JP6373280B2 - イミダゾピリジン化合物及びその使用 - Google Patents

イミダゾピリジン化合物及びその使用 Download PDF

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JP6373280B2
JP6373280B2 JP2015555508A JP2015555508A JP6373280B2 JP 6373280 B2 JP6373280 B2 JP 6373280B2 JP 2015555508 A JP2015555508 A JP 2015555508A JP 2015555508 A JP2015555508 A JP 2015555508A JP 6373280 B2 JP6373280 B2 JP 6373280B2
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methyl
salt
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salt according
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JP2016506935A5 (enExample
JP2016506935A (ja
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クリストフ・ブオン
ルイ−ダヴィド・カンタン
ユイン−ジン・ホゥ
シュエホーン・ルオ
ミロスロー・ジャージー・トマスゼウスキー
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ネオメド・インスティチュート
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015555508A 2013-01-31 2014-01-31 イミダゾピリジン化合物及びその使用 Active JP6373280B2 (ja)

Applications Claiming Priority (3)

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US201361759123P 2013-01-31 2013-01-31
US61/759,123 2013-01-31
PCT/CA2014/050062 WO2014117274A1 (en) 2013-01-31 2014-01-31 Imidazopyridine compounds and uses thereof

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JP2016506935A JP2016506935A (ja) 2016-03-07
JP2016506935A5 JP2016506935A5 (enExample) 2017-11-30
JP6373280B2 true JP6373280B2 (ja) 2018-08-15

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US (9) US9598409B2 (enExample)
EP (3) EP3998267A1 (enExample)
JP (1) JP6373280B2 (enExample)
KR (1) KR102120513B1 (enExample)
CN (2) CN107485612B (enExample)
AU (1) AU2014211962B2 (enExample)
BR (1) BR112015018317B1 (enExample)
CA (1) CA2898665C (enExample)
DK (2) DK3381917T3 (enExample)
ES (2) ES2674087T3 (enExample)
MX (1) MX372934B (enExample)
NO (1) NO2910833T3 (enExample)
PL (2) PL2951177T3 (enExample)
PT (2) PT2951177T (enExample)
RU (1) RU2656593C2 (enExample)
TR (1) TR201807602T4 (enExample)
WO (1) WO2014117274A1 (enExample)

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IL282087B2 (en) * 2018-10-10 2025-11-01 Bellus Health Cough Inc 4-(imidazo[1,2-a]pyridin-3-yl)-benzamide derivatives for treating pruritus
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KR102797127B1 (ko) * 2018-12-29 2025-04-21 우한 크리에이터나 사이언스 앤드 테크놀로지 컴퍼니, 리미티드 헤테로고리계 화합물, 중간체, 이의 제조 방법 및 용도
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JP2023513373A (ja) * 2020-02-14 2023-03-30 べルス・ヘルス・コフ・インコーポレーテッド Ｐ２ｘ３修飾薬
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CN114085220B (zh) * 2020-06-22 2023-06-16 上海海雁医药科技有限公司 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途
WO2022001820A1 (zh) * 2020-06-29 2022-01-06 武汉朗来科技发展有限公司 杂环类化合物的晶型及其制备方法和应用
CN113912601B (zh) * 2020-07-10 2023-06-06 上海拓界生物医药科技有限公司 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途
WO2022033567A1 (zh) * 2020-08-13 2022-02-17 上海拓界生物医药科技有限公司 苯并咪唑类衍生物、其制备方法及医药用途
CN112485351A (zh) * 2020-11-18 2021-03-12 天津华津制药有限公司 一种右佐匹克隆光学异构体的检测方法
TW202227458A (zh) * 2020-12-04 2022-07-16 大陸商上海拓界生物醫藥科技有限公司 含有稠合三環的化合物及其醫藥用途
WO2022156784A1 (zh) * 2021-01-22 2022-07-28 武汉人福创新药物研发中心有限公司 杂环类化合物的制备方法及其中间体
WO2022156783A1 (zh) * 2021-01-22 2022-07-28 武汉人福创新药物研发中心有限公司 咪唑并吡啶类化合物的制备方法及其中间体
WO2022258059A1 (zh) * 2021-06-10 2022-12-15 武汉朗来科技发展有限公司 一种药物组合物、制剂及其制备方法和应用
CN117460720B (zh) * 2021-06-24 2026-02-24 武汉朗来科技发展有限公司 一种杂环烷基类化合物的制备方法、其中间体及其应用
WO2023021328A1 (en) * 2021-08-17 2023-02-23 Bellus Health Cough Inc. Preparation of a p2x3 antagonist
WO2023020156A1 (zh) * 2021-08-20 2023-02-23 苏州璞正医药有限公司 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途
WO2024194352A1 (en) 2023-03-23 2024-09-26 Glaxosmithkline Intellectual Property (No.3) Limited Deuterated p2x3 modulators
CN119490467A (zh) * 2023-08-17 2025-02-21 武汉朗来科技发展有限公司 一种含二溴乙烯基的杂环烷化合物及其制备方法和应用
CN122374304A (zh) 2023-12-12 2026-07-10 葛兰素史密斯克莱知识产权(第3号)有限公司 包括卡姆利皮克桑特的p2x3拮抗剂的制造方法
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US9598409B2 (en) 2017-03-21
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US20190030040A1 (en) 2019-01-31
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