JP6458168B2 - グレリンｏ−アシルトランスフェラーゼ阻害剤 - Google Patents
グレリンｏ−アシルトランスフェラーゼ阻害剤 Download PDFInfo
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- JP6458168B2 JP6458168B2 JP2017553922A JP2017553922A JP6458168B2 JP 6458168 B2 JP6458168 B2 JP 6458168B2 JP 2017553922 A JP2017553922 A JP 2017553922A JP 2017553922 A JP2017553922 A JP 2017553922A JP 6458168 B2 JP6458168 B2 JP 6458168B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
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| EP15382180.6 | 2015-04-15 | ||
| EP15382180 | 2015-04-15 | ||
| PCT/US2016/027177 WO2016168222A1 (en) | 2015-04-15 | 2016-04-13 | Ghrelin o-acyl transferase inhibitors |
Publications (2)
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| JP2018511630A JP2018511630A (ja) | 2018-04-26 |
| JP6458168B2 true JP6458168B2 (ja) | 2019-01-23 |
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| EP (1) | EP3283473B1 (ko) |
| JP (1) | JP6458168B2 (ko) |
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| CN (1) | CN107428723B (ko) |
| AR (1) | AR104672A1 (ko) |
| AU (1) | AU2016247901A1 (ko) |
| BR (1) | BR112017017835A2 (ko) |
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| EA (1) | EA201791992A1 (ko) |
| ES (1) | ES2715763T3 (ko) |
| IL (1) | IL253969A0 (ko) |
| MX (1) | MX2017013073A (ko) |
| TW (1) | TWI589574B (ko) |
| WO (1) | WO2016168222A1 (ko) |
| ZA (1) | ZA201705675B (ko) |
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| PT3494120T (pt) | 2016-08-05 | 2021-05-26 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina para utilização como inibidores de grelina o-acil transferase (goat) |
| JP7225253B2 (ja) | 2018-02-02 | 2023-02-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのピラゾール置換及びインダゾール置換オキサジアゾロピリジン誘導体 |
| EP3746443B1 (en) | 2018-02-02 | 2022-07-06 | Boehringer Ingelheim International GmbH | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
| CN111655700B (zh) | 2018-02-02 | 2023-07-18 | 勃林格殷格翰国际有限公司 | 作为饥饿素o-酰基转移酶(goat)抑制剂的噁二唑并吡啶衍生物 |
| KR20200118124A (ko) | 2018-02-02 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로 사용하기 위한 헤테로사이클릴-치환된 옥사디아졸로피리딘 유도체 |
| CN108610337A (zh) * | 2018-05-30 | 2018-10-02 | 王丽萍 | 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用 |
| WO2021233884A1 (en) | 2020-05-22 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate |
| WO2021233882A1 (en) | 2020-05-22 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate |
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| US20060233788A1 (en) | 2003-09-05 | 2006-10-19 | Heiman Mark L | Anti-ghrelin antibodies |
| US20050070712A1 (en) * | 2003-09-26 | 2005-03-31 | Christi Kosogof | Pyrimidine derivatives as ghrelin receptor modulators |
| JP2008515771A (ja) | 2004-07-14 | 2008-05-15 | イーライ リリー アンド カンパニー | 抗グレリン抗体 |
| EP1814916A2 (en) | 2004-11-15 | 2007-08-08 | Eli Lilly And Company | Desacyl ghrelin antibodies and therapeutic uses thereof |
| EP1856154A1 (en) | 2005-02-23 | 2007-11-21 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| ES2640258T3 (es) * | 2012-02-24 | 2017-11-02 | Takeda Pharmaceutical Company Limited | Compuesto anular aromático como inhibidor de grelina o-aciltransferasa |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
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| IL253969A0 (en) | 2017-10-31 |
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| CN107428723B (zh) | 2020-05-05 |
| JP2018511630A (ja) | 2018-04-26 |
| WO2016168222A1 (en) | 2016-10-20 |
| US10093651B2 (en) | 2018-10-09 |
| US20180086732A1 (en) | 2018-03-29 |
| AU2016247901A1 (en) | 2017-09-14 |
| ES2715763T3 (es) | 2019-06-06 |
| CN107428723A (zh) | 2017-12-01 |
| AR104672A1 (es) | 2017-08-09 |
| KR20170123693A (ko) | 2017-11-08 |
| EP3283473A1 (en) | 2018-02-21 |
| EA201791992A1 (ru) | 2018-03-30 |
| TWI589574B (zh) | 2017-07-01 |
| TW201704225A (zh) | 2017-02-01 |
| CA2976636A1 (en) | 2016-10-20 |
| ZA201705675B (en) | 2019-07-31 |
| EP3283473B1 (en) | 2019-01-02 |
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