CN107252436A - 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 - Google Patents
使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 Download PDFInfo
- Publication number
- CN107252436A CN107252436A CN201710301127.0A CN201710301127A CN107252436A CN 107252436 A CN107252436 A CN 107252436A CN 201710301127 A CN201710301127 A CN 201710301127A CN 107252436 A CN107252436 A CN 107252436A
- Authority
- CN
- China
- Prior art keywords
- calcium
- area
- preparation
- drone
- organism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Insects & Arthropods (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本发明是使骨骼的干骺端区(小梁区)空腔钙饱和和防止钙流失的方法。所提供的方法在于向有机体联合输送雄蜂幼虫和钙。已有的方法不能保证达到有机体充分补钙的预期效果。
Description
本申请是申请日为2012年01月31日、申请号为201280003254.8、发明名称为“使干骺端区(小梁区)空腔充满钙和预防其钙流失的方法”的发明申请的分案申请。
本发明属于医学范畴，包括治疗有机体骨骼系统中缺钙和预防缺钙现象的方法，缺钙的表现形式是干骺端区(小梁区)空腔的数量增加、尺寸增大。
已有的针对有机体的缺钙问题的治疗和预防方法不能使骨组织中的钙达到饱和。为此采用各种含钙制剂，包括维他命D、激素类药物(例如睾酮)。
这些方法有很多重要弊端。一方面，虽然钙不是有毒物质，也没有规定其最大允许的吸收剂量，但长期大量吸收钙的结果可能增加中风的风险。在吸收补钙制剂时，钙可能不止进入到骨骼中，还进入到其他组织和系统中，包括在肾脏中钙化成结石，引发肾功能问题。
另一方面，还存在有机体中的维他命D超出安全数量的风险。从医学角度讲，某些情况下不适合或完全不允许使用激素类药物。女性(即使是健康的人)一般都不适合人为增加睾酮数量。还有一个同样重要的事实是，除了所有上述列出的副作用和禁忌之外，含钙制剂无论是单独使用还是与维他命和/或激素一起使用，可能只是使骨组织的矿化作用加强。干骺端区(小梁区)已有的和新形成的空腔仍然没有得到改变，或者其数量、大小可能还继续增加。这些空腔会使骨骼的强度降低，从而在各类负荷的情况下创伤的概率会增加。
尽管定期参加这方面的研究活动，本发明的申请人也不知道达到预期结果的方法。
已有的提高有机体骨组织中钙含量的方法能使骨骼的矿化作用增强，但不能填满空腔。
所提出的解决方法致力于减少并尽可能消除已形成的空腔，预防新空腔的形成。现通过雄蜂幼虫与钙结合进入有机体达到预期的结果。
正如试验结果所示，在有机体定期结合吸收雄蜂幼虫和钙的情况下可以保证达到预期效果。
图1为了更直观地理解该方法的使用范围、指出空腔在骨骼中的分布，而分别示出健康的骨骼和有骨质疏松症状的有机体的骨骼的示意图。
图2示出治疗开始前的X光研究结果。其中示出了骨骼顶部和低部的两个黑色空腔。
图3示出了一个疗程后的X光研究结果。空腔被填满并开始变蓝。
研究过程是使用《NORLAND》、《OSTEOMETR》DTX-100、200设备采用X射线吸收法对10000名病人进行治疗。
空腔中的钙主要是以由各种钙盐组成的矿物成分的形式存在的。
除了采用钙随普通食物一起进入到有机体中的方法，还可以服用其他含钙制剂，包括碳酸钙、柠檬酸钙、葡萄糖酸钙、天门冬氨酸钙、抗坏血酸钙、氨基酸螯合钙、富马酸钙、丁二酸钙、磷酸钙、柠檬酸钙–其中的任何一种或者任意组合服用。
在结果的试验证明过程中，给病人口服的是粉末状的、片状的或胶囊状的雄蜂幼虫–作为单一的活性剂服用或与含钙化合物共同服用。
根据有机体的独立特点、随食物吸收的钙的数量、空腔的数量和大小，要达到预期的结果有快有慢，但是在任何情况下都一定会有效果。实践证明，长期的，约9个月，服用的情况下100％的病人都有显著的效果。
Claims (11)
1.一种组合物用于制备使干骺端区骨空腔充满钙和预防其钙流失的药物的用途，所述组合物包括雄蜂幼虫和钙。
2.根据权利要求1的用途，其中所述雄蜂幼虫的制剂形态为粉末状、片状或胶囊状。
3.根据权利要求1的用途，其中所述雄蜂幼虫是与含钙的制剂一起服用的。
4.根据权利要求1的用途，其中所述钙是下列项的任何一种或任意组合：碳酸钙、柠檬酸钙、葡萄糖酸钙、天冬氨酸钙、抗坏血酸钙、氨基酸螯合钙、富马酸钙、丁二酸钙、磷酸钙、柠檬酸钙。
5.一种包括雄蜂幼虫和至少一种含钙制剂的组合用于制备用于填充干骺端区骨空腔的药物的用途。
6.根据权利要求5的用途，其中所述雄蜂幼虫的制剂形态为粉末状、片状或胶囊状。
7.根据权利要求5的用途，其中所述含钙制剂选自由下列项组成的组：碳酸钙、柠檬酸钙、葡萄糖酸钙、天冬氨酸钙、抗坏血酸钙、氨基酸螯合钙、富马酸钙、丁二酸钙、磷酸钙、柠檬酸钙。
8.使干骺端区(小梁区)空腔充满钙和预防其钙流失的方法，该方法是使有机体结合吸收雄蜂幼虫和钙。
9.根据权利要求8的方法，其中，通过有机体口服粉末状的、片状的、胶囊状的雄蜂幼虫。
10.根据权利要求1的方法，其中，雄蜂幼虫与含钙制剂一起进入有机体。
11.根据权利要求3的方法，其中，将下面制剂中的其中之一或其任意组合作为含钙制剂：碳酸钙、柠檬酸钙、葡萄糖酸钙、天门冬氨酸钙、抗坏血酸钙、氨基酸螯合钙、富马酸钙、丁二酸钙、磷酸钙、柠檬酸钙。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2011121932 | 2011-05-31 | ||
| RU2011121932/15A RU2466732C1 (ru) | 2011-05-31 | 2011-05-31 | Способ заполнения полостных образований в метафизарных (трабекулярных) участках костей кальцием и предотвращения выведения из них кальция |
| CN2012800032548A CN103153319A (zh) | 2011-05-31 | 2012-01-31 | 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012800032548A Division CN103153319A (zh) | 2011-05-31 | 2012-01-31 | 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107252436A true CN107252436A (zh) | 2017-10-17 |
Family
ID=47259596
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012800032548A Pending CN103153319A (zh) | 2011-05-31 | 2012-01-31 | 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 |
| CN201710358047.9A Pending CN107252437A (zh) | 2011-05-31 | 2012-01-31 | 用于使干骺端区或小梁区的骨空腔充满钙及预防其钙流失的产品 |
| CN201710301127.0A Pending CN107252436A (zh) | 2011-05-31 | 2012-01-31 | 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012800032548A Pending CN103153319A (zh) | 2011-05-31 | 2012-01-31 | 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 |
| CN201710358047.9A Pending CN107252437A (zh) | 2011-05-31 | 2012-01-31 | 用于使干骺端区或小梁区的骨空腔充满钙及预防其钙流失的产品 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20140106000A1 (zh) |
| EP (1) | EP2740481B1 (zh) |
| JP (3) | JP5917687B2 (zh) |
| CN (3) | CN103153319A (zh) |
| AU (2) | AU2012263018A1 (zh) |
| CA (1) | CA2837697C (zh) |
| DK (1) | DK2740481T3 (zh) |
| EA (1) | EA024641B1 (zh) |
| ES (1) | ES2690219T3 (zh) |
| IL (2) | IL229551A (zh) |
| IN (1) | IN2013MN02450A (zh) |
| LT (1) | LT2740481T (zh) |
| MX (1) | MX358040B (zh) |
| PL (1) | PL2740481T3 (zh) |
| PT (1) | PT2740481T (zh) |
| RS (1) | RS57782B1 (zh) |
| RU (1) | RU2466732C1 (zh) |
| SI (1) | SI2740481T1 (zh) |
| UA (1) | UA107638C2 (zh) |
| WO (1) | WO2012166003A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2549461C2 (ru) * | 2013-01-11 | 2015-04-27 | Общество С Ограниченной Ответственностью "Парафарм" | Способ и препарат для лечения артритов и артрозов |
| RU2564111C9 (ru) * | 2013-07-03 | 2016-03-20 | Общество С Ограниченной Ответственностью "Парафарм" | Применение адсорбированного гомогената трутневого расплода и витаминов группы d и/или их активных метаболитов для профилактики и лечения острых респираторных заболеваний и гриппа |
| RU2664838C1 (ru) * | 2017-11-07 | 2018-08-23 | Наиля Зиафутдиновна Хисматуллина | Добавка пищевая комплексная и способ её применения |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1954695A (zh) * | 2005-10-27 | 2007-05-02 | 天津中英纳米科技发展有限公司 | 雄蜂制品及其生产方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO74872A2 (ro) * | 1980-01-21 | 1983-11-01 | Cooperativa Agricola De Productie,Ro | Procedeu pentru obtinerea unui produs apicol biologic activ |
| US4772467A (en) * | 1985-02-19 | 1988-09-20 | Board Of Regents, U T Systems | Osteoporosis inhibition by dietary calcium supplementation |
| CN1028200C (zh) * | 1988-09-07 | 1995-04-19 | 刘本华 | 雄蜂营养素的提取方法 |
| CN1045276A (zh) * | 1989-03-02 | 1990-09-12 | 刘本华 | 雄蜂营养成分的提取工艺及其用途 |
| US5731299A (en) * | 1992-05-29 | 1998-03-24 | The Procter & Gamble Company | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| RO119924B1 (ro) * | 2000-02-22 | 2005-06-30 | Ionuţ Moraru | Produs medicamentos natural, pentru tratamentul osteoporozei |
| RU2233666C1 (ru) * | 2002-12-30 | 2004-08-10 | Пятигорская государственная фармацевтическая академия | Таблетки "апилар" на основе трутневого расплода, обладающие анаболическим, актопротекторным действием |
| KR20050040660A (ko) * | 2003-10-29 | 2005-05-03 | 박인희 | 해조칼슘 깨벌꿀의 제조방법 |
| RU2338551C1 (ru) * | 2007-08-31 | 2008-11-20 | Римма Галиевна Сайфутдинова | Средство для профилактики остеопороза |
| RU2412616C1 (ru) * | 2009-11-30 | 2011-02-27 | Общество С Ограниченной Ответственностью "Парафарм" | Биологически активная добавка к пище для профилактики заболеваний остеопорозом |
-
2011
- 2011-05-31 RU RU2011121932/15A patent/RU2466732C1/ru active
-
2012
- 2012-01-31 IN IN2450MUN2013 patent/IN2013MN02450A/en unknown
- 2012-01-31 WO PCT/RU2012/000049 patent/WO2012166003A1/ru active Application Filing
- 2012-01-31 JP JP2014513475A patent/JP5917687B2/ja active Active
- 2012-01-31 PT PT12793897T patent/PT2740481T/pt unknown
- 2012-01-31 SI SI201231409T patent/SI2740481T1/sl unknown
- 2012-01-31 UA UAA201315284A patent/UA107638C2/ru unknown
- 2012-01-31 RS RS20181196A patent/RS57782B1/sr unknown
- 2012-01-31 PL PL12793897T patent/PL2740481T3/pl unknown
- 2012-01-31 EP EP12793897.5A patent/EP2740481B1/en active Active
- 2012-01-31 ES ES12793897.5T patent/ES2690219T3/es active Active
- 2012-01-31 US US14/123,136 patent/US20140106000A1/en not_active Abandoned
- 2012-01-31 MX MX2013014097A patent/MX358040B/es active IP Right Grant
- 2012-01-31 CN CN2012800032548A patent/CN103153319A/zh active Pending
- 2012-01-31 LT LTEP12793897.5T patent/LT2740481T/lt unknown
- 2012-01-31 DK DK12793897.5T patent/DK2740481T3/en active
- 2012-01-31 AU AU2012263018A patent/AU2012263018A1/en not_active Abandoned
- 2012-01-31 EA EA201301348A patent/EA024641B1/ru unknown
- 2012-01-31 CN CN201710358047.9A patent/CN107252437A/zh active Pending
- 2012-01-31 CA CA2837697A patent/CA2837697C/en active Active
- 2012-01-31 CN CN201710301127.0A patent/CN107252436A/zh active Pending
-
2013
- 2013-11-21 IL IL229551A patent/IL229551A/en active IP Right Grant
-
2016
- 2016-01-05 JP JP2016000336A patent/JP6404244B2/ja active Active
-
2017
- 2017-06-02 AU AU2017203767A patent/AU2017203767B2/en not_active Ceased
- 2017-06-27 IL IL253198A patent/IL253198A/en active IP Right Grant
-
2018
- 2018-06-07 JP JP2018109236A patent/JP2018135398A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1954695A (zh) * | 2005-10-27 | 2007-05-02 | 天津中英纳米科技发展有限公司 | 雄蜂制品及其生产方法 |
Non-Patent Citations (1)
| Title |
|---|
| 李幸阳: "雄蜂幼虫(蛹)的特殊营养及利用价值", 《养蜂科技》 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107252436A (zh) | 使干骺端区（小梁区）空腔充满钙和预防其钙流失的方法 | |
| CN105288567A (zh) | 一种泡脚中药粉及其制备方法 | |
| CA2870823C (en) | A method for preventing and treating atypical osteoporosis with normal or increased bone tissue mineralizarion with the presence of cavities in trabecular sections of bone (and conditions similar thereto involving excess mass and metabolic syndrome) | |
| CN101152511A (zh) | 一种用于治疗甲亢病的药物及制备方法 | |
| CN112546183A (zh) | 艾脐红豆保健贴 | |
| CN107951764A (zh) | 一种具有预防口腔溃疡和修复口腔黏膜功效的中药牙膏 | |
| CN1087619C (zh) | 抗骨松片 | |
| CN108704095A (zh) | 一种用于治疗肾虚的药酒的制备方法 | |
| US20200254009A1 (en) | Potassium enriched topical formulations for pain relief and sleep aid | |
| CN105943920A (zh) | 一种预防缓解碘造影剂副作用的中药制剂 | |
| CN105853997A (zh) | 一种用于治疗骨软化症的药物组合 | |
| CN106852987A (zh) | 一种治疗老寒腿的中药配方 | |
| CN104958322A (zh) | 一种治疗咽喉炎的喷雾试剂及其制备方法 | |
| CN102178719A (zh) | 一种补钙胶囊及其制作工艺 | |
| CN105213865A (zh) | 一种治疗冠心病的中药组合物 | |
| CN103239560B (zh) | 用于护肝保肝的组合物及其药贴和药油 | |
| CN108704117A (zh) | 治疗骨质增生的复方中药浸泡剂及其制备方法 | |
| FI119101B (fi) | Magnesiumsuoloja sisältävä hoitoaine kasvainten tai vastaavien hoitoon ja magnesiumsulfaatin käyttö | |
| CN103239584B (zh) | 一种治疗腰椎间盘突出和腰椎骨质增生的中药 | |
| NZ619215B2 (en) | Method for filling bone cavities with calcium | |
| CN107929442A (zh) | 一种治疗糖尿病足溃疡的药粉及其制备方法 | |
| CN101313921A (zh) | 中老年用龟板钙胶囊 | |
| CN107536951A (zh) | 一种接骨散 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171017 |
|
| RJ01 | Rejection of invention patent application after publication |