JP6437443B2 - 大環状広域抗生物質 - Google Patents

大環状広域抗生物質 Download PDF

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JP6437443B2
JP6437443B2 JP2015544117A JP2015544117A JP6437443B2 JP 6437443 B2 JP6437443 B2 JP 6437443B2 JP 2015544117 A JP2015544117 A JP 2015544117A JP 2015544117 A JP2015544117 A JP 2015544117A JP 6437443 B2 JP6437443 B2 JP 6437443B2
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formula
compounds
alkyl
optionally substituted
another embodiment
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Japanese (ja)
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JP2016501864A5 (cg-RX-API-DMAC7.html
JP2016501864A (ja
Inventor
ロバーツ，タッカー，カラン
スミス，ピーター，アンドリュー
ヒグチ，ロバート，アイ．
キャンベル，デイビッド
パラセッリ，プラスナ
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アールキューエックス ファーマシューティカルズ，インク．
アールキューエックス ファーマシューティカルズ，インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015544117A 2012-11-21 2013-11-20 大環状広域抗生物質 Active JP6437443B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261729249P 2012-11-21 2012-11-21
US201261729253P 2012-11-21 2012-11-21
US61/729,249 2012-11-21
US61/729,253 2012-11-21
PCT/US2013/071093 WO2014081886A1 (en) 2012-11-21 2013-11-20 Macrocyclic broad spectrum antibiotics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018135357A Division JP6662960B2 (ja) 2012-11-21 2018-07-18 大環状広域抗生物質

Publications (3)

Publication Number Publication Date
JP2016501864A JP2016501864A (ja) 2016-01-21
JP2016501864A5 JP2016501864A5 (cg-RX-API-DMAC7.html) 2017-01-05
JP6437443B2 true JP6437443B2 (ja) 2018-12-12

Family

ID=50728492

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015544117A Active JP6437443B2 (ja) 2012-11-21 2013-11-20 大環状広域抗生物質
JP2018135357A Active JP6662960B2 (ja) 2012-11-21 2018-07-18 大環状広域抗生物質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018135357A Active JP6662960B2 (ja) 2012-11-21 2018-07-18 大環状広域抗生物質

Country Status (12)

Country Link
US (1) US9309285B2 (cg-RX-API-DMAC7.html)
EP (1) EP2922829B1 (cg-RX-API-DMAC7.html)
JP (2) JP6437443B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150088292A (cg-RX-API-DMAC7.html)
CN (1) CN104903302B (cg-RX-API-DMAC7.html)
AR (1) AR093581A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015011697A2 (cg-RX-API-DMAC7.html)
CA (1) CA2892027A1 (cg-RX-API-DMAC7.html)
EA (1) EA201590871A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015006340A (cg-RX-API-DMAC7.html)
TW (1) TWI631127B (cg-RX-API-DMAC7.html)
WO (1) WO2014081886A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017517567A (ja) * 2014-05-20 2017-06-29 アールキューエックス ファーマシューティカルズ，インク． 大環状広域スペクトル抗生物質

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP2984166B1 (en) 2013-03-15 2020-04-22 The Trustees Of The University Of Pennsylvania Compositions for treating mpsi
JP6923449B2 (ja) * 2015-04-30 2021-08-18 アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． 腎疾患の検出方法
PL3368544T3 (pl) 2015-10-27 2020-11-16 F. Hoffmann-La Roche Ag Peptydowe związki makrocykliczne przeciwko Acinetobacter baumannii
TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
RU2761476C2 (ru) * 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
KR102671585B1 (ko) * 2017-02-15 2024-06-04 알큐엑스 파마슈티컬스, 인크. 거대환형 광범위 항생제
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
HRP20231497T8 (hr) * 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra

Family Cites Families (14)

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US5204328A (en) 1990-06-26 1993-04-20 Merck & Co., Inc. Peptides having atrial natriuretic factor activity
EP0895999A1 (en) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
US6660832B1 (en) * 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
EA010294B1 (ru) 2003-07-17 2008-08-29 Майджиникс, Инк. Композиции на основе производных липопептидных антибиотиков и способы их применения
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
WO2011112441A1 (en) * 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
WO2011120071A1 (en) 2010-04-01 2011-10-06 The University Of Queensland Oxytocin peptide analogues
WO2012036907A2 (en) * 2010-09-15 2012-03-22 Romesberg Floyd E Broad spectrum antibiotic arylomycin analogs
TWI642684B (zh) 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
CN104284664A (zh) 2012-03-14 2015-01-14 斯克里普斯研究所 广谱抗生素Arylomycin类似物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017517567A (ja) * 2014-05-20 2017-06-29 アールキューエックス ファーマシューティカルズ，インク． 大環状広域スペクトル抗生物質

Also Published As

Publication number Publication date
WO2014081886A1 (en) 2014-05-30
CN104903302B (zh) 2019-03-29
AR093581A1 (es) 2015-06-10
EP2922829A4 (en) 2016-11-02
MX2015006340A (es) 2015-09-07
US9309285B2 (en) 2016-04-12
EP2922829A1 (en) 2015-09-30
CA2892027A1 (en) 2014-05-30
EA201590871A1 (ru) 2015-11-30
BR112015011697A2 (pt) 2017-07-11
US20140142029A1 (en) 2014-05-22
TWI631127B (zh) 2018-08-01
JP6662960B2 (ja) 2020-03-11
EP2922829B1 (en) 2021-08-11
CN104903302A (zh) 2015-09-09
TW201434848A (zh) 2014-09-16
KR20150088292A (ko) 2015-07-31
JP2016501864A (ja) 2016-01-21
JP2018184435A (ja) 2018-11-22

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