JP6393682B2 - 併用療法ｉｉｉ - Google Patents
併用療法ｉｉｉ Download PDFInfo
- Publication number
- JP6393682B2 JP6393682B2 JP2015521033A JP2015521033A JP6393682B2 JP 6393682 B2 JP6393682 B2 JP 6393682B2 JP 2015521033 A JP2015521033 A JP 2015521033A JP 2015521033 A JP2015521033 A JP 2015521033A JP 6393682 B2 JP6393682 B2 JP 6393682B2
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- Prior art keywords
- hdac4
- pharmaceutical composition
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- gene silencing
- silencing agent
- Prior art date
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- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
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- C12Y—ENZYMES
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- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01098—Histone deacetylase (3.5.1.98), i.e. sirtuin deacetylase
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- Neurology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| FI20125795 | 2012-07-13 | ||
| FI20125795 | 2012-07-13 | ||
| PCT/FI2013/050745 WO2014009609A1 (en) | 2012-07-13 | 2013-07-11 | Combination therapy iii |
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| JP2015527316A JP2015527316A (ja) | 2015-09-17 |
| JP2015527316A5 JP2015527316A5 (enExample) | 2016-09-01 |
| JP6393682B2 true JP6393682B2 (ja) | 2018-09-19 |
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| JP (1) | JP6393682B2 (enExample) |
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| CN106344923B (zh) * | 2016-09-23 | 2019-09-27 | 中国人民解放军第二军医大学第二附属医院 | 组蛋白去乙酰化酶-4抑制剂在制备治疗多发性骨髓瘤疾病药物中的应用 |
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
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| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| CN1646558B (zh) * | 2002-02-20 | 2010-05-12 | 国立大学法人九州工业大学 | 组蛋白脱乙酰酶抑制剂 |
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| CA2533861A1 (en) | 2003-08-08 | 2005-02-17 | Novartis Ag | Combinations comprising staurosporines |
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| US20080021198A1 (en) | 2005-10-12 | 2008-01-24 | Yigong Shi | Modulators of protein phosphatase 2A and PP2A methyl esterase |
| CN101400362B (zh) * | 2006-02-14 | 2016-10-12 | 哈佛大学校长及研究员协会 | 双官能组蛋白去乙酰化酶抑制剂 |
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| MX2010003417A (es) * | 2007-10-01 | 2010-09-10 | Lixte Biotechnology Inc | Inhibidores de histona desacetilasa. |
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| CA2878873C (en) | 2018-08-21 |
| US10166241B2 (en) | 2019-01-01 |
| US20150209369A1 (en) | 2015-07-30 |
| JP2015527316A (ja) | 2015-09-17 |
| CN104619845A (zh) | 2015-05-13 |
| EP2872631B1 (en) | 2017-05-03 |
| ES2627500T3 (es) | 2017-07-28 |
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| WO2014009609A1 (en) | 2014-01-16 |
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