JP6440259B2 - Ｈｂｖ感染及び関連疾患を処置するためのポリペプチド及び抗体 - Google Patents

Ｈｂｖ感染及び関連疾患を処置するためのポリペプチド及び抗体 Download PDF

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JP6440259B2
JP6440259B2 JP2015516418A JP2015516418A JP6440259B2 JP 6440259 B2 JP6440259 B2 JP 6440259B2 JP 2015516418 A JP2015516418 A JP 2015516418A JP 2015516418 A JP2015516418 A JP 2015516418A JP 6440259 B2 JP6440259 B2 JP 6440259B2
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protein
hbsag
hbv
antibody
fragment
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JP2015522563A (ja
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ユアン、クアン
チャン、ティエンイン
ルオ、ウェンシン
チェン、イーシン
チャン、ジュン
シャ、ニンシャオ
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Yang Sheng Tang Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/20—Antivirals for DNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/01—DNA viruses
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
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    • G01—MEASURING; TESTING
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    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G01N33/5764—Hepatitis B surface antigen
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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JP2015516418A 2012-06-11 2013-06-06 Ｈｂｖ感染及び関連疾患を処置するためのポリペプチド及び抗体 Active JP6440259B2 (ja)

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CN201210190329 2012-06-11
CN201210190329.X 2012-06-11
PCT/CN2013/076832 WO2013185558A1 (zh) 2012-06-11 2013-06-06 用于治疗hbv感染及相关疾病的多肽及抗体

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JP2015522563A JP2015522563A (ja) 2015-08-06
JP6440259B2 true JP6440259B2 (ja) 2018-12-19

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US (2) US9751914B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP2860188B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP6440259B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (2) KR101944263B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN106046155B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2013276015B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (2) BR112014030797A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (2) CA2943258C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES2843675T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2014DN10288A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2013185558A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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CN108690134B (zh) * 2017-04-07 2021-07-30 厦门大学 用于治疗乙肝感染及相关疾病的抗体
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CN111978392B (zh) * 2019-05-23 2024-05-24 厦门大学 抗乙肝病毒抗体及其用途
DK4037708T3 (da) 2019-09-30 2024-09-30 Gilead Sciences Inc HBV-vacciner og fremgangsmåder til at behandle HBV
CN111187349A (zh) * 2019-10-30 2020-05-22 四川迈克生物新材料技术有限公司 单克隆抗体的制备方法
CN113138276B (zh) * 2020-01-19 2022-09-16 厦门万泰凯瑞生物技术有限公司 用于检测HBcAg的方法及抗体
CN113717283B (zh) * 2020-05-25 2023-05-26 厦门万泰凯瑞生物技术有限公司 一种抗乙型肝炎病毒e抗原的单克隆抗体及其应用
CN111879932B (zh) * 2020-06-24 2022-09-27 南方医科大学南方医院 乙型肝炎病毒(hbv)特异性b细胞表位检测方法及其应用
CN115246881B (zh) * 2021-02-02 2025-04-11 浙江理工大学 一种抗HBsAg鲨鱼单域抗体或其抗原结合片段及其应用
CN113234143B (zh) * 2021-05-10 2021-12-14 合肥金域医学检验实验室有限公司 一种快速检测病毒的核酸抗体试剂盒
CN114671947B (zh) * 2022-02-28 2024-04-09 中国科学院生物物理研究所 乙肝病毒不同亚型表面s蛋白高亲和力纳米抗体及其应用
CN116162153B (zh) * 2022-09-01 2024-09-10 复旦大学附属中山医院 一种乙肝病毒表面抗原的单克隆抗体及其应用
CN116751262B (zh) * 2023-07-31 2024-09-06 重庆医科大学国际体外诊断研究院 靶向乙型肝炎病毒核心蛋白的多肽及其应用
CN119161462B (zh) * 2024-10-09 2025-08-19 深圳市第三人民医院(深圳市肝病研究所) 一株乙型肝炎病毒核心蛋白的单克隆抗体cAbD4及其制备与应用

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CN101748129A (zh) * 2008-12-04 2010-06-23 上海裕隆临床检验中心有限公司 人源乙肝病毒表面抗体的制备方法
CA2943258C (en) * 2012-06-11 2020-12-22 Xiamen University Polypeptides and antibodies for treating hbv infection and related diseases

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CA2943258C (en) 2020-12-22
WO2013185558A1 (zh) 2013-12-19
BR122020023349B1 (pt) 2023-02-07
US9751914B2 (en) 2017-09-05
US20180002382A1 (en) 2018-01-04
EP2860188B1 (en) 2020-10-21
KR20150043289A (ko) 2015-04-22
CA2943258A1 (en) 2013-12-19
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CN106046155B (zh) 2019-11-22
AU2013276015A1 (en) 2014-12-18
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EP3308798A3 (en) 2018-05-30
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US10246494B2 (en) 2019-04-02
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