアミノ酸配列を含む化合物を意味する。テトラペプチドとは、連続した4個のアミノ酸配列を含む化合物を意味する。ペンタペプチドとは、連続した5個のアミノ酸配列を含む化合物を意味する。
本発明のエマルションは、好ましくはトリペプチドを含む。前記トリペプチドは天然由来であっても合成由来であってもよい。好適なトリペプチドとしては、トリペプチド−1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、これらの誘導体およびこれらの混合物が挙げられる。
本発明のエマルションは、好ましくはテトラペプチドを含む。これらは1種以上のriginをベースとするテトラペプチド、1種以上のALAMCAT−テトラペプチドまたはこれらの混合物とすることができる。これらのテトラペプチドは天然由来であっても合成由来であってもよい。本発明の組成物に使用するのに好適なテトラペプチドとしては、テトラペプチド−1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、34、35、これらの誘導体またはこれらの混合物からなる群から選択されるものが挙げられる。
本発明の組成物は、任意選択的にペンタペプチド、ペンタペプチドの誘導体およびこれらの混合物を含むことができる。本明細書において使用される「ペンタペプチド」は、天然ペンタペプチドおよび合成ペンタペプチドの両方を指す。本明細書においては、ペンタペプチドを含む天然の組成物および市販の組成物も同様に有用である。好適なペンタペプチドは、ペンタペプチド−1、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、21、22、23、24、25、26、28、29、30、31、33、34、35、36、38、39、これらの誘導体およびこれらの混合物からなる群から選択される。
「マトリックスメタロプロテアーゼ阻害物質」という語は、皮膚近傍または皮膚内部で発現するかまたは合成される少なくとも1種のマトリックスメタロプロテアーゼに対する阻害活性を有するあらゆる分子および/または植物抽出物もしくは細菌抽出物を指す。マトリックスメタロプロテアーゼファミリーは、その構造および基質特異性に関する類似性に基づき明確に定められた幾つかの群からなる(Woessner J.F.,Faseb Journal,vol.5,1991,2145)。これらの群には、線維性コラーゲンを分解することができるコラゲナーゼ群(MMP−1もしくは間質コラゲナーゼ、MMP−8もしくは好中球コラゲナーゼ、MMP−13もしくはコラゲナーゼ−3、MMP−18もしくはコラゲナーゼ−4);IV型コラーゲンまたは他の変性コラーゲン形態を分解するゼラチナーゼ群(MMP−2もしくはゼラチナーゼA(72kDa)、MMP−9もしくはゼラチナーゼB(92kDa));糖タンパク質(フィブロネクチン、ラミニン)、プロテオグリカン等の細胞外基質のタンパク質を標的とする幅広い活性を有するストロムライシン群(MMP−3もしくはストロムライシン−1、MMP−10もしくはストロムライシン−2、MMP−11もしくはストロムライシン−3);マトリライシン(MMP−7);メタロエラスターゼ(MMP−12);またはメタロプロテアーゼ群(MMP−14、MMP−15、MMP−16およびMMP−17)がある。
本発明のエマルションは、任意選択的にスキンコンディショニング剤を含むことができる。前記スキンコンディショニング剤は、好ましくは、湿潤剤、エモリエント剤、保湿剤またはこれらの混合物からなる群から選択することができる。スキンコンディショニング剤が存在する場合、好ましくは、エマルションの0.01重量%〜20重量%、より好ましくは0.1重量%〜10重量%、最も好ましくは0.5重量%〜7重量%の量で存在する。
本発明のエマルションは任意選択的に酸化防止剤を含むことができる。好適な酸化防止剤としては、a)アスコルビン酸、その塩、エステル、グルコシドおよびグルコサミン塩(特にリン酸アスコルビルナトリウム、リン酸アスコルビルマグネシウムおよびパルミチン酸アスコルビル)、b)ビタミンE(トコフェロール)およびそのエステル(特に、酢酸トコフェリル、加えて、Lipotec S.A(polygon Industrial Camri Ral)よりLipochroman−6の商品名で入手可能なガンマトコフェロールの合成類縁体であるジメチルメトキシクロマノール)、c)薬用植物エキス、特に、イチョウ葉エキス(Univar PLCより「Gingko Biloba Leaf Powder」の商品名で入手可能なものなど)、マグワ(Solabiaより「Mulberry Concentrate」の商品名で入手可能なものなど)、ハナハッカ(S Black Ltdより「Pronalen Origanum HSC」の商品名で入手可能なものなど)、オタネニンジン(S Black Ltdより「Panax ginseng 1.1 extract 4294」の商品名で入手可能なもの、Croda Chemicals Ltdより「Phytexcell Panax ginseng」の商品名で入手可能なものなど)、シラカバエキス(Cosmetochem(U.K.)Ltdより「Super Herbasol Extract Birch」および「HP Herbasol Betula」の商品名で入手可能なもの、Blagden Chemicalsより「Phytelene of Birch」および「Aqueous Spray Dried Birch」の商品名で入手可能なものなど)、チャ(Nichimen Europeより「Herbal Extract Green Tea 75% Solids」の商品名で入手可能なもの)、ロスマリヌス・オフィシナリス(S.Blackより「Pronalen Rosemary」の商品名で入手可能なもの)、アセロラチェリーパウダー(Gee Lawsonより「Acerola PE」の商品名で入手可能なもの)、エムブリカエキス(Merck Speciality chemicalsよりEmblica(商標)の商品名で販売されているもの)ならびにブドウ種子油(Chesham Chemicals Limitedより入手可能なもの)を挙げることができる。
本発明の組成物は1種以上のビタミンを含むことができる。エマルション組成物は、アスコルビン酸塩、例えば、ビタミンC、ビタミンC誘導体、アスコルビン酸、アスコルビルグルコシド、パルミチン酸アスコルビル、リン酸アスコルビルマグネシウム、リン酸アスコルビルナトリウムを含むことができる。エマルションは、ビタミンB、ビタミンB誘導体、ビタミンB1〜ビタミンB12およびこれらの誘導体、ビタミンK、ビタミンK誘導体、ビタミンH、ビタミンD、ビタミンD誘導体、ビタミンE、ビタミンE誘導体(トコフェロール、酢酸トコフェリル等)およびこれらのプロビタミン(パンテノール等)ならびにこれらの混合物を含むことができる。ビタミン化合物は、実質的に純粋な物質として、または天然の供給源(例えば、植物)から好適な物理的および/もしくは化学的分離により得られる抽出物として含有させることができる。一実施形態において、ビタミン化合物が本発明の組成物中に存在する場合、エマルション組成物は、組成物の約0.0001重量%〜50重量%、より好ましくは0.001重量%〜10重量%、さらに好ましくは0.01重量%〜8重量%、一層好ましくは0.1重量%〜5重量%のビタミン化合物を含む。
本発明のエマルション組成物は、サリチル酸化合物、そのエステル、その塩またはこれらの組合せを含むことができる。本発明の組成物の一実施形態においては、このサリチル酸化合物は、好ましくは、組成物の0.0001重量%〜25重量%、より好ましくは0.001重量%〜15重量%、さらに好ましくは0.01重量%〜10重量%、一層好ましくは0.1重量%〜5重量%、より一層好ましくは0.01重量%〜2重量%のサリチル酸を含む。
本発明のエマルションは、任意選択的に日焼け止め成分を含むことができる。日焼け止め剤は有機もしくは無機日光遮蔽剤またはこれらの2種の組合せを含むことができる。好適な無機日光遮蔽剤としては、微粉状二酸化チタン、微粉状酸化亜鉛、窒化ホウ素およびこれらの混合物からなる群から選択されるものが挙げられる。
本発明のエマルションは任意選択的に1種以上の次に示す任意選択的な成分も含むことができる。本発明のエマルションには、防腐剤、例えば、2−ブロモ−2−ニトロプロパン−1,3−ジオール(Myacide RTMの商品名で市販されているブロノポール)、ベンジルアルコール、ジアゾリジニル尿素、イミダゾリジニル尿素、メチルパラベン、フェノキシエタノール、エチルパラベン、プロピルパラベン、ナトリウムメチルパラベン、デヒドロ酢酸ナトリウム、ポリヘキサメチレンビグアニド塩酸塩、イソチアゾロンおよびプロピルパラベンナトリウムを、好適にはエマルションの0.01重量%〜10重量%の量で添加することもできる。
1.主容器内でジメチコン、ジメチコンクロスポリマー、PEG/PPG−18/18ジメチコンおよびセチルPEG/PPG−10/1ジメチコンを混ぜ合わせて油相を調製する。
2.これとは別に、水、硫酸マグネシウム、グリセリン、アセチルジペプチド−1セチルエステル、パルミトイルオリゴペプチドおよびパルミトイルテトラペプチド−7、ヒアルロン酸ナトリウム、加水分解コメタンパクおよびアルファルファエキスを秤量し、固体が溶解するまで撹拌することにより水相を調製する。
3.これとは別に、フェノキシエタノール、メチルパラベンおよびエチルパラベンを混合する。溶解するまで加熱し、(ステップ2の)水相に加える。
4.高速の一定速度で撹拌しながら(渦流を生成させ)、水相を油相にゆっくりと加える。撹拌を5分間継続する。
5.生成物をSilverson mixerまたは均等物を用いて3500rpmで5分間均質化させる。
1.主容器内にジメチコン、ジメチコンクロスポリマー、PEG/PPG−18/18ジメチコンおよびセチルPEG/PPG−10/1ジメチコンを加えることにより油相を生成させる。
2.これとは別に、水、硫酸マグネシウム、グリセリン、アセチルジペプチド−1セチルエステル、パルミトイルオリゴペプチドおよびパルミトイルテトラペプチド−7、ヒアルロン酸ナトリウム、加水分解コメタンパクおよびアルファルファエキスを秤量し、固体が溶解するまで撹拌することにより水相を生成させる。
3.これとは別に、フェノキシエタノール、メチルパラベンおよびエチルパラベンを混合する。溶解するまで加熱し、(ステップ2の)水相に加える。
4.高速の一定速度で撹拌しながら(渦流を生成させ)、水相を油相にゆっくりと加える。撹拌を5分間継続する。
5.生成物をSilverson mixerまたは均等物を用いて3500rpmで5分間均質化させる。
1.主容器に、ジメチコン、ジメチコンクロスポリマー、PEG/PPG−18/18ジメチコンおよびセチルPEG/PPG−10/1ジメチコンを加えることにより油相を生成させる。
2.これとは別に、水、硫酸マグネシウム、グリセリン、アセチルジペプチド−1セチルエステル、パルミトイルオリゴペプチドおよびパルミトイルテトラペプチド−7、ヒアルロン酸ナトリウム、加水分解コメタンパクおよびアルファルファエキスを秤量し、固体が溶解するまで撹拌することにより水相を調製する。
3.これとは別に、フェノキシエタノール、メチルパラベンおよびエチルパラベンを混合する。溶解するまで加熱した後、(ステップ2の)水相に加える。
4.高速の一定速度で撹拌しながら(渦流を生成させ)、油相に水相をゆっくりと加える。撹拌を5分間継続する。
5.生成物をSilverson mixerまたは均等物を用いて3500rpmで5分間均質化させる。
1.主容器に、ジメチコン、ジメチコンクロスポリマー、PEG/PPG−18/18ジメチコンおよびセチルPEG/PPG−10/1ジメチコンを加えることにより油相を生成させる。
2.これとは別に、水、硫酸マグネシウム、グリセリン、アセチルジペプチド−1セチルエステル、パルミトイルオリゴペプチドおよびパルミトイルテトラペプチド−7、ブチレングリコール、加水分解コメタンパクおよびアルファルファエキスを秤量し、固体が溶解するまで撹拌することにより水相を生成させる。
3.これとは別に、フェノキシエタノール、メチルパラベンおよびエチルパラベンを混合する。溶解するまで加熱した後、(ステップ2の)水相に加える。
4.高速の一定速度で撹拌しながら(渦流を生成させ)、油相に水相をゆっくりと加える。撹拌を5分間継続する。
5.生成物をSilverson mixerまたは均等物を用いて3500rpmで5分間均質化させる。
1.主容器に、ジメチコン、ジメチコンクロスポリマー、PEG/PPG−18/18ジメチコンおよびセチルPEG/PPG−10/1ジメチコンを加えることにより油相を生成させる。
2.これとは別に、水、硫酸マグネシウム、グリセリン、アセチルジペプチド−1セチルエステル、パルミトイルオリゴペプチドおよびパルミトイルテトラペプチド−7、ヒアルロン酸ナトリウムを秤量し、固体が溶解するまで撹拌することにより水相を生成させる。
3.これとは別にフェノキシエタノール、メチルパラベンおよびエチルパラベンを混合する。溶解するまで加熱した後、(ステップ2の)水相に加える。
4.高速の一定速度で撹拌しながら(渦流を生成させ)、油相に水相をゆっくりと加える。撹拌を5分間継続する。
5.生成物をSilverson mixerまたは均等物を用いて3500rpmで5分間均質化させる。
Claims (16)
- 水を50質量%未満含む油中水型エマルションであって、油相および水相を含み、前記水相が、アセチルジペプチド−1セチルエステル、アミノヘキサン酸アセチルジペプチド−3、アゼラオイルビスジペプチド−10、クマロイルジペプチド−3、ジセチルジペプチド−9、ジ酢酸ジペプチドジアミノブチロイルベンジルアミド、ジペプチド−1、ジペプチド−10、ジペプチド−11、ジペプチド−12、ジペプチド−15、ジペプチド−16、ジペプチド−17、ジペプチド−18、ジペプチド−19、ジペプチド−2、ジペプチド−20、ジペプチド−3、ジペプチド−4、ジペプチド−5、ジペプチド−6、ジペプチド−7、ジペプチド−8、ジペプチド−8HCL、ジペプチド−9、酢酸ヘキサノイルジペプチド−3ノルロイシン、メチルウンデシレノイルジペプチド−16、ニコチノイルジペプチド−22、ニコチノイルジペプチド−23、ニコチノイルジペプチド−24、ニコチノイルジペプチド−26、オレオイルジペプチド−15、パルミトイルジペプチド−10、パルミトイルジペプチド−13、パルミトイルジペプチド−17、パルミトイルジペプチド−5ジアミノブチロイルヒドロキシトレオニン、パルミトイルジペプチド−5ジアミノヒドロキシ酪酸、パルミトイルジペプチド−7およびこれらの混合物からなる群から選択されるジペプチド、並びにトリペプチド、テトラペプチド、ペンタペプチドおよびこれらの混合物からなる群から選択されるさらなるペプチドを含む、油中水型エマルション。
- 前記ジペプチドが、アミノ酸配列Tyr−Arg、Val−Trpおよびこれらの混合物を有するものから選択される、請求項1に記載の油中水型エマルション。
- 前記ジペプチドが、前記エマルションの重量の0.1〜10000ppmの量で存在する、請求項1または2に記載のエマルション。
- 前記ジペプチドが、前記エマルションの重量の1〜1000ppmの量で存在する、請求項1〜3のいずれか一項に記載のエマルション。
- 前記ジペプチドがTyr−Argである、請求項1〜4のいずれか一項に記載のエマルション。
- 前記ジペプチドがN−アセチルTyr−Arg−1セチルエステルである、請求項1〜5のいずれか一項に記載のエマルション。
- 前記さらなるペプチドが、トリペプチド、テトラペプチドおよびこれらの混合物からなる群から選択される、請求項5又は6に記載のエマルション。
- ヒアルロン酸またはその塩をさらに含む、請求項1〜7のいずれか一項に記載のエマルション。
- マトリックスメタロプロテアーゼ阻害物質(MMPi)をさらに含む、請求項1〜8のいずれか一項に記載のエマルション。
- 前記MMPiが、レチノイド、N−アセチルシステイン、グルタチオン、2−フリルジオキシム、ビタミンC、フラボン、イソフラボン、加水分解コメタンパク、アルファルファエキス、シロバナルピナス、ナツメ果実エキス、ジヒドロキシメチルクロモン、クズエキス、ブドウエキス、メマツヨイグサエキス、アノゲイススレイオカルプスエキスおよびこれらの混合物からなる群から選択される、請求項9に記載のエマルション。
- 前記エマルションの0.1重量%〜55重量%の油相を含む、請求項1〜10のいずれか一項に記載のエマルション。
- 前記エマルションの15重量%〜50重量%の油相を含む、請求項1〜11のいずれか一項に記載のエマルション。
- 前記エマルションの30重量%〜45重量%の油相を含む、請求項1〜12のいずれか一項に記載のエマルション。
- 前記油相がシリコーン含有化合物を含む、請求項1〜13のいずれか一項に記載のエマルション。
- 前記油相がジメチコン、ジメチルシロキサン、シリコーンエラストマーまたはこれらの混合物を含む、請求項1〜14のいずれか一項に記載のエマルション。
- 治療の必要に応じて哺乳動物の皮膚に局所適用することにより哺乳動物の皮膚の状態を整える医薬の製造における、請求項1〜15のいずれか一項に記載のスキンケアエマルションの使用。
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EP0545002A1 (en) | 1991-11-21 | 1993-06-09 | Kose Corporation | Silicone polymer, paste-like composition and water-in-oil type cosmetic composition comprising the same |
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CA2528101C (fr) * | 2002-12-30 | 2012-01-31 | Jean-Noel Thorel | Bio-activateur metabolique cutane |
WO2005048968A1 (en) | 2003-11-17 | 2005-06-02 | Sederma | Compositions containing mixtures of tetrapeptides and tripeptides |
EP1694343A1 (en) | 2003-11-21 | 2006-08-30 | Beta Peptide Pty Ltd. | Compositions and methods for the treatment of skin damage |
DE202004006865U1 (de) * | 2004-04-29 | 2004-12-09 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Zubereitung, insbesondere kosmetische oder pharmazeutische Zubereitung |
DE102004062430A1 (de) * | 2004-12-20 | 2006-06-29 | Henkel Kgaa | Pigmenthaltige Wasser-in-Siliconöl-Emulsion zur Verbesserung des Erscheinungsbildes der Haut |
KR20070091630A (ko) * | 2004-12-29 | 2007-09-11 | 라보 코스프로파르 아게 | 표정 주름을 이완시키는데 적합한 피부 적용을 위한 미용조성물 |
CN101321561A (zh) * | 2005-12-02 | 2008-12-10 | 宝洁公司 | 包含硅氧烷弹性体的油包水乳液组合物 |
EP1979054A1 (en) * | 2005-12-02 | 2008-10-15 | The Procter and Gamble Company | Water in oil emulsion compositions containing siloxane elastomers |
EA016247B1 (ru) * | 2007-04-19 | 2012-03-30 | Мэри Кэй Инк. | Топическая композиция для уменьшения темных кругов, отечности и отвисания кожи в области глаз человека и способ ее применения |
JP2011516585A (ja) * | 2008-04-15 | 2011-05-26 | イマネンス・インテグラル・デルモ・コレクション・インコーポレーテッド | スキンケア組成物およびその使用方法 |
WO2010085532A2 (en) * | 2009-01-22 | 2010-07-29 | The Procter & Gamble Company | Skin-care composition comprising dill extract |
US20100215726A1 (en) * | 2009-02-25 | 2010-08-26 | Peter Thomas Roth | Compositions for Diminishing the Appearance of Wrinkles |
FR2945939B1 (fr) * | 2009-05-26 | 2011-07-15 | Sederma Sa | Utilisation cosmetique du dipeptide tyr-arg pour lutter contre le relachement cutane. |
CA2770283A1 (en) * | 2009-08-06 | 2011-02-10 | Peter Thomas Roth Labs, Llc | Compositions for promoting a healthy appearance of the skin |
EP2537513A3 (en) * | 2011-03-11 | 2015-04-29 | ELC Management LLC | Use of anogeissus extract for fibrillin production in skin |
EP2514403A1 (en) * | 2011-04-20 | 2012-10-24 | Coty Germany GmbH | Cosmetic composition for increasing the collagen synthesis in the skin cells |
US9233062B2 (en) * | 2011-05-10 | 2016-01-12 | Mary Kay Inc. | Cosmetic compositions |
US20130251644A1 (en) * | 2012-03-22 | 2013-09-26 | Precision Dermatology, Inc. | Cyclodextrin-Based Microemulsions, and Dermatological Uses Thereof |
US11285115B2 (en) * | 2013-02-28 | 2022-03-29 | Ramot At Tel-Aviv University Ltd. | Peptide-based hydrogel particles and uses thereof |
-
2014
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- 2014-05-15 EP EP14726189.5A patent/EP3145592B1/en active Active
- 2014-05-15 AU AU2014393628A patent/AU2014393628B2/en active Active
- 2014-05-15 CA CA2947234A patent/CA2947234C/en active Active
- 2014-05-15 WO PCT/GB2014/051496 patent/WO2015170064A1/en active Application Filing
- 2014-05-15 US US15/312,086 patent/US10335357B2/en active Active
- 2014-05-15 PL PL14726189T patent/PL3145592T3/pl unknown
- 2014-05-15 JP JP2017510778A patent/JP6464258B2/ja active Active
- 2014-05-15 ES ES14726189T patent/ES2843677T3/es active Active
- 2014-05-15 BR BR112016025828-2A patent/BR112016025828B1/pt active IP Right Grant
- 2014-05-15 MX MX2016014410A patent/MX2016014410A/es active IP Right Grant
- 2014-05-15 KR KR1020167034385A patent/KR101965560B1/ko active IP Right Grant
- 2014-05-15 CN CN201480078682.6A patent/CN106659915B/zh active Active
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PL3145592T3 (pl) | 2021-08-02 |
AU2014393628A1 (en) | 2016-11-24 |
GB2525894A (en) | 2015-11-11 |
ES2843677T3 (es) | 2021-07-20 |
SA516380246B1 (ar) | 2020-06-25 |
BR112016025828B1 (pt) | 2021-02-02 |
KR20170002590A (ko) | 2017-01-06 |
EP3145592B1 (en) | 2020-12-02 |
JP2017514920A (ja) | 2017-06-08 |
HK1213793A1 (zh) | 2016-07-15 |
CA2947234A1 (en) | 2015-11-12 |
EP3145592A1 (en) | 2017-03-29 |
GB201408079D0 (en) | 2014-06-18 |
WO2015170064A1 (en) | 2015-11-12 |
CN106659915B (zh) | 2021-05-07 |
CL2016002779A1 (es) | 2017-05-05 |
CN106659915A (zh) | 2017-05-10 |
BR112016025828A2 (pt) | 2018-01-16 |
US10335357B2 (en) | 2019-07-02 |
CA2947234C (en) | 2019-02-12 |
US20170112744A1 (en) | 2017-04-27 |
KR101965560B1 (ko) | 2019-04-04 |
MX2016014410A (es) | 2017-05-23 |
AU2014393628B2 (en) | 2018-05-10 |
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