JP6450679B2 - マルチマーカーリスク層別化 - Google Patents
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- JP6450679B2 JP6450679B2 JP2015528625A JP2015528625A JP6450679B2 JP 6450679 B2 JP6450679 B2 JP 6450679B2 JP 2015528625 A JP2015528625 A JP 2015528625A JP 2015528625 A JP2015528625 A JP 2015528625A JP 6450679 B2 JP6450679 B2 JP 6450679B2
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Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Health & Medical Sciences (AREA)
- Pathology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Primary Health Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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Applications Claiming Priority (3)
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| US201261691706P | 2012-08-21 | 2012-08-21 | |
| US61/691,706 | 2012-08-21 | ||
| PCT/US2013/056020 WO2014031764A1 (en) | 2012-08-21 | 2013-08-21 | Multimarker risk stratification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018230514A Division JP6621520B2 (ja) | 2012-08-21 | 2018-12-10 | マルチマーカーリスク層別化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015532715A JP2015532715A (ja) | 2015-11-12 |
| JP6450679B2 true JP6450679B2 (ja) | 2019-01-09 |
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| JP2015528625A Expired - Fee Related JP6450679B2 (ja) | 2012-08-21 | 2013-08-21 | マルチマーカーリスク層別化 |
| JP2018230514A Expired - Fee Related JP6621520B2 (ja) | 2012-08-21 | 2018-12-10 | マルチマーカーリスク層別化 |
| JP2019208375A Expired - Fee Related JP6902083B2 (ja) | 2012-08-21 | 2019-11-19 | マルチマーカーリスク層別化 |
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| JP2018230514A Expired - Fee Related JP6621520B2 (ja) | 2012-08-21 | 2018-12-10 | マルチマーカーリスク層別化 |
| JP2019208375A Expired - Fee Related JP6902083B2 (ja) | 2012-08-21 | 2019-11-19 | マルチマーカーリスク層別化 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20140058743A1 (https=) |
| EP (1) | EP2888687B1 (https=) |
| JP (3) | JP6450679B2 (https=) |
| CN (2) | CN104737170A (https=) |
| AU (3) | AU2013305829A1 (https=) |
| CA (1) | CA2882303A1 (https=) |
| HK (2) | HK1208092A1 (https=) |
| IN (1) | IN2015DN01767A (https=) |
| MX (2) | MX375520B (https=) |
| RU (1) | RU2015110054A (https=) |
| SG (2) | SG10201608854TA (https=) |
| WO (1) | WO2014031764A1 (https=) |
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| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| DK3072978T3 (en) | 2002-05-09 | 2018-09-17 | Brigham & Womens Hospital Inc | : 1L1RL-1 AS A CARDIOVASCULAR DISEASE MARKER |
| AU2007244927B2 (en) | 2006-04-24 | 2012-01-12 | Critical Care Diagnostics, Inc. | Predicting mortality and detecting severe disease |
| EP2021796B1 (en) | 2006-05-01 | 2012-02-08 | Critical Care Diagnostics, Inc. | Diagnosis of cardiovascular disease |
| PL2269063T3 (pl) | 2008-04-18 | 2014-04-30 | Critical Care Diagnostics Inc | Rokowanie ryzyka głównych niekorzystnych zdarzeń sercowych |
| BR112012025728B1 (pt) | 2010-04-09 | 2022-01-11 | Critical Care Diagnostics, Inc | Anticorpos isolados ou fragmentos que se liga a st2 humano solúvel, hibridoma, kit, bem como métodos para quantificação de um nível de st2 solúvel humano em uma amostra de um indivíduo, e para a predição do risco de morte dentro de um ano em um indivíduo |
| ES2750126T3 (es) | 2011-03-17 | 2020-03-25 | Critical Care Diagnostics Inc | Procedimientos de predicción del riesgo de un resultado clínico adverso |
| DK2734222T3 (en) | 2011-07-18 | 2017-01-30 | Critical Care Diagnostics Inc | PROCEDURES FOR TREATING CARDIOVASCULAR DISEASES AND PREDICTING THE EFFECTIVENESS OF MOTION THERAPY |
| CA2873896A1 (en) | 2012-05-18 | 2013-11-21 | Critical Care Diagnostics, Inc. | Methods for treating or predicting risk of a ventricular tachyarrhythmia event |
| MX382403B (es) | 2012-08-16 | 2025-03-13 | Critical Care Diagnostics Inc | Métodos para predecir el riesgo de desarrollar hipertensión. |
| CN104737170A (zh) | 2012-08-21 | 2015-06-24 | 重症监护诊断股份有限公司 | 多标记风险分层 |
| CA2935958A1 (en) * | 2014-01-10 | 2015-07-16 | Critical Care Diagnostics, Inc. | Methods and systems for determining risk of heart failure |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| WO2017035639A1 (en) | 2015-08-28 | 2017-03-09 | Mcmaster University | Method of determining risk of an adverse cardiac event |
| US20170220749A1 (en) * | 2016-02-01 | 2017-08-03 | MD Aware LLC | Systems and methods for identifying and using medical calculators |
| JP6983223B2 (ja) * | 2016-04-18 | 2021-12-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 一般集団におけるlvhへの進行因子の同定のための可溶性st2 |
| WO2018220600A1 (en) * | 2017-06-02 | 2018-12-06 | University Of Florida Research Foundation, Inc. | Method and apparatus for prediction of complications after surgery |
| RU2677611C1 (ru) * | 2018-04-16 | 2019-01-17 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ прогнозирования неблагоприятных сердечно-сосудистых событий в течение 12 месяцев у больных хронической сердечной недостаточностью с рецидивом стенокардии после реваскуляризации миокарда |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| EP3969620B1 (en) * | 2019-05-17 | 2025-06-25 | Regeneron Pharmaceuticals, Inc. | Genome-based methods for reducing cardiovascular risk |
| US20220399122A1 (en) * | 2019-11-01 | 2022-12-15 | Nec Corporation | Risk prediction apparatus, risk prediction method, and computer program |
| CN118760892B (zh) * | 2024-09-05 | 2024-11-19 | 温州市中心医院 | 铁死亡评分确定方法、系统及设备 |
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| US4208479A (en) | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US5206140A (en) | 1988-06-24 | 1993-04-27 | Research Corporation Technologies, Inc. | Assay for soluble crosslinked fibrin polymers |
| JPH0731479Y2 (ja) | 1989-06-02 | 1995-07-19 | 内橋エステック株式会社 | 温度ヒューズ |
| US5217899A (en) | 1990-08-24 | 1993-06-08 | The General Hospital Corporation | Cell stretching apparatus |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | hBNPのC端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| JP2732005B2 (ja) | 1992-12-14 | 1998-03-25 | 眞一 富永 | ヒトst2をコードするdna、該dnaの発現産物、該dnaを発現させることによる発現産物の製造方法 |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| CA2263832A1 (en) | 1996-08-23 | 1998-02-26 | Human Genome Sciences, Inc. | T1 receptor-like ligand ii |
| WO1998038311A1 (en) | 1997-02-28 | 1998-09-03 | Human Genome Sciences, Inc. | T1/st2-receptor ligand iii |
| ATE530180T1 (de) | 1997-04-02 | 2011-11-15 | Brigham & Womens Hospital | Verfahren zur ermittlung der individualen risikoprofile atherosklerotischen erkrankungen |
| CA2293718A1 (en) | 1997-06-10 | 1998-12-17 | Medlyte Diagnostics, Inc. | Methods for early detection of heart disease |
| CN1161609C (zh) | 1997-09-11 | 2004-08-11 | 盐野义制药株式会社 | 哺乳类γ-BNP衍生物特异的免疫测定方法及其试剂盒 |
| US6309888B1 (en) | 1998-09-04 | 2001-10-30 | Leuven Research & Development Vzw | Detection and determination of the stages of coronary artery disease |
| GB9827348D0 (en) | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| AU2055300A (en) | 1998-12-18 | 2000-07-03 | Scios Inc. | Methods for detection and use of differentially expressed genes in disease states |
| WO2000073498A1 (en) | 1999-06-02 | 2000-12-07 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| FR2795823B1 (fr) | 1999-07-01 | 2001-11-23 | Inst Nat Sante Rech Med | Methodes et kits pour le diagnostic ou le suivi d'une pathologie synoviale ou osteoarticulaire comprenant l'utilisation d'un marqueur specifique de la degradation du tissu synovial |
| US6323334B1 (en) | 1999-09-24 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding a 103 gene product and uses therefor |
| AU2001218871A1 (en) | 2000-03-21 | 2001-10-03 | Takao Arai | Monoclonal antibody and method and kit for the immunoassay of soluble human st2 with the use of the same |
| FR2807170B1 (fr) | 2000-03-30 | 2002-06-28 | Sipal | Charniere elastique a frottement reduit |
| EP1311547A2 (en) | 2000-08-22 | 2003-05-21 | The Brigham And Women's Hospital, Inc. | Diagnosis and treatment of cardiovascular conditions |
| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| US6537221B2 (en) | 2000-12-07 | 2003-03-25 | Koninklijke Philips Electronics, N.V. | Strain rate analysis in ultrasonic diagnostic images |
| FI20010019L (fi) | 2001-01-05 | 2002-07-06 | Biohit Oyj | Menetelmä atrofisen diagnostisoimiseksi |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| ATE458199T1 (de) | 2001-05-04 | 2010-03-15 | Biosite Inc | Diagnostische marker der akuten koronaren syndrome und ihre verwendungen |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| WO2003022987A2 (en) | 2001-07-26 | 2003-03-20 | Eos Biotechnology, Inc. | Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection |
| US6810284B1 (en) | 2001-11-21 | 2004-10-26 | Pacesetter, Inc. | Implantable cardiac stimulation system and method for monitoring diastolic function |
| DK3072978T3 (en) | 2002-05-09 | 2018-09-17 | Brigham & Womens Hospital Inc | : 1L1RL-1 AS A CARDIOVASCULAR DISEASE MARKER |
| US8263325B2 (en) | 2002-11-15 | 2012-09-11 | Ottawa Heart Institute Research Corporation | Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis |
| WO2004056868A2 (en) | 2002-12-19 | 2004-07-08 | Endocube Sas | Nf-hev compositions and methods of use |
| US20040133079A1 (en) | 2003-01-02 | 2004-07-08 | Mazar Scott Thomas | System and method for predicting patient health within a patient management system |
| US20040220155A1 (en) | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| US20050123451A1 (en) | 2003-10-31 | 2005-06-09 | Hiroshi Nomura | System and apparatus for body fluid analysis using surface-textured optical materials |
| CA2547072C (en) | 2003-11-26 | 2015-06-23 | Applera Corporation | Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof |
| EP2306192B1 (en) | 2003-12-05 | 2015-10-14 | The Cleveland Clinic Foundation | Risk Markers For Cardiovascular Disease |
| US20050196817A1 (en) | 2004-01-20 | 2005-09-08 | Molecular Staging Inc. | Biomarkers for sepsis |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| JP2005291899A (ja) | 2004-03-31 | 2005-10-20 | Akira Matsumori | 心疾患の検査法 |
| EP1849009B1 (en) | 2005-01-24 | 2008-10-29 | F. Hoffmann-La Roche AG | The use of cardiac hormones for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs. |
| EP1731910A1 (en) | 2005-06-07 | 2006-12-13 | F. Hoffmann-La Roche Ag | Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases |
| US20070021977A1 (en) | 2005-07-19 | 2007-01-25 | Witt Biomedical Corporation | Automated system for capturing and archiving information to verify medical necessity of performing medical procedure |
| JP4820192B2 (ja) | 2006-03-17 | 2011-11-24 | 一般財団法人化学及血清療法研究所 | 急性冠症候群でのadamts13の測定と利用 |
| AU2007244927B2 (en) | 2006-04-24 | 2012-01-12 | Critical Care Diagnostics, Inc. | Predicting mortality and detecting severe disease |
| ATE517341T1 (de) | 2006-04-27 | 2011-08-15 | Critical Care Diagnostics Inc | Interleukin-33 (il-33) zur diagnose und vorhersage von herz-gefäss-erkrankungen |
| EP2021796B1 (en) * | 2006-05-01 | 2012-02-08 | Critical Care Diagnostics, Inc. | Diagnosis of cardiovascular disease |
| PL2019965T3 (pl) | 2006-05-02 | 2015-10-30 | Critical Care Diagnostics Inc | Rozpoznawanie różnicowe chorób układu oddechowego i sercowo-naczyniowego |
| US8147817B2 (en) | 2006-05-04 | 2012-04-03 | The Brigham And Women's Hospital, Inc. | IL-33 in the treatment and diagnosis of diseases and disorders |
| RU2312591C1 (ru) | 2006-06-14 | 2007-12-20 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ прогнозирования развития риска внезапной смерти у больных с лево- и правожелудочковой экстрасистолией |
| CA2554659A1 (en) * | 2006-07-25 | 2006-11-24 | 1128971 Alberta Ltd. | Hanger flange for hanging a tubular body in a well |
| US20080233191A1 (en) * | 2007-03-22 | 2008-09-25 | Brent Blackburn | Use of ranolazine for elevated brain-type natriuretic peptide |
| US20090111708A1 (en) * | 2007-05-11 | 2009-04-30 | Seddon Johanna M | Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk |
| US20100267062A1 (en) * | 2007-09-26 | 2010-10-21 | Norbert Frey | Osteopontin as Novel Prognostic Biomarker for Heart Failure |
| FR2923029B1 (fr) | 2007-10-26 | 2009-11-20 | Minima | Lunettes de type sans entourage a branches filaires |
| WO2009075566A1 (en) * | 2007-12-12 | 2009-06-18 | Erasmus University Medical Center Rotterdam | Biomarkers for cardiovascular disease |
| PL2269063T3 (pl) * | 2008-04-18 | 2014-04-30 | Critical Care Diagnostics Inc | Rokowanie ryzyka głównych niekorzystnych zdarzeń sercowych |
| US20100159474A1 (en) * | 2008-11-11 | 2010-06-24 | B.R.A.H.M.S. Aktiengesellschaft | Prognosis and risk assessment in patients suffering from heart failure by determining the level of adm and bnp |
| JP2012531605A (ja) * | 2009-07-01 | 2012-12-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 心血管死亡率リスクを予測するための方法 |
| KR20120101064A (ko) * | 2009-11-13 | 2012-09-12 | 비쥐 메디신, 인코포레이티드 | 심근 경색의 위험 인자 및 예측 |
| US8258456B2 (en) * | 2009-11-27 | 2012-09-04 | Himax Imaging, Inc. | Image sensor |
| BR112012025728B1 (pt) | 2010-04-09 | 2022-01-11 | Critical Care Diagnostics, Inc | Anticorpos isolados ou fragmentos que se liga a st2 humano solúvel, hibridoma, kit, bem como métodos para quantificação de um nível de st2 solúvel humano em uma amostra de um indivíduo, e para a predição do risco de morte dentro de um ano em um indivíduo |
| WO2012059477A1 (en) * | 2010-11-01 | 2012-05-10 | B.R.A.H.M.S Gmbh | Prognosis and risk assessment of patients with non-specific complaints |
| RU2452394C1 (ru) | 2010-11-09 | 2012-06-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Ульяновский государственный университет | Способ прогнозирования риска смерти больных хронической сердечной недостаточностью |
| ES2750126T3 (es) | 2011-03-17 | 2020-03-25 | Critical Care Diagnostics Inc | Procedimientos de predicción del riesgo de un resultado clínico adverso |
| DK2734222T3 (en) | 2011-07-18 | 2017-01-30 | Critical Care Diagnostics Inc | PROCEDURES FOR TREATING CARDIOVASCULAR DISEASES AND PREDICTING THE EFFECTIVENESS OF MOTION THERAPY |
| CA2873896A1 (en) | 2012-05-18 | 2013-11-21 | Critical Care Diagnostics, Inc. | Methods for treating or predicting risk of a ventricular tachyarrhythmia event |
| MX382403B (es) | 2012-08-16 | 2025-03-13 | Critical Care Diagnostics Inc | Métodos para predecir el riesgo de desarrollar hipertensión. |
| CN104737170A (zh) | 2012-08-21 | 2015-06-24 | 重症监护诊断股份有限公司 | 多标记风险分层 |
| JP6178687B2 (ja) | 2013-09-27 | 2017-08-09 | 富士機械工業株式会社 | グラビア塗工装置 |
| CA2935958A1 (en) | 2014-01-10 | 2015-07-16 | Critical Care Diagnostics, Inc. | Methods and systems for determining risk of heart failure |
| USD770057S1 (en) | 2014-04-14 | 2016-10-25 | Critical Care Diagnostics, Inc. | Blood test kit |
| US9934249B2 (en) | 2014-06-03 | 2018-04-03 | Conduent Business Machines Services, Llc | Systems and methods for context-aware and personalized access to visualizations of road events |
| USD800332S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| USD800333S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
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