JP2015513403A5 - - Google Patents

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JP2015513403A5
JP2015513403A5 JP2014560106A JP2014560106A JP2015513403A5 JP 2015513403 A5 JP2015513403 A5 JP 2015513403A5 JP 2014560106 A JP2014560106 A JP 2014560106A JP 2014560106 A JP2014560106 A JP 2014560106A JP 2015513403 A5 JP2015513403 A5 JP 2015513403A5
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treg
donor
cells
reactive
sbc
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JP2014560106A
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JP6422344B2 (ja
JP2015513403A (ja
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Priority claimed from PCT/US2013/028734 external-priority patent/WO2013131045A1/en
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JP2014560106A 2012-03-02 2013-03-01 同種抗原反応性の制御性t細胞を増大させる方法 Active JP6422344B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606329P 2012-03-02 2012-03-02
US61/606,329 2012-03-02
PCT/US2013/028734 WO2013131045A1 (en) 2012-03-02 2013-03-01 Expansion of alloantigen-reactive regulatory t cells

Publications (3)

Publication Number Publication Date
JP2015513403A JP2015513403A (ja) 2015-05-14
JP2015513403A5 true JP2015513403A5 (enExample) 2017-08-10
JP6422344B2 JP6422344B2 (ja) 2018-11-14

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JP2014560106A Active JP6422344B2 (ja) 2012-03-02 2013-03-01 同種抗原反応性の制御性t細胞を増大させる方法

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US (2) US9801911B2 (enExample)
EP (2) EP2820125B1 (enExample)
JP (1) JP6422344B2 (enExample)
CN (1) CN104245923B (enExample)
AU (2) AU2013225721B2 (enExample)
CA (1) CA2866116C (enExample)
ES (1) ES2675317T3 (enExample)
WO (1) WO2013131045A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
US20190062706A1 (en) * 2015-10-28 2019-02-28 Life Technologies As Selective expansion of different subpopulations of t cells by the alteration of cell surfacing signals and signal ratio
CN105420190B (zh) * 2016-01-08 2018-07-31 无锡药明生基医药科技有限公司 B27添加剂及其类似物在利用无血清培养基培养淋巴细胞中的应用
EP3216861A1 (en) * 2016-03-11 2017-09-13 Fropharm GmbH Immunoregulatory cells and methods for their production
CN110662834B (zh) 2017-05-26 2023-09-12 Gc细胞治疗 使用转化的t细胞培养自然杀伤细胞的方法
WO2018231803A1 (en) * 2017-06-12 2018-12-20 The Trustees Of Columbia University In The City Of New York Methods for generating polyclonal regulatory t cells
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
KR102232321B1 (ko) * 2018-03-23 2021-03-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
CA3103385A1 (en) 2018-07-10 2020-01-16 Novartis Ag 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
EP3892721A4 (en) 2018-11-14 2022-08-31 GC Cell Corporation METHOD FOR CULTIVATING NATURAL KILLER CELLS DERIVED FROM UMBILICAL CORD BLOOD USING TRANSFORMED T LYMPHOCYTES
BR112021021528A2 (pt) * 2019-04-30 2022-04-19 Univ California Expansão ex vivo livre de contas de células t reguladoras humanas
CN110195041B (zh) * 2019-06-20 2023-04-25 威海正生生物科技有限公司 利用ASC三维培养体系获得高活性Tregs细胞的方法
EP3997212A4 (en) 2019-07-09 2024-01-17 The Children's Mercy Hospital GENETICALLY MODIFIED REGULATORY T CELLS
PL238336B1 (pl) * 2019-08-22 2021-08-09 Gdanski Univ Medyczny Sposób otrzymywania in vitro antygenowo-specyficznych limfocytów T regulatorowych
WO2022182763A1 (en) * 2021-02-23 2022-09-01 KSQ Therapeutics, Inc. Methods for expanding regulatory t cells
WO2025081193A1 (en) * 2023-10-13 2025-04-17 Northwestern University Antigen specific expansion of regulatory t cells
JP7627920B1 (ja) 2023-12-11 2025-02-07 浩 宮内 移植材料の評価方法

Family Cites Families (15)

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US5540926A (en) 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
ATE460475T1 (de) 2000-04-11 2010-03-15 Univ Southern California Methode zur verhinderung der transplantatabstossung unter verwendung von tgf- beta zur induktion von t-suppressorzellen
US6746670B2 (en) 2000-08-15 2004-06-08 Schering Corporation Regulatory T cells; methods
US6670146B2 (en) 2000-10-04 2003-12-30 Schering Corporation Regulatory T cells; methods
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
WO2004090095A2 (en) 2003-04-01 2004-10-21 University Of Southern California Generation of human regulatory t cells by bacterial toxins for the treatment of inflammatory disorders
US7651855B2 (en) 2003-04-17 2010-01-26 The Trustees Of The University Of Pennsylvania Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
FR2856700B1 (fr) 2003-06-24 2007-06-08 Txcell Procede d'identification de lymphocytes tr1 regulateurs par la presence et la surexpression de molecules specifiques et ses applications
CA2552891A1 (en) 2004-01-08 2005-08-04 Regents Of The University Of California Regulatory t cells suppress autoimmunity
CA2655392A1 (en) * 2006-05-31 2007-12-06 The Regents Of The University Of California Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs
KR20100094997A (ko) 2007-11-30 2010-08-27 테라코스, 인크. 생체 외에서 확장된 cd4+cd25+ 조절 t 세포를 사용하여 이식편 대 숙주 질환의 영향을 감소시키는 방법
US8658159B2 (en) 2008-06-30 2014-02-25 Versitech Limited Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale
WO2010129770A1 (en) 2009-05-07 2010-11-11 The University Of Utah Research Foundation Methods for expanding human t regulatory cells and uses of same

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