JP6392890B2 - カチオン性活性成分を含む抗菌組成物 - Google Patents
カチオン性活性成分を含む抗菌組成物 Download PDFInfo
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- JP6392890B2 JP6392890B2 JP2016558710A JP2016558710A JP6392890B2 JP 6392890 B2 JP6392890 B2 JP 6392890B2 JP 2016558710 A JP2016558710 A JP 2016558710A JP 2016558710 A JP2016558710 A JP 2016558710A JP 6392890 B2 JP6392890 B2 JP 6392890B2
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- FZGFBJMPSHGTRQ-UHFFFAOYSA-M trimethyl(2-prop-2-enoyloxyethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCOC(=O)C=C FZGFBJMPSHGTRQ-UHFFFAOYSA-M 0.000 description 1
- SCRSFLUHMDMRFP-UHFFFAOYSA-N trimethyl-(methyl-octyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C SCRSFLUHMDMRFP-UHFFFAOYSA-N 0.000 description 1
- OEIXGLMQZVLOQX-UHFFFAOYSA-N trimethyl-[3-(prop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCNC(=O)C=C OEIXGLMQZVLOQX-UHFFFAOYSA-N 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- 229940113164 trimyristin Drugs 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000010508 watermelon seed oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- PHXATPHONSXBIL-UHFFFAOYSA-N xi-gamma-Undecalactone Chemical compound CCCCCCCC1CCC(=O)O1 PHXATPHONSXBIL-UHFFFAOYSA-N 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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Description
(a)約0.1質量%〜約10.0質量%のカチオン性活物質と;
(b)約0.1質量%〜約20質量%の泡促進性界面活性剤と;
(c)約0.5質量%〜約25質量%の皮膚補助剤と
(d)約0.05質量%〜約12.0質量%の泡促進性ポリマーと;
(e)約0.1質量%〜約10質量%の泡安定剤と;
(f)キレート剤が5.5より大きい安定度定数(対数形で表す)を有するカルシウム−キレート剤錯体を形成するような、約0.1質量%〜約6.0質量%のキレート剤と;
(g)水又は他の適切な希釈剤とを含み、
組成物は、トリクロサン、アニオン性界面活性剤、及びC1〜C4アルコールを本質的に含まない。
本発明は、迅速な殺抗菌効果及び高発泡性を示す抗菌組成物に関する。抗菌組成物は、カチオン性活性成分と、アニオン性界面活性剤、非イオン性界面活性剤、両性界面活性剤、又はカチオン性界面活性剤を包含してもよい泡促進性界面活性剤と、水とを含む。本抗菌組成物は、抗菌剤トリクロサン(すなわち、2,4,4’−トリクロロ−2’ヒドロキシ−ジフェニルエーテル)、アニオン性界面活性剤、及びC1〜C4アルコールを含まず、迅速な殺効果を有し、安定で大量の泡を提供し、皮膚適合性及び皮膚の健康を増大させる成分を任意に含んでもよい。
(a)約0.1質量%〜約10.0質量%のカチオン性活物質と;
(b)約0.1質量%〜約20質量%の泡促進性界面活性剤と;
(c)約0.5質量%〜約25質量%の皮膚補助剤と;
(d)水又は他の適切な希釈剤とを含む。
カチオン性活物質は、哺乳類の皮膚組織上の微生物個体群を減少させるための本発明の抗菌組成物中に、組成物の質量で約0.1質量%〜約10.0質量%、好ましくは約0.1質量%〜約5.0質量%の量で存在する。
カチオン性成分又はカチオン的に活性な成分は、正味の正電荷を有する窒素中心カチオン種部分に基づく物質である。カチオン性成分又はカチオン的に活性な成分は、カチオン性ポリマー、カチオン性界面活性剤、カチオン性モノマー、カチオン性シリコン化合物、カチオン性誘導体化タンパク質加水分解物、及び少なくとも一つのカチオン性基又はカチオン的に活性な基を有するベタインからなる群から好ましくは選択される。
N(+)R1R2R3R4X(−)
哺乳類の皮膚組織上の微生物個体群を減少させるための本発明の抗菌組成物は、抗菌剤、及び四級化糖に由来する界面活性剤に加えて、一つ又は複数の泡促進性界面活性剤もまた含む。一つ又は複数の泡促進性界面活性剤は、組成物に約0.1質量%〜約40.0質量%、好ましくは約1質量%〜約25質量%の量で存在する。
非イオン性泡促進性共界面活性剤の例としては、限定されないが、アルキルアミンオキシド、アルキルエーテルアミンオキシド、アルキルアルコールアルコキシレート、アリールアルコールアルコキシレート、置換アルコールアルコキシレート、ブロック非イオン性コポリマー、ヘテリック非イオン性コポリマー、アルカノールアミド、置換アミド、又はポリエトキシル化グリセロール誘導体が挙げられる。
抗菌組成物は、洗浄量の両性界面活性剤又は両性界面活性剤の混合物を含む両性界面活性剤成分を含むことができる。使用することができる適切な両性界面活性剤としては、限定されないが、イミダゾリン及びイミダゾリン誘導体、イセチオネート、ベタイン誘導体、アンホアセテート誘導体、プロピオネート、及びこれらの混合物が挙げられる。
抗菌組成物は、洗浄量のカチオン性界面活性剤又はカチオン性界面活性剤の混合物を含むカチオン性界面活性剤成分を含んでもよい。抗菌組成物中に用いることができるカチオン性界面活性剤としては、限定されないが、四級化糖に由来する界面活性剤、四級化多糖類、アルキル多糖類、アルコキシル化アミン、アルコキシル化エーテルアミン、リン脂質、リン脂質誘導体、及びこれらの混合物が挙げられる。四級化糖に由来する界面活性剤が特に好ましい。四級化糖界面活性剤は、組成物中に約0.1質量%〜約18質量%、好ましくは約0.25質量%〜約12.5質量%の量で存在してもよい。
組成物は、約1質量%〜約30質量%の皮膚補助剤、好ましくは約5質量%〜約25質量%の皮膚補助剤を含むことができる。皮膚補助剤/スキンケア活性成分は、皮膚バリアの健康を増大又は維持する任意の物質を一般に含む。いくつかの例としては、限定されないが、皮膚軟化剤、及び皮膚保湿剤/保護剤が挙げられる。
組成物は、ポリマー、例えばジメチルシロキサンである皮膚軟化剤を含むことができる。上記の例としては、限定されないが、炭酸ジカプリリル、アジピン酸ジブチル、ラウリン酸へキシル、ジカプリリルエーテル、カプリル酸プロピルヘプチル、4〜10センチストークシリコーンオイル、4、5、又は6員環の環状シロキサン、パルミチン酸イソセチル、水素化ポリイソブテン、及び炭酸ジエチルヘキシルが挙げられる。
組成物は、少なくとも一つの更なる皮膚調整剤、例えばビタミン、湿潤剤、閉鎖剤、又は他の保湿剤を含んで、皮膚加湿、皮膚軟化、皮膚バリア維持、抗刺激性、若しくは他の皮膚の健康上の利益を提供することができる。更なる皮膚調整剤のいくつかの非限定的な例としては、アルキルベンゾエート、ミリスチン酸ミリスチル、ミリスチン酸セチル、ゼラチン、カルボン酸、乳酸、ジオレイン酸グリセリル、ラウリン酸メチル、PPG−9ラウレート、アクリル酸ラウリルアラントイン、パルミチン酸オクチル、ラノリン、プロピレングリコール、ブチレングリコール、エチレングリコール、カプリリルグリコール、モノブチルエーテル、グリセリン、脂肪酸、プロリン、天然オイル、例えばアーモンド、ミネラル、カノーラ、ゴマ、大豆、ピロリジン、小麦麦芽、加水分解した小麦タンパク質、加水分解したオート麦タンパク質、加水分解したコラーゲン、コーン、ピーナッツ、及びオリーブオイル、ミリスチル酸イソプロピル、ミリスチルアルコール、アロエベラ、藻類抽出物、グルコン酸、加水分解したシルクプロテイン、1,3−プロパンジオール、ビタミンE、ニコチンアミド、ステアリルアルコール、パルミチン酸イソプロピル、ソルビトール、アミノ酸錯体、パンテノール、アラントイン、ジヒドロキシプロピルトリモニウムクロリド、四級化加水分解タンパク質、例えばコラーゲン、オート麦、小麦など…、イノシトール、フルクトース、スクロース、加水分解した植物タンパク質、海草抽出物、ポリエチレングリコール、乳酸アンモニウム、ヒアルロン酸ナトリウム、及び環状ペプチドが挙げられる。
本発明の組成物は、新規な泡促進性ポリマーを含む。泡促進性ポリマーは、約0.05質量%〜約18質量%、好ましくは約0.1〜約10質量%の量で存在する。
(i)一つ又は複数のカチオン性エチレン性不飽和モノマーに由来する第一の構造単位と;
(ii)一つ又は複数の水溶性モノマーに由来する第二の構造単位と
の重合から得られる疎水性変性カチオン性ポリマーが挙げられる。
第一の構造単位は、水溶性カチオン性エチレン性不飽和モノマーである。第一の構造単位は、式(I)で表される、カウンターイオンとしてハロゲン化物、硫酸水素、又はメソ硫酸を有する、ジアルキルジアリルアンモニウムであることができる:
・R1及びR2は、互いに独立して、水素、又はC1〜C4アルキルであり;
・R3及びR4は、互いに独立して、水素、1〜18個の炭素原子を有する、アルキル、ヒドロキシアルキル、カルボキシルアルキル、カルボキシアミドアルキル、又はアルコキシアルキル基であり;
・Y−は、塩化物、臭化物、ヨウ素、又は硫酸水素、又はメソ硫酸からなる群から選択されるカウンターイオンである。
・R1は、H又はC1〜C4アルキルであり;
・R2は、H又はメチルであり;
・R3は、C1〜C4アルキレンであり;
・R4、R5、及びR6は、それぞれ独立して、H又はC1〜C30アルキルであり;
・Xは、−O−又は−NH−であり;
・Yは、Cl;Br;I;硫酸水素又はメソ硫酸である。
・R1及びR2がそれぞれHであるか、又は
・R1はHであり、R2はCH3若しくはHであることが好ましい。
第二の構造単位は、アシルアミド又はメタクリルアミドである。
組成物は、短鎖アルコール以外の有機溶媒を含み、典型的に水及び油の両方に可溶性の、泡可溶化剤を含む。本発明における泡可溶化剤の例としては:ポリオール、例えばグリセロール(グリセリン)、プロピレングリコール、ヘキシレングリコール、ジエチレングリコール、プロピレングリコール n−アルカノール、テルペン、ジテルペン、トリテルペン、テルペノール(terpen-ols)、リモネン、テルペノール(terpene-ol)、l−メントール、ジオキソラン、エチレングリコール、他のグリコール、スルホキシド、例えばジメチルスルホキシド(DMSO)、ジメチルホルムアミド、メチルドデシルスルホキシド、ジメチルアセトアミド;エトキシル化グリセリド(8〜10個のエチレンオキシド単位を有する)のモノオレエート;アゾン(1−ドデシルアザシクロヘプタン−2−オン)、2−(n−ノニル)−1,3−ジオキソラン;エステル、例えばミリスチル酸/パルミチン酸イソプロピル、酢酸エチル、酢酸ブチル、プロピオン酸メチル、カプリン酸/カプリル酸トリグリセリド、ミリスチル酸オクチル、ミリスチン酸ドデシル;ミリスチルアルコール、ラウリルアルコール、ラウリン酸、ラウリルラクタートケトン;アミド、例えばオレイン酸アセトアミド、例えばトリオレイン;様々なアルカノン酸、例えばカプリル酸;ラクタム化合物、例えばアゾン;アルカノール、例えばジアルキルアミノアセテート、及びこれらの混合物が挙げられる。1つの好ましい実施形態によれば、泡可溶化剤は、ヘキシレングリコールである。
組成物は、一般に、キレート剤を含む濃縮物又は即使用可能な組成物である。一般に、キレート剤は、一般に水源中に見つかる金属イオンに配位(すなわち結合)して、金属イオンが他の成分の作用を妨げることを防止することができる分子である。キレート剤の例としては、ホスホン酸、及びホスホネート、ホスフェート、アミノカルボキシレート、及びこれらの誘導体、ピロホスフェート、エチレンジアミン、及びエチレントリアミン誘導体、ヒドロキシ酸、及びモノ−、ジ−、及びトリ−カルボキシレート、及びこれらの対応する酸が挙げられる。特定の実施形態において、組成物はホスフェートを含まない。好ましいキレート剤は、約5.5以上で安定化定数(対数の形で表す)を有するカルシウム−キレート剤錯体を形成する。カルシウム−キレート剤安定化定数(K)は、水溶液中のカルシウムイオン(Ca)とキレート剤(L)との反応によって形成されるカルシウム−キレート剤錯体(CaL)の安定性の測定である。
Kはカルシウム−キレート剤錯体の安定化定数であり、
[CaL]はカルシウム−キレート剤錯体の濃度(mol/L)であり、
[Ca]はカルシウムイオンの濃度(mol/L)であり、
[L]はキレート剤の濃度(mol/L)である。
本抗菌組成物のキャリアは、水、プロピレングリコール、グリセロール、アルコール、又はこれらの混合物を含む。水は、脱イオン水として、又は軟水として提供してもよいことを理解すべきである。組成物の一部として提供される水は、比較的硬度を有しないことができる。水は、溶解した固体の一部を除去するよう脱イオン化することができると考えられる。すなわち、濃縮物は、溶解した固体を含む水を用いて処方することができ、また、硬水として特徴づけることができる水を用いて処方することができる。
抗菌物質組成物は、更なる成分又は剤、例えば更なる機能性材料を含むことができる。このように、いくつかの実施形態において、カチオン性活性成分、及び四級化糖に由来する界面活性剤を含む抗菌組成物は、例えば、その中に処方される更なる機能性材料をほとんど又は全く有しない実施形態では、抗菌組成物の合計質量の大部分又は全てさえ提供してもよい。機能性材料は、抗菌物質組成物に所望の特性及び機能性を提供する。本出願において、用語「機能性材料」は、使用溶液又は濃縮溶液、例えば水溶液中に分散又は溶解した際に、特定の用途において有益な特性を提供する材料を含む。カチオン性活性成分、及び四級化糖に由来する界面活性剤を含む抗菌組成物は、更なる界面活性剤、pH調整化合物、防腐剤、酸化防止剤、香料、染料、他の防感染剤、殺菌剤、増粘剤又はゲル化剤、又はこれらの混合物を任意に含んでもよい。機能性材料のいくつかの特定の例を以下更に詳細に記載するが、しかしながら、当業者等であれば、記載される特定の材料は単に例として与えられ、広いさまざまな他の機能性材料を使用してもよいことが理解されよう。例えば、以下に述べる機能性材料は、消毒及び/又は洗浄用途に使用する材料に関することがあるが、しかしながら、他の実施形態は、他の用途に使用するための機能性材料を含んでもよいことを理解すべきである。
組成物は、任意に防腐剤を含んでもよい。一般に、防腐剤は、フェノール化合物、ハロゲン化合物、第四級アンモニウム化合物、金属誘導体、アミン、アルカノールアミン、ニトロ誘導体、ビグアニド、アニリド、有機硫黄、及び硫黄−窒素化合物、アルキルパラベンなどの化合物を含む特定の分類に含まれる。フェノール抗菌剤のいくつかの非限定的な例としては、ペンタクロロフェノール、オルトフェニルフェノール、クロロキシレノール、p−クロロ−m−クレゾール、p−クロロフェノール、クロロチモール、m−クレゾール、o−クレゾール、p−クレゾール、イソプロピルクレゾール、混合クレゾール、フェノキシエタノール、フェノキシエチルパラベン、フェノキシイソプロパノール、フェニルパラベン、レゾルシノール、及びこれらの誘導体が挙げられる。ハロゲン化合物のいくつかの非限定的な例としては、トリクロロヒドロキシジフェニルエーテル(トリクロサン)、トリクロロイソシアン酸ナトリウム、ジクロロイソシアヌル酸ナトリウム、ヨード−ポリ(ビニルピロリジノネン)錯体、及び臭素化合物、例えば2−ブロモ−2−ニトロプロパン−1,3−ジオール、及びこれらの誘導体が挙げられる。第四級アンモニウム化合物のいくつかの非限定的な例としては、塩化ベンザルコニウム、塩化ベンゼトニウム、塩化ベヘントリモニウム、塩化セトリモニウム、及びこれらの誘導体が挙げられる。アミン及びニトロ含有化合物のいくつかの非限定的な例としては、ヘキサヒドロ−1,3,5−トリス(2−ヒドロキシエチル)−s−トリアジン、ジチオカルバメート、例えばジメチルジチオカルバミン酸ナトリウム、及びこれらの誘導体が挙げられる。ビグアニドのいくつかの非限定的な例としては、ポリアミノプロピルビグアニド、及びクロルヘキシジングルコネートが挙げられる。アルキルパラベンのいくつかの非限定的な例としては、メチル、エチル、プロピル、及びブチルパラベンが挙げられる。
組成物は、任意に増粘剤を含んでもよい。例示的な増粘剤としては、(1)セルロース増粘剤及びそれらの誘導体、(2)天然ゴム、(3)澱粉、(4)ステアリン酸、及び(5)脂肪酸アルコール、(6)アクリル酸ポリマー、及びクロスポリマー(例えば「カーボマー(carbomer)」)、(7)Aristoflex AVC(一般的なカテゴリー名が必要)。セルロース増粘剤のいくつかの非限定的な例としては、カルボキシメチルヒドロキシエチルセルロース、セルロース、ヒドロキシブチルメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、メチルセルロース、微結晶性セルロース、セルロース硫酸ナトリウム等が挙げられる。天然ゴムのいくつかの非限定的な例としては、アカシア、カルシウムカラギーナン、グアー、ゼラチン、グアーゴム、ヒドロキシプロピルグアー、カラヤゴム、ケルプ、ローカストビーンゴム、ペクチン、ナトリウムカラギーナン、トラガカントゴム、キサンタンゴム等が挙げられる。澱粉のいくつかの非限定的な例としては、オート麦粉、ジャガイモ澱粉、小麦粉、小麦澱粉等が挙げられる。ステアリン酸のいくつかの非限定的な例としては、PEG−150ジステアリン酸、メトキシPEG−22/ドデシルグリコールコポリマー等が挙げられる。脂肪酸アルコールのいくつかの非限定的な例としては、カプリルアルコール、セテアリルアルコール、ラウリルアルコール、オレイルアルコール、パーム核アルコール等が挙げられる。
組成物は、更なる界面活性剤又は界面活性剤の組合せを任意に含んでもよい。これらは、水溶性若しくは水分散性の、非イオン性、半極性非イオン性、カチオン性、両性、若しくは界面活性剤;又はこれらのあらゆる組み合わせから選択することができる。本発明の方法及び製品に用いるために選択される特定の界面活性剤又は界面活性剤の混合物は、製造方法、物理的な製品形状、使用pH等を含む最終的な用途の条件に依存する可能性がある。組成物は、アニオン性又は両性界面活性剤を実質的に含まない。
本発明の殺菌剤組成物のpHは約4.0〜約8である。この範囲のpHで、本組成物は効果的に微生物個体群を減少させ、また、消費者が許容できる、すなわち皮膚に穏和で、相安定性で、大量で安定な泡を生成する。いくつかの例において、pH調整化合物は、組成物の所望のpHを提供する程度に十分な量が必要であることがある。本発明の全ての利点を達成するために、pH調整化合物は、約0.05質量%〜約3.5質量%の量で存在する。
組成物は、フリーラジカルの除去をとおして皮膚疾患を改善するため、及び製品安定性を改善するために、酸化防止剤を任意に含んでもよい。酸化防止剤のいくつかの非限定的な例としては、レチノール及びレチノール誘導体、アスコルビン酸及びアスコルビン酸誘導体、BHA、BHT、βカロチン、システイン、エリソルビン酸、ヒドロキノン、トコフェロール及びトコフェロール誘導体等が挙げられる。
組成物は、任意に香料を含んでもよい。可能性がある香料の例としては、限定されないが、天然オイル、又は天然に由来する材料、並びに合成香料、例えば炭化水素、アルコール、アルデヒド、ケトン、エステル、ラクトン、エーテル、ニトリル、及び多官能物質が挙げられる。天然オイルの非限定的な例としては:バジル(Ocimum basilicum)オイル、ベイ(Pimento acris)オイル、ビーバーム(Monarda didyma)オイル、ベルガモット(Citrus aurantium bergamia)オイル、カルダモン(Elettaria cardamomum)オイル、シーダーウッド(Cedrus atlantica)オイル、カモミール(Anthemis nobilis)オイル、シナモン(Cinnamomum cassia)オイル、シトロネラ(Cymbopogon nardus)オイル、クラリー(Salvia sclarea)オイル、クローブ(Eugenia caryophyllus)オイル、クローブリーフ(Eufenia caryophyllus)オイル、ショクヨウガヤツリオイル、イトスギ(Cupressus sempervirens)オイル、ユーカリシトリオドラオイル、ゲラニウムマクラツムオイル、ショウガ(Zingiber officinale)オイル、グレープフルーツ(Citrus grandis)オイル、ヘーゼル(Corylus avellana)ナッツオイル、ジャスミン(Jasminum officinale)オイル、セイヨウネズオイル、ケードネズタール、エンピツビャクシンオイル、キーウィ(Actinidia chinensis)ウォーター、ラバンディン(Lavandula hybrida)オイル、ラベンダー(Lavandula angustifolia)オイル、ラベンダー(Lavandula angustifolia)ウォーター、レモン(Citrus medica limonum)オイル、レモングラス(Cymbopogon schoenanthus)オイル、ライム(Citrus aurantifolia)オイル、リンデン(Tilia cordata)オイル、リンデン(Tilia cordata)ウォーター、マンダリンオレンジ(Citrus nobilis)オイル、ナツメグ(Myristica fragrans)オイル、オレンジ(Citrus aurantium dulcis)花精油、橙色(Citrus aurantium dulcis)オイル、オレンジ(Citrus aurantium dulcis)ウォーター、パチョリ(Pogostemon cablin)オイル、ペパーミント(Menthe piperita)オイル、ペパーミント(Menthe peperita)ウォーター、ローズマリー(Rosmarinus officinalis)オイル、薔薇油、薔薇(Rosa damascena)抽出物、薔薇(Rosa multiflora)抽出物、ローズウッド(Aniba rosaeodora)抽出物、セージ(Salvia officinalis)オイル、ビャクダン(Santalum album)オイル、スペアミント(Menthe viridis)オイル、ティーツリー(Melaleuca alternifolia)オイル、及びイランイラン(Cananga odorata)オイルが挙げられる。合成炭化水素香料のいくつかの非限定的な例としては、カリオフィレン、β−ファルネセン、リモネン、α−ピネン、及びβ−ピネンが挙げられる。合成アルコール香料のいくつかの非限定的な例としては、バクダノール(bacdanol)、シトロネロール、リナロール、フェネチルアルコール、及びα−テルピネオール(R=H)が挙げられる。合成アルデヒド香料のいくつかの非限定的な例としては、2−メチルウンデカナール、シトラール、ヘキシルシンナムアルデヒド、イソシクロシトラール、リリアール、及び10−ウンデカナールが挙げられる。合成ケトン香料のいくつかの非限定的な例としては、カシュメラン、α−イオノン、イソシクレモンE、コアボン、ムスコン、及びトナリドが挙げられる。合成エステル香料のいくつかの非限定的な例としては、ベンジルアセテート、4−t−ブチルシクロヘキシルアセテート(シス及びトランス)、酢酸セドリル、シクラセット、酢酸イソボニル、及びα−酢酸テルピニル(R=アセチル)が挙げられる。合成ラクトン香料のいくつかの非限定的な例としては、クマリン、ジャスミンラクトン、ムスカラクトン、及びピーチアルデヒドが挙げられる。合成のエーテル香料のいくつかの非限定的な例は、アンブロキサン、アンテラ(anther)、及びガラクソリドが挙げられる。合成のニトリル香料のいくつかの非限定的な例は、シンナモニトリル、及びゲルノニトリル(gernonitrile)を含む。最後に、合成多官能香料のいくつかの非限定的な例としては、サリチル酸アミル、イソオイゲノール、ヘジオン、ヘリオトロピン、ライラル(lyral)、及びバニリンが挙げられる。
組成物は、任意に染料を含んでもよい。染料の例としては、あらゆる水溶性又は製品可溶性染料、FD&C又はD&Cが承認したあらゆる染料が挙げられる。
本発明の組成物は、多くの公知技術のいずれかによって容易に製造される。便宜には、水の一部を適切な混合容器に供給し、攪拌機又はアジテーターを更に提供し、撹拌しながら、100質量%の本発明の組成物を提供するのに必要な任意の最終的な量の水を含む残りの成分を混合容器に加える。
本発明は、皮膚上の微生物数を減少させる組成物及び方法、皮膚の病気を処理する方法などを含む。これらの組成物及び方法は、本発明の組成物を身体に接触させることによって行うことができる。接触としては、本発明の組成物を適用するための多くの方法、例えば組成物を吹き付けること、浸漬すること、皮膚を組成物で処理する泡若しくはゲル、又はこれらの組み合わせを挙げることができる。組成物及び方法は、水若しくは他の適切な希釈剤で更に希釈することなく用いてもよく、又は濃縮組成物として供給してもよい。濃縮組成物は、包装する前に希釈してもよく、又は使用前/使用時に希釈してもよい。濃縮組成物は、約1:1〜約1:10の濃縮物:希釈剤の比率で希釈してもよい。より好ましくは、濃縮組成物は、約1:3〜約1:8の濃縮物:希釈剤の比率で希釈してもよい。濃縮組成物は、手動で、又は自動分配及び/若しくは希釈設備を通して、希釈してもよい。
本発明の抗菌組成物は、高く広範囲な抗菌効果、高発泡性、及び哺乳類の組織に対する低減された刺激性を有する。例示的な組成物を以下の表に提供する。
(a)タイムキル(Time Kill)効果の決定:抗菌組成物の活性はタイムキル法(ASTM E 2315 Standard Guide for Assessment of Antimicrobial Activity Using a Time Kill Procedure)で測定し、抗菌性試験組成物に暴露した被検微生物の残存を時間の関数として決定した。この試験では、組成物の希釈した分割量を既知数の試験細菌に特定の温度で特定の時間接触させた。時間の終わりに試験組成物を中和し、組成物の抗菌活性を抑えた。元の細菌数からのパーセント、又は代替的に指数減少値を算出した。一般に、タイムキル法は当業者に知られている。更に、代表的な系の泡プロファイルに関する比較データを示す。
指数減少値は、下式を使用して算出される:
指数減少値=log10(対照数)−log10(試験サンプル生存数)
泡高さは、以下の手順によって決定した:
1. 5グレインの水中に製品1%の溶液を準備する。
2. 溶液150mLをブレンダーへ注ぐ。
3. 中速で10秒間混合する。
4. 1000mLビーカーに注ぎ、泡高さを測定する。
5. 3分及び5分の泡高さを測定する。
泡安定性は、1%の溶液を1000mLのビーカーに注いだ5分後の泡/空気の境界と泡/水の界面との差を用いて決定した。
インビトロ刺激性は、Matek Corporationの「EpiDerm MTT ET-50 Protocol (EPI-200)」を使用した外部の試験施設によって評価した。
泡抵抗は、65グラムの試験製品をブレンダー内に測定し、中間速度で約10秒間混合することによって決定した。その後、試験溶液を筒状体内に注ぎ、プラスチックボールを試験溶液内に落とし、プラスチックボールが第一の所定高さから第二の所定高さへ、例えば、筒状体の100mLの印から筒状体の40mLの印へ落ちるまでに何秒かかるかを測定した。
以下の数値は、様々なカチオン性活性成分、四級化糖に由来する界面活性剤、及び任意の泡促進性界面活性剤を用いた、本抗菌組成物の有効性のデータを実証する。
表15及び図3は、泡促進性界面活性剤、具体的にはアミンオキシドの濃度を増加させたときの有効性を示す。カチオン性活性成分(0.5%のADBAC Quat)、及び四級化糖に由来する界面活性剤(1.25%のポリトリモニウムヒドロキシプロピルココグルコシドクロリド)の量及び種類は一定に保った。下表9はこの試験の定量的な結果を示し、図3は視覚的な結果を示す。
Mackernium 007S − DADMAC/アクリルアミドコポリマー(Rhodia)
Uniquat QAC50 − 塩化ベンザルコニウム(Lonza)
Dissolvine 100S − エチレンジアミン四酢酸ナトリウム塩(Akzo Nobel)
Barlox 12 − N−アルキル(C12〜16)ジメチルアミンオキシド(Lonza)
Cola Lipid C − ココアミドプロピルPGジモニウムクロロホスフェート(Colonial Chemical)
PolySugaQuat TM8610P − ポリクォータニウム77(Colonial Chemical)
Glucam E20 − メチルグルセス20(Lubrizol)
Cetiol HE − PEG−7ヤシ脂肪酸グリセリル(Cognis)
Ritasol SP 1005 − PEG−12ジメチコン(Rita Corporation)
Hest G-18-O − グリセレス−18ヘキサン酸エチル(Global Seven)
Kathon CG − メチルイソチアゾリノン(DOW Chemical)
下表18に示すように、2つの異なるキレート剤以外は同じ成分で作った本発明の抗菌組成物。
Ca2+=5.2
EDTAの対数安定度定数
Ca2+=10.7
[1]
(a)カチオン性活性成分と;
(b)泡促進性界面活性剤と;
(c)泡促進性コポリマーと;
(d)下記の構造
式中、R 1 は、H、CH 3 、CH 2 CH 3 、CH 2 CH 2 CH 3 、C(CH 3 ) 3 、CH(CH 3 ) 2 又はこれらの組み合わせであり、R 2 は、分岐鎖又は直鎖C 1 〜C 9 アルキル鎖である、ジオールと;
(e)安定化定数(対数で表す)が5.5以上のカルシウム−キレート剤錯体を形成することができる、アミノカルボキシレートキレート剤と;
(f)水と
を含む、抗菌皮膚用濃縮物であって、
洗浄剤は、アニオン性界面活性剤、トリクロサン、及びC 1〜4 アルコールを実質的に含まない、抗菌皮膚用濃縮物。
[2]
前記洗浄剤は、少なくとも一つの前記カチオン性活性成分を約0.1質量%〜約10質量%含む、項目1に記載の抗菌皮膚用濃縮物。
[3]
カチオン性活性成分は、ビグアニドの塩、置換ビグアニド誘導体、第四級アンモニウム含有化合物の有機塩又は第四級アンモニウム含有化合物の無機塩、グルコン酸クロロヘキシデン(CHG)、及びグルコン酸クロロヘキシデン(CHG)の有機塩を含む群から選択される、項目1に記載の抗菌皮膚用濃縮物。
[4]
前記抗菌皮膚用濃縮物は、前記泡促進性界面活性剤を約0.05質量%〜約12質量%含む、項目1に記載の抗菌皮膚用濃縮物。
[5]
前記泡促進性界面活性剤は、四級化アルキルポリグルコシド、ポリ四級化アルキルポリグルコシド、アルキルアミンオキシド、アルキルエーテルアミンオキシド、及びポリエトキシル化グリセロールエステル、又はこれらの組み合わせを含む、項目1に記載の抗菌皮膚用濃縮物。
[6]
前記泡促進性界面活性剤は、アルキルアミンオキシド又はアルキルエーテルアミンオキシドを含む、項目1に記載の抗菌皮膚用濃縮物。
[7]
泡促進性ポリマーは、以下の構造を有するジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーである、項目1に記載の抗菌皮膚用濃縮物。
[8]
前記ジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーの分子量が、約500,000〜約5,000,000g/molである、項目7に記載のポリマー。
[9]
泡安定剤は、以下の構造
式中、Rは、H、CH 3 、CH 2 CH 3 、CH 2 CH 2 CH 3 、C(CH 3 ) 3 、CH(CH 3 ) 2 、又はこれらの組み合わせであり、R 2 は、分岐鎖又は直鎖C 1 〜C 9 アルキル鎖である、項目1に記載の抗菌濃縮物。
[10]
泡安定剤はヘキシレングリコールである、項目1に記載の抗菌濃縮物。
[11]
前記キレート剤は、エチレンジアミン四酢酸(EDTA);ジエチレントリアミン五酢酸(DTPA);メチルグリシン二酢酸(MGDA)、グルタミン酸−N,N−二酢酸(GLDA)、アスパラギン酸−N,N−二酢酸(ASDA)、並びにこれらのアルカリ金属塩及び/又はアンモニウム塩である、項目1に記載の抗菌皮膚用濃縮物。
[12]
前記濃縮物は、使用前又は使用時に希釈されて使用溶液を形成し、前記濃縮物対水の比率が約1:1〜約1:10である、項目1に記載の抗菌皮膚用濃縮物。
[13]
哺乳類の皮膚組織上の細菌、微生物、真菌、又はウィルスの数を減少させる方法であって:
項目1に記載の皮膚用濃縮物を、哺乳類の皮膚組織に十分な時間接触させて、細菌、微生物、真菌、又はウィルスの実質的な減少を提供することを含む、方法。
[14]
前記接触の充分な時間は約1〜約60秒である、項目13に記載の方法。
[15]
前記皮膚用濃縮物が、接触の後皮膚組織からすすぎ落とされる、又は接触の後皮膚組織上に残存する、項目13の方法。
[16]
前記皮膚用濃縮物を水で希釈して、前記濃縮物対水の比率が約1:1〜約1:10の使用溶液を形成する、項目13に記載の方法。
[17]
(a)カチオン性活性成分と;
(b)泡促進性界面活性剤と;
(c)泡促進性コポリマーと;
(d)下記の構造
式中、R 1 は、H、CH 3 、CH 2 CH 3 、CH 2 CH 2 CH 3 、C(CH 3 ) 3 、CH(CH 3 ) 2 又はこれらの組み合わせであり、R 2 は、分岐鎖又は直鎖C 1 〜C 9 アルキル鎖である、ジオールと;
(e)安定化定数(対数で表す)が5.5以上のカルシウム−キレート剤錯体を形成することができる、アミノカルボキシレートキレート剤と;
(f)水と
を含む、抗菌使用溶液であって、
洗浄剤は、アニオン性界面活性剤を実質的に含まず、トリクロサンを実質的に含まない、抗菌使用溶液。
[18]
前記洗浄剤は、ビグアニドの塩、置換ビグアニド誘導体、第四級アンモニウム含有化合物の有機塩又は第四級アンモニウム含有化合物の無機塩、グルコン酸クロロヘキシデン(CHG)、及びグルコン酸クロロヘキシデン(CHG)の有機塩からなる群から選択される少なくとも一つのカチオン成分を約100ppm〜約50,000ppm含む、項目17に記載の抗菌使用溶液。
[19]
前記泡促進性界面活性剤は、四級化アルキルポリグルコシド、第四級アルキルポリグルコシド、及びアルキルアミンオキシド、アルキルエーテルアミンオキシド、及びポリエトキシル化グリセロールエステル、又はこれらの組み合わせを含む、項目17に記載の抗菌組成物。
[20]
前記組成物は、前記泡促進性界面活性剤を約50ppm〜約50,000ppm含む、項目17に記載の抗菌組成物。
[21]
前記泡促進性ポリマーはジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーである、項目17に記載の抗菌組成物。
[22]
前記ジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーの分子量が、約500,000〜約5,000,000g/molである、項目17に記載のポリマー。
[23]
泡安定剤は、以下の構造
式中、Rは、H、CH 3 、CH 2 CH 3 、CH 2 CH 2 CH 3 、C(CH 3 ) 3 、CH(CH 3 ) 2 、又はこれらの組み合わせであり、R 2 は、分岐鎖又は直鎖C 1 〜C 9 アルキル鎖である、項目17に記載の抗菌濃縮物。
[24]
泡安定剤はヘキシレングリコールである、項目17に記載の抗菌組成物。
[25]
前記キレート剤は、エチレンジアミン四酢酸(EDTA)、ジエチレントリアミン五酢酸(DTPA)、メチルグリシン二酢酸(MGDA)、グルタミン酸−N,N−二酢酸(GLDA)、アスパラギン酸−N,N−二酢酸(ASDA)、並びにこれらのアルカリ金属塩及び/又はアンモニウム塩である、項目19に記載の抗菌組成物。
[26]
前記キレート剤は約10ppm〜約20,000ppmで存在する、項目25に記載の抗菌組成物。
[27]
哺乳類の皮膚組織上の細菌、微生物、真菌、又はウィルスの数を減少させる方法であって:
項目16に記載の組成物を、哺乳類の皮膚組織に十分な時間接触させて、細菌、微生物、真菌、又はウィルスの実質的な減少を提供することを含む、方法。
[28]
前記接触の充分な時間は約1〜約60秒である、項目17に記載の方法。
[29]
前記皮膚濃縮物が、接触の後皮膚組織からすすぎ落とされる、又は接触の後皮膚組織上に残存する、項目17に記載の方法。
Claims (17)
- (a)カチオン性活性成分と;
(b)泡促進性界面活性剤と;
(c)泡促進性コポリマーと;
(d)下記の構造
式中、R1は、H、CH3又はこれらの組み合わせであり、R2は、分岐鎖又は直鎖C1〜C9アルキル鎖であり、ただし、一分子内の炭素原子の総数は5〜12個である、泡安定剤と;
(e)安定化定数(対数で表す)が5.5以上のカルシウム−キレート剤錯体を形成することができる、アミノカルボキシレートキレート剤と;
(f)水と
を含む、抗菌皮膚用濃縮物であって、
前記抗菌皮膚用濃縮物は、アニオン性界面活性剤、トリクロサン、及びC1〜4アルコールを実質的に含まず、
前記泡促進性コポリマーは、以下の構造単位(i)及び(ii):
(i)一つ又は複数のカチオン性エチレン性不飽和モノマーに由来する第一の構造単位と;
(ii)一つ又は複数の水溶性モノマーに由来する第二の構造単位と
からなる疎水性変性カチオン性ポリマーを含み、
前記カチオン性活性成分は、ビグアニドの塩、置換ビグアニド誘導体、第四級アンモニウム含有化合物の有機塩又は第四級アンモニウム含有化合物の無機塩、グルコン酸クロロヘキシデン(CHG)、及びグルコン酸クロロヘキシデン(CHG)の有機塩からなる群から選択され、
前記泡促進性界面活性剤は、四級化アルキルポリグルコシド、ポリ四級化アルキルポリグルコシド、アルキルアミンオキシド、アルキルエーテルアミンオキシド、及びポリエトキシル化グリセロールエステル、又はこれらの組み合わせを含む、
抗菌皮膚用濃縮物。 - 前記抗菌皮膚用濃縮物は、少なくとも一つの前記カチオン性活性成分を0.1質量%〜10質量%含む、請求項1に記載の抗菌皮膚用濃縮物。
- 前記抗菌皮膚用濃縮物は、前記泡促進性界面活性剤を0.05質量%〜12質量%含む、請求項1に記載の抗菌皮膚用濃縮物。
- 前記泡促進性界面活性剤は、アルキルアミンオキシド又はアルキルエーテルアミンオキシドを含む、請求項1に記載の抗菌皮膚用濃縮物。
- 前記泡促進性コポリマーは、ジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーである、請求項1に記載の抗菌皮膚用濃縮物。
- 前記ジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーの分子量が、500,000〜5,000,000g/molである、請求項5に記載の抗菌皮膚用濃縮物。
- 前記泡安定剤はヘキシレングリコールである、請求項1に記載の抗菌皮膚用濃縮物。
- 前記キレート剤は、エチレンジアミン四酢酸(EDTA);ジエチレントリアミン五酢酸(DTPA);メチルグリシン二酢酸(MGDA)、グルタミン酸−N,N−二酢酸(GLDA)、アスパラギン酸−N,N−二酢酸(ASDA)、並びにこれらのアルカリ金属塩及び/又はアンモニウム塩である、請求項1に記載の抗菌皮膚用濃縮物。
- 前記抗菌皮膚用濃縮物は、使用前又は使用時に希釈されて使用溶液を形成し、前記濃縮物対水の比率が1:1〜1:10である、請求項1に記載の抗菌皮膚用濃縮物。
- (a)カチオン性活性成分と;
(b)泡促進性界面活性剤と;
(c)泡促進性コポリマーと;
(d)下記の構造
式中、R1は、H、CH3又はこれらの組み合わせであり、R2は、分岐鎖又は直鎖C1〜C9アルキル鎖であり、ただし、一分子内の炭素原子の総数は5〜12個である、泡安定剤と;
(e)安定化定数(対数で表す)が5.5以上のカルシウム−キレート剤錯体を形成することができる、アミノカルボキシレートキレート剤と;
(f)水と
を含む、抗菌使用溶液であって、
前記抗菌使用溶液は、アニオン性界面活性剤を実質的に含まず、トリクロサンを実質的に含まず、
前記泡促進性コポリマーは、以下の構造単位(i)及び(ii):
(i)一つ又は複数のカチオン性エチレン性不飽和モノマーに由来する第一の構造単位と;
(ii)一つ又は複数の水溶性モノマーに由来する第二の構造単位と
からなる疎水性変性カチオン性ポリマーを含み、
前記カチオン性活性成分は、ビグアニドの塩、置換ビグアニド誘導体、第四級アンモニウム含有化合物の有機塩又は第四級アンモニウム含有化合物の無機塩、グルコン酸クロロヘキシデン(CHG)、及びグルコン酸クロロヘキシデン(CHG)の有機塩からなる群から選択され、
前記泡促進性界面活性剤は、四級化アルキルポリグルコシド、ポリ四級化アルキルポリグルコシド、アルキルアミンオキシド、アルキルエーテルアミンオキシド、及びポリエトキシル化グリセロールエステル、又はこれらの組み合わせを含む、
抗菌使用溶液。 - 前記抗菌使用溶液は、前記カチオン活性成分を100ppm〜50,000ppm含む、請求項10に記載の抗菌使用溶液。
- 前記抗菌使用溶液は、前記泡促進性界面活性剤を50ppm〜50,000ppm含む、請求項10に記載の抗菌使用溶液。
- 前記泡促進性コポリマーはジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーである、請求項10に記載の抗菌使用溶液。
- 前記ジメチルジアリルアンモニウムクロリド−アクリルアミドコポリマーの分子量が、500,000〜5,000,000g/molである、請求項13に記載の抗菌使用溶液。
- 前記泡安定剤はヘキシレングリコールである、請求項10に記載の抗菌使用溶液。
- 前記キレート剤は、エチレンジアミン四酢酸(EDTA)、ジエチレントリアミン五酢酸(DTPA)、メチルグリシン二酢酸(MGDA)、グルタミン酸−N,N−二酢酸(GLDA)、アスパラギン酸−N,N−二酢酸(ASDA)、並びにこれらのアルカリ金属塩及び/又はアンモニウム塩である、請求項10に記載の抗菌使用溶液。
- 前記キレート剤は10ppm〜20,000ppmで存在する、請求項10に記載の抗菌使用溶液。
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PCT/US2015/018370 WO2015148063A1 (en) | 2014-03-25 | 2015-03-03 | Antimicrobial compositions containing cationic active ingredients |
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CN (1) | CN106232092B (ja) |
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Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150272124A1 (en) * | 2014-03-25 | 2015-10-01 | Ecolab Usa Inc. | Antimicrobial compositions containing cationic active ingredients |
US9956153B2 (en) * | 2014-08-01 | 2018-05-01 | Ecolab Usa Inc. | Antimicrobial foaming compositions containing cationic active ingredients |
US9775346B1 (en) | 2016-04-01 | 2017-10-03 | Roger Wilson | Hand sanitizer composition and method of manufacture |
US10561698B2 (en) | 2015-04-01 | 2020-02-18 | Roger Wilson | Hand sanitizer composition and method of manufacture |
EP3393240A1 (en) * | 2015-12-23 | 2018-10-31 | FMC Corporation | In situ treatment of seed in furrow |
JP6634284B2 (ja) * | 2015-12-25 | 2020-01-22 | 日油株式会社 | 濃縮抗菌剤組成物 |
EP3445169A4 (en) * | 2016-04-21 | 2019-09-25 | OMS Investments, Inc. | COMPOSITIONS OF A QUATERNARY AMMONIUM COMPOUND WITH A MONOCARBONATE ACID |
GB201611745D0 (en) * | 2016-07-05 | 2016-08-17 | Biocillin Therapeutics Ltd | Hygiene products |
JP6251787B1 (ja) * | 2016-08-18 | 2017-12-20 | 株式会社Adeka | 除菌用シート |
WO2018160818A1 (en) * | 2017-03-01 | 2018-09-07 | Ecolab Usa Inc. | Reduced inhalation hazard sanitizers and disinfectants via high molecular weight polymers |
WO2019046409A1 (en) | 2017-08-30 | 2019-03-07 | Ecolab Usa Inc. | MOLECULES HAVING A HYDROPHOBIC GROUP AND TWO IDENTICAL HYDROPHILIC IONIC GROUPS AND CORRESPONDING COMPOSITIONS |
RU2696259C2 (ru) * | 2017-10-23 | 2019-08-01 | Общество С Ограниченной Ответственностью "Сан Системз" | Солюбилизация хлоргексидина основания, антисептическая и дезинфицирующая композиции |
US11116220B2 (en) | 2017-12-22 | 2021-09-14 | Ecolab Usa Inc. | Antimicrobial compositions with enhanced efficacy |
US11419333B2 (en) * | 2018-01-19 | 2022-08-23 | Championx Usa Inc. | Compositions and methods for biofilm removal |
WO2019147496A1 (en) * | 2018-01-23 | 2019-08-01 | Kegel, Llc | Personal care cleaning product in tablet form |
CN112584910B (zh) | 2018-08-29 | 2023-03-14 | 埃科莱布美国股份有限公司 | 衍生自多胺的带多个电荷的离子化合物及其组合物和其作为反相破乳剂用于油气操作的用途 |
JP7171895B2 (ja) | 2018-08-29 | 2022-11-15 | エコラボ ユーエスエー インコーポレイティド | ポリアミンから誘導される多重荷電イオン性化合物およびその組成物、ならびにその調製方法 |
CN112601718A (zh) | 2018-08-29 | 2021-04-02 | 埃科莱布美国股份有限公司 | 衍生自伯胺或多胺的多电荷阳离子化合物在水系统中控制微生物结垢的用途 |
US11084974B2 (en) | 2018-08-29 | 2021-08-10 | Championx Usa Inc. | Use of multiple charged cationic compounds derived from polyamines for clay stabilization in oil and gas operations |
CA3110365C (en) | 2018-08-29 | 2023-05-09 | Ecolab Usa Inc. | Use of multiple charged ionic compounds derived from polyamines for waste water clarification |
US11155480B2 (en) | 2019-01-29 | 2021-10-26 | Ecolab Usa Inc. | Use of cationic sugar-based compounds as corrosion inhibitors in a water system |
US11155481B2 (en) | 2019-01-29 | 2021-10-26 | Ecolab Usa Inc. | Use of cationic sugar-based compounds for microbial fouling control in a water system |
JP2022520089A (ja) * | 2019-02-13 | 2022-03-28 | ローディア オペレーションズ | 長期間持続する殺菌剤洗浄組成物及びその使用方法 |
AU2019441168B2 (en) | 2019-04-16 | 2023-02-02 | Ecolab Usa Inc. | Use of multiple charged cationic compounds derived from polyamines and compositions thereof for corrosion inhibition in a water system |
JP2021138652A (ja) * | 2020-03-05 | 2021-09-16 | 日油株式会社 | 消毒剤組成物 |
RU2738595C1 (ru) * | 2020-03-17 | 2020-12-14 | Марина Михайловна Бурмина | Лечебно-косметическая композиция |
US20210330698A1 (en) | 2020-04-23 | 2021-10-28 | Johnson & Johnson Consumer Inc. | Methods and compositions for inhibiting enveloped viruses using low molecular weight hydrophobically modified polymers |
US20210330700A1 (en) | 2020-04-23 | 2021-10-28 | Johnson & Johnson Consumer Inc. | Methods and compositions for inhibiting influenza viruses using low molecular weight hydrophobically modified polymers and polyalkylene glycols |
US11690869B2 (en) | 2020-04-23 | 2023-07-04 | Johnson & Johnson Consumer Inc. | Methods of inhibiting enveloped viruses using low molecular weight hydrophobically modified polymers |
US20210330701A1 (en) | 2020-04-23 | 2021-10-28 | Johnson & Johnson Consumer Inc. | Methods and compositions for inhibiting enveloped viruses using high molecular weight hydrophobically modified alkali swellable emulsion polymers and surfactant |
US12076414B2 (en) | 2020-04-23 | 2024-09-03 | Johnson & Johnson Consumer Inc. | Methods and compositions inhibiting enveloped viruses using high molecular weight hydrophobically modified alkali swellable emulsion polymers |
MX2022016361A (es) * | 2020-06-30 | 2023-01-30 | Unilever Ip Holdings B V | Composicion desinfectante. |
US20240016148A1 (en) * | 2022-05-20 | 2024-01-18 | The Procter & Gamble Company | Methods for potentiating a biocide |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3664961A (en) | 1970-03-31 | 1972-05-23 | Procter & Gamble | Enzyme detergent composition containing coagglomerated perborate bleaching agent |
US4764365A (en) | 1986-10-27 | 1988-08-16 | Calgon Corporation | Personal skin care products containing dimethyl diallyl ammonium chloride/acrylic acid-type polymers |
US5234618A (en) | 1989-10-09 | 1993-08-10 | Kao Corporation | Liquid detergent composition |
US5225095A (en) * | 1991-08-02 | 1993-07-06 | Chubb National Foam, Inc. | Foam concentrate |
US5188756A (en) | 1991-08-07 | 1993-02-23 | Kolmar Laboratories, Inc. | Topical cleansing and conditioning composition |
US6592873B1 (en) | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
US5415814A (en) | 1993-08-27 | 1995-05-16 | The Procter & Gamble Company | Concentrated liquid or gel light duty dishwashing detergent composition containing calcium xylene sulfonate |
US5417893A (en) | 1993-08-27 | 1995-05-23 | The Procter & Gamble Company | Concentrated liquid or gel light duty dishwashing detergent compositions containing calcium ions and disulfonate surfactants |
US5635462A (en) * | 1994-07-08 | 1997-06-03 | Gojo Industries, Inc. | Antimicrobial cleansing compositions |
US5653970A (en) | 1994-12-08 | 1997-08-05 | Lever Brothers Company, Division Of Conopco, Inc. | Personal product compositions comprising heteroatom containing alkyl aldonamide compounds |
US5707959A (en) | 1995-05-31 | 1998-01-13 | The Procter & Gamble Company | Processes for making a granular detergent composition containing a crystalline builder |
US5756446A (en) | 1996-05-07 | 1998-05-26 | Henkel Corporation | Sugar surfactants having enhanced tactile properties |
AU726543B2 (en) | 1996-07-10 | 2000-11-09 | S.C. Johnson & Son, Inc. | Triclosan skin wash with enhanced efficacy |
AUPO690997A0 (en) | 1997-05-20 | 1997-06-12 | Novapharm Research (Australia) Pty Ltd | Alkylpolyglucosides containing disinfectant compositions active against pseudomonas microorganism |
US6057274A (en) | 1997-08-22 | 2000-05-02 | Henkel Corporation | Antibacterial composition having enhanced tactile properties |
SE511873C2 (sv) | 1997-08-27 | 1999-12-13 | Akzo Nobel Nv | Katjoniska sockertensider från etoxilerade ammoniumföreningar och reducerande sackarider samt användning därav som hydrotoper för tensider |
CO5040174A1 (es) | 1997-12-12 | 2001-05-29 | Colgate Palmolive Co | Composiciones antimicrobianas para multiples propositos en microemulsion que contienen un tensioactivo cationico |
DE60045761D1 (de) | 1999-01-28 | 2011-05-05 | Canon Kk | Elektronenstrahlgerät |
US6221828B1 (en) | 1999-02-12 | 2001-04-24 | Kao Corporation | Detergent composition comprising an alkylpolyglycoside, a germicide, and a fatty acid salt |
US6369021B1 (en) | 1999-05-07 | 2002-04-09 | Ecolab Inc. | Detergent composition and method for removing soil |
US6130196A (en) | 1999-06-29 | 2000-10-10 | Colgate-Palmolive Co. | Antimicrobial multi purpose containing a cationic surfactant |
US7074747B1 (en) * | 1999-07-01 | 2006-07-11 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
DE19933404A1 (de) | 1999-07-21 | 2001-01-25 | Henkel Kgaa | Reinigungsmittel für harte Oberflächen |
US6140289A (en) | 2000-01-24 | 2000-10-31 | Colgate-Palmolive Company | Antimicrobial cleaning composition containing a cationic surfactant |
US20010044393A1 (en) * | 2000-02-18 | 2001-11-22 | Peterson Robert Frederick | Rinse-off antimicrobial liquid cleansing composition |
US20030074742A1 (en) | 2000-03-03 | 2003-04-24 | General Electric Company | Siloxane dry cleaning composition and process |
US6764989B1 (en) | 2000-10-02 | 2004-07-20 | Huish Detergents, Inc. | Liquid cleaning composition containing α-sulfofatty acid ester |
US20020183233A1 (en) | 2000-12-14 | 2002-12-05 | The Clorox Company, Delaware Corporation | Bactericidal cleaning wipe |
US7345015B1 (en) | 2006-12-19 | 2008-03-18 | The Clorox Company | Low residue cleaning solution for disinfecting wipes comprising a C8-10 alkyl polyglycoside |
US6395691B1 (en) | 2001-02-28 | 2002-05-28 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Personal wash compositions containing particle-in-oil dispersion |
US6616922B2 (en) * | 2001-03-27 | 2003-09-09 | The Dial Corporation | Antibacterial compositions |
WO2003070867A1 (en) | 2002-02-22 | 2003-08-28 | Kao Corporation | Antifouling detergent for hard surfaces |
JP4230153B2 (ja) | 2002-02-22 | 2009-02-25 | 花王株式会社 | 硬質表面用防汚洗浄剤 |
GB2392450A (en) * | 2002-08-31 | 2004-03-03 | Reckitt Benckiser Inc | Liquid detergent compositions |
US20050176614A1 (en) | 2002-10-16 | 2005-08-11 | Heinz-Dieter Soldanski | Transparent abrasive cleaning product, especially manual dishwashing liquid |
US20040136940A1 (en) | 2002-10-31 | 2004-07-15 | Virginia Lazarowitz | Cleaner compositions |
JP2004224703A (ja) * | 2003-01-20 | 2004-08-12 | Teepol Diversey Kk | 手指用殺菌洗浄剤組成物 |
US7250392B1 (en) | 2003-03-07 | 2007-07-31 | Cognis Corporation | Surfactant blend for cleansing wipes |
CN1759168A (zh) | 2003-04-14 | 2006-04-12 | 花王株式会社 | 清洁剂组合物 |
US20050000030A1 (en) | 2003-06-27 | 2005-01-06 | Dupont Jeffrey Scott | Fabric care compositions for lipophilic fluid systems |
JP4050676B2 (ja) | 2003-08-22 | 2008-02-20 | 花王株式会社 | 洗浄料 |
US7084129B1 (en) | 2003-09-15 | 2006-08-01 | Colonial Chemical | Antimicrobial quaternary surfactants based upon alkyl polyglycoside |
JP2005154360A (ja) * | 2003-11-27 | 2005-06-16 | Lion Corp | 皮膚洗浄剤組成物 |
US7507399B1 (en) | 2004-08-05 | 2009-03-24 | Surfatech Corporation | Functionalized polymeric surfactants based upon alkyl polyglycosides |
US20090069436A1 (en) | 2004-08-05 | 2009-03-12 | Ebiox, Ltd. | Antimicrobial skin composition comprising a biguanide or a quaternium compound |
US6906023B1 (en) | 2004-08-18 | 2005-06-14 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Soap bars comprising high levels of sugars made by extrusion route |
US6906018B1 (en) | 2004-08-18 | 2005-06-14 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Extrudable soap bars comprising high levels of sugars |
WO2006042316A1 (en) | 2004-10-12 | 2006-04-20 | Pantheon Chemical, Inc | Composition for cleaning and degreasing, system for using the composition, and methods of forming and using the composition |
DE102004051420A1 (de) | 2004-10-22 | 2006-05-04 | Merz Pharma Gmbh & Co. Kgaa | Treibgasfreie schaumbildende, insbesondere hypoallergene Systeme für pharmazeutisch-dermatologische, kosmetische und hygienische Anwendungen und deren Herstellung |
KR101292027B1 (ko) | 2005-05-23 | 2013-08-05 | 다우 코닝 코포레이션 | 사카라이드-실록산 공중합체를 포함하는 표면처리 조성물 |
GB0525504D0 (en) * | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
US7179779B1 (en) | 2006-01-06 | 2007-02-20 | North Carolina State University | Cationic bleach activator with enhanced hydrolytic stability |
DE102007039649A1 (de) | 2006-12-05 | 2008-06-12 | Henkel Kgaa | Reinigungsmittel für harte Oberflächen |
EP2192887A1 (en) | 2007-08-29 | 2010-06-09 | Agency for Science, Technology And Research | Sugar-based surfactant microemulsions containing essential oils for cosmetic and pharmaceutical use |
JP5522647B2 (ja) * | 2008-03-31 | 2014-06-18 | 株式会社 資生堂 | 起泡性皮膚洗浄料 |
US9095134B2 (en) | 2010-09-22 | 2015-08-04 | Ecolab Usa Inc. | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants |
US9232790B2 (en) | 2011-08-02 | 2016-01-12 | Kimberly-Clark Worldwide, Inc. | Antimicrobial cleansing compositions |
CA2867879A1 (en) * | 2012-03-30 | 2013-10-03 | Gojo Industries, Inc. | Cationic antimicrobial handwash |
US20150272124A1 (en) * | 2014-03-25 | 2015-10-01 | Ecolab Usa Inc. | Antimicrobial compositions containing cationic active ingredients |
US9956153B2 (en) * | 2014-08-01 | 2018-05-01 | Ecolab Usa Inc. | Antimicrobial foaming compositions containing cationic active ingredients |
-
2014
- 2014-03-25 US US14/225,039 patent/US20150272124A1/en not_active Abandoned
-
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- 2015-03-03 AU AU2015236680A patent/AU2015236680B2/en active Active
- 2015-03-03 BR BR112016022235-0A patent/BR112016022235B1/pt active IP Right Grant
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- 2015-03-03 CN CN201580020889.2A patent/CN106232092B/zh active Active
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- 2015-03-03 JP JP2016558710A patent/JP6392890B2/ja active Active
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2016
- 2016-05-20 US US15/160,580 patent/US11590065B2/en active Active
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US20160262999A1 (en) | 2016-09-15 |
US20150272124A1 (en) | 2015-10-01 |
BR112016022235B1 (pt) | 2021-03-23 |
MX2016012370A (es) | 2016-12-02 |
CN106232092B (zh) | 2020-07-14 |
EP3122327A4 (en) | 2017-12-13 |
EP3122327A1 (en) | 2017-02-01 |
JP2017510581A (ja) | 2017-04-13 |
US11590065B2 (en) | 2023-02-28 |
WO2015148063A1 (en) | 2015-10-01 |
CA2943619C (en) | 2021-05-04 |
AU2015236680A1 (en) | 2016-09-29 |
CN106232092A (zh) | 2016-12-14 |
AU2015236680B2 (en) | 2017-07-06 |
CA2943619A1 (en) | 2015-10-01 |
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