JP6418579B2 - ホタテ貝外套膜のタンパク質分解物を有効成分とする脂質吸収促進剤及びこれを含む飲食品 - Google Patents
ホタテ貝外套膜のタンパク質分解物を有効成分とする脂質吸収促進剤及びこれを含む飲食品 Download PDFInfo
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Description
(2)タンパク質分解物がAla−Pro−Lys、Gly−Gln−Gly、Ile−Met−Asp、Glu−Gln−Gly−Glu又はGly−Gln−Asp−Gln−Glyのいずれかのアミノ酸配列からなるペプチドの少なくとも一種以上を含有してなる、(1)に記載の脂質吸収促進剤。
(3)タンパク質分解物がホタテ貝外套膜をパパイン処理又はトリプシン処理して得られるタンパク質分解物である、(1)又は(2)に記載の脂質吸収促進剤。
(4)脂質がオレイン酸を主成分とする脂質である、(1)〜(3)のいずれかに記載の脂質吸収促進剤。
(5)(1)〜(4)のいずれかに記載の脂質吸収促進剤を含む飲食品。
(6)高齢者用又は病者用の栄養補助飲食品である、(5)に記載の飲食品。
(7)(1)〜(4)のいずれかに記載の脂質吸収促進剤を含む非ヒト動物用飼料。
(8)Ile−Met−Asp、Glu−Gln−Gly−Glu又はGly−Gln−Asp−Gln−Glyのいずれかのアミノ酸配列からなるペプチドの少なくとも一種以上を有効成分とする、脂質吸収促進剤。
(9)脂質がオレイン酸を主成分とする脂質である、(8)に記載の脂質吸収促進剤。
(10)(8)又は(9)に記載の脂質吸収促進剤を含む飲食品。
(11)高齢者用又は病者用の栄養補助飲食品である、(10)に記載の飲食品。
(12)(8)〜(11)のいずれかに記載の脂質吸収促進剤を含む非ヒト動物用飼料。
サロマ湖産の冷凍ホタテ貝外套膜(市販品)を解凍し、流水で洗浄して黒膜を除去した後、ミンチ処理した。ホタテ貝外套膜のミンチに対して、食品添加物として市販されている酵素製剤であるパパイン(商品名スミチームP、300U/mg、新日本化学工業株式会社製)を0.1重量%となるように添加し、55℃で6時間、酵素処理を行った。処理後の反応液の一部はそのまま真空凍結乾燥処理して、粉状のタンパク質分解物(以下、SMPとする)を得た。また処理後の反応液の一部については、12,000×gで30分間遠心分離して上清を回収し、これをけい藻土濾過し、さらに真空凍結乾燥を行って、粉状のタンパク質分解物(以下、SMP−supとする)とした。
特開2009−35538号公報に記載の海苔を含む脂質吸収促進剤をボジティブコントロール(以下、ポジコンとする)とするため、海苔として例示されている紅藻を選択した。紅藻粉末20gに20倍容量(w/v)の蒸留水を加えて4℃で7時間浸漬させたのち、4℃で15,000×g、10分間遠心分離した。上清を回収後、使用時まで−30℃で凍結保管した。
7週齢のSD雄性ラットを日本チャールズ・リバー株式会社より購入し、温度23±1℃、湿度30±10%、照明12時間(8:00〜20:00)の環境下で、ケージあたり3〜4尾収容し、固形飼料MF(オリエンタル酵母工業株式会社製)を、イオン交換水を自由摂取させながら予備飼育を行った。1週間の検疫期間を含む予備飼育の後、一般状態に異常がみられなかった動物35匹をランダムに、コントロール群、脂質群、SMP群、SMP−sup群及びポジコン群の計5群(n=7/群)に分けた。
展開溶媒:0.1%TFA、1%−30%アセトニトリル(直線濃度勾配)
温度:40℃
検出:220nm
Claims (11)
- ホタテ貝外套膜のパパイン分解物を有効成分とする脂質吸収促進剤。
- パパイン分解物がIle−Met−Asp、Glu−Gln−Gly−Glu又はGly−Gln−Asp−Gln−Glyのいずれかのアミノ酸配列からなるペプチドの少なくとも一種以上を含有してなる、請求項1に記載の脂質吸収促進剤。
- 脂質がオレイン酸を主成分とする脂質である、請求項1又は2に記載の脂質吸収促進剤。
- 請求項1〜3のいずれかに記載の脂質吸収促進剤を含む脂質吸収促進用飲食品組成物。
- 高齢者用又は病者用の栄養補助飲食品である、請求項4に記載の脂質吸収促進用飲食品組成物。
- 請求項1〜3のいずれかに記載の脂質吸収促進剤を含む非ヒト動物用脂質吸収促進用飼料組成物。
- Ile−Met−Asp、Glu−Gln−Gly−Glu又はGly−Gln−Asp−Gln−Glyのいずれかのアミノ酸配列からなるペプチドの少なくとも一種以上を有効成分とする、脂質吸収促進剤。
- 脂質がオレイン酸を主成分とする脂質である、請求項7に記載の脂質吸収促進剤。
- 請求項7又は8に記載の脂質吸収促進剤を含む脂質吸収促進用飲食品組成物。
- 高齢者用又は病者用の栄養補助飲食品である、請求項9に記載の脂質吸収促進用飲食品組成物。
- 請求項7又は8に記載の脂質吸収促進剤を含む非ヒト動物用脂質吸収促進用飼料組成物。
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