JP6407248B2 - 細胞外核酸の安定化および単離 - Google Patents
細胞外核酸の安定化および単離 Download PDFInfo
- Publication number
- JP6407248B2 JP6407248B2 JP2016503570A JP2016503570A JP6407248B2 JP 6407248 B2 JP6407248 B2 JP 6407248B2 JP 2016503570 A JP2016503570 A JP 2016503570A JP 2016503570 A JP2016503570 A JP 2016503570A JP 6407248 B2 JP6407248 B2 JP 6407248B2
- Authority
- JP
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- Prior art keywords
- sample
- cell
- nucleic acid
- stabilization
- oxyethylene
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159834 | 2013-03-18 | ||
| EP13159834.4 | 2013-03-18 | ||
| EP13180086 | 2013-08-12 | ||
| EP13180086.4 | 2013-08-12 | ||
| PCT/EP2014/000724 WO2014146780A1 (en) | 2013-03-18 | 2014-03-18 | Stabilization and isolation of extracellular nucleic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520293A JP2016520293A (ja) | 2016-07-14 |
| JP2016520293A5 JP2016520293A5 (https=) | 2017-02-16 |
| JP6407248B2 true JP6407248B2 (ja) | 2018-10-17 |
Family
ID=50434155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503570A Active JP6407248B2 (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
| JP2016503572A Pending JP2016518827A (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503572A Pending JP2016518827A (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20160281133A1 (https=) |
| EP (2) | EP2976425B1 (https=) |
| JP (2) | JP6407248B2 (https=) |
| CN (2) | CN105121643A (https=) |
| WO (2) | WO2014146782A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6329072B2 (ja) | 2011-09-26 | 2018-05-23 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 細胞外核酸の安定化および単離 |
| CN103827303B (zh) | 2011-09-26 | 2021-10-22 | 普瑞阿那利提克斯有限公司 | 细胞外核酸的稳定化和分离 |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP2888363B1 (en) * | 2012-08-21 | 2018-06-06 | Qiagen GmbH | Method for isolating nucleic acids from a formaldehyde releaser stabilized sample |
| CN104755628B (zh) | 2012-09-25 | 2019-03-01 | 凯杰有限公司 | 生物样品的稳定化 |
| US10233440B2 (en) | 2012-09-28 | 2019-03-19 | Cepheid | Methods for DNA and RNA extraction from fixed paraffin-embedded tissue samples |
| US11525155B2 (en) | 2013-03-18 | 2022-12-13 | Qiagen Gmbh | Stabilisation of biological samples |
| JP6407248B2 (ja) | 2013-03-18 | 2018-10-17 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| JP6664332B2 (ja) | 2014-03-18 | 2020-03-13 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| AU2016298048B2 (en) * | 2015-07-24 | 2022-08-04 | Cepheid | Compositions and methods for DNA and RNA extraction from tissue samples |
| EP3377645B1 (en) | 2015-11-20 | 2023-10-04 | Qiagen GmbH | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| CA3020728A1 (en) | 2016-03-31 | 2017-10-05 | Berkeley Lights, Inc. | Nucleic acid stabilization reagent, kits, and methods of use thereof |
| CA3025569A1 (en) | 2016-05-27 | 2017-11-30 | Norgen Biotek Corp. | Preservation of cell-free nucleic acids in biological samples |
| WO2018035340A1 (en) | 2016-08-17 | 2018-02-22 | The Regents Of The University Of California | A novel immunoprobe-based method to assess organ injury status through a biofluid-based cell-free dna (cfdna) assay |
| US10870891B2 (en) | 2017-01-05 | 2020-12-22 | Biodesix, Inc. | Diagnostic test system for specific, sensitive and reproducible detection of circulating nucleic acids in whole blood |
| PL3662080T3 (pl) * | 2017-08-02 | 2022-04-19 | Sarstedt Ag & Co. Kg | Sposób i formulacja do stabilizacji bezkomórkowych kwasów nukleinowych i komórek |
| EP4397771A3 (en) | 2019-01-04 | 2024-10-16 | PreAnalytiX GmbH | Urine stabilization |
| CN114450402A (zh) * | 2019-09-24 | 2022-05-06 | 恰根有限公司 | 稳定化的含细胞体液样品的多模式分析 |
| US20230203586A1 (en) * | 2020-05-29 | 2023-06-29 | The Rockefeller University | Method and system for rna isolation from self-collected and small volume samples |
| JP7635480B2 (ja) * | 2020-11-27 | 2025-02-26 | 大王製紙株式会社 | Rfidタグ、採血管、及びアンテナ |
| EP4263383A4 (en) | 2020-12-17 | 2024-10-23 | Nephrosant, Inc. | KITS FOR STABILIZATION OF URINE SAMPLES |
| WO2023089183A1 (en) | 2021-11-19 | 2023-05-25 | Branca Bunus Limited | A composition comprising a therapeutically active agent packaged within a drug delivery vehicle |
| JP7586593B2 (ja) * | 2022-09-29 | 2024-11-19 | 積水メディカル株式会社 | 血液保存用組成物及び血液採取容器 |
| EP4356731A1 (en) | 2022-10-19 | 2024-04-24 | Olga Alekseevna Gra | Medium and device for collecting, storing and transporting biological samples, as well as their use for the stabilization of extracellular nucleic acids |
| EP4477751A1 (en) | 2023-06-16 | 2024-12-18 | QIAGEN GmbH | Body fluid stabilization and processing |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3389133A (en) * | 1966-08-10 | 1968-06-18 | Schwarz Biores Inc | Process for isolating and purifying soluble ribonucleic acid |
| US3903179A (en) | 1973-10-15 | 1975-09-02 | Gulf Research Development Co | Method for preparing nitrocyclopropane from 3-chloro-1-nitropropane |
| JPS6083581A (ja) * | 1983-10-13 | 1985-05-11 | Hideaki Yamada | シユ−ドモナス属細菌の培養法 |
| US4938961A (en) | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
| US5460797A (en) | 1991-05-08 | 1995-10-24 | Streck Laboratories, Inc. | Method for fixing tissues and cells for analysis using oxazolidine compounds |
| US5459073A (en) | 1991-05-08 | 1995-10-17 | Streck Laboratories, Inc. | Method and composition for preserving antigens and process for utilizing cytological material produced by same |
| GB9215002D0 (en) | 1992-07-15 | 1992-08-26 | Univ Singapore | Method of fixing biological tissue |
| US6180778B1 (en) | 1994-02-11 | 2001-01-30 | Qiagen Gmbh | Process for the separation of double-stranded/single-stranded nucleic acid structures |
| US5705628A (en) | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| CA2208974C (en) | 1994-12-29 | 2007-03-27 | Brookfield Engineering Laboratories, Inc. | Support system with radially rigid wire suspension |
| US20050158699A1 (en) | 1995-06-07 | 2005-07-21 | Kadkade Prakash G. | Cryopreservation of plant cells |
| US6673364B1 (en) | 1995-06-07 | 2004-01-06 | The University Of British Columbia | Liposome having an exchangeable component |
| AU7514896A (en) * | 1995-10-06 | 1997-04-28 | E.I. Du Pont De Nemours And Company | Nucleic acid fragments encoding stereospecific nitrile hydratase and amidase enzymes and recombinant microorganisms expressing those enzymes useful for the production of chiral amides and acides |
| ATE284891T1 (de) | 1996-02-14 | 2005-01-15 | Biomerieux Bv | Isolierung von einzelsträngigen nukleinsäuren |
| AU2324997A (en) | 1996-03-15 | 1997-10-01 | Penn State Research Foundation, The | Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays |
| ATE471150T1 (de) | 1996-03-26 | 2010-07-15 | Kopreski Michael S | Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden |
| WO1998029126A1 (en) | 1996-12-27 | 1998-07-09 | Sherwood Medical Company | Anticoagulant composition |
| WO1998041651A1 (en) | 1997-03-18 | 1998-09-24 | Hsc Research & Development Limited Partnership | Method for preparing chromatin |
| DE19726362A1 (de) | 1997-06-21 | 1998-12-24 | Schaeffler Waelzlager Ohg | Vorrichtung zum Verändern der Steuerzeiten von Gaswechselventilen einer Brennkraftmaschine |
| US6723564B2 (en) * | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| US6534262B1 (en) | 1998-05-14 | 2003-03-18 | Whitehead Institute For Biomedical Research | Solid phase technique for selectively isolating nucleic acids |
| DE19836559A1 (de) | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| JP2000187033A (ja) * | 1998-12-21 | 2000-07-04 | Wako Pure Chem Ind Ltd | 細胞染色液 |
| US6407107B1 (en) * | 1999-05-28 | 2002-06-18 | The Board Of Trustees Of The Unversity Of Arkansas | Derivatives of butyric acid and uses thereof |
| US6379930B1 (en) | 1999-07-30 | 2002-04-30 | Applied Gene Technologies, Inc. | Stabilization of nucleic acid amplification cocktails |
| US6492103B1 (en) | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| DE10006662A1 (de) | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
| KR20030011279A (ko) | 2000-03-23 | 2003-02-07 | 클리어런트, 인코포레이티드 | 생물학적 성분의 살균방법 |
| WO2001079272A2 (en) * | 2000-04-18 | 2001-10-25 | Tularik Inc. | Sitosterolemia susceptibility gene (ssg): compositions and methods of use |
| DE10031236A1 (de) | 2000-06-27 | 2002-01-10 | Qiagen Gmbh | Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien |
| US6602718B1 (en) | 2000-11-08 | 2003-08-05 | Becton, Dickinson And Company | Method and device for collecting and stabilizing a biological sample |
| EP1425294B2 (en) * | 2001-08-23 | 2012-12-12 | Veridex, LLC | Analysis of circulating tumor cells, fragments, and debris |
| JP2005525345A (ja) * | 2002-02-15 | 2005-08-25 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Trx媒介性疾患を処置する方法 |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| AU2002367863A1 (en) | 2002-04-10 | 2003-10-27 | Clearant, Inc. | Methods for sterilizing biological materials |
| EP1516181A2 (en) * | 2002-05-07 | 2005-03-23 | Becton Dickinson and Company | Container for taking samples and in particular blood samples |
| US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20040054160A1 (en) | 2002-09-16 | 2004-03-18 | Santona Pal | Nucleic-acid ink compositions for arraying onto a solid support |
| US20060212020A1 (en) | 2002-10-10 | 2006-09-21 | Lynne Rainen | Sample collection system with caspase inhibitor |
| US20040167165A1 (en) * | 2003-01-16 | 2004-08-26 | Geetha Shankar | Methods of treating conditions associated with an Edg-7 receptor |
| US7601491B2 (en) * | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
| US7250270B2 (en) | 2003-06-13 | 2007-07-31 | Ambion, Inc. | Methods and compositions for preparing tissue samples for RNA extraction |
| EP1678121A4 (en) * | 2003-10-24 | 2007-07-25 | Exelixis Inc | MODULATORS OF TAO KINASES AND METHODS OF USE |
| US7270799B2 (en) | 2004-01-15 | 2007-09-18 | Nst Neurosurvival Technologies Ltd. | Perturbed membrane-binding compounds and methods of using the same |
| JP4880484B2 (ja) | 2004-02-20 | 2012-02-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 唾液mRNAプロファイリング、バイオマーカーならびに関連した方法およびキット |
| US20050260624A1 (en) * | 2004-02-28 | 2005-11-24 | Wang Chang N J | Novel nucleic acid complexes and detection thereof |
| US20080176209A1 (en) | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| EP1758937B1 (en) | 2004-05-24 | 2009-09-02 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
| EP1773348A4 (en) | 2004-07-12 | 2009-05-20 | Idun Pharmaceuticals Inc | TETRA PEPTIDE ANALOGS |
| US7086126B2 (en) * | 2004-07-30 | 2006-08-08 | Speaks, Inc. | Elastic band with snap-buckles for holding garment waistband |
| FR2883003B1 (fr) * | 2005-03-14 | 2008-04-11 | Aldivia Sa | Nouveaux antioxydants a base d'especes d'anacardiacees, plus particulierement de sclerocarya birrea, leurs procedes d'obtention et leurs applications |
| DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
| AU2011253662A1 (en) | 2005-11-30 | 2011-12-22 | Massachusetts Institute Of Technology | Pathogen-detecting cell preservation systems |
| EP1804045B1 (de) | 2005-12-30 | 2014-03-12 | QIAGEN GmbH | Ein Verfahren und ein Kit zur Behandlung einer biologischen Probe |
| US20090029340A1 (en) | 2006-01-04 | 2009-01-29 | Do-Coop Technologies Ltd. | Cryoprotective Compositions and Methods of Using Same |
| JP5459823B2 (ja) | 2006-01-20 | 2014-04-02 | リニューロン インコーポレイテッド | 膵臓細胞培養における膵臓前駆細胞の細胞増殖促進方法 |
| US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| GB0626021D0 (en) | 2006-12-29 | 2007-02-07 | Insense Ltd | The stabilisation of proteins |
| US7828887B2 (en) | 2007-04-23 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Dye-based ink formulations |
| JP5311760B2 (ja) | 2007-05-25 | 2013-10-09 | 雪印メグミルク株式会社 | 美白剤 |
| DE102007025277A1 (de) * | 2007-05-31 | 2008-12-04 | Qiagen Gmbh | Verfahren zur Stabilisierung einer biologischen Probe |
| EP2027922A1 (de) | 2007-08-02 | 2009-02-25 | Qiagen GmbH | Verfahren und Vorrichtung für das Fixieren/Stabilisieren einer Probe |
| WO2009042728A1 (en) | 2007-09-24 | 2009-04-02 | Allelogic Biosciences Corporation | Detection and /or quantification of nucleic acids |
| RU2496482C2 (ru) * | 2008-03-05 | 2013-10-27 | Бакстер Интернэшнл Инк. | Композиции и способы для доставки лекарственных средств |
| WO2010065420A2 (en) | 2008-12-03 | 2010-06-10 | Integrated Nano-Technologies, Inc. | Universal biological sample processing |
| US11634747B2 (en) * | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| DE202010018569U1 (de) | 2009-02-18 | 2017-09-26 | Streck Inc. | Konservierung zellfreier Nukleinsäuren |
| US20100280233A1 (en) | 2009-05-04 | 2010-11-04 | Connolly Dennis M | Method for sample preparation |
| US20150056604A1 (en) | 2009-06-15 | 2015-02-26 | Biovec Transfusion, Llc | Compositions and methods for preserving platelet function |
| WO2011014741A1 (en) | 2009-07-31 | 2011-02-03 | Artemis Health, Inc. | Methods and compositions for cell stabilization |
| US8222397B2 (en) * | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US8039613B2 (en) * | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US8986609B2 (en) | 2009-10-29 | 2015-03-24 | Ascendis Pharma A/S | Sterilization of biodegradable hydrogels |
| HUE052213T2 (hu) | 2009-11-06 | 2021-04-28 | Univ Leland Stanford Junior | Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben |
| CA2780536C (en) | 2009-11-09 | 2018-01-02 | Streck, Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
| JP5773347B2 (ja) | 2009-11-27 | 2015-09-02 | 国立大学法人 千葉大学 | 血液細胞の凍結保存剤 |
| US8093427B2 (en) * | 2010-06-09 | 2012-01-10 | National Tsing Hua University | Construction and screening of solution-phase derived library of fenbufen and ethacrynic acid |
| US20130095473A1 (en) | 2010-06-14 | 2013-04-18 | Qiagen Gmbh | Method for determination of target cells or tissue for extraction of biomolecules from fixed biological samples |
| FR2964567B1 (fr) | 2010-09-14 | 2013-03-15 | Lvmh Rech | Extrait d'orchidee |
| EP3372230B1 (en) | 2011-05-03 | 2020-08-12 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| EP2761001B1 (en) | 2011-09-26 | 2018-08-01 | Qiagen GmbH | Rapid method for isolating extracellular nucleic acids |
| CN103827303B (zh) | 2011-09-26 | 2021-10-22 | 普瑞阿那利提克斯有限公司 | 细胞外核酸的稳定化和分离 |
| JP6329072B2 (ja) * | 2011-09-26 | 2018-05-23 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 細胞外核酸の安定化および単離 |
| EP2760999A1 (en) | 2011-09-26 | 2014-08-06 | Qiagen GmbH | Methods for separating nucleic acids by size |
| EP3663408B1 (en) | 2011-10-11 | 2024-05-01 | QIAGEN GmbH | Sample processing method and sample processing cartridge |
| TWI719277B (zh) | 2011-11-14 | 2021-02-21 | 美商安斯泰來再生醫藥協會 | 人類rpe細胞之醫藥組合物及其用途 |
| US9546358B2 (en) * | 2012-06-04 | 2017-01-17 | New England Biolabs, Inc. | Compositions and methods for reducing background DNA amplification |
| CN104755628B (zh) | 2012-09-25 | 2019-03-01 | 凯杰有限公司 | 生物样品的稳定化 |
| WO2014055936A1 (en) | 2012-10-04 | 2014-04-10 | Integenx Inc. | Preservation of biological materials in non-aqueous fluid media |
| GB201303666D0 (en) | 2013-03-01 | 2013-04-17 | Goldsborough Andrew S | Sample fixation and stabilisation |
| US11525155B2 (en) | 2013-03-18 | 2022-12-13 | Qiagen Gmbh | Stabilisation of biological samples |
| JP6407248B2 (ja) | 2013-03-18 | 2018-10-17 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| JP6664332B2 (ja) | 2014-03-18 | 2020-03-13 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| EP3698628A1 (en) | 2014-08-07 | 2020-08-26 | The General Hospital Corporation | Stabilization of whole blood samples |
-
2014
- 2014-03-18 JP JP2016503570A patent/JP6407248B2/ja active Active
- 2014-03-18 JP JP2016503572A patent/JP2016518827A/ja active Pending
- 2014-03-18 US US14/777,882 patent/US20160281133A1/en not_active Abandoned
- 2014-03-18 CN CN201480021291.0A patent/CN105121643A/zh active Pending
- 2014-03-18 EP EP14714932.2A patent/EP2976425B1/en active Active
- 2014-03-18 WO PCT/EP2014/000726 patent/WO2014146782A1/en not_active Ceased
- 2014-03-18 US US14/777,878 patent/US10144952B2/en active Active
- 2014-03-18 EP EP14714933.0A patent/EP2976426A1/en not_active Withdrawn
- 2014-03-18 CN CN201480021235.7A patent/CN105164258B/zh active Active
- 2014-03-18 WO PCT/EP2014/000724 patent/WO2014146780A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN105121643A (zh) | 2015-12-02 |
| JP2016520293A (ja) | 2016-07-14 |
| WO2014146782A1 (en) | 2014-09-25 |
| JP2016518827A (ja) | 2016-06-30 |
| EP2976426A1 (en) | 2016-01-27 |
| CN105164258A (zh) | 2015-12-16 |
| WO2014146780A1 (en) | 2014-09-25 |
| EP2976425A1 (en) | 2016-01-27 |
| US20160281133A1 (en) | 2016-09-29 |
| CN105164258B (zh) | 2021-05-18 |
| US20160281132A1 (en) | 2016-09-29 |
| EP2976425B1 (en) | 2019-11-06 |
| US10144952B2 (en) | 2018-12-04 |
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