JP6422344B2 - 同種抗原反応性の制御性t細胞を増大させる方法 - Google Patents
同種抗原反応性の制御性t細胞を増大させる方法 Download PDFInfo
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- JP6422344B2 JP6422344B2 JP2014560106A JP2014560106A JP6422344B2 JP 6422344 B2 JP6422344 B2 JP 6422344B2 JP 2014560106 A JP2014560106 A JP 2014560106A JP 2014560106 A JP2014560106 A JP 2014560106A JP 6422344 B2 JP6422344 B2 JP 6422344B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
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- A61K40/00—Cellular immunotherapy
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/00—Cellular immunotherapy
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- A61K40/22—Immunosuppressive or immunotolerising
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- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/04—Immunosuppressors, e.g. cyclosporin, tacrolimus
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1107—B cells
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261606329P | 2012-03-02 | 2012-03-02 | |
| US61/606,329 | 2012-03-02 | ||
| PCT/US2013/028734 WO2013131045A1 (en) | 2012-03-02 | 2013-03-01 | Expansion of alloantigen-reactive regulatory t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513403A JP2015513403A (ja) | 2015-05-14 |
| JP2015513403A5 JP2015513403A5 (enExample) | 2017-08-10 |
| JP6422344B2 true JP6422344B2 (ja) | 2018-11-14 |
Family
ID=49083363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560106A Active JP6422344B2 (ja) | 2012-03-02 | 2013-03-01 | 同種抗原反応性の制御性t細胞を増大させる方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9801911B2 (enExample) |
| EP (2) | EP2820125B1 (enExample) |
| JP (1) | JP6422344B2 (enExample) |
| CN (1) | CN104245923B (enExample) |
| AU (2) | AU2013225721B2 (enExample) |
| CA (1) | CA2866116C (enExample) |
| ES (1) | ES2675317T3 (enExample) |
| WO (1) | WO2013131045A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| US20190062706A1 (en) * | 2015-10-28 | 2019-02-28 | Life Technologies As | Selective expansion of different subpopulations of t cells by the alteration of cell surfacing signals and signal ratio |
| CN105420190B (zh) * | 2016-01-08 | 2018-07-31 | 无锡药明生基医药科技有限公司 | B27添加剂及其类似物在利用无血清培养基培养淋巴细胞中的应用 |
| EP3216861A1 (en) * | 2016-03-11 | 2017-09-13 | Fropharm GmbH | Immunoregulatory cells and methods for their production |
| CN110662834B (zh) | 2017-05-26 | 2023-09-12 | Gc细胞治疗 | 使用转化的t细胞培养自然杀伤细胞的方法 |
| WO2018231803A1 (en) * | 2017-06-12 | 2018-12-20 | The Trustees Of Columbia University In The City Of New York | Methods for generating polyclonal regulatory t cells |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| KR102232321B1 (ko) * | 2018-03-23 | 2021-03-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| CA3103385A1 (en) | 2018-07-10 | 2020-01-16 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| EP3892721A4 (en) | 2018-11-14 | 2022-08-31 | GC Cell Corporation | METHOD FOR CULTIVATING NATURAL KILLER CELLS DERIVED FROM UMBILICAL CORD BLOOD USING TRANSFORMED T LYMPHOCYTES |
| BR112021021528A2 (pt) * | 2019-04-30 | 2022-04-19 | Univ California | Expansão ex vivo livre de contas de células t reguladoras humanas |
| CN110195041B (zh) * | 2019-06-20 | 2023-04-25 | 威海正生生物科技有限公司 | 利用ASC三维培养体系获得高活性Tregs细胞的方法 |
| EP3997212A4 (en) | 2019-07-09 | 2024-01-17 | The Children's Mercy Hospital | GENETICALLY MODIFIED REGULATORY T CELLS |
| PL238336B1 (pl) * | 2019-08-22 | 2021-08-09 | Gdanski Univ Medyczny | Sposób otrzymywania in vitro antygenowo-specyficznych limfocytów T regulatorowych |
| WO2022182763A1 (en) * | 2021-02-23 | 2022-09-01 | KSQ Therapeutics, Inc. | Methods for expanding regulatory t cells |
| WO2025081193A1 (en) * | 2023-10-13 | 2025-04-17 | Northwestern University | Antigen specific expansion of regulatory t cells |
| JP7627920B1 (ja) | 2023-12-11 | 2025-02-07 | 浩 宮内 | 移植材料の評価方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540926A (en) | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| ATE460475T1 (de) | 2000-04-11 | 2010-03-15 | Univ Southern California | Methode zur verhinderung der transplantatabstossung unter verwendung von tgf- beta zur induktion von t-suppressorzellen |
| US6746670B2 (en) | 2000-08-15 | 2004-06-08 | Schering Corporation | Regulatory T cells; methods |
| US6670146B2 (en) | 2000-10-04 | 2003-12-30 | Schering Corporation | Regulatory T cells; methods |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| WO2004090095A2 (en) | 2003-04-01 | 2004-10-21 | University Of Southern California | Generation of human regulatory t cells by bacterial toxins for the treatment of inflammatory disorders |
| US7651855B2 (en) | 2003-04-17 | 2010-01-26 | The Trustees Of The University Of Pennsylvania | Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses |
| FR2856700B1 (fr) | 2003-06-24 | 2007-06-08 | Txcell | Procede d'identification de lymphocytes tr1 regulateurs par la presence et la surexpression de molecules specifiques et ses applications |
| CA2552891A1 (en) | 2004-01-08 | 2005-08-04 | Regents Of The University Of California | Regulatory t cells suppress autoimmunity |
| CA2655392A1 (en) * | 2006-05-31 | 2007-12-06 | The Regents Of The University Of California | Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs |
| KR20100094997A (ko) | 2007-11-30 | 2010-08-27 | 테라코스, 인크. | 생체 외에서 확장된 cd4+cd25+ 조절 t 세포를 사용하여 이식편 대 숙주 질환의 영향을 감소시키는 방법 |
| US8658159B2 (en) | 2008-06-30 | 2014-02-25 | Versitech Limited | Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale |
| WO2010129770A1 (en) | 2009-05-07 | 2010-11-11 | The University Of Utah Research Foundation | Methods for expanding human t regulatory cells and uses of same |
-
2013
- 2013-03-01 JP JP2014560106A patent/JP6422344B2/ja active Active
- 2013-03-01 CN CN201380021317.7A patent/CN104245923B/zh not_active Expired - Fee Related
- 2013-03-01 US US14/382,537 patent/US9801911B2/en active Active
- 2013-03-01 EP EP13754740.2A patent/EP2820125B1/en active Active
- 2013-03-01 ES ES13754740.2T patent/ES2675317T3/es active Active
- 2013-03-01 EP EP18156148.1A patent/EP3366768B1/en active Active
- 2013-03-01 AU AU2013225721A patent/AU2013225721B2/en not_active Ceased
- 2013-03-01 WO PCT/US2013/028734 patent/WO2013131045A1/en not_active Ceased
- 2013-03-01 CA CA2866116A patent/CA2866116C/en active Active
-
2017
- 2017-09-29 US US15/721,439 patent/US20180036345A1/en not_active Abandoned
-
2018
- 2018-08-20 AU AU2018219968A patent/AU2018219968B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2866116A1 (en) | 2013-09-06 |
| US20180036345A1 (en) | 2018-02-08 |
| AU2018219968A1 (en) | 2018-09-06 |
| EP2820125A4 (en) | 2015-07-29 |
| WO2013131045A1 (en) | 2013-09-06 |
| EP3366768B1 (en) | 2020-07-08 |
| ES2675317T3 (es) | 2018-07-10 |
| JP2015513403A (ja) | 2015-05-14 |
| EP2820125A1 (en) | 2015-01-07 |
| US20150110761A1 (en) | 2015-04-23 |
| AU2013225721B2 (en) | 2018-06-14 |
| AU2018219968B2 (en) | 2020-09-17 |
| CN104245923B (zh) | 2018-04-20 |
| AU2013225721A1 (en) | 2014-10-09 |
| CA2866116C (en) | 2021-06-15 |
| US9801911B2 (en) | 2017-10-31 |
| EP2820125B1 (en) | 2018-05-09 |
| EP3366768A1 (en) | 2018-08-29 |
| CN104245923A (zh) | 2014-12-24 |
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