JP6456823B2 - 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 - Google Patents

疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 Download PDF

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JP6456823B2
JP6456823B2 JP2015523576A JP2015523576A JP6456823B2 JP 6456823 B2 JP6456823 B2 JP 6456823B2 JP 2015523576 A JP2015523576 A JP 2015523576A JP 2015523576 A JP2015523576 A JP 2015523576A JP 6456823 B2 JP6456823 B2 JP 6456823B2
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charom
arom
mmol
pain
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JP2015522650A (ja
JP2015522650A5 (show.php
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ピエール、ソコロフ
フレデリック、カシュー
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ピエール、ファーブル、メディカマン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015523576A 2012-07-27 2013-07-29 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 Active JP6456823B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305922.2A EP2689778A1 (en) 2012-07-27 2012-07-27 Derivatives of azaindoles or diazaindoles for treating pain
EP12305922.2 2012-07-27
PCT/EP2013/065907 WO2014016433A1 (en) 2012-07-27 2013-07-29 Derivatives of azaindazole or diazaindazole type for treating pain

Related Child Applications (1)

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JP2018200317A Division JP6732855B2 (ja) 2012-07-27 2018-10-24 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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JP2015522650A JP2015522650A (ja) 2015-08-06
JP2015522650A5 JP2015522650A5 (show.php) 2016-09-15
JP6456823B2 true JP6456823B2 (ja) 2019-01-23

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JP2015523576A Active JP6456823B2 (ja) 2012-07-27 2013-07-29 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体
JP2018200317A Active JP6732855B2 (ja) 2012-07-27 2018-10-24 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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Country Status (28)

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US (1) US9381195B2 (show.php)
EP (2) EP2689778A1 (show.php)
JP (2) JP6456823B2 (show.php)
KR (1) KR102120505B1 (show.php)
CN (1) CN104684554B (show.php)
AU (1) AU2013294920B2 (show.php)
BR (1) BR112015001502B1 (show.php)
CA (1) CA2879595C (show.php)
CY (1) CY1118478T1 (show.php)
DK (1) DK2877177T3 (show.php)
ES (1) ES2612349T3 (show.php)
HR (1) HRP20170104T1 (show.php)
HU (1) HUE032919T2 (show.php)
IL (1) IL236917A (show.php)
LT (1) LT2877177T (show.php)
MA (1) MA37866B1 (show.php)
MX (1) MX363605B (show.php)
MY (1) MY183398A (show.php)
NZ (1) NZ705253A (show.php)
PL (1) PL2877177T3 (show.php)
PT (1) PT2877177T (show.php)
RS (1) RS55646B1 (show.php)
RU (1) RU2640046C2 (show.php)
SI (1) SI2877177T1 (show.php)
TN (1) TN2015000034A1 (show.php)
UA (1) UA116107C2 (show.php)
WO (1) WO2014016433A1 (show.php)
ZA (1) ZA201501209B (show.php)

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JP2019031542A (ja) * 2012-07-27 2019-02-28 ピエール、ファーブル、メディカマン 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
CN105693720B (zh) 2010-05-20 2019-01-18 阵列生物制药公司 作为trk激酶抑制剂的大环化合物
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
CA2963640A1 (en) 2014-10-06 2016-04-14 Flatley Discovery Lab, Llc Triazolopyridine compounds and methods for the treatment of cystic fibrosis
TWI746426B (zh) 2014-11-16 2021-11-21 美商亞雷生物製藥股份有限公司 (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
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WO2018079759A1 (ja) * 2016-10-31 2018-05-03 塩野義製薬株式会社 ＴｒｋＡ阻害活性を有する縮合複素環および縮合炭素環誘導体
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
KR102653799B1 (ko) * 2018-05-02 2024-04-03 제이더블유중외제약 주식회사 신규한 헤테로 사이클 유도체
KR102129114B1 (ko) * 2018-07-26 2020-07-02 주식회사 온코파마텍 TrkA 저해 활성을 갖는 화합물 및 이를 유효성분으로 함유하는 통증의 예방 또는 치료용 약학적 조성물
EP3725777A1 (en) * 2019-04-17 2020-10-21 Rottapharm Biotech S.r.l. Benzo- and pyrido-pyrazoles as protein kinase inhibitors
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JP2019031542A (ja) * 2012-07-27 2019-02-28 ピエール、ファーブル、メディカマン 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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RU2015106434A (ru) 2016-09-20
IL236917A (en) 2016-11-30
MA37866B1 (fr) 2016-12-30
TN2015000034A1 (en) 2016-06-29
CA2879595C (en) 2020-07-28
BR112015001502B1 (pt) 2023-03-07
UA116107C2 (uk) 2018-02-12
DK2877177T3 (en) 2017-02-06
CN104684554B (zh) 2017-05-10
LT2877177T (lt) 2017-01-25
MX2015001009A (es) 2015-06-04
HK1207302A1 (en) 2016-01-29
JP2019031542A (ja) 2019-02-28
EP2877177B1 (en) 2016-10-26
EP2877177A1 (en) 2015-06-03
CN104684554A (zh) 2015-06-03
JP2015522650A (ja) 2015-08-06
CA2879595A1 (en) 2014-01-30
HUE032919T2 (hu) 2017-11-28
BR112015001502A2 (pt) 2017-07-04
JP6732855B2 (ja) 2020-07-29
MX363605B (es) 2019-03-26
ES2612349T3 (es) 2017-05-16
RS55646B1 (sr) 2017-06-30
RU2640046C2 (ru) 2017-12-26
PT2877177T (pt) 2017-02-06
HRP20170104T1 (hr) 2017-03-24
US9381195B2 (en) 2016-07-05
KR102120505B1 (ko) 2020-06-08
MA37866A1 (fr) 2016-05-31
SI2877177T1 (sl) 2017-02-28
KR20150038295A (ko) 2015-04-08
MY183398A (en) 2021-02-18
WO2014016433A1 (en) 2014-01-30
AU2013294920B2 (en) 2017-08-24
AU2013294920A1 (en) 2015-03-12
NZ705253A (en) 2017-05-26
PL2877177T3 (pl) 2017-04-28
CY1118478T1 (el) 2017-07-12
US20150190394A1 (en) 2015-07-09
ZA201501209B (en) 2016-03-30
EP2689778A1 (en) 2014-01-29

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