JP6345690B2 - 改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用 - Google Patents

改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用 Download PDF

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JP6345690B2
JP6345690B2 JP2015547567A JP2015547567A JP6345690B2 JP 6345690 B2 JP6345690 B2 JP 6345690B2 JP 2015547567 A JP2015547567 A JP 2015547567A JP 2015547567 A JP2015547567 A JP 2015547567A JP 6345690 B2 JP6345690 B2 JP 6345690B2
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axl
mer
tyro3
polypeptide
gas6
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Japanese (ja)
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JP2016510309A5 (enExample
JP2016510309A (ja
Inventor
ジェイ． ジャシア，アマート
ジェイ． ジャシア，アマート
ブルーノ ランキン，エリン
ブルーノ ランキン，エリン
アール． コクラン，ジェニファー
アール． コクラン，ジェニファー
ジョーンズ，ダグラス
カリオリス，ミハリス
フウ，キャサリン
ミャオ，ユー
ハーシェンソン，スーザン
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Aravive Biologics Inc
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Aravive Biologics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015547567A 2012-12-14 2013-12-12 改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用 Active JP6345690B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261737276P 2012-12-14 2012-12-14
US61/737,276 2012-12-14
PCT/US2013/074786 WO2014093690A1 (en) 2012-12-14 2013-12-12 Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy

Related Child Applications (1)

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JP2018098435A Division JP6832887B2 (ja) 2012-12-14 2018-05-23 改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用

Publications (3)

Publication Number Publication Date
JP2016510309A JP2016510309A (ja) 2016-04-07
JP2016510309A5 JP2016510309A5 (enExample) 2017-02-02
JP6345690B2 true JP6345690B2 (ja) 2018-06-20

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JP2015547567A Active JP6345690B2 (ja) 2012-12-14 2013-12-12 改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用
JP2018098435A Expired - Fee Related JP6832887B2 (ja) 2012-12-14 2018-05-23 改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用

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JP2018098435A Expired - Fee Related JP6832887B2 (ja) 2012-12-14 2018-05-23 改変ａｘｌペプチド及び抗転移療法のａｘｌシグナル伝達阻害におけるその使用

Country Status (11)

Country Link
US (3) US9822347B2 (enExample)
EP (2) EP3326622B1 (enExample)
JP (2) JP6345690B2 (enExample)
AU (3) AU2013359179B2 (enExample)
CA (1) CA2894539C (enExample)
DK (2) DK3326622T3 (enExample)
ES (2) ES2862335T3 (enExample)
FI (1) FI2931265T6 (enExample)
NO (1) NO3049208T3 (enExample)
PT (2) PT3326622T (enExample)
WO (1) WO2014093690A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9074192B2 (en) * 2010-01-22 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
RU2556822C2 (ru) * 2010-01-22 2015-07-20 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Ингибирование axl сигнализации в антиметастатической терапии
WO2013090776A1 (en) 2011-12-15 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of axl/gas6 signaling in the treatment of disease
FI2931265T6 (fi) 2012-12-14 2023-05-23 Muokattuja axl-peptidejä ja niiden käyttö axl-viestinvälityksen estossa etäispesäkkeitä estävässä hoidossa
CA2909669C (en) 2014-10-20 2023-12-12 Ruga Corporation Antiviral activity of gas6 inhibitor
EP3233902B1 (en) * 2014-12-18 2020-09-09 Aravive Biologics, Inc. Antifibrotic activity of gas6 inhibitor
KR20200085307A (ko) * 2017-11-04 2020-07-14 아라바이브 바이올로직스, 인크. Axl 유인 수용체를 이용한 전이성 암의 치료 방법
JP2024533362A (ja) * 2021-09-11 2024-09-12 アラヴィヴ インコーポレイテッド Ａｘｌデコイ受容体を一次治療として使用する局所進行又は転移性膵臓腺がんを治療する方法

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US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP0394827A1 (en) 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
US5538861A (en) 1994-07-29 1996-07-23 Amgen Inc. DNA encoding a stimulating factor for the axl receptor
US20030166107A1 (en) 1997-09-18 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP1382969A1 (en) 2002-07-17 2004-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnosis and prevention of cancer cell invasion
AU2003304180A1 (en) 2002-09-24 2005-01-04 Dow, Kenneth, Centocor, Inc. Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
US20070142273A1 (en) 2003-04-18 2007-06-21 Sherif Daouti Methods and compositions targeting tyrosine kinases for the diagnosis and treatment of osteoarthritis
JP2005278631A (ja) 2004-03-04 2005-10-13 National Institute Of Advanced Industrial & Technology Ａｘｌリガンド結合領域蛋白質、その製造方法及びそれを用いたスクリーニング方法
CA2630475A1 (en) 2004-11-24 2006-06-01 The Regents Of The University Of Colorado Mer diagnostic and therapeutic agents
US7932032B2 (en) 2005-05-02 2011-04-26 Toray Industries, Inc. Method for diagnosing esophageal cancer
US8168415B2 (en) * 2007-02-07 2012-05-01 The Regents Of The University Of Colorado Axl fusion proteins as Axl tyrosine kinase inhibitors
CN101679313A (zh) 2007-04-13 2010-03-24 休普基因公司 用于治疗癌症或过度增殖性疾病的axl激酶抑制剂
CA2692320A1 (en) 2007-07-02 2009-01-08 Wyeth Methods of treating bone disorders with modulators of axl
US20120230991A1 (en) 2008-07-29 2012-09-13 Douglas Kim Graham Methods and compounds for enhancing anti-cancer therapy
CA2747678A1 (en) * 2008-12-19 2010-06-24 Novartis Ag Soluble polypeptides for use in treating autoimmune and inflammatory disorders
KR20120035145A (ko) 2009-05-11 2012-04-13 우드라이 파마 게엠베하 인간화 ａｘｌ 항체
US9074192B2 (en) * 2010-01-22 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
RU2556822C2 (ru) * 2010-01-22 2015-07-20 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Ингибирование axl сигнализации в антиметастатической терапии
AU2011326164B2 (en) 2010-11-08 2016-05-05 The Board Of Trustees Of The Leland Stanford Junior University Fusion proteins comprising an engineered knottin peptide and uses thereof
WO2013090776A1 (en) * 2011-12-15 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of axl/gas6 signaling in the treatment of disease
US20150315552A1 (en) 2012-12-14 2015-11-05 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL Signaling in Primary Tumor Therapy
FI2931265T6 (fi) 2012-12-14 2023-05-23 Muokattuja axl-peptidejä ja niiden käyttö axl-viestinvälityksen estossa etäispesäkkeitä estävässä hoidossa
US20160266136A1 (en) * 2013-08-30 2016-09-15 The Board Of Trustees Of The Leland Stanford Junior University High-affinity binding to gas6
CA2909669C (en) * 2014-10-20 2023-12-12 Ruga Corporation Antiviral activity of gas6 inhibitor
EP3233902B1 (en) * 2014-12-18 2020-09-09 Aravive Biologics, Inc. Antifibrotic activity of gas6 inhibitor

Also Published As

Publication number Publication date
DK2931265T3 (en) 2018-04-16
FI2931265T6 (fi) 2023-05-23
ES2665323T7 (es) 2023-06-15
EP3326622B1 (en) 2021-01-20
AU2013359179B2 (en) 2017-10-05
ES2862335T3 (es) 2021-10-07
AU2017272193A1 (en) 2017-12-21
AU2013359179A1 (en) 2015-07-02
WO2014093690A1 (en) 2014-06-19
US9822347B2 (en) 2017-11-21
DK2931265T6 (da) 2023-05-01
NO3049208T3 (enExample) 2018-04-14
CA2894539C (en) 2021-09-28
JP6832887B2 (ja) 2021-02-24
ES2665323T3 (es) 2018-04-25
CA2894539A1 (en) 2014-06-19
US20150315553A1 (en) 2015-11-05
US20180030422A1 (en) 2018-02-01
AU2019210662A1 (en) 2019-08-22
US11136563B2 (en) 2021-10-05
EP2931265A1 (en) 2015-10-21
HK1256071A1 (en) 2019-09-13
PT3326622T (pt) 2021-04-07
EP2931265A4 (en) 2016-08-31
JP2016510309A (ja) 2016-04-07
PT2931265T (pt) 2018-04-16
EP2931265B1 (en) 2018-01-31
US20220220458A1 (en) 2022-07-14
EP2931265B3 (en) 2023-04-05
EP3326622A1 (en) 2018-05-30
AU2019210662B2 (en) 2021-07-01
DK3326622T3 (da) 2021-04-06
JP2018154641A (ja) 2018-10-04

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