JP6404244B2 - カルシウムで骨空洞形成を充填するための組成物、その組成物の使用、および組み合わせ - Google Patents
カルシウムで骨空洞形成を充填するための組成物、その組成物の使用、および組み合わせ Download PDFInfo
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- JP6404244B2 JP6404244B2 JP2016000336A JP2016000336A JP6404244B2 JP 6404244 B2 JP6404244 B2 JP 6404244B2 JP 2016000336 A JP2016000336 A JP 2016000336A JP 2016000336 A JP2016000336 A JP 2016000336A JP 6404244 B2 JP6404244 B2 JP 6404244B2
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- calcium
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- bone
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims description 29
- 239000011575 calcium Substances 0.000 title claims description 29
- 229910052791 calcium Inorganic materials 0.000 title claims description 29
- 210000000988 bone and bone Anatomy 0.000 title claims description 11
- 239000000203 mixture Substances 0.000 title claims description 10
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960005069 calcium Drugs 0.000 claims description 28
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- RWYRUDPAALLKPX-UHFFFAOYSA-N 2,2-difluoro-n-methylethanamine;hydrochloride Chemical compound Cl.CNCC(F)F RWYRUDPAALLKPX-UHFFFAOYSA-N 0.000 claims description 4
- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 claims description 4
- 239000001749 Calcium fumarate Substances 0.000 claims description 4
- 235000010376 calcium ascorbate Nutrition 0.000 claims description 4
- 229940047036 calcium ascorbate Drugs 0.000 claims description 4
- 239000011692 calcium ascorbate Substances 0.000 claims description 4
- 229940034055 calcium aspartate Drugs 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 229960003563 calcium carbonate Drugs 0.000 claims description 4
- 235000019296 calcium fumarate Nutrition 0.000 claims description 4
- 239000004227 calcium gluconate Substances 0.000 claims description 4
- 229960004494 calcium gluconate Drugs 0.000 claims description 4
- 235000013927 calcium gluconate Nutrition 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 4
- 235000011010 calcium phosphates Nutrition 0.000 claims description 4
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims description 4
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 4
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 210000001585 trabecular meshwork Anatomy 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 3
- 239000001354 calcium citrate Substances 0.000 claims description 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 206010006956 Calcium deficiency Diseases 0.000 description 3
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 241000257303 Hymenoptera Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- CPGKMLVTFNUAHL-UHFFFAOYSA-N [Ca].[Ca] Chemical compound [Ca].[Ca] CPGKMLVTFNUAHL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 230000018678 bone mineralization Effects 0.000 description 1
- 230000037118 bone strength Effects 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229960004256 calcium citrate Drugs 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Insects & Arthropods (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
Description
Claims (7)
- カルシウムによって骨粗しょう症と診断されていない患者における骨幹端(小柱網)骨切片における空洞を充填するための組成物であって、カルシウム含有製剤と雄蜂児とを含む、組成物。
- 請求項1に記載の組成物であって、前記カルシウム含有製剤が、炭酸カルシウム、グルコン酸カルシウム、アスパラギン酸カルシウム、アスコルビン酸カルシウム、アミノキレートカルシウム、フマル酸カルシウム、コハク酸カルシウム、リン酸カルシウム、およびクエン酸カルシウムからなる群から選択される少なくとも1つである、組成物。
- カルシウムによって骨粗しょう症と診断されていない患者における骨幹端(小柱網)骨切片における空洞を充填するための製剤の製造における、請求項1に記載の組成物の使用。
- 請求項3に記載の使用であって、前記カルシウム含有製剤が、炭酸カルシウム、グルコン酸カルシウム、アスパラギン酸カルシウム、アスコルビン酸カルシウム、アミノキレートカルシウム、フマル酸カルシウム、コハク酸カルシウム、リン酸カルシウム、およびクエン酸カルシウムからなる群から選択される少なくとも1つである、使用。
- カルシウムによって骨粗しょう症と診断されていない患者における骨幹端(小柱網)骨切片における空洞を充填するための、カルシウム含有製剤と雄蜂児とを含む、組み合わせ物。
- 請求項5に記載の組み合わせであって、前記雄蜂児が、粉末、錠剤、またはカプセル中に存在する型である、組み合わせ物。
- 請求項5または6に記載の組み合わせであって、前記カルシウム含有製剤が、炭酸カルシウム、グルコン酸カルシウム、アスパラギン酸カルシウム、アスコルビン酸カルシウム、アミノキレートカルシウム、フマル酸カルシウム、コハク酸カルシウム、リン酸カルシウム、およびクエン酸カルシウムからなる群から選択される少なくとも1つである、組み合わせ物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2011121932/15A RU2466732C1 (ru) | 2011-05-31 | 2011-05-31 | Способ заполнения полостных образований в метафизарных (трабекулярных) участках костей кальцием и предотвращения выведения из них кальция |
RU2011121932 | 2011-05-31 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014513475A Division JP5917687B2 (ja) | 2011-05-31 | 2012-01-31 | カルシウムで骨空洞形成を充填するための方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018109236A Division JP2018135398A (ja) | 2011-05-31 | 2018-06-07 | カルシウムで骨空洞形成を充填するための組成物、その組成物の使用、および組み合わせ |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016047856A JP2016047856A (ja) | 2016-04-07 |
JP6404244B2 true JP6404244B2 (ja) | 2018-10-10 |
Family
ID=47259596
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014513475A Active JP5917687B2 (ja) | 2011-05-31 | 2012-01-31 | カルシウムで骨空洞形成を充填するための方法 |
JP2016000336A Active JP6404244B2 (ja) | 2011-05-31 | 2016-01-05 | カルシウムで骨空洞形成を充填するための組成物、その組成物の使用、および組み合わせ |
JP2018109236A Pending JP2018135398A (ja) | 2011-05-31 | 2018-06-07 | カルシウムで骨空洞形成を充填するための組成物、その組成物の使用、および組み合わせ |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014513475A Active JP5917687B2 (ja) | 2011-05-31 | 2012-01-31 | カルシウムで骨空洞形成を充填するための方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018109236A Pending JP2018135398A (ja) | 2011-05-31 | 2018-06-07 | カルシウムで骨空洞形成を充填するための組成物、その組成物の使用、および組み合わせ |
Country Status (20)
Country | Link |
---|---|
US (1) | US20140106000A1 (ja) |
EP (1) | EP2740481B1 (ja) |
JP (3) | JP5917687B2 (ja) |
CN (3) | CN107252437A (ja) |
AU (2) | AU2012263018A1 (ja) |
CA (1) | CA2837697C (ja) |
DK (1) | DK2740481T3 (ja) |
EA (1) | EA024641B1 (ja) |
ES (1) | ES2690219T3 (ja) |
IL (2) | IL229551A (ja) |
IN (1) | IN2013MN02450A (ja) |
LT (1) | LT2740481T (ja) |
MX (1) | MX358040B (ja) |
PL (1) | PL2740481T3 (ja) |
PT (1) | PT2740481T (ja) |
RS (1) | RS57782B1 (ja) |
RU (1) | RU2466732C1 (ja) |
SI (1) | SI2740481T1 (ja) |
UA (1) | UA107638C2 (ja) |
WO (1) | WO2012166003A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2549461C2 (ru) * | 2013-01-11 | 2015-04-27 | Общество С Ограниченной Ответственностью "Парафарм" | Способ и препарат для лечения артритов и артрозов |
RU2564111C9 (ru) * | 2013-07-03 | 2016-03-20 | Общество С Ограниченной Ответственностью "Парафарм" | Применение адсорбированного гомогената трутневого расплода и витаминов группы d и/или их активных метаболитов для профилактики и лечения острых респираторных заболеваний и гриппа |
RU2664838C1 (ru) * | 2017-11-07 | 2018-08-23 | Наиля Зиафутдиновна Хисматуллина | Добавка пищевая комплексная и способ её применения |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO74872A2 (ro) * | 1980-01-21 | 1983-11-01 | Cooperativa Agricola De Productie,Ro | Procedeu pentru obtinerea unui produs apicol biologic activ |
US4772467A (en) * | 1985-02-19 | 1988-09-20 | Board Of Regents, U T Systems | Osteoporosis inhibition by dietary calcium supplementation |
CN1028200C (zh) * | 1988-09-07 | 1995-04-19 | 刘本华 | 雄蜂营养素的提取方法 |
CN1045276A (zh) * | 1989-03-02 | 1990-09-12 | 刘本华 | 雄蜂营养成分的提取工艺及其用途 |
US5731299A (en) * | 1992-05-29 | 1998-03-24 | The Procter & Gamble Company | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
RO119924B1 (ro) * | 2000-02-22 | 2005-06-30 | Ionuţ Moraru | Produs medicamentos natural, pentru tratamentul osteoporozei |
RU2233666C1 (ru) * | 2002-12-30 | 2004-08-10 | Пятигорская государственная фармацевтическая академия | Таблетки "апилар" на основе трутневого расплода, обладающие анаболическим, актопротекторным действием |
KR20050040660A (ko) * | 2003-10-29 | 2005-05-03 | 박인희 | 해조칼슘 깨벌꿀의 제조방법 |
CN1954695A (zh) * | 2005-10-27 | 2007-05-02 | 天津中英纳米科技发展有限公司 | 雄蜂制品及其生产方法 |
RU2338551C1 (ru) * | 2007-08-31 | 2008-11-20 | Римма Галиевна Сайфутдинова | Средство для профилактики остеопороза |
RU2412616C1 (ru) * | 2009-11-30 | 2011-02-27 | Общество С Ограниченной Ответственностью "Парафарм" | Биологически активная добавка к пище для профилактики заболеваний остеопорозом |
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2011
- 2011-05-31 RU RU2011121932/15A patent/RU2466732C1/ru active
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2012
- 2012-01-31 US US14/123,136 patent/US20140106000A1/en not_active Abandoned
- 2012-01-31 WO PCT/RU2012/000049 patent/WO2012166003A1/ru active Application Filing
- 2012-01-31 RS RS20181196A patent/RS57782B1/sr unknown
- 2012-01-31 DK DK12793897.5T patent/DK2740481T3/en active
- 2012-01-31 EP EP12793897.5A patent/EP2740481B1/en active Active
- 2012-01-31 CN CN201710358047.9A patent/CN107252437A/zh active Pending
- 2012-01-31 CA CA2837697A patent/CA2837697C/en active Active
- 2012-01-31 CN CN201710301127.0A patent/CN107252436A/zh active Pending
- 2012-01-31 ES ES12793897.5T patent/ES2690219T3/es active Active
- 2012-01-31 CN CN2012800032548A patent/CN103153319A/zh active Pending
- 2012-01-31 SI SI201231409T patent/SI2740481T1/sl unknown
- 2012-01-31 PT PT12793897T patent/PT2740481T/pt unknown
- 2012-01-31 PL PL12793897T patent/PL2740481T3/pl unknown
- 2012-01-31 EA EA201301348A patent/EA024641B1/ru unknown
- 2012-01-31 UA UAA201315284A patent/UA107638C2/ru unknown
- 2012-01-31 MX MX2013014097A patent/MX358040B/es active IP Right Grant
- 2012-01-31 JP JP2014513475A patent/JP5917687B2/ja active Active
- 2012-01-31 LT LTEP12793897.5T patent/LT2740481T/lt unknown
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