JP6417401B2 - Acc阻害剤及びその使用 - Google Patents
Acc阻害剤及びその使用 Download PDFInfo
- Publication number
- JP6417401B2 JP6417401B2 JP2016513082A JP2016513082A JP6417401B2 JP 6417401 B2 JP6417401 B2 JP 6417401B2 JP 2016513082 A JP2016513082 A JP 2016513082A JP 2016513082 A JP2016513082 A JP 2016513082A JP 6417401 B2 JP6417401 B2 JP 6417401B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- sulfur
- membered
- nitrogen
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC**(C12)*(C)*C1*(C*)C(C)(*)[*@@](C(C)C)C2=NC Chemical compound CC**(C12)*(C)*C1*(C*)C(C)(*)[*@@](C(C)C)C2=NC 0.000 description 8
- PGQBDBZXFDIDSF-QFIPXVFZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=S Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=S PGQBDBZXFDIDSF-QFIPXVFZSA-N 0.000 description 1
- GNTNTDQHLHMQLW-QFIPXVFZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2cc(-c3ncc[o]3)[s]1)C2=O Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2cc(-c3ncc[o]3)[s]1)C2=O GNTNTDQHLHMQLW-QFIPXVFZSA-N 0.000 description 1
- HCKYPVIFCJOLSN-QFIPXVFZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)Oc1ccncc1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)Oc1ccncc1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O HCKYPVIFCJOLSN-QFIPXVFZSA-N 0.000 description 1
- VLJUWKAIITYRLU-FQEVSTJZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(nccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(nccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O VLJUWKAIITYRLU-FQEVSTJZSA-N 0.000 description 1
- NKSGOUWLHFXUOX-SFHVURJKSA-N CC(C)O[C@@H](CC(c1c2c(C)c(C(F)(F)F)[s]1)=CN(C(C)(C)C(O)=O)C2=O)c(cccc1)c1OC Chemical compound CC(C)O[C@@H](CC(c1c2c(C)c(C(F)(F)F)[s]1)=CN(C(C)(C)C(O)=O)C2=O)c(cccc1)c1OC NKSGOUWLHFXUOX-SFHVURJKSA-N 0.000 description 1
- YPLYEGSFNIDVEN-KRWDZBQOSA-N CC(C)O[C@@H](CC(c1c2nc(-c3ncc[o]3)[o]1)=CN(CC(O)=O)C2=O)c(cccc1)c1OC Chemical compound CC(C)O[C@@H](CC(c1c2nc(-c3ncc[o]3)[o]1)=CN(CC(O)=O)C2=O)c(cccc1)c1OC YPLYEGSFNIDVEN-KRWDZBQOSA-N 0.000 description 1
- CACAWMGYQDAERJ-HNNXBMFYSA-N CC(C)O[C@@H](CN(c1c(C(N2CC(O)=O)=O)nc(-[n]3nccn3)[s]1)C2=O)c1ccccc1OC Chemical compound CC(C)O[C@@H](CN(c1c(C(N2CC(O)=O)=O)nc(-[n]3nccn3)[s]1)C2=O)c1ccccc1OC CACAWMGYQDAERJ-HNNXBMFYSA-N 0.000 description 1
- IGBQUNUUPTVHAU-QHCPKHFHSA-N Cc1c(-c2ncc[o]2)[s]c(C(C[C@@H](c(cccc2)c2OC)OC2CCOCC2)=CN2CCC#N)c1C2=O Chemical compound Cc1c(-c2ncc[o]2)[s]c(C(C[C@@H](c(cccc2)c2OC)OC2CCOCC2)=CN2CCC#N)c1C2=O IGBQUNUUPTVHAU-QHCPKHFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361821824P | 2013-05-10 | 2013-05-10 | |
| US61/821,824 | 2013-05-10 | ||
| PCT/US2014/037360 WO2014182943A1 (en) | 2013-05-10 | 2014-05-08 | Acc inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526024A JP2016526024A (ja) | 2016-09-01 |
| JP2016526024A5 JP2016526024A5 (enExample) | 2017-07-06 |
| JP6417401B2 true JP6417401B2 (ja) | 2018-11-07 |
Family
ID=51867752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513082A Active JP6417401B2 (ja) | 2013-05-10 | 2014-05-08 | Acc阻害剤及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9988399B2 (enExample) |
| EP (1) | EP2994138A4 (enExample) |
| JP (1) | JP6417401B2 (enExample) |
| KR (1) | KR20160007598A (enExample) |
| CN (1) | CN105358152A (enExample) |
| AR (1) | AR096241A1 (enExample) |
| AU (1) | AU2014262636A1 (enExample) |
| BR (1) | BR112015028171A8 (enExample) |
| CA (1) | CA2911926A1 (enExample) |
| CL (1) | CL2015003314A1 (enExample) |
| EA (1) | EA201591959A1 (enExample) |
| HK (2) | HK1221659A1 (enExample) |
| MX (1) | MX2015015417A (enExample) |
| WO (1) | WO2014182943A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2776038T3 (pl) * | 2011-11-11 | 2018-06-29 | Gilead Apollo, Llc | Inhibitory acc i ich zastosowania |
| US10208044B2 (en) | 2013-05-10 | 2019-02-19 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| HK1221661A1 (zh) | 2013-05-10 | 2017-06-09 | Gilead Apollo, Llc | Acc抑制剂和其用途 |
| CN105358143B (zh) | 2013-05-10 | 2019-01-22 | 吉利德阿波罗公司 | Acc抑制剂和其用途 |
| JPWO2015056782A1 (ja) | 2013-10-17 | 2017-03-09 | 塩野義製薬株式会社 | 新規アルキレン誘導体 |
| HK1246232A1 (zh) | 2015-01-09 | 2018-09-07 | Gilead Apollo, Llc | 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗 |
| UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
| AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| BR112018009212B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Método para controlar patógenos fúngicos agrícolas |
| KR20180082556A (ko) * | 2015-11-25 | 2018-07-18 | 길리어드 아폴로, 엘엘씨 | 피라졸 acc 억제제 및 그의 용도 |
| EP3380479B1 (en) * | 2015-11-25 | 2022-12-07 | Gilead Apollo, LLC | Triazole acc inhibitors and uses thereof |
| MX2018006288A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc tipo ester y usos de los mismos. |
| MX2018010427A (es) | 2016-03-02 | 2019-03-06 | Gilead Apollo Llc | Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. |
| WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
| JP2019529452A (ja) | 2016-09-23 | 2019-10-17 | バイエル・アクチエンゲゼルシヤフト | N3−環状置換チエノウラシルおよびその使用 |
| KR102577824B1 (ko) | 2017-01-22 | 2023-09-13 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 티에노피리미딘 유도체 및 의약에서 이의 용도 |
| CN110431144B (zh) | 2017-03-24 | 2022-08-05 | 浙江海正药业股份有限公司 | 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| CN110431143B (zh) * | 2017-03-24 | 2022-08-12 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| PT3600309T (pt) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças hepáticas |
| EP3805230B1 (en) * | 2018-06-05 | 2024-08-07 | Medshine Discovery Inc. | Thieno[2,3-c]pyridazin-4(1h)-one derivative and application thereof |
| WO2020103851A1 (zh) * | 2018-11-20 | 2020-05-28 | 中国医药研究开发中心有限公司 | 螺环类化合物及其医药用途 |
| WO2020197926A1 (en) * | 2019-03-22 | 2020-10-01 | Kallyope, Inc. | Gpcr combination therapies |
| EP3995498A4 (en) | 2019-07-02 | 2023-03-01 | Sunshine Lake Pharma Co., Ltd. | THIENOPYRIMIDINE DERIVATIVES HAVING STEREO CONFIGURATION AND THEIR USE IN MEDICINE |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| ES2960703T3 (es) * | 2019-12-05 | 2024-03-06 | Zhangzhou Pien Tze Huang Pharm | Forma cristalina del compuesto de tieno[2,3-c]piridazina-4(1H)-ona, método de preparación de la misma y uso de la misma |
| WO2021110135A1 (zh) * | 2019-12-05 | 2021-06-10 | 漳州片仔癀药业股份有限公司 | 作为acc1和acc2抑制剂的晶型及其制备方法和应用 |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN111793566B (zh) * | 2020-07-31 | 2021-11-16 | 南京林业大学 | 一种杉木内生真菌及其生物防治应用 |
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| WO2010127212A1 (en) | 2009-04-30 | 2010-11-04 | Forest Laboratories Holdings Limited | Inhibitors of acetyl-coa carboxylase |
| KR20140001965A (ko) | 2010-11-30 | 2014-01-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 바이시클릭 화합물 |
| JP5657174B2 (ja) * | 2011-04-22 | 2015-01-21 | ファイザー・インク | アセチルCoAカルボキシラーゼ阻害剤として使用するためのピラゾロスピロケトン誘導体 |
| JPWO2013035827A1 (ja) | 2011-09-09 | 2015-03-23 | 塩野義製薬株式会社 | 新規オレフィン誘導体 |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| PL2776038T3 (pl) * | 2011-11-11 | 2018-06-29 | Gilead Apollo, Llc | Inhibitory acc i ich zastosowania |
| US10208044B2 (en) | 2013-05-10 | 2019-02-19 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| HK1221661A1 (zh) | 2013-05-10 | 2017-06-09 | Gilead Apollo, Llc | Acc抑制剂和其用途 |
| CN105358143B (zh) * | 2013-05-10 | 2019-01-22 | 吉利德阿波罗公司 | Acc抑制剂和其用途 |
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2014
- 2014-05-08 KR KR1020157035041A patent/KR20160007598A/ko not_active Withdrawn
- 2014-05-08 EP EP14795076.0A patent/EP2994138A4/en not_active Withdrawn
- 2014-05-08 AU AU2014262636A patent/AU2014262636A1/en not_active Abandoned
- 2014-05-08 EA EA201591959A patent/EA201591959A1/ru unknown
- 2014-05-08 JP JP2016513082A patent/JP6417401B2/ja active Active
- 2014-05-08 BR BR112015028171A patent/BR112015028171A8/pt not_active Application Discontinuation
- 2014-05-08 WO PCT/US2014/037360 patent/WO2014182943A1/en not_active Ceased
- 2014-05-08 HK HK16109917.3A patent/HK1221659A1/zh unknown
- 2014-05-08 CA CA2911926A patent/CA2911926A1/en not_active Abandoned
- 2014-05-08 HK HK16109586.3A patent/HK1221410A1/zh unknown
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- 2014-05-08 MX MX2015015417A patent/MX2015015417A/es unknown
- 2014-05-08 CN CN201480036133.2A patent/CN105358152A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2016526024A (ja) | 2016-09-01 |
| AR096241A1 (es) | 2015-12-16 |
| MX2015015417A (es) | 2016-06-21 |
| WO2014182943A1 (en) | 2014-11-13 |
| HK1221659A1 (zh) | 2017-06-09 |
| US9988399B2 (en) | 2018-06-05 |
| AU2014262636A1 (en) | 2015-11-26 |
| CA2911926A1 (en) | 2014-11-13 |
| EP2994138A4 (en) | 2016-12-28 |
| US20160108060A1 (en) | 2016-04-21 |
| BR112015028171A8 (pt) | 2017-08-22 |
| EP2994138A1 (en) | 2016-03-16 |
| CN105358152A (zh) | 2016-02-24 |
| CL2015003314A1 (es) | 2016-07-15 |
| HK1221410A1 (zh) | 2017-06-02 |
| KR20160007598A (ko) | 2016-01-20 |
| EA201591959A1 (ru) | 2016-03-31 |
| BR112015028171A2 (pt) | 2017-07-25 |
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